• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1553-1558
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• 2015

Background: COX-2 has been shown to play an important role in the development of breast cancer and increased expression has been mooted as a poor prognostic factor. The purpose of this study was to investigate the relationship between COX-2 immunohistochemical expression and known predictive and prognostic factors in breast cancer in a routine diagnostic histopathology setting. Materials and Methods: Formalin-fixed paraffin-embedded tumour tissue of 144 no special type (NST) invasive breast carcinomas histologically diagnosed between January 2009 and December 2012 in Hospital Sultanah Bahiyah, Alor Setar, Kedah were immunostained with COX-2 antibody. COX-2 overexpression was analysed against demographic data, hormone receptor status, HER2-neu overexpression, histological grade, tumour size and lymph node status. Results: COX-2 was overexpressed in 108/144 (75%) tumours and was significantly more prevalent (87%) in hormone receptor-positive tumours. There was no correlation between COX-2 overexpression and HER2/neu status. Triple negative cancers had the lowest prevalence (46%) (p<0.05). A rising trend of COX-2 overexpression with increasing age was observed. There was a significant inverse relationship with tumour grade (p<0.05), prevalences being 94%, 83% and 66% in grades 1, 2 and 3 tumours, respectively. A higher prevalence of COX-2 overexpression in smaller size tumours was observed but this did not reach statistical significance. There was no relationship between COX-2 expression and lymph node status. Conclusions: This study did not support the generally held notion that COX-2 overexpression is linked to poor prognosis, rather supporting a role in tumorigenesis. Larger scale studies with outcome data and basic studies on cancer pathogenetic pathways will be required to cast further light on whether COX-2 inhibitors would have clinical utility in cancer prevention or blockage of cancer progression. In either setting, the pathological assessment for COX-2 overexpression in breast cancers would have an important role in the selection of cancer patients for personalized therapy with COX-2 inhibitors.

• 성인간호학회지
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• 제28권5호
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• pp.585-594
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• 2016

Purpose: The purpose of this study was to develop and test a predictive model on the male nurses' turnover intention. Methods: This study utilized the model-testing design based on the Price's causal model of turnover. This study collected data from 306 male nurses on a national scale with structured questionnaires measuring job opportunity, kinship responsibility, positive emotion, work autonomy, role conflict, work satisfaction, organizational commitment, and turnover intention. The data were analyzed using SPSS/WIN 22.0 program and AMOS 20.0 program. Results: As the outcomes satisfied the recommended level, the hypothetical model appeared to fit the data. Twenty-seven of the 38 hypotheses selected for the hypothetical model were statistically significant. 54.2% of turnover intention was explained by job opportunity, kinship responsibility, positive emotion, work autonomy, role conflict, work satisfaction and organizational commitment. Conclusion: The hypothetical model of this study was confirmed to be adequate in explaining and predicting male nurses' turnover intention. Findings from this study can be used to design appropriate strategies to decrease the male nurse's turnover intention.

• 통합자연과학논문집
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• 제6권3호
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• pp.163-169
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• 2013

The chemokine receptor CCR1 a GPCR super family protein contains seven transmembrane domains. It plays an important role in rheumatoid arthritis, organ transplant rejection, Alzheimer's disease and also causes inflammation. Because of its role in disease processes, antagonism of CCR1 became an attractive therapeutic target. In the current study, we have taken a novel series of recently reported CCR1 antagonist of 1-(4-Phenylpiperazin-1-yl_-2-(1H-Pyrazol-1-yl) ethanone derivatives and performed a HQSAR analysis. The model was developed with Atom (A) and bond (B) parameters and with different set of atom counts to improve the model. The results of HQSAR showed good predictive ability in terms of $r^2$ (0.904) and $q^2$ (0.590) with 0.710 as standard error of prediction and 0.344 as standard error of estimate. The contribution map depicted the atom contribution in inhibitory effect. Compound-14 which was reported to be a highly active compound showed positive atom contribution in three R groups ($R^3$. $R^{5a}$ and $R^{2b}$) in inhibitory effect, which could be the reason why this compound is highly active compound whereas, the lowest active compound-6 showed negative contribution to inhibitory effect.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4049-4052
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• 2013

Resistance to chemotherapy treatment, which may lead to limited efficacy of systemic therapy in breast cancer patients, is multifactorial. Among the mechanisms of resistance to chemotherapy treatment, there are those closely related to estrogen receptor ${\alpha}$, P-glycoprotein, multidrug resistance-related protein, glutathione S-transferase pi and topoisomerase-II. $ER{\alpha}$ is ligand-activated transcription factor that regulates gene expression and plays a critical role in endocrine signaling. In previous preclinical and clinical studies, positive $ER{\alpha}$ expression in breast cancer cells was correlated with decreased sensitivity to chemotherapy. This article reviews current knowledge on the predictive value of $ER{\alpha}$ with regard to response to chemotherapy. Better understanding of its role may facilitate patient selection of therapeutic regimens and lead to optimal clinical outcomes.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.53-58
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• 2015

Background: The purpose of this study was to assess the the efficacy of oral glutamine (GLN) in prevention of acute radiation-induced esophagitis in patients with lung cancer and determine the predictive role of clinical and dosimetric parameters. Materials and Methods: Thirty-two patients diagnosed with lung cancer were studied prospectively. Sixteen patients (50%) received prophylactic powdered GLN orally in doses of 10g/8h. Patients were treated 2 Gy per fraction daily, 5 days a week. We evaluated the grading of esophagitis daily at the end of each fraction of each treatment day until a cumulative dose of 50 Gy was reached. The primary end point was radiation-induced esophagitis. Results: All patients tolerated GLN well. Toxicity grade, weight loss, serum cytokine levels and esophageal transit times exhibited statistically significant improvement in the GLN receiving group. GLN suppressed the inflammation related to the disease and treatment and reduced toxicity with statistical significance. Conclusions: This study suggests a benefical role of oral GLN use in prevention and/or delay of radiation-induced esophagitis, in terms of esophageal transit time and serum immunological parameters, as well as weight loss.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1992년도 춘계학술대회 논문집
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• pp.385-389
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• 1992

The position control of the electro-hydraulic servo indexing system in a flexible forging machine was investigated. The role of an Electro-hydraulic servoindexing system is to rotate a workpiect fast and accurately to a desired position. Since the inertia of a workpiece changes during each forging step, an adapt control scheme could be adopted to the position control of the workpiece. A generalized predictive control method which depends on predicting the plant output over several steps ahead based on the assumption about future control actions is proposed. The perormance of the proposed GPC algorithm is investigated experimentally and compared with that of PID control. Experimental results show that the proposed GPC algorithm is satisfactory for the position control of the workpiece of an electrohydraulic indexing system.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3119-3121
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• 2012

Non-small-cell lung cancer (NSCLC) is a leading cause of cancer deaths worldwide. Crizotinib has been approved by the U.S. Food and Drug Administration for the treatment of patients with advanced NSCLC. However, understanding of mechanisms of action is still limited. In our studies, we confirmed crizotinib-induced apoptosis in A549 lung cancer cells. In order to assess mechanisms, small molecular docking technology was used as a preliminary simulation of signaling pathways. Interesting, our results of experiments were consistent with the results of computer simulation. This indicates that small molecular docking technology should find wide use for its reliability and convenience.

• 유통과학연구
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• 제18권11호
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• pp.69-77
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• 2020

Purpose: This research aims to verify the role of mobile shopping attributes, trustworthiness, and cultural dimensions on mobile shopping intentions in Saudi Arabia. The originality of the model stems from the verification of the moderating impact of cultural variables, namely collectivism and masculinity, and from the integration of trustworthiness as a variable depending on mobile shopping attributes. Research design, data and methodology: A survey was distributed to 233 consumers with different nationalities living in the Kingdom of Saudi Arabia. Structural equation modeling and multi-group analysis were carried out to verify the conceptual model and the moderating variables. Results: The findings support the influence of several innovation attributes, namely complexity and trialability on behavioral intentions, while relative advantage has a direct impact on trustworthiness. A few paths are moderated by masculinity and collectivism. Conclusions: Culture and mobile commerce attributes need to be thought out by managers as factors influencing mobile commerce segmentation for expatriates and locals. Trustworthiness is also a key factor of mobile shopping adoption. Limitations and future research ideas are presented to enrich the proposed model and improve its predictive validity.

• Computers and Concrete
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• 제22권2호
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• pp.239-248
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• 2018

TBM penetration rate is a function of intact rock properties, rock mass conditions and TBM operational parameters. Machine rate of penetrationcan be predicted by knowledge of the ground conditions and its effects on machine performance. The variation of TBM operational parameters such as penetration rate and thrust plays an important role in its performance. This study presents the results of the analysis on the TBM penetration rates in schistose rock types present along the alignment of Golab tunnel based on the analysis of a TBM performance database established for every stroke through different schistose rock types. The results of the analysis are compared to the results of some empirical and theoretical predictive models such as NTH and QTBM. Additional analysis was performed to find the optimum thrust and revolution per minute values for different schistose rock types.

• Asian Journal for Public Opinion Research
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• 제10권4호
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• pp.277-292
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• 2022

Cognizant of the role of the family in influencing health behaviors among its young members, especially during the time of COVID-19 in the Philippines where stay-at-home measures were in place from March 2020 until March 2022, this study sought to determine the predictive relationship of family relationship to COVID-19 preventive behavioral intention and pandemic fatigue among young Filipino undergraduates. A total of 1,665 undergraduate students participated in this cross-sectional online survey. Findings reveal that family cohesion significantly increases COVID-19 prevention behavioral intention among undergraduates. Moreover, students who report high levels of conflict in the family are less likely to comply with preventive behaviors and exhibit higher levels of pandemic fatigue.