• Clinical and Experimental Pediatrics
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• 제58권7호
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• pp.251-255
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• 2015

Purpose: The widespread introduction of bacterial conjugate vaccines has decreased the risk of cerebrospinal fluid (CSF) pleocytosis due to bacterial meningitis (BM) in children. However, most patients with CSF pleocytosis are hospitalized and treated with parenteral antibiotics for several days. The bacterial meningitis score (BMS) is a validated multivariate model derived from a pediatric population in the postconjugate vaccine era and has been evaluated in several studies. In the present study, we examined the usefulness of BMS in South Korean patients. Methods: This study included 1,063 patients with CSF pleocytosis aged between 2 months and 18 years. The BMS was calculated for all patients, and the sensitivity and negative predictive value (NPV) of the test were evaluated. Results: Of 1,063 patients, 1,059 (99.6%) had aseptic meningitis (AM). Only four patients (0.4%) had BM. The majority of patients (98%) had a BMS of ${\leq}1$, indicating a diagnosis of AM. The BMS was 0 in 635 patients (60%) and 1 in 405 patients (38%). All four BM patients had a BMS of ${\geq}4$. Conclusion: To our knowledge, this is the first study to investigate the diagnostic strength of the BMS in South Korea. In our study, the BMS showed 100% sensitivity and 100% NPV. Therefore, we believe that the BMS is a good clinical prediction rule to identify children with CSF pleocytosis who are at a risk of BM.

• Journal of Trauma and Injury
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• 제23권2호
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• pp.151-156
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• 2010

Purpose: The liver is the second most common organ injured by blunt abdominal trauma. The purpose of this study was to determine the utility of liver transaminase in screening blunt abdominal trauma patients for traumatic liver injury. Methods: We retrospectively reviewed the medical records of 231 patients who sustained blunt trauma and were at risk for traumatic liver injury between June 2009 and August 2010. All of them underwent a focused assessment with sonography for trauma (FAST) and abdominal computed tomography (CT). Based on the diagnosis of abdominal CT, patients were divided into two groups: group I with liver injury and group II without liver injury. We compared the two groups and calculated the sensitivity, the specificity and the predictive values of serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) by using multiple cutoff values. Results: Of 231 patients with no abdominal free fluid in the FAST, 33 had traumatic liver injury on abdominal CT. The mean AST and ALT levels in group I (311.6 IU/L and 228.1 IU/L, respectively) were significantly higher than the values in group II (48.4 IU/L and 35.6 IU/L, respectively). The cutoff to distinguish liver injury is 60 IU/L for AST and 58 IU/L for ALT, with 93.8% sensitivity and 79.8% specificity for AST, and 90.6% sensitivity and 87.4% specificity for ALT. Conclusion: We recommend that all patient with suspected blunt abdominal trauma be evaluated using serum liver transaminase as a screening test for liver injury even though no abdominal free fluid is shown on the FAST. If AST > 60 IU/L and/or ALT > 58 IU/L, abdominal CT was useful to confirm liver injury in this study.

• Toxicological Research
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• 제32권1호
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• pp.47-56
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• 2016

The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important. Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidity and mortality. Conventional biomarkers, such as serum creatinine (SCr) and blood urea nitrogen (BUN), are frequently used to diagnose AKI. However, these biomarkers increase only after significant structural damage has occurred. Recent efforts have focused on identification and validation of new noninvasive biomarkers for the early detection of AKI, prior to extensive structural damage. Furthermore, AKI biomarkers can provide valuable insight into the molecular mechanisms of this complex and heterogeneous disease. Our previous study suggested that pyruvate kinase M2 (PKM2), which is excreted in the urine, is a sensitive biomarker for nephrotoxicity. To appropriately and optimally utilize PKM2 as a biomarker for AKI requires its complete characterization. This review highlights the major studies that have addressed the diagnostic and prognostic predictive power of biomarkers for AKI and assesses the potential usage of PKM2 as an early biomarker for AKI. We summarize the current state of knowledge regarding the role of biomarkers and the molecular and cellular mechanisms of AKI. This review will elucidate the biological basis of specific biomarkers that will contribute to improving the early detection and diagnosis of AKI.

• 한국콘텐츠학회논문지
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• 제18권1호
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• pp.108-116
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• 2018

본 연구의 목적은 정상 집단과 성대결절 집단의 음성을 음향학적 측정(AVQI), 청지각적 평가(GRBAS, CAPE-V)를 수행하여 그 차이와 상관관계를 조사하는 것이다. 이를 위해 성대결절 환자 335명의 음성 샘플을 음향학적으로 분석하고, 3명의 평가자를 통해서 청지각적 평가를 실시하였다. 연구결과, 정상 집단의 AVQI, grade(G), overall severity(OS) 점수는 성대결절 집단의 점수보다 낮게 평가되었다. 청지각적 척도간의 상관관계에서는 GRBAS의 G 척도와 CAPE-V의 OS 척도는 상관관계가 높은 것으로 나타났고, 음향학적 측정 AVQI와 G, OS 간의 상관관계도 높은 것으로 확인되었다. 두 집단 간의 AVQI, G, OS를 감별하는 역치값은 각각 ${\leq}4.06$, ${\leq}1$, ${\leq}26$ 였으며, 예측진단력은 0.840, 0.860,0.848이었다. 결론적으로 AVQI와 청지각적 평가를 통하여 성대결절 음성에 대한 선별 가능성을 높일 수 있고, 음성장애의 진단 및 치료 계획수립에 도움을 줄 것으로 사료된다.

• 한국사회복지학
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• 제69권3호
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• pp.165-191
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• 2017

본 연구는 국내 약물사용자의 치료서비스 이용 의도에 대한 주요 예측요인을 규명하는 데 목적이 있다. 건강서비스이용행동모형에 계획행동이론을 수렴한 확장된 건강서비스이용행동모형을 이론적 틀로 하여, 약물사용자의 개인 특성 요인(선행, 가능, 욕구요인)과 약물중독 치료서비스 이용에 대한 태도, 주관적 규범, 지각된 행동통제감이 약물중독 치료서비스 이용 의도에 미치는 영향을 분석하였다. 분석결과, 약물사용자의 개인 특성 중 치료서비스 이용 의도에 직 간접적으로 유의한 영향을 미치는 요인은 선행요인 중 성별, 과거치료경험, 그리고 욕구요인 중 정신과적 진단, 불안 우울, 약물남용심각도로 나타났다. 계획행동이론의 설명 요인 중 치료서비스 이용 의도에 통계적으로 유의한 영향을 미치는 요인은 주관적 규범과 지각된 행동통제감으로 분석되었다. 본 연구결과를 통해 약물사용자의 약물중독 치료서비스 이용 증진을 위하여 여성에 대한 고려, 긍정적 치료 노출 확대, 치료서비스에 대한 주관적 규범 및 지각된 행동통제감 강화 등의 노력이 필요함을 확인하였다.

• 구강회복응용과학지
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• 제32권4호
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• pp.330-337
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• 2016

치은퇴축의 원인 중 하나인 의원성 치은퇴축은 교정치료 또는 근관치료에 의하여 발생할 수 있다. 이는 기능적, 심미적 문제뿐만 아니라 치료에 대한 만족도도 낮출 수 있다. 이를 위한 치료 방법으로 다양한 술식이 존재하나, 상피하결합조직 이식을 동반한 측방변위판막술은 각화치은량의 증대, 치유된 치은의 수여부 연조직과의 조화로운 형태 및 색을 얻을 수 있는 장점이 있다. 술 전 임상적 및 방사선학적 검사를 통한 예지성 있는 적절한 증례 선택을 필요로 하며 술식에 있어 적합한 양의 상피하결합조직 획득과 판막의 피개량을 고려해야 한다. 본 증례보고의 두 가지 다른 원인의 의원성 치은퇴축의 치료 결과를 살펴보았을 때, 상피하결합조직 이식을 동반한 측방변위판막술은 의원성 치은퇴축의 치료법으로 우수한 결과를 나타내었으며, 1년 이상의 추적관찰시 높은 예지성을 보였다.

• 한국지능시스템학회논문지
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• 제16권3호
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• pp.332-337
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• 2006

It has been suggested that the endoscopic color of intramucosal gastric carcinoma is correlated with mucosal vascularity within the carcinomatous tissue. The development of electronic endoscopy has made it possible to quantitatively measure the mucosal hemoglobin volume, using a hemoglobin index. The aim of this study was to make a software program to calculate the hemoglobin index (IHb) and then investigate whether the mucosal IHb determined from the electronic endoscopic data is a useful marker for evaluating the color of intramucosal gastric carcinoma, in particular with regard to its value for discriminating between the histologic types. The mean values of IHb for the carcinoma (IHb-C) and the mean values of IHb for the surrounding non-cancerous mucosa (IHb-N) were calculated in 75 intestinal-type and 34 diffuse-type gastric carcinomas. Then, we analyzed the ratio of the IHb-C to IHb-N. The mean IHb-C/IHb-N ratio in the intestinal-type carcinoma group was higher than that in the diffuse-type carcinoma group (1.28$\pm$0.19 vs. 0.81$\pm$0.18, respectively, p<0.001). When the cut-off point of the C/N ratio was set at 1.00, the accuracy rate, the sensitivity, the specificity, and the positive and negative predictive values of a C/R ratio below 1.00 for the differential diagnosis of diffuse-type carcinoma from intestinal-type carcinoma were 94.5%, 94.1%, 94.7%, 88.9% and 97.3%, respectively. IHb is useful for quantitative measurement of the endoscopic color in intramucosal gastric carcinoma and the IHb-C/IHb-N ratio would be helpful in distinguishing diffuse-type carcinoma from intestinal-type carcinoma.

• 대한응급의학회지
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• 제26권1호
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• pp.29-37
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• 2015

Purpose: Stool exams are a useful tool for the early presumptive diagnosis of infectious bacterial diarrhea in the Emergency Department (ED). CT scans are often used to increase the physician's level of certainty and to facilitate patient triage by identifying the source of pain in most patients with an acute abdomen in the ED. This study was designed to investigate the correlation between stool exams and abdominal CT in patients with acute diarrhea visiting the ED. Methods: We conducted a retrospective study in the emergency department of a national university hospital from January 1, 2012 to June 30, 2013. The subjects consisted of 156 patients with acute diarrhea and abdominal pain who had stool exam results and abdominal CT findings. We divided the patients into three groups according to the stool exam results. Simultaneously, we evaluated their CT findings of the bowel and adjacent structures. Results: A total of 156 patients were enrolled. Frequency of abnormal CT findings showed statistically significant correlation with stool exams (p-value <0.001). Abnormal CT findings increased as WBCs and RBCs in stool increased (p-value <0.001). Conclusion: The stool exam was a statistically significant predictive variable in indirectly determining the severity of acute diarrhea and it showed correlation with the frequency of abnormal CT findings. It is suggested that stool exams can be used as a susceptible marker for predicting the probability of severe infectious colitis, and for making an early decision regarding close medical attention.

• 한국환경보건학회지
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• 제45권5호
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• pp.511-519
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• 2019

Objectives: The standard method for the enumeration of environmental Legionella is culturing, which has several disadvantages, including long incubation and poor sensitivity. The purpose of this study is to demonstrate the usefulness of real-time PCR and to improve the standard method. Methods: In 200 environmental water samples, a real-time PCR and culture were conducted to detect and quantify Legionella. Using with the results of the survey, we compared the real-time PCR with the culture. Results: Each real-time PCR assay had 100% specificity and excellent sensitivity (5 GU/reaction). In the culture, 36 samples were positive and 164 samples were negative. Based on the results of the culture, real-time PCR showed a high negative predictive value of 99%, 35 samples were true positive, 105 samples were true negative, 59 samples were false positive and one sample was a false negative. Quantitative analysis of the two methods indicated a weak linear correlation ($r^2=0.29$, $r^2=0.61$, respectively). Conclusions: Although it is difficult to directly apply quantitative analysis results of real-time PCR in the enumeration of environmental Legionella, it can be used as a complementary means of culturing to rapidly screen negative samples and to improve the accuracy of diagnosis.

• 한방비만학회지
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• 제17권2호
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• pp.127-132
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• 2017

Objectives: Recently, many studies have demonstrated that the waist-to-height ratio (WHtR) is more correlated with metabolic syndrome than the waist-hip ratio (WHR), body mass index (BMI). The aim of this study was to investigate and compare WHtR as a predictor of metabolic syndrome with other anthropometric indices. Methods: Approximately 3,800 data of subjects were used for the analysis, and data from Korean Medicine Data Centar). Receiver operating characteristic curve was performed and area under the curve (AUC) was calculated to find the usefulness of WHtR, WHR, and BMI. Results: WHtR was the most predictive factor with the highest diagnostic value for metabolic syndrome than WHR, BMI. AUC of WHtR was significantly higher in total subjects, men and women. Conclusions: WHtR may be the simple and effective anthropometric index for metabolic syndrome.