• Journal of Integrative Natural Science
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• v.9 no.4
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• pp.241-248
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• 2016

Corticotropin-releasing factor receptors (CRFRs) activate the hypothalamic-pituitary-adrenal axis, which is an integral part of the fight or flight response to stress. Increase in CRH level is observed in Alzheimer's disease and major depression and hypoglycemia. Here, we report on the relevant physicochemical parameters required for the CRFR inhibitors. Comparative molecular similarity indices analysis (CoMSIA) was performed with the derivatives of 8-substituted-2-aryl-5-alkylaminoquinolinesas CRFR inhibitors. The best predictions were obtained for the best CoMSIA model with a $q^2$ of 0.576 with 6 components and $r^2$ of 0.977. The statistical parameters from the generated CoMSIA models indicated that the data are well fitted and have high predictive ability. CoMSIA contour maps could be useful in the designing of more potent and novel CRFR derivatives.

• Communications for Statistical Applications and Methods
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• v.24 no.1
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• pp.67-80
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• 2017

Over the last few decades, ensemble forecasts based on global climate models have become an important part of climate forecast due to the ability to reduce uncertainty in prediction. Moreover in ensemble forecast, assessing the prediction uncertainty is as important as estimating the optimal weights, and this is achieved through a probabilistic forecast which is based on the predictive distribution of future climate. The Bayesian model averaging has received much attention as a tool of probabilistic forecasting due to its simplicity and superior prediction. In this paper, we propose a new Bayesian model averaging method for probabilistic ensemble forecasting. The proposed method combines a deterministic ensemble forecast based on a multivariate regression approach with Bayesian model averaging. We demonstrate that the proposed method is better in prediction than the standard Bayesian model averaging approach by analyzing monthly average precipitations and temperatures for ten cities in Korea.

• The Journal of the Acoustical Society of Korea
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• v.17 no.4E
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• pp.17-21
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• 1998

This paper presents an implementation of a multi-channel speech surveillance system over telephone lines using TMS320C31 DSP chips. The incoming speech into each telephone line are first compressed simultaneously in real-time by the popular vector-sum excited linear predictive (VSELP) speech coding algorithm at the rate of 8 Kbps. The compressed steech bit streams are then multiplexed with those of other users. The multiplexed speech bit streams are transferred to the system storage equipments with some other required information so that a system operator can later monitor the stored speech data whenever it is necessary. The host program runs under Microsoft Windows95 for an efficient man-machine interface and a future upgrade-ability. We have confirmed that the overall 64-channel system operates satisfactorily in realtime. We also have checked approximately up to 2,880 total hours of recording capability of the system on a playback module and two removable backup drives.

• Bulletin of the Korean Chemical Society
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• v.27 no.2
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• pp.266-272
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• 2006

Three-dimensional quantitative structure-activity relationship (3D-QSAR) models were developed for 67 molecules of 2-amino-benzothiazole-6-anilide derivatives against lymphocyte-specific protein tyrosine kinase (P56 LCK). The molecular field analysis (MFA) and receptor surface analysis (RSA) were employed for QSAR studies and the predictive ability of the model was validated by 15 test set molecules. Structure-based investigations using molecular docking simulation were performed with the crystal structure of P56 LCK. Good correlation between predicted fitness scores versus observed activities was demonstrated. The results suggested that the nature of substitutions at the 2-amino and 6-anilide positions were crucial in enhancing the activity, thereby providing new guidelines for the design of novel P56 LCK inhibitors.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2004.10a
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• pp.31-34
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• 2004

For solving multiresponse problems, a variety of loss function approaches have been proposed assuming that a cost matrix is known and fixed. However a cost matrix is also an important factor in loss function approaches, because the optimal solution is very sensitive to the cost matrix. In this paper. we propose a novel method for adjusting the cost matrix by considering the predictive ability of the estimated response models. Simulation results for the generated data set show that the proposed method is competitive with previously reported methods.

• Bulletin of the Korean Chemical Society
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• v.24 no.12
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• pp.1757-1762
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• 2003

The interrelation between retention factors of several L-amino acids and their physico-chemical and structural properties can be determined in chromatographic research. In this paper we describe a predictor for retention factors with various properties of the L-amino acids. Eighteen L-amino acids are included in this study, and retention factors are measured experimentally by RP-HPLC. Binding energy ($E_b$), hydrophobicity (log P), molecular refractivity (MR), polarizability (${\alpha}$), total energy ($E_t$), water solubility (log S), connectivity index (${\chi}$) of different orders and Wiener index (w) are theoretically calculated. Relationships between these properties and retention factors are established, and their predictive and interpretive ability are evaluated. The equation of the relationship between retention factors and various descriptors of L-amino acids is suggested as linear and multiple linear form, and the correlation coefficients estimated are relatively higher than 0.90.

• Proceedings of the KIEE Conference
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• 2000.07d
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• pp.3001-3003
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• 2000

In this paper. we propose Fuzzy Self-Organizing Networks (FSON) using both Polynomial Neural Networks(PNN) and Fuzzy Neural Networks(FNN) for model identification of complex and nonlinear systems. The proposed FSON is generated from the mutually combined structure of both FNN and PNN. Accordingly it is possible to consider the nonlinearity characteristics of process and to get the better output performance with superb predictive ability. In order to evaluate the performance of proposed models. we use the nonlinear data sets. The results show that the proposed FSON can produce the model with higher accuracy and more robustness than previous any other method.

• Child Studies in Asia-Pacific Contexts
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• v.6 no.2
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• pp.73-85
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• 2016

Speech-print mapping awareness is defined as the awareness of the principles underpinning how speech sound is matched to print symbols. Chinese is unique in that it follows the one syllable one character mapping principle. The present study examined the predictive power of speech-print mapping awareness in young children's word reading. Seventy-four Hong Kong children from the first and second kindergarten years were tested with phonological awareness, visual skills, syllable-level mapping awareness, and Chinese reading ability at Time 1. Chinese reading abilities were tested again 1 year later. It was found that syllable-level mapping awareness predicted Chinese word reading abilities 12 months later. Further, it seemed that the link of syllable mapping to Chinese reading is particularly significant for beginning readers. The findings suggest that understanding the language-specific speech-print mapping principle is critical for reading acquisition at the early stage of reading development.

• East Asian Economic Review
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• v.24 no.2
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• pp.165-184
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• 2020

Applying Ismailov and Rossi (2018), I newly construct the Korea FX uncertainty based on the density distribution of historical forecast errors. This uncertainty index properly captures the rare but significant events in the Korean currency market and provides information distinct from other uncertainty measures in recent studies. I show that 1) FX uncertainty arising from unexpected depreciation has a stronger impact on Korea-U.S. exchange rates and that 2) macro variables, such as capital flows or interest rate differentials, have predictive ability regarding Korea FX uncertainty for short horizons. These findings enable us to predict the events of sudden currency crashes and understand the Korea-U.S. exchange rate dynamics.

• Nuclear Engineering and Technology
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• v.49 no.6
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• pp.1189-1198
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• 2017

Computer-aided design (CAD)-based Monte Carlo radiation transport is of value to the nuclear engineering community for its ability to conduct transport on high-fidelity models of nuclear systems, but it is more computationally expensive than native geometry representations. This work describes the adaptation of a rendering data structure, the signed distance field, as a geometric query tool for accelerating CAD-based transport in the direct-accelerated geometry Monte Carlo toolkit. Demonstrations of its effectiveness are shown for several problems. The beginnings of a predictive model for the data structure's utilization based on various problem parameters is also introduced.