• Journal of the Korean Society of Earth Science Education
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• v.9 no.2
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• pp.186-198
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• 2016

The purpose of this study is to identify the composition elements and processes of the rock cycle that pre-service teachers in earth science field understand. Second-year students majoring in earth science were selected as research objects, all of whom attended teacher's university located in the southern region. The methods of arranging the composition elements of the rock cycle in a structured way and displaying the cycle direction through the arrow and describing the cycle processes in detail were applied. Pre-service teachers recognized 5 composition elements: magma, igneous rocks, sediments, sedimentary rocks, metamorphic rocks of the rock cycle and cycle processes was represented into 20 branches. The cycle type was analyzed by four criteria: linear, triangular, circular, complex, some pre-teachers did not complete the loop of the cycle or some showed incomplete understanding of the cycle structure simply displayed in one direction. The rock cycle is an important theme of the earth system education characterized by dynamism and complexity.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.8 no.7
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• pp.341-350
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• 2018

The purpose of this study was to develop science essay writing activities for developing elementary pre-service teacher's scientific thinking ability and scientific emotion and to analyze its effects. For the study, 60 first grade students attending teacher training institutes in the G region of Korea were selected. All 60 elementary pre-service teachers were students who selected a liberal arts lecture related to 'science inquiry'. As a result of the study, we confirmed that the preliminary teacher uses the scientific method of 'induction' in the article related to scientific thinking and the description related to the past time, agency, and purpose of the story is included in the essay related to scientific emotion. In addition, it was confirmed that elementary school teachers' writing ability was improved as the writing was repeated, and that the image of 'science' changed positively in many areas. This study suggests that a various and interesting scientific inquiry activities are needed to improve the science writing skills.

• Journal of the Korean Society of Earth Science Education
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• v.5 no.1
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• pp.88-94
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• 2012

This study was created to resolve the problems embedded in the formal measuring experiments to determine the earth's size in the current curriculum, to develop an updated measuring experiment to determine the earth's size and to establish its effect. For this study, pre-service elementary teachers, who had attempted the experiment of measuring the size of the earth when they were in middle school, performed the experiments in the existing national curriculum, and their responses, collected through in-depth interviews, were examined. To begin with, the pre-service elementary teachers conducted the experiment of measuring the earth size and they recorded the problems while performing it. At the end, an in-depth interview was administered. Based on the problems, an updated measuring experiment to determine the earth's size was suggested to be applied to the same contents and be analyzed through the in-depth interviews. Common themes which were mutually categorized and analyzed by the two researchers were obtained based on the records produced while conducting the experiment and the in-depth interview data. The teachers mentioned that the experiments for measuring the size of the earth in the current curriculum gave rise to difficulties in measuring precisely the angles between the string and the post. Also, there has been a scientific contradiction that solar altitudes were increased in a high latitude region, instead of decreased. For this reason, an alternative method has been developed to measure the earth's size using the distance and the solar altitude difference of two places. The teachers all agreed that by using the updated measuring experiment, they can acquire more precise measurements and it is easier, faster and consequently more effective than the existing methods. Through the results of this study, I suggest that the newly developed experiment by the researchers can overhaul the problems of the current experiments and it can be an effective alternative to the current experiment.

• Korean Journal of Microbiology
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• v.27 no.1
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• pp.1-9
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• 1989

The locations of 5' ends as well as the splicing pattern of viral poly A(-) 19S RNA from monkey cells infected with SV40 were determined by a modification of primer extension method. The 5' end of this RNA mapped at the major cap site at nucleotide residue 325, used most frequently by SV40 late RNAs. The intron from nt.373 to nt.558 was removed as the ordinary cytoplasmic poly A(+) 19S RNA. The 3'end of this RNA was very heterogeneous and distributed over 1 kb upstream of polyadenylation site, as determined by S1 nuclease mapping. The reason for this normally initiated and spliced RNA to accumulate in the nucleus was investigated. In order to test whether the presence of unused 3' splice region on this RNA caused such subcellular distribution, cells were transfected with SV40 mutant KNA containing deletion around 3' splice site. The RNA deleted of 3' splice region accumulated mainly in the cytoplasm. This accumulation did not result from the increased stability of the RNA due to the deletion, since the wild type and mutant RNAs exhibited similar half lives after chase with actinomycin D. Therefore it is likely that the 19S spliced RNA is hindered from being transported into the cytoplasm due to some pre-splicing complexes formed at the unused 3' splice site.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3495-3501
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• 2014

Melanoma-associated antigen (MAGE) family genes have been considered as potentially promising targets for anticancer immunotherapy. MAGED4 was originally identified as a glioma-specific antigen. Current knowledge about MAGED4 expression in glioma is only based on mRNA analysis and MAGED4 protein expression has not been elucidated. In the present study, we investigated this point and found that MAGED4 mRNA and protein were absent or very lowly expressed in various normal tissues and glioma cell line SHG44, but overexpressed in glioma cell lines A172,U251,U87-MG as well as glioma tissues, with significant heterogeneity. Furthermore, MAGED4 protein expression was positively correlated with the glioma type and grade. We also found that the expression of MAGED4 inversely correlated with the overall methylation status of the MAGED4 promoter CpG island. Furthermore, when SHG44 and A172 with higher methylation were treated with the DNA demethylating agent 5-aza-2'-deoxycytidine (5-AZA-CdR) reactivation of MAGED4 mRNA was mediated by significant demethylation in SHG44 instead of A172. However, 5-AZA-CdR treatment had no effect on MAGED4 protein in both SHG44 and A172 cells. In conclusion, MAGED4 is frequently and highly expressed in glioma and is partly regulated by DNA methylation. The results suggest that MAGED4 might be a promising target for glioma immunotherapy combined with 5-AZA-CdR to enhance its expression and eliminate intratumor heterogeneity.

• Nutritional Sciences
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• v.5 no.1
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• pp.13-19
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• 2002

A mutation in the promoter region of uncoupling protein 3 (UCF3), specifically the -55C longrightarrow T transition, may influence an individual's energy metabolism and body weight. The objective of this study was to investigate the effect of a weight reduction program on endocrine functions and body fat distribution, related to UCP3 promoter genotype. Ninety overweight pre-menopausal female subjects participated in the weight reduction program at Yonsei University Hospital, and were placed on a calorie-restricted diet (300 kcal less than their daily requirements) for 12 weeks. After 12 weeks, all subjects on the program lost approximately 5% of their initial body weights and had lower Body Mass Index (BMI) values. Among the 90 women, 56 had a normal (without mutation) UCP3 genotype, while 34 women had mutations in the promoter region of UCP3. Despite similar weight reductions in both groups, a significantly higher decrease in abdominal adipose tissue was observed in the normal UCP3 genotype group, compared to the group with mutations. In particular, there was a significant reduction of fat at the lumbar 1 (Ll) level in the without-mutation group. Serum levels of total cholesterol, apolipoprotein Al were significantly decreased in the without-mutation group, by 4.4% and 5.7% respectively. Serum levels of hormones were not significantly changed in both groups artier the intervention. However, in the group without the mutations, the leptin level significantly reduced by 23.4% (p<0.001). Serum free fatty acid (FFA) concentration was significantly increased in the group with mutation following the weight reduction program. On the other hand, FFA responses were shown similar increases in both groups. In conclusion, although no difference was found in the magnitude of weight reduction in both groups, there were significant differences in body fat distribution and in endocrine function between the groups.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.42.2-42.2
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• 2020

We report on multi-wavelength observations of AA Ori, a Young Stellar Object in Orion-A star-forming region. AA Ori is known to have a pre-transitional disk based on infrared observations including Spitzer/IRS data. We construct its broadband spectral energy distribution (SED) by not only taking data in the optical and IR region but also including Herschel/PACS, JCMT/SCUBA, and SMA observational data. We use the Monte Carlo radiative transfer code (RADMC-3D) to reconstruct the SED with a viscous accretion disk model initialized by a radially continuous disk and finally having an inner and outer dusty disk separated by a dust-depleted radial gap. By comparing the model SEDs with different configurations of disk parameters, we discuss the limits to find a single solution of model parameters to fit the data. We suggest that some models with a modified inner disk surface density gradient and some degree of dust depletion in the inner disk can explain the AA Ori's SED, from which we infer that the inner disk of AA Ori has evolved. We present that model configurations of a pre-transitional disk with a large gap extended to 60-80 AU in a settled dusty disk of a few hundred AU size with a high inclination angle (~60°) also create model SEDs close to the observed one. To distinguish whether the disk has a just-opened narrow gap or a large gap, with an altered surface density of the inner disk extended to 10 AU, we suggest a further investigation of AA Ori with high angular resolution observations.

• The Journal of the Acoustical Society of Korea
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• v.27 no.2
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• pp.66-74
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• 2008

In this paper, we propose new techniques that can improve the quality of AAC and SBR encoders comprised in low bitrate HE-AAC. To reduce the pre-echo artifacts often occurring for transient blocks in AAC, we propose an extended Temporal Noise Shaping (sTNS) in which the frequency range is selectively extended down to the low-frequency region. Also, for he high-frequency region being coded by SBR encoder, tones are identified through a sinusoidal modeling and their frequencies are adjusted within the QMF band in order to reduce the noise floor due to aliasing. Spectrograms of the decoded signals were compared and listening tests were conducted to evaluate the proposed algorithm. Results confirmed the effectiveness of the proposed algorithm.

• Journal of KIISE:Information Networking
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• v.34 no.2
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• pp.120-133
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• 2007

A multicast tree includes several, possibly a large number of, paths connecting source-receiver pairs, and network failure may disable part of the multicast tree. Reconstruction of the entire multicast tree to recover from a component failure is highly undesirable, because some group members have to suffer service disruptions even though the communication paths to/from them are not affected by the failure. To limit reconfiguration region and to maximize the likelihood of successful reconfiguration, we propose and evaluate a pre-planned reconfiguration policy for QoS multicast sessions. Specifically, we equip a reconfiguration path (RP) with each end-to-end path that connects a source-receiver pair in the multicast tree, and reserve resources in advance along the RPs. Efficient resource-sharing techniques are applied to reduce the amount of resources reserved for RPs but not used in the absence of failures. This way, we prevent uncontrolled competition among different multicast sessions which may simultaneously try to recover from failures. We evaluate the performance of the proposed scheme using simulation on randomly-generated networks. We use the shortest-path routing for QoS multicast sessions, and simulate both source-based and shared multicast trees. The evaluation results indicates that successful pre-planned reconfiguration can be achieved for all group members with reasonable overhead. Our scheme is also shown to adapt well to dynamic changes of group membership.

• Publications of The Korean Astronomical Society
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• v.32 no.1
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• pp.127-129
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• 2017

We have observed ~60 Weak-line T Tauri stars (WTTSs) toward the Chamaeleon star forming region using the AKARI Far-Infrared Surveyor (FIS) All-Sky maps. We could not detect any significant emission from each source even at the most sensitive WIDE-S band. Then, we have performed stacking analysis of these WTTSs using the WIDE-S band images to improve the sensitivity. However, we could not detect any significant emission in the resultant image with a noise level of $0.05MJy\;sr^{-1}$, or 3 mJy for a point source. The three-sigma upper limit of 9 mJy leads to the disk dust mass of $0.01M_{\oplus}$. This result suggests that the disks around Chamaeleon WTTSs are already evolved to debris disks.