• Journal of Yeungnam Medical Science
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• v.3 no.1
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• pp.269-278
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• 1986

The purpose of this study was to know the effect of shourt termed fasting on the usage of metabolic energy sources and the metabolic differences between non-athletic and athletic subjects. Subjects were divided into non-athletic and athletic group and exercise was loaded on both groups after feeding and fasting. Exercise was loaded by a treadmill running at the speed of 8km/hour for 30 minutes in both groups. The experiment yielded following results. In the fed state, the level of plasma FFA increased markedly after 15 and 30 minutes of exercise compared with it's level of pre-exercise period in both groups. In the fasted state, the level of plasma FFA in non-athletic group increased steadily according to the duration of exercise, while it's level in athletic group showed no changes. At pre-exercise period, the level of plasma FFA was higher in fasted state than fed state. Immediately before the exercise and 15 and 30 minutes after the exercise, blood for the determination of plasma free fatty acid(FFA), glucose, triglyceride(TG)and cholesterol was sampled from antecubital vein, and simultaneously heart rate was measured. In the fed state, the level of plasma glucose was increased mildly according to exercise, and in the fasted state it's level increased according to exercise in both groups also. In the fasted state, the level of plasma TG was lower than that in the fed state. The level of plasma TG and cholesterol in the fed state was no changed by the exercise from the pre-exercise period. The level of plasma cholesterol in athletic group had tendency to lower than that in non-athletic group. Heart rate increased markedly according to exercise in both groups, but the athletic group's increasing rate of heart rate was lower than the non-athletic group's heart rate increased according to exercise and athletic groups heart rate increased early period of exercise, but did not change during lates post-period of exercise.

• Journal of The Korean Association For Science Education
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• v.18 no.3
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• pp.427-441
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• 1998

The present study tested the hypothesis that adolescents' performance on scientific reasoning tasks and their ability to change theoretical concepts during instruction are mediated by prefrontal-cognitive functions, such as planning and inhibiting. Subjects sampled from four Korean secondary schools were administered a test of scientific reasoning ability and tests of the prefrontal lobe functions. A series of lessons on theoretical concepts was also administered. Subjects' performance on the test of scientific reasoning and pre- to posttest gains in the concept test were used as dependent variables. This study found that students' planning and inhibiting abilities were highly correlated with and they significantly predicted their scientific reasoning ability and conceptual gains. Further, principal component analysis showed prefrontal lobe functions were categorized into two main components. Component 1, which was loaded by planning and working memory functions, was termed as the representing process. Component 2, which was loaded primarily by the inhibiting functions, was termed as the inhibiting process. Scientific reasoning and conceptual change were also linked to these two components, indicating that these cognitive processes are mediated by both representing and inhibiting processes.

• Journal of the Korean Geotechnical Society
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• v.32 no.4
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• pp.41-49
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• 2016

Pile foundations used as offshore support structures are dominantly subjected to cyclic lateral loads due to wind and waves. In this study, a series of cyclic lateral load tests were performed on a pre-installed aluminum flexible pile in sandy soil with three different relative densities (40%, 70% and 90%) in order to evaluate the effect of cyclic lateral loads on lateral load capacity of a pile. The cyclic lateral loads increased the lateral load capacity of a pile at 40% relative density, whereas they decreased it at 70% and 90% relative densities. This can be explained by the fact that the cyclic lateral loads slightly densified the surrounding soil in relatively loose sand (40%), while the surrounding soil was disturbed in relatively dense sand (70% and 90%). These effects were more obvious as the cyclic lateral load amplitude increased, being independent with the saturation. Also, from the test results, an empirical equation for the lateral load capacity of a cyclic laterally loaded pile in sandy soil was developed in terms of relative density of the soil and the cyclic lateral load amplitude.

• Journal of the Korean Geotechnical Society
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• v.33 no.2
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• pp.17-26
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• 2017

Pile foundations that support offshore structures or transmission towers are dominantly subjected to cyclic lateral loads due to wind and waves, causing permanent displacement which can severely affect stability of the structures. In this study, a series of cyclic lateral load tests were conducted on a pre-installed aluminum flexible pile in sandy soil with three different relative densities (40%, 70% and 90%) in order to evaluate the permanent displacement of a cyclic laterally loaded pile. Test results showed that the cyclic lateral loads accumulated the irreversible lateral displacement, so-called permanent displacement. As the number of cyclic lateral load increased, accumulated permanent displacement increased, but the permanent displacement due to one loading cycle gradually decreased. In addition, the permanent displacement of a pile increased with decrement of relative density and decreased by soil saturation. From the test results, the normalized permanent displacement defined as the cumulative permanent displacement to the initial permanent displacement ratio was investigated, and empirical equations for predicting the normalized permanent displacement was developed in terms of relative density of the soil and the number of cyclic lateral load.

• Journal of Pharmacopuncture
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• v.27 no.1
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• pp.1-13
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• 2024

Background: Diabetic nephropathy (DN) is one of the major complications of chronic hyperglycaemia affecting normal kidney functioning. The ayurvedic medicine curcumin (CUR) is pharmaceutically accepted for its vast biological effects. Objectives: The Curcuma-derived diferuloylmethane compound CUR, loaded on Poly (lactide-co-glycolic) acid (PLGA) nanoparticles was utilized to combat DN-induced renal apoptosis by selectively targeting and modulating Bcl2. Methods: Upon in silico molecular docking and screening study CUR was selected as the core phytocompound for nanoparticle formulation. PLGA-nano-encapsulated-curcumin (NCUR) were synthesized following standard solvent displacement method. The NCUR were characterized for shape, size and other physico-chemical properties by Atomic Force Microscopy (AFM), Dynamic Light Scattering (DLS) and Fourier-Transform Infrared (FTIR) Spectroscopy studies. For in vivo validation of nephro-protective effects, Mus musculus were pre-treated with CUR at a dose of 50 mg/kg b.w. and NCUR at a dose of 25 mg/kg b.w. (dose 1), 12.5 mg/kg b.w (dose 2) followed by alloxan administration (100 mg/kg b.w) and serum glucose levels, histopathology and immunofluorescence study were conducted. Results: The in silico study revealed a strong affinity of CUR towards Bcl2 (dock score -10.94 Kcal/mol). The synthesized NCUR were of even shape, devoid of cracks and holes with mean size of ~80 nm having -7.53 mV zeta potential. Dose 1 efficiently improved serum glucose levels, tissue-specific expression of Bcl2 and reduced glomerular space and glomerular sclerosis in comparison to hyperglycaemic group. Conclusion: This study essentially validates the potential of NCUR to inhibit DN by reducing blood glucose level and mitigating glomerular apoptosis by selectively promoting Bcl2 protein expression in kidney tissue.

• Restorative Dentistry and Endodontics
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• v.38 no.1
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• pp.21-25
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• 2013

Objectives: The aim of this study was to evaluate the shaping ability of newly marketed single-file instruments, Wave One (Dentsply-Maillefer) and Reciproc (VDW GmbH), in terms of maintaining the original root canal configuration and curvature, with or without a glide-path. Materials and Methods: According to the instruments used, the blocks were divided into 4 groups (n = 10): Group 1, no glide-path / Wave One; Group 2, no glide-path / Reciproc; Group 3, #15 K-file / Wave One; Group 4, #15 K-file / Reciproc. Pre- and post-instrumented images were scanned and the canal deviation was assessed. The cyclic fatigue stress was loaded to examine the cross-sectional shape of the fractured surface. The broken fragments were evaluated under the scanning electron microscope (SEM) for topographic features of the cross-section. Statistically analysis of the data was performed using one-way analysis of variance followed by Tukey's test (${\alpha}$ = 0.05). Results: The ability of instruments to remain centered in prepared canals at 1 and 2 mm levels was significantly lower in Group 1 (p < 0.05). The centering ratio at 3, 5, and 7 mm level were not significantly different. Conclusions: The Wave One file should be used following establishment of a glide-path larger than #15.

• Clinics in Shoulder and Elbow
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• v.18 no.4
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• pp.197-205
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• 2015

Background: The purpose of this study was to evaluate the postoperative magnetic resonance imaging (MRI) results of minimal-tying (one medial-row tie among 4 medial-row sutures) on the medial-row in double-row suture-bridge configuration ($2{\times}2$ anchor with $4{\times}4$ suture stands). Methods: From 2011 March to 2012 July, 79 patients underwent arthroscopic rotator cuff repair using $2{\times}2$ anchor double-row configuration. The mean age was 61.3 years (range, 31-81 years). Two double-loaded suture anchors were used for medial-row. Four medial-row stitches were made with only one medial-row knot-tying (the most anterior suture). Lateral-row was secured using the conventional suture-bridge anchor technique; all 4 strands were used for each anchor. Repair integrity was evaluated with MRI at mean 6.2 months postoperatively. Retear and the pattern of retear, change of fatty infiltration, and muscle atrophy of supraspinatus were evaluated using pre- and postoperative MRI. Results: Repaired tendon integrity was 38 for type I, 30 for type II, 6 for type III, 4 for type IV, and 1 for type V, according to Sugaya classification. Considering type IV/V as retear, the rate was 6.3% (5 out of 79 patients). Medial cuff failure was observed in 4 patients. Fatty atrophy of supraspinatus was significantly improved postoperatively according to Goutallier grading (p=0.01). The level of muscle atrophy of supraspinatus was not changed significantly after surgery. Conclusions: Minimal tying technique with suture configuration of four-by-four strand double-row suture-bridge yielded a lower retear rate (6.3%) in medium to large rotator cuff tears.

• Transactions of the Korean Society of Mechanical Engineers
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• v.14 no.1
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• pp.112-118
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• 1990

Catastrophic fracture cannot be avoided after cracks(initiated from pre-existing defects) propagate rapidly with speeds comparable to a sound wave velocity of the materials. Preventing catastropic failure, crack arrest fracture toughness defined from dynamic(or kinetic) fracture mechanics point of view has been introduced in determining accurate and/or proper crack arrest fracture toughness of a material. For the past decades, many studies have been carried out to render proper theoretical and experimental backgrounds on the use of the static plain strain crack arrest fracture toughness, $K_{1a}$ (which seems to be a material property). $K_{1a}$ has been used to predict the performance of thick walled structures and has been considered as a measure of the ability of a material to stop a fast running crack. Determination of such a material property is of prime importance to the nuclear reactor pressure vessel and bridge materials industries. However, standards procedures for measuring toughness associated with fast running cracks are yet to exist. This study intends to give insight on the determination of the crack arrest fracture toughness of materials such as polymethylmethacrylate(PMMA), SM45C-steel, and A1 7075-T6. The effects of crack jump lengths and fast crack initiation stress intensity factor on the determination of $K_{1a}$ have been experimentally observed.erved.

• Journal of Embryo Transfer
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• v.26 no.1
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• pp.71-78
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• 2011

This study was undertaken to find out the effect of cholesterol and serum albumin on sperm ability and lipid peroxidation levels period to the liquid storage of miniature pig sperm. Ejaculated semen from miniature pigs was collected by gloved-hand method into a pre-warmed ($37^{\circ}C$) thermos bottle, and extended with Modena solution {with and without BSA, methyl-beta-cyclodextrin (-cholesterol) and cholesterol loaded cyclodextrin (+cholesterol)}. Each semen was assessed for viability (SYBR-14/PI staining) and acrosome intactness, intensity and capacitation status by chlorotetracycline (CTC) staining at 1, 3, 5, 7 and 10 days of storage. At for the effects of cholesterol and serum albumin on lipid peroxidation, semen were incubated with $H_2O_2$ ($10\;{\mu}M$), and lipid peroxidation level were measured by flow cytometry using the lipid peroxidation reporter probe $C_{11}-BODIPY^{581/591}$. The result, lipid peroxidation level in sperm added with cholesterol were lower in $10\;{\mu}M$ $H_2O_2$ compared to the added sperm with serum albumin. Also, added cholesterol to sperm had significant (p<0.05) higher viability when storage for 7 and 10 days and lower when 10 days of storage percentage of acrosome-reacted sperm (AR pattern) in acrosome state as say result compared to other treated groups. In conclusion, role of cholesterol during lipid storage in miniature pig spermatozoa was protected boar spermatozoa from lipid peroxidation prior to lipid storage. Addition serum albumin during lipid storage in sperm may be induce sperm membrane damage by lipid peroxidation. Therefore, addition of cholesterol to miniature pig sperm will be lead to extension of liquid storage periods.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.8
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• pp.3745-3751
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• 2011

In this study flexural strength of damaged concrete beams reinforced by CFS is analysed. Nonlinear section analysis is used to include stress status of tension bars and compressive concrete under loads acting on the original member at the time of strengthening. Calculated flexural strength is compared with Sin-Hong formula which is frequently used in CFS reinforcement design. Nonlinear analysis with variation of the number of strengthening CFS, the ratio of tensile reinforcement, the ratio of section dimension shows that the flexural strength of CFS reinforced beams much depends on reinforcing stage. From the result of this analysis, the flexural strength of CFS reinforced concrete beam is reduced according to the magnitude of pre-loaded service loads.