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Feasibility of Deep Learning-Based Analysis of Auscultation for Screening Significant Stenosis of Native Arteriovenous Fistula for Hemodialysis Requiring Angioplasty

  • Jae Hyon Park;Insun Park;Kichang Han;Jongjin Yoon;Yongsik Sim;Soo Jin Kim;Jong Yun Won;Shina Lee;Joon Ho Kwon;Sungmo Moon;Gyoung Min Kim;Man-deuk Kim
    • Korean Journal of Radiology
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    • v.23 no.10
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    • pp.949-958
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    • 2022
  • Objective: To investigate the feasibility of using a deep learning-based analysis of auscultation data to predict significant stenosis of arteriovenous fistulas (AVF) in patients undergoing hemodialysis requiring percutaneous transluminal angioplasty (PTA). Materials and Methods: Forty patients (24 male and 16 female; median age, 62.5 years) with dysfunctional native AVF were prospectively recruited. Digital sounds from the AVF shunt were recorded using a wireless electronic stethoscope before (pre-PTA) and after PTA (post-PTA), and the audio files were subsequently converted to mel spectrograms, which were used to construct various deep convolutional neural network (DCNN) models (DenseNet201, EfficientNetB5, and ResNet50). The performance of these models for diagnosing ≥ 50% AVF stenosis was assessed and compared. The ground truth for the presence of ≥ 50% AVF stenosis was obtained using digital subtraction angiography. Gradient-weighted class activation mapping (Grad-CAM) was used to produce visual explanations for DCNN model decisions. Results: Eighty audio files were obtained from the 40 recruited patients and pooled for the study. Mel spectrograms of "pre-PTA" shunt sounds showed patterns corresponding to abnormal high-pitched bruits with systolic accentuation observed in patients with stenotic AVF. The ResNet50 and EfficientNetB5 models yielded an area under the receiver operating characteristic curve of 0.99 and 0.98, respectively, at optimized epochs for predicting ≥ 50% AVF stenosis. However, Grad-CAM heatmaps revealed that only ResNet50 highlighted areas relevant to AVF stenosis in the mel spectrogram. Conclusion: Mel spectrogram-based DCNN models, particularly ResNet50, successfully predicted the presence of significant AVF stenosis requiring PTA in this feasibility study and may potentially be used in AVF surveillance.

The role of antioxidant and DNA damage in the UVB-induced skin tumors of hairless mice

  • Bito, Toshinori;Budiyanto, Arief;Ueda, Masato;Ichihashi, Masamitsu
    • Journal of Photoscience
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    • v.9 no.2
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    • pp.146-149
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    • 2002
  • Oxidative stress evoked hy Ultraviolet (UV) exposure has been suggested to be involved in UV-induced skin carcinogenesis. In this study, the role of oxidative stress in UV-carcinogenesis was evaluated by applying N-Acetylcysteine (NAC) in animal model of hairless-mouse. NAC is known to be a precursor of glutathione, which was converted to glutathione in cytoplasm, acting as an intracellular free radical scavenger. The glutathione levels in hairless mouse skin after one time application of NAC increased significantly. With and without the pre-treatment of NAC, hairless-mice were exposed to UVB three times a week, at total dose 274.4 kJ in 80 times, and the timing of tumor-development, incidence of skin tumor and the histopathology of tumors were observed. 8-hydroxy-2'-deoxyguanosine (8-0HdG), a typical form of oxidative damage in DNA has been also investigated in the course of experiment. The decrease of 8-0HdG formation of UVB- exposed skin compared to controls was observed in the early stage of experiment in the NAC-treated mice. In addition, initial tumor development delayed significantly in NAC-treated group. Finally the number of the tumor developed in the NAC-treated mice was fewer though not significant. These results suggest that antioxidants may have inhibitory effect in the initial step of UVB-induced carcinogenesis of hairless mice.

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The Heating Performance Evaluation of Heating System with Building-Integrated Photovoltaic/Thermal Collectors (실험을 통한 건물통합형 태양광·열(BIPVT) 시스템의 난방성능 평가)

  • Jeong, Seon-Ok;Kim, Jin-Hee;Kim, Ji-Seong;Park, Se-Hyeon;Kim, Jun-Tae
    • Journal of the Korean Solar Energy Society
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    • v.32 no.6
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    • pp.113-119
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    • 2012
  • The heat from PV modules should be removed for better electrical performance, and can be converted into useful thermal energy. A photovoltaic-thermal(PVT) module is a combination of PV module with a solar thermal collector which forms one device that produce thermal energy as well as electricity. In many studies various water type PVT collectors have been proposed in effort to increase their electrical and thermal efficiency. The aim of this study is to evaluate the heating performance of heating system combined with PVT collectors that on integrated building roof. For this study, the BIPVT system of 1.5kWp was installed at the experimental house, and it was incorporated with its heating system. From the experimental results, the solar fraction of the heating system with BIPVT was 15%. It was also found that was analyzed that the heating energy for the house can be reduced by 47%, as the heat gained from BIPVT system pre-heated the water used for heating system.

Identification of the Relationship between Surface Variations of Lower Body Parts by Movement Using 3D Scan Data - A Focus on Women Aged 20 to 24 Years - (3D 스캔데이터를 활용한 동작에 따른 하반신 주요 부위별 체표면 변화 및 상관관계 - 20-24세 여성을 중심으로 -)

  • Lee, So-Young;Kim, Ji Min
    • Journal of the Korean Society of Costume
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    • v.67 no.3
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    • pp.81-98
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    • 2017
  • The purpose of this study is to provide basic information for the development of pants patterns with a high level of fit and comfort through calculating surface variations of lower body parts by movement, grouping them into factors, and analyzing how their surface variations link to one another. The achieved results will help determine essential elements for constructing pants patterns, such as key measurements of lower body parts, the amount of ease values and selection of fabrics, which should be taken into consideration for allowing better movement in clothing. The study required lower body 3D scanning of women for analysis, and 13 women between the ages of 20-24 participated in the scanning, which was done by using Artec Eva 3D scanner. Their scanned data were digitalized and converted to measure the values of their lower body surface length and girth in pre-determined positions such as walking, stair climbing and sitting on a chair. These measurements have been statistically analyzed through SPSS 21.0 to obtain the average amounts and rates of extension for each of the measurement item. Some of the highlighted study results are as follows: The surface length and girth measurements were grouped into 4 factors based on their average extension rates. The results from correlation analysis between measurement items within each factor demonstrated that common items linked to all the changes in the values of other items in the three movements. But in most cases, items were not always correlated with each other for different movements. The results also showed that there were correlations between girth measurements, length measurements, and girth and length measurements. Therefore, key measurements for daily pants should be determined within reasonable estimations between relevant measurement items, while the measurements for work pants, which often withstand certain postures or repetitive movements, may require measurement items that are appro priate for, and closely related to, certain movements or tasks.

Development and Application of an Experimental Program for Mapping Temperature and Salinity Distribution around the Korean Marginal Seas Using Ocean Data View (ODV를 이용한 한반도 주변 해역의 수온 염분 분포도 작성에 관한 실험 프로그램의 개발과)

  • Chang, You-Soon
    • Journal of the Korean earth science society
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    • v.36 no.4
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    • pp.367-389
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    • 2015
  • This study developed an experimental program for mapping temperature and salinity distribution around the Korean marginal seas using Ocean Data View (ODV) software. Serial ocean observational data have been analyzed after being converted to the ODV compatible format using a separated program newly developed for this study. When this new experimental program was applied to 65 pre-service teachers, it was found that the quality of assignment completion with a new program improved compared with that of the same group who used the existing program. A questionnaires was employed to delve into participants' satisfaction of the new program. Findings depicted that accurate and quick drawing of isoline drew the highest responses of satisfaction, and confirmed positive responses to the understanding and application of this new experimental program.

Study on Improving Vulhearability in IPv4/IPv6 Header Translation Mechanism (IPv4/IPv6 헤더변환 방식에서의 취약성 개선에 관한 연구)

  • 황호준;유승재;김귀남
    • Convergence Security Journal
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    • v.3 no.1
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    • pp.73-84
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    • 2003
  • The IPv4 that used to be generally used as a medium of computer communications in 1980s has reached its limits now. IPv6 (IP Version 6) is being prepared to solve the limitations of the IPv4. However, the biggest problem of IPv6 is that it is not compatible with the IPv4. To resolve the compatibility issue, Dual Stack, Tunneling and Header Converting methods have been proposed. The Header Converting method allows communications between the IPv4 and IPv6 networks with the converter. This method's strength is that it is easy to embody and the procedures for embodiment is simple. However, this method still contains the weaknesses that the existing IPv4 has. On the current document, the Header Converting method among the three methods is discussed to resolve the problems this method has. To solve the Header Converting method's weakness, the security problem between sections, the IP Header field values are converted to the relative field values and IPSec (IP Security) and ESP (Encapsulation Security Payload) are applied. The proposed "Encrypted Header Converting Method" that is encrypted in packet units has solved the weakness that the pre-existing Header Converting method used to have.d to have.

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Selection and Characterization of Staphylococcus hominis subsp. hominis WiKim0113 Isolated from Kimchi as a Starter Culture for the Production of Natural Pre-converted Nitrite

  • Hwang, Hyelyeon;Lee, Ho Jae;Lee, Mi-Ai;Sohn, Hyejin;Chang, You Hyun;Han, Sung Gu;Jeong, Jong Youn;Lee, Sung Ho;Hong, Sung Wook
    • Food Science of Animal Resources
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    • v.40 no.4
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    • pp.512-526
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    • 2020
  • Synthetic nitrite is considered an undesirable preservative for meat products; thus, controlling synthetic nitrite concentrations is important from the standpoint of food safety. We investigated 1,000 species of microorganisms from various kimchi preparations for their potential use as a starter culture for the production of nitrites. We used 16S rRNA gene sequence analysis to select a starter culture with excellent nitrite and nitric oxide productivity, which we subsequently identified as Staphylococcus hominis subspecies hominis WiKim0113. That starter culture was grown in NaCl (up to 9%; w/v) at 10℃-40℃; its optimum growth was observed at 30℃ at pH 4.0-10.0. It exhibited nonproteolytic activity and antibacterial activity against Clostridium perfringens, a bacterium that causes food poisoning symptoms. Analysis of Staphylococcus hominis subspecies hominis WiKim0113 with an API ZYM system did not reveal the presence of β-glucuronidase, and tests of the starter culture on 5% (v/v) sheep blood agar showed no hemolytic activity. Our results demonstrated the remarkable stability of coagulase-negative Staphylococcus hominis subspecies hominis WiKim0113, especially in strain negative for staphylococcal enterotoxins and sensitive to clinically relevant antibiotics. Moreover, Staphylococcus hominis subspecies hominis WiKim0113 exhibited a 45.5% conversion rate of nitrate to nitrite, with nitrate levels reduced to 25% after 36 h of culturing in the minimal medium supplemented with nitrate (200 ppm). The results clearly demonstrated the safety and utility of Staphylococcus hominis subspecies hominis WiKim0113, and therefore its suitability as a starter culture.

Improvement of System for Grain Drying, Storing , and Processing in Rural Area (농촌의 주곡 건조.저장.가공 작업체계 개선확립)

  • 서상용;이승규;김용환
    • Journal of Biosystems Engineering
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    • v.3 no.1
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    • pp.33-46
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    • 1978
  • To get the goal of self-supply of food grain, improvement of post-harvest grain operations in rural area is under consideration as an important task of agriculture in Korea. This is study is focused on elimination of losses and deteriorations of grain and reduction of labour requirements and funds for post-harvest grain operations. The purpose of this study are presentation of basic data referring to conventional post-harvest grain operations in rural area and suggestion of improving methods for the operations, and also finding out reasonable operating processes of the operations. The result of this study are follows; 1. Grain drying in-the-filed which is performed before threshing has major factors of grain loss during drying, and so should be restrained as possible. Combine harvesting system is recommended among other king of mechanized harvesting systems for restraining in-the-field drying and securing available labors for drying. 2. It is predicted that mechanical grain drying could be prevalent when combine harvesting is taken place. Recommended grain drier for pre-combine harvesting system and for combine harvesting system is batch-type drier and circulating -type drier, respectively. 3. As existing farm storages for grain have insufficient spaces and offer poor conditions for grain storing , it is greatly needed to build up new storage which store only grains. And it is concluded that storing grain in community common storages in desirable. 4. Power supplying system for milling machinery in local milling plants, that a large capacity prime mover supplies power to 4 to 6 kinds of milling machinery simultaeously, should be converted to a system of several small capacity prime movers supplying power to each machiner y for the purpose of reducing extra consumption of energy. 5. Governmental grain, of which Korean farms produced, should be milled and stored in the local milling plant successively for the purpose of reducing transportation fee and stroing facilities. 6. Furture post-havest grain operations-drying, storing and milling should be periormed successively in he community common plant. And average optimum processing capacity of the plant is estimated about 300 metric ton of grain every year.

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Detection Method of Human Face, Facial Components and Rotation Angle Using Color Value and Partial Template (컬러정보와 부분 템플릿을 이용한 얼굴영역, 요소 및 회전각 검출)

  • Lee, Mi-Ae;Park, Ki-Soo
    • The KIPS Transactions:PartB
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    • v.10B no.4
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    • pp.465-472
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    • 2003
  • For an effective pre-treatment process of a face input image, it is necessary to detect each of face components, calculate the face area, and estimate the rotary angle of the face. A proposed method of this study can estimate an robust result under such renditions as some different levels of illumination, variable fate sizes, fate rotation angels, and background color similar to skin color of the face. The first step of the proposed method detects the estimated face area that can be calculated by both adapted skin color Information of the band-wide HSV color coordinate converted from RGB coordinate, and skin color Information using histogram. Using the results of the former processes, we can detect a lip area within an estimated face area. After estimating a rotary angle slope of the lip area along the X axis, the method determines the face shape based on face information. After detecting eyes in face area by matching a partial template which is made with both eyes, we can estimate Y axis rotary angle by calculating the eye´s locations in three dimensional space in the reference of the face area. As a result of the experiment on various face images, the effectuality of proposed algorithm was verified.

Decrease of Thyrotropin Binding Inhibiting Immunoglobin (TBII) in Sera of Graves' Disease Patients Related with Remission Induced by Thionamide Regimens (Graves병에서 Thionamide 치료시 관해 여부에 연관한 TSH 수용체 항체의 변동에 관한 연구)

  • Lee, C.S.;Seo, B.K.;Chung, S.I.
    • The Korean Journal of Nuclear Medicine
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    • v.22 no.1
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    • pp.21-26
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    • 1988
  • Serum TBII measured by radioreceptor assay using $^{125}I-bovine$ TSH and porcine thyroid well membrane was checked before, 6 months and 12 months after initiation of thionamide regimens in 63 Graves' disease patients and was related with their remission state. 1) A significant difference (p < 0.01) in pre-treatment TBII was noted between the remitted [N = 45, TBII $40.9{\pm}18.2%$ $(mean{\pm}S.D)$] and the unremitted (N = 18, TBII $64.1{\pm}15.3%$) groups. 2) After 6 months of therapy, TBII were significantly decreased in both groups (to $20.2{\pm}10.3%$ and to $45.2{\pm}16.3%$, p<0.05 for each group) 3) At 12th month, TBII activities were not significantly decreased compared to the 6th month levels in both groups. 4) 3 of the 58 patients who were initially TBII positive (over 15%) converted negative. All the 3 belonged to the remitted group. 5) No significant differences were seen in initial and posttreatment TBII levels between propylthiouracil treated (N = 36) and methimazole treated (N = 27) cases. with above mentioned results, we observed that the TBII decreased significantly with 6 months of thionamide therapy and concluded that the pretreatment measurement of serum TBII may be clinically useful in predicting the response to thionamide regimen in the treatment of Graves' disease.

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