• Journal of Advanced Marine Engineering and Technology
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• 제38권10호
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• pp.1212-1216
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• 2014

This study aims to find out the best anode location for buried pipelines. Numerical simulation program known as CATPRO (Elsyca, Belgium) were used for confirming the best location of anodes and the effects of impressed current cathodic protection system. Applied conditions for numerical simulation were similar to on-site environmental conditions for optimal application of cathodic protection system. Used criterion of cathodic protection was NACE SP 0169, which describes that minimum requirement for cathodic protection is -850mV vs. CSE. Various layouts for anodes' installation were applied, which were distance between anodes, anode installation location, and applied current. The areas where cathodic protection potential was lower than -850mV vs. CSE was limited up to 50m from anode installation locations. It was founded numerical analysis obtain cost-effective and efficient cathodic protection methods before design and application the impressed cathodic protection system to on-site environment.

• 대한안전경영과학회지
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• 제18권2호
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• pp.29-36
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• 2016

This study of small & Medium-Sized construction sites construction disaster prevention technology conduction-site visits from the map results report by the inspector on-site advice and technical guidance for the analysis of deficiencies and potential construction of disaster revealed the potential factors causing an accident as follows. As a results, Should not be a once a month visits. Therefore should be changed at least twice a month to help prevent accidents of this system is to be judged.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2002년도 춘계공동학술대회
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• pp.306-311
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• 2002

This paper propose a personalized defection detection and prevention procedure based on the observation that potential defectors have tendency to take a couple of months or weeks. For this purpose, possible states of customer behavior are determined from past behavior data using SOM (Self-Organizing Map). For the evaluation of the proposed procedure, a case study has been conducted for a Korean online game site. The result demonstestes that the proposed procedure can assist defection prevention effectively and detect potential defectors without deterioration of prediction accuracy comparison to prediction by MLP. Our procedure can be applied to various service industries that can capture fluent customer behavior data such as telecommunications, internet access services, and content services, too.

• 통합자연과학논문집
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• 제10권1호
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• pp.20-26
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• 2017

Chemerin receptor, which predominantly expressed in immune cells as well as adipose tissue, was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. Chemerin is a widely distributed multifunctional secreted protein implicated in immune cell migration, adipogenesis, osteoblastogenesis, angiogenesis, myogenesis, and glucose homeostasis. Recent studies suggest chemerin may play an important role in the pathogenesis of obesity and insulin resistance and it becomes a potential therapeutic target for treating type II diabetes. The crystal structure of chemerin receptor has not yet been resolved. Therefore, in the present study, homology modelling of CMKLR1 was done utilizing the crystal structure of human angiotension receptor in complex with inverse agonist olmesartan as the template. Since the template has low sequence identity, we have incorporated both threading and comparative modelling approach to generate the three dimensional structure. 3D models were generated and validated. The reported models can be used to characterize the critical amino acid residues in the binding site of CMKLR1.

• 약학회지
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• 제33권2호
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• pp.87-100
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• 1989

Salicylic acids as anti-inflammatory agents were analyzed by ab initio, quantum chemical methods to study the possible modes of binding to the receptor. As the result of multiple regression analysis of reactivity indices and interpretation of normalized frontier orbital charges of drugs, potency seems to be related to energy of HOMO and LUMO at the 5 position of benzene ring, and in the 5-phenyl substituted case, the para position of substituting ring is important. The binding occurs first at the positive site of its receptor. The charge density exhibited by the frontier orbitals suggests that charge moves from receptor site to carboxyl group. The electrostatic orientation effect makes an important contribution to the binding of the active molecules to their receptors. Also the electrostatic potential model may be able to rationalize the source of activity or inactivity of the drugs under investigation.

• 국제학술발표논문집
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• The 1th International Conference on Construction Engineering and Project Management
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• pp.587-591
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• 2005

The case of laboratory-acquired SARS Corona virus infection in Taiwan has revealed a number of weaknesses in management, construction, and oversight of laboratories. Also, with the increased demands for bio-safety laboratory, there is an urgent need to develop a uniform and comprehensive guidance for architects and construction engineers in the preparation of design and construction. This research investigates the key elements for designers, engineers, and potential owners in biosafety laboratory design and construction. It defines key elements and determines major relationships and standards that should be adhered to when developing site layout. In addition to layout planning and design guidance of biosafety laboratory, this research also interviews the perspective of architects and survey the state-of-the-art technology in Taiwan. It represents the portraits by site investigation. The purpose of the research is to provide guideline of design and avoid potential future conflict to ensure the critical continuity of functions.

• Bulletin of the Korean Chemical Society
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• 제33권9호
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• pp.2981-2984
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• 2012

Active site mapping has been done for ${\Delta}^5$-3-ketosteroid isomerase (KSI) by analyses of paramagnetic effect on $^1H-^{15}N$ HSQC spectra using 4-hydroxyl-2,2,6,6-tetramethylpiperidinyl-1-oxy (HyTEMPO) and an intermediate analog (equilenin). Our result revealed that residues in hydrophobic cavity of KSI, particularly active site region, mainly experienced a high line-broadening effect of NMR signal with HyTEMPO, while they experienced full recovery of a lineshape upon the addition of equilenin. The mapped region was very similar to the active site of KSI as described by the crystal structure. These observations indicate that a combined use of paramagnetic reagent and substrate (or analog) could rapidly identify the residues in potential active site of KSI, and can be applied to the analysis of both active site and function in unknown protein.

• 한국정보시스템학회지:정보시스템연구
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• 제18권3호
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• pp.111-134
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• 2009

Today many owners of Web sites are looking to user's satisfaction survey as a key means of measuring the usability of a Web site. While it is preferred for it simplicity and ease of use, this survey method is not without potential risks. This paper focuses on showing that the existing practice of questionnaire-based usability measurement is subject to human recall errors, and that such flaws can be reduced when the questionnaire survey is followed by the users hands-on experience of the site. An empirical study was conducted, and the results indicate that the above speculation holds true. Even if respondents felt highly confident about their responses on a recall survey, a hands-on experience with a focal Web site increased the extent to which the respondents were satisfied with the shopping mall site. This indicates that a user's perception of the quality of a Web site may be distorted or lost as time goes by. In addition, the findings have shown that the use of the verbal protocol analysis method can reveal critical information that can help track the root causes of Web site usability problems, thereby helping to develop site enhancement strategies. The paper concludes with directions for future research.

• Archives of Plastic Surgery
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• 제47권6호
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• pp.528-534
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• 2020

Split-thickness skin grafting (STSG) is the gold standard for coverage of acute burns and reconstructive wounds. However, the choice of the donor site for STSG varies among surgeons, and the scalp represents a relatively under-utilized donor site. Understanding the validity of potential risks will assist in optimizing wound management. A comprehensive literature search was conducted of the PubMed database to identify studies evaluating scalp skin grafting in human subjects published between January 1, 1964 and December 31, 2019. Data were collected on early and late complications at the scalp donor site. In total, 27 articles comparing scalp donor site complications were included. The selected studies included analyses of acute burn patients only (21 of 27 articles), mean total body surface area (20 of 27), age distribution (22 of 27), sex (12 of 27), ethnicity (5 of 27), tumescent technique (21 of 27), depth setting of the dermatome (24 of 27), number of harvests (20 of 27), mean days of epithelization (18 of 27), and early and late complications (27 of 27). The total rate of early complications was 3.82% (117 of 3,062 patients). The total rate of late complications was 5.19% (159 of 3,062 patients). The literature on scalp skin grafting has not yet identified an ideal surgical technique for preventing donor site complications. Although scalp skin grafting provided superior outcomes with fewer donor site complications, there continues to be a lack of standardization. The use of scalp donor sites for STSG can prevent early and late complications if proper surgical planning, procedures, and postoperative care are performed.

• Nuclear Engineering and Technology
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• 제49권2호
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• pp.286-294
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• 2017

The events at the Fukushima Daiichi Nuclear Power Station in March 2011 point out, among other matters, that concurrent accidents at multiple units of a site can occur in reality. Although site risk has been deterministically considered to some extent in nuclear power plant siting and design, potential occurrence of multi-unit accident sequences at a site was not investigated in sufficient detail thus far in the nuclear power community. Therefore, there is considerable worldwide interest and research effort directed toward multi-unit site risk assessment, especially in the countries with high-density nuclear-power-plant sites such as Korea. As the technique of probabilistic safety assessment (PSA) has been successfully applied to evaluate the risk associated with operation of nuclear power plants in the past several decades, the PSA having primarily focused on single-unit risks is now being extended to the multi-unit PSA. In this paper we first characterize the site risk with explicit consideration of the risk associated with spent fuel pools as well as the reactor risks. The status of multi-unit risk assessment is discussed next, followed by a description of the emerging issues relevant to the multi-unit risk evaluation from a practical standpoint.