• Korean Journal of Veterinary Research
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• v.53 no.4
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• pp.231-237
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• 2013

This study aimed to assess the attraction effect against Lycorma delicatula and antioxidant activity of hexane, chloroform, butanol and water fraction obtained from Ailanthus altissima methanol extract. The attraction effect of chloroform fraction showed the highest activity (47%) as compared to that of other fractions. In the DPPH radical scavenging activity, methanol and butanol fraction showed higher antioxidant activity than other solvent fractions. From the above results, the potential chloroform fraction was further performed by local irritation test in New Zealand white rabbits. In eye irritation test, chloroform fraction showed moderate irritant at high concentration 0.5 g/site/mL, but there was no eye irritation at low concentration (0.05 g/site/mL). In accordance with the Draize evaluation of skin irritation, the primary irritation index was calculated to 3.3 and 0.68 at high (0.5 g/site/mL) and low concentration (0.05 g/site/mL) causing moderate and mild irritation, respectively. On the basis of this study, Ailanthus altissima chloroform fraction could be safely considered to be a candidate of attractant against Lycorma delicatula.

• BMB Reports
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• v.43 no.6
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• pp.419-426
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• 2010

Aeromonas hydrophila is a bacterial pathogen that infects a large number of eukaryotes, including humans. The UDP-galactose 4'-epimerase (GalE) catalyzes interconversion of UDP-galactose to UDP-glucose and plays a key role in lipopolysaccharide biosynthesis. This makes it an important virulence determinant, and therefore a potential drug target. Our earlier studies revealed that unlike other GalEs, GalE of A. hydrophila exists as a monomer. This uniqueness necessitated elucidation of its structure and active site. Chemical modification of the 6xHis-rGalE demonstrated the role of histidine residue in catalysis and that it did not constitute the substrate binding pocket. Loss of the 6xHis-rGalE activity and coenzyme fluorescence with thiol modifying reagents established the role of two distinct vicinal thiols in catalysis. Chemical modification studies revealed arginine to be essential for catalysis. Site-directed mutagenesis indicated Tyr149 and Lys153 to be involved in catalysis. Use of glycerol as a cosolvent enhanced the GalE thermostability significantly.

• 한국전산유체공학회:학술대회논문집
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• 2011.05a
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• pp.286-290
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• 2011

This paper introduces the optimum macro-siting of a potential site for an offshore wind farm around Jeju Island using the RDAPS sea wind model. The statistical model was developed by analyzing the sea wind data from RDAPS model, and the meso-scale digital wind map was prepared. To develop the high resolution spatial calibration model, Artificial Neural Network(ANN) models were used to construct the wind and bathymetric maps. Accuracy and consistency of wind/bathymetric spatial calibration models were obtained using analysis of variance. The optimization problem was defined to maximize the energy density satisfying the criteria of maximum water depth and maximum distance from the coastline. The candidate site was selected through Genetic Algorithm(GA). From the results, it is possible to predict roughly a candidate site location for the installation of the offshore wind jam, and to evaluate the wind resources of the proposed site.

• Corrosion Science and Technology
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• v.2 no.3
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• pp.109-116
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• 2003

It is well known that SSCC (sulfide stress corrosion cracking) is caused by drastic ingression of hydrogen during the service and accumulation of hydrogen near the potential crack initiation site in the material. It is important to characterize the hydrogen trapping behavior to evaluate the service performance of the high strength pipeline steels. In this study. the relationship between the hydrogen trapping behavior and SSCC susceptibility is evaluated in terms of alloy composition, microstructure and carbide behavior. The hydrogen trapping behavior was measured by electrochemical hydrogen permeation test cell (Devanathan cell). The SSCC susceptibility is evaluated by constant extension rate test and constant strain lest method. The hydrogen trapping behavior is affected greatly by microstructure and nature of carbide particles. The fine TiC, and NbC in the matrix of ferritic structure acts as strong irreversible trap sites whereas the bainitic structure acts as reversible trap site. The SSCC susceptibility is closely related to not only the hydrogen trapping behavior but also the loading condition. As the activity of reversible trap site increases, SSCC susceptibility decreases under static loading condition below yield strength, whereas SSCC susceptibility increases under dynamic loading condition or above yield strength. As the activity of irreversible trap site increases. SSCC susceptibility increases regardless of loading condition. It is cased by the mixed effect of dislocation on hydrogen diffusion and trapping behavior.

• Journal of the Korean Academy of Esthetic Dentistry
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• v.29 no.1
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• pp.54-61
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• 2020

Forced orthodontic eruption(FOE) is a non-surgical treatment approach that allows augmenting both soft- and hard-tissue profiles of potential implant sites, by forced orthodontic extrusion of "hopeless" teeth and their periodontal apparatus. By stretching the gingival and periodontal ligament fibers during extrusion, tension is imparted to the entire alveolar socket, stimulating osseous apposition at the alveolar crest. FOE increases the width of the attached gingiva, and the mucogingival junction remains stable when the gingival margin migrates coronally. Based on these effects, FOE of non-restorable teeth prior to implant placement is a viable alternative to conventional surgical augmentative procedures in implant site development. The aim of this case report is to describes coronal soft-tissue augmentation around fractured teeth, which was achieved by FOE before implant placement.

• Proceedings of the KSR Conference
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• 2001.05a
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• pp.443-450
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• 2001

This paper shows the reduction effect of tile earthquake-induced liquefaction potential of soils that improved by Vibro-Replacement Stone Columns. The Vibro-Replacement Stone Columns method transforms soft cohesive soils into a composite mass of compacted granular or crushed stone columns by using vibrating equipment and water jets. This study investigated and analyzed the behavior of the stone columns and composite ground using the results of in situ test and measurement at the job-site. This paper shows the evaluation of the earthquake-induced liquefaction potential of soils using in situ test. There are different types of in situ test used in the evaluation the liquefaction potential. In the particular study the Standard penetration test, and Cone penetration test were used. The N value of Standard Penetration test has been used all over for a very long time. The evaluation of the liquefaction of soil was performed using the worldwide renewed Cone penetration test

• Proceedings of the Korean Geotechical Society Conference
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• 2002.03a
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• pp.431-438
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• 2002

Reclaimed coastal areas for the construction of ports and harbors are in general subjected to strong possibility of liquefaction. In this research, a new method for liquefaction hazard microzonation based on liquefaction settlements was developed. Severity of liquefaction hazard was defined by liquefaction settlements obtained from the method proposed by Tokimatsu and Seed. 10 coastal areas, representing typical geological and geotechnical characteristics of Korean ports and harbors, and 3 real earthquake records for site response analysis were selected. From this research, liquefaction settlement criteria is adapted as a new quantitative index for the liquefaction hazard microzonation. Liquefaction settlements were also compared with LPI (Liquefaction Potential Index), obtained from the assessment of liquefaction potential based on the modified Seed and Idriss's method. As an example, 2 and 3 dimensional liquefaction hazard microzonations of Pusan port and harbor area were mapped by overlapped liquefaction settlement contours.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2021.05a
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• pp.110-111
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• 2021

The eggshell is a type of bio-waste which is considered hazardous to the environment. In this research, the waste eggshell is utilized as a potential filler in cementitious material. This study has measured by zeta potential to analyze the interaction between the surface of the filler and the calcium ion in the solution. Meanwhile, the effect of eggshell powder on cement hydration process has been determined by isothermal calorimeter. The results show that the surface of eggshell powder have a strong adsorption of Ca2+, and addition of the eggshell powder provides a heterogeneous nucleation site for cement, which promotes the growth of hydration products.

• Genomics & Informatics
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• v.21 no.3
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• pp.43.1-43.13
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• 2023

Melanin is synthesized by tyrosinase to protect the skin from ultraviolet light. However, overproduction and accumulation of melanin can result in hyperpigmentation and skin melanoma. Tyrosinase inhibitors are commonly used in the treatment of hyperpigmentation. Natural tyrosinase inhibitors are often favoured over synthetic ones due to the potential side effects of the latter, which can include skin irritation, allergies, and other adverse reactions. Nuciferine, an alkaloid derived from Nelumbo nucifera, exhibits potent antioxidant and anti-proliferative properties. This study focused on the in silico screening of nuciferine for anti-tyrosinase activity, using kojic acid, ascorbic acid, and resorcinol as standards. The tyrosinase protein target was selected through homology modeling. The residues of the substrate binding pocket and active site pockets were identified for the purposes of grid box optimization and docking. Therefore, nuciferine is a potent natural tyrosinase inhibitor and shows promising potential for application in the treatment of hyperpigmentation and skin melanoma.

• Journal of Korea Water Resources Association
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• v.53 no.7
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• pp.545-555
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• 2020

A feasibility modeling for potential hydroelectric dam site selection was suggested using 1 sec ASTGTM (ASTER Global Digital Elevation Model) and Terra/Aqua MODIS (Moderate Resolution Imaging Spectroradiometer) derived land use (MCD12Q1) data. The modeling includes DEM pre-processing of peak, sink, and flat, river network generation, watershed delineation and segmentation, terrain analysis of stream cross section and reservoir storage, and estimation of submerged area for compensation. The modeling algorithms were developed using Python and as an open source GIS. When a user-defined stream point is selected, the model evaluates potential hydroelectric head, reservoir surface area and storage capacity curve, watershed time of concentration from DEM, and compensation area from land use data. The model was tested for 4 locations of already constructed Buhang, BohyunMountain, Sungdeok, and Yeongju dams. The modeling results obtained maximum possible heads of 37.0, 67.0, 73.0, 42.0 m, surface areas of 1.81, 2.4, 2.8, 8.8 ㎢, storages of 35.9, 68.0, 91.3, 168.3×10⁶ ㎥ respectively. BohyunMountain and Sungdeok show validity but in case of Buhang and Yeongju dams have maximum head errors. These errors came from the stream generation error due to ASTGTM. So, wrong dam watershed boundary limit the head. This study showed a possibility to estimate potential hydroelectric dam sites before field investigation especially for overseas project.