• Korean Journal of Remote Sensing
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• v.14 no.2
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• pp.165-174
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• 1998

The observation of liquid water content(LWC) and the estimation of precipitation enhancement by cloud seeding were made over the Andong in Korea from March 1997 through Feb 1998. A dual-channel microwave radiometer was used to measure the liquid water content and water vapor. It was shown that the 90% of observational period had the amount of less than 0.1 mm in LWC, and that the amount of precipitation was proportionally increased to liquid water content. The amount of LWC has maximum in summer and minimum in winter. The content of liquid cloud water was showed higher value from the time of 12 to the time of 17 except for summer season in which it extremely fluctuated with a large precipitation. The majority of liquid water content over the area occurred with westerly and southwesterly wind which were flowed from the Sobaek mountain. The ratio of horizontal LWC flux and vertical precipitation flux, $P_{en}$ is almost ranked in the interval of 0.0~0.5 with maximum of 0.5 in spring, 0.2 in summer and fall, and 0.1 in winter. Accordingly, it is estimated that the potential enhancement of precipitation over Andong area by cloud seeding has high value in spring with westerly wind.

• Atmosphere
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• v.24 no.4
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• pp.533-540
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• 2014

Statistical forecast models for the prediction of the summertime Changma precipitation have been developed in this study. As effective predictors for the Changma precipitation, the springtime sea surface temperature (SST) anomalies over the North Atlantic (NA1), the North Pacific (NPC) and the tropical Pacific Ocean (CNINO) has been suggested in Lee and Seo (2013). To further improve the performance of the statistical prediction scheme, we select other potential predictors and construct 2 additional statistical models. The selected predictors are the Northern Indian Ocean (NIO) and the Bering Sea (BS) SST anomalies, and the spring Eurasian snow cover anomaly (EUSC). Then, using the total three statistical prediction models, a simple ensemble-mean prediction is performed. The resulting correlation skill score reaches as high as ~0.90 for the last 21 years, which is ~16% increase in the skill compared to the prediction model by Lee and Seo (2013). The EUSC and BS predictors are related to a strengthening of the Okhotsk high, leading to an enhancement of the Changma front. The NIO predictor induces the cyclonic anomalies to the southwest of the Korean peninsula and southeasterly flows toward the peninsula, giving rise to an increase in the Changma precipitation.

• Atmosphere
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• v.19 no.4
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• pp.297-307
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• 2009

The synoptic structures and the dynamic and thermodynamic characteristics of Changma in 2007 are investigated using the ECMWF analysis data and the radiosonde data from KEOP-2007 IOP. The enhancement of the North-Pacific High into the Korean peninsula and the retreat of the Okhotsk High are shown during the onset of Changma and the change of wind component from southwesterly to northwesterly is appeared during the end of Changma. The baroclinic atmosphere is dominant during Changma at most regions over the Korean peninsula except at Gosan and Sokcho. The quasi-barotropic atmosphere is induced at Gosan by warm air mass and Sokcho by cold air mass. Precipitation in the Korean peninsula occurs when dynamic instability is strengthened as the baroclinic and qusi-barotropic structure is weakened. An empirical orthogonal function (EOF) analysis is performed to find the dominant modes of variability in Changma. The first EOF explains the onset of Changma. The second EOF is related to the discrimination for existence and nonexistence of precipitation during Changma period according to the alternation of equivalent potential temperature between middle and lower atmosphere.

• Journal of Microbiology and Biotechnology
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• v.14 no.3
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• pp.607-611
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• 2004

Glycinin, one of the predominant storage proteins in soybeans, was examined as to whether it could be used as a calcium-binding mediator after chemical phosphorylation and enzymatic hydrolysis. Glycinin is composed of six subunits. One of the proglycinin subunits $(A_{la}B_{lb})$ was overexpressed in E. coli to obtain nonphosphorylated proteins with homogeneity. To investigate the enhanced calcium-binding properties of the phosphopeptides, the proglycinin was purified, phosphorylated, and hydrolyzed with trypsin. The proglycinin expressed in E. coli was purified by ammonium sulfate precipitation, ion-exchange chromatography, and cryoprecipitation. Chemical phosphorylation by sodium trimetaphosphate was performed to obtain phosphorylated proglycinin. After the phosphorylation, one-dimensional isoelectric focusing gel electroanalysis confirmed the phosphorylation of the proglycinin. The phosphorylated peptides were then hydrolyzed with trypsin, followed by a binding reaction with calcium chloride. The calcium-bound phosphopeptides were finally separated using immobilized metal $(Ca^{2+})$ chromatography. Consequently, a limited tryptic hydrolysate of the isolated phosphopeptides exhibited an enhanced calcium-binding ability, suggesting the potential of glycinin phosphopeptides as a calcium-binding mediator with greater availability.

• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.127-134
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• 2008

Peroral administration is the most convenient one for the administration of pharmaceutically active compounds. Most of poorly water-soluble drugs administered via the oral route, however, remain poorly available due to their precipitation in the gastrointestinal (GI) tract and low permeability through intestinal mucosa. In this study, one of drug delivery carriers, lipid nanoparticles (LNPs) were designed in order to reduce side effects and improve solubility and stability in GI tract of the poorly water soluble drugs. However, plain LNPs are generally unstable in the GI tract and susceptible to the action of acids, bile salts and enzymes. Accordingly, the surface of LNPs was modified with polyethylene glycol (PEG) for the purpose of improving solubility and GI stability of paclitaxel (PTX) in vitro. PEG-modified LNPs containing PTX was prepared by spontaneous emulsification and solvent evaporation (SESE) method and characterized for mean particle diameter, entrapping efficiency, zeta potential value and in vitro GI stability. Mean particle diameter and zeta potential value of PEG-modified LNP containing PTX showed approximately 86.9 nm and -22.9 mV, respectively. PTX entrapping efficiency was about 70.5% determined by UV/VIS spectrophotometer. Futhermore, change of particle diameter of PTX-loaded PEG-LNPs in simulated GI fluids and bile fluid was evaluated as a criteria of GI stability. Particle diameter of PTX-loaded PEG-LNPs were preserved under 200 nm for 6 hrs in simulated GI fluids and bile fluid at $37^{\circ}C$ when DSPE-mPEG2000 was added to formulation of LNPs above 4 mole ratio. As a result, PEG-modified LNPs improved stability of plain LNPs that would aggregate in simulated GI fluids and bile solution. These results indicate that LNPs modified with biocompatible and nontoxic polymer such as PEG might be useful for enhancement of GI stability of poorly water-soluble drugs and they might affect PTX absorption affirmatively in gastrointestinal mucosa.