• The Korean Journal of Physiology and Pharmacology
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• v.10 no.1
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• pp.7-11
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• 2006

Interstitial cells of Cajal (ICCs) are pacemakers in gastrointestinal tracts, regulating rhythmicity by activating nonselective cation channels (NSCCs). In the present study, we investigated the general characteristics and pH-mediated regulation of pacemaker activity in cultured interstitial cells of Cajal. Under voltage clamp mode and at the holding potential of -60 mV, the I-V relationships and difference current showed that there was no reversal potential and voltage-independent inward current. Also, when the holding potentials were changed from +20 mV to -80 mV with intervals of 20 mV, there was little difference in inward current. In pacemaker activity, the resting membrane potential (RMP) was depolarized (In pH 5.5, $23{\pm}1.5$ mV depolarized) and the amplitude was decreased by a decrease of the extracellular pH. However, in case of increase of extracellular pH, the RMP was slightly hyperpolarized and the amplitude was decreased a little. The melastatin type transient receptor potential (TRPM) channel 7 has been suggested to be required for intestinal pacemaking activity. TRPM7 produced large outward currents and small inward currents by voltage ramps, ranging from +100 to -100 mV from a holding potential of -60 mV. The inward current of TRPM7 was dramatically increased by a decrease in the extracellular pH. At pH 4.0, the average inward current amplitude measured at -100 mV was increased by about 7 fold, compared with the current amplitude at pH 7.4. Changes in the outward current (measured at +100 mV) were much smaller than those of the inward current. These results indicate that the resting membrane potential of pacemaking activity might be depolarized by external acidic pH through TRPM7 that is required for intestinal pacemaking activity.

• Journal of the Korean Vacuum Society
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• v.9 no.4
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• pp.428-435
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• 2000

Negative ion generation in an inductively coupled oxygen plasma was investigated by using a Langmuir probe. It was observed that the probe current ratio of the positive ion saturation current and the negative current which is consisted of the electron current and the negative ion current, and also the potential difference between the floating potential and plasma potential vary with the RF input power and more sensitively with the operating pressure, respectively. Results show that the operating condition to achieve the maximum probe current ratio and the minimum potential difference shift from the low pressure region to the high pressure regions with increasing the input power. It implies that the generation of the negative oxygen ions increases and the recombination of the positive and negative ions are enhanced in the plasma.

• Journal of Electrochemical Science and Technology
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• v.15 no.2
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• pp.268-275
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• 2024

The study examined the electrogeneration of hypochlorite ions (ClO^-) via electrolysis of aqueous NaCl solutions using a dimensionally stable anode-type (DSA-type) electrode based on platinum and palladium oxides supported on titanium mesh (Ti/PtPd(10%)O_x). The electrogenerated ClO^- was quantified on the basis of the absorption band at 292 nm (A_λ = 292) of the UV-Vis spectrum. The effect of initial pH, concentration of NaCl, cell potential difference and electrolysis time were investigated in this study. The results showed that the electrolysis of aqueous NaCl solutions increases the solution pH up to high values (≥ 8.0) that favor the formation of ClO^- over chlorine or hypochlorous acid. The hypochlorite concentration increases significantly at pH values > 7.0 and shows a linear trend with increasing NaCl concentration and with increasing cell potential difference. When the cell potential and NaCl concentration are held constant, the maximum hypochlorite value during electrolysis depends on both the cell potential and NaCl concentration. The Ti/PtPd(10%)O_x anode favors the production of hypochlorite ions, making this anode a promising material for use in electrochemical oxidation of wastewater via an indirect mechanism.

• Communications of the Korean Mathematical Society
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• v.26 no.4
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• pp.591-601
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• 2011

In this paper, we deal with the discrete p-Laplacian operators with a potential term having the smallest nonnegative eigenvalue. Such operators are classified as its smallest eigenvalue is positive or zero. We discuss differences between them such as an existence of solutions of p-Laplacian equations on networks and properties of the energy functional. Also, we give some examples of Poisson equations which suggest a difference between linear types and nonlinear types. Finally, we study characteristics of the set of a potential those involving operator has the smallest positive eigenvalue.

• Bulletin of the Korean Chemical Society
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• v.17 no.1
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• pp.19-24
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• 1996

The potential energies of HIV-1 protease, inhibitor, and their complex have been calculated by molecular mechanics and the "binding energy", defined as the difference between the potential energy of complex and the sum of potential energies of HIV-1 protease and its inhibitor, has been compared to the free energy in inhibition reaction. The trend in these binding energies seems to agree with that in free energies.

• Journal of Korean Physical Therapy Science
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• v.15 no.1
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• pp.11-20
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• 2008

This study was designed to test the effects of comprehensive rehabilitation management on functional recovery after attack of cerebrovascular disease. 16 cerebrovascular disease patients applied comprehensive rehabilitation management of physical therapy at department of physical Therapy, C medical center in Gwang－ju. The collection of the data had been executed for 4months(April 15, 2007${\sim}$July 15, 2007). For evaluating, Functional Independence measure(FIM) and Somatosensory Evoked Potential(SSEP) were used to assess functional recovery. The results of this study were as follows: 1. In the comparison of latency of median nerve SSEP before and after treatment, the lat. N20 and P25 increased, the ampl. P25/N20 was decreased. In the comparison difference data of median nerve SSEP, however there was no significant difference in the group(p>0.05). 2. In the comparison of latency of Post Tibial nerve SSEP before and after treatment, the lat. P40, P50, P60 increased, the ampl. P40 was decreased. In the comparison difference data of post tibial nerve SSEP, however there was no significant difference in the group(p>0.05). 3. In the comparison of FIM scores of Self－care, Sphincter Control, Mobility: Transfer, Locomotion before and after treatment, the scores of FIM was significantly increased. In the comparison of difference of the motor part of FIM, however there was significant difference(p<0.05). 4. In the comparison of FIM scores of Communication, Social Cognition before and after treatment, the scores of FIM was significantly increased. In the comparison of difference of the motor part of FIM, however there was no significant difference in the group(p>0.05). Based on these results, it is concluded that the comprehensive rehabilitation management for cerebrovascular disease case was not significant difference in the SSEP, was significant difference in the motor part of FIM. Further study should be done to analyze the effect of intervention duration of treatment, optimal time to apply the treatment in more long period.

• International conference on construction engineering and project management
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• 2020.12a
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• pp.425-432
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• 2020

In order to improve the sustainability and smart construction, it is discussed arguably that developing and applying consistent "standard model" to plan business, design, construct and operate a building is considered to be one of the effective and efficient approach. The scope of this article is to examine, from the international developer's perspective, the "standard model" approach of a hotel brand to building projects in the UK, and also to explore potential role of project team to mitigate any local difference at the project level. These projects are developed by the same developer adopting the same business plan, design and operation to each project. In order to clarify the actual and likely difference in construction results, reference is also made to those building projects located in other geographical markets including Japan, Germany and USA, and focus is given on the analysis of its programme and cost. Principle findings are that there exists geographical difference especially in environmental and planning system, and that major local difference is found at least in the programme at the design stage. In contrast, the difference in the building cost itself may not be necessarily considered major if currency exchange rate being taken into account appropriately. It is also observed that there were cases where any difference in the programme was mitigated by taking different approach to procuring and defining roles of management and professional team at the project level. In conclusion, from the international developer's perspective, the geographical difference of the "construction system" surrounding building projects can typically lead to major prolongation of programme, however, these different construction results could be mitigated at least to a certain extent by introducing appropriate changes to the role of project team.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6979-6983
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• 2013

Background: Oral lichen planus (OLP) is categorized as premalignant lesion although its malignant potential is a matter of controversy. The objective of this study was to investigate Ki67 expression in OLP, oral epithelial dysplasia and oral squamous cell carcinoma (OSCC). Materials and Methods: Expression of Ki67 was evaluated through immunohistochemistry (IHC) in groups of A (17 cases of epithelial hyperplasia), B (16 cases of OLP), C1 (10 cases of mild epithelial dysplasia), C2 (10 cases of severe epithelial dysplasia), D1 (10 cases of well-differentiated OSCC), and D2 (10 cases of poorly-differentiated OSCC). Results: There was a significant difference in Ki67 expression based on quantitative analysis among the six studied groups as well as group B compared bilaterally with groups C2, D1 and D2 (p< 0.0001). However, there was no significant difference between groups B and C1 or between groups D1 and D2 (p> 0.05). Conclusions: Based on the results of the present study it may not be possible to definitely consider malignant transformation potential for OLP. However, expression of Ki67 was significantly higher in OLP than that of epithelial hyperplasia with no significant difference from that of mild epithelial dysplasia. This should be considered by clinicians to carefully and regularly follow up OLP lesions to detect potential subtle changes at an early stage.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.22 no.5
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• pp.411-420
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• 2009

This study presents an extended finite difference method based on moving least squares(MLS) method for solving potential problems with interfacial boundary. The approximation constructed from the MLS Taylor polynomial is modified by inserting of wedge functions for the interface modeling. Governing equations are node-wisely discretized without involving element or grid; immersion of interfacial condition into the approximation circumvents numerical difficulties owing to geometrical modeling of interface. Interface modeling introduces no additional unknowns in the system of equations but makes the system overdetermined. So, the numbers of unknowns and equations are equalized by the symmetrization of the stiffness matrix. Increase in computational effort is the trade-off for ease of interface modeling. Numerical results clearly show that the developed numerical scheme sharply describes the wedge behavior as well as jumps and efficiently and accurately solves potential problems with interface.

• Journal of Korea Water Resources Association
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• v.50 no.12
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• pp.863-875
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• 2017

In this study, the effects of potential evapotranspiration method on drought index results were evaluated using SC-PDSI. Monthly heat index method, Penman-Monteith method, and Hargreaves equation were used as potential evapotranspiration method. SC-PDSI was calculated using three potential evapotranspiration method at 56 stations and compared the results. As a result, it was confirmed that the results by Penman-Monteith method and Hargreaves equation showed similar SC-PDSI calculation results without much difference, and the result by monthly heat index method showed a relatively large difference. It was confirmed that the results of SC-PDSI and drought situation judgment for the period of spring and winter season showed a big difference by the month. In conclusion, when calculating PDSI in Korea, using Penman-Monteith method and Hargreaves equation will be able to express the drought situation well.