• Title/Summary/Keyword: positive equilibrium

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Association of PINX1 but not TEP1 Polymorphisms with Progression to Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection

  • Sriprapun, Methee;Chuaypen, Natthaya;Khlaiphuengsin, Apichaya;Pinjaroen, Nutcha;Payungporn, Sunchai;Tangkijvanich, Pisit
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.4
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    • pp.2019-2025
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    • 2016
  • Hepatocellular carcinoma (HCC) is major health problem with high mortality rates, especially in patients with hepatitis B virus (HBV) infection. Telomerase function is one of common mechanisms affecting genome stability and cancer development. Recent studies demonstrated that genetic polymorphisms of telomerase associated genes such as telomerase associated protein 1 (TEP1) rs1713449 and PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1) rs1469557 may be associated with risk of HCC and other cancers. In this study, 325 patients with HCC and 539 non-HCC groups [193 healthy controls, 80 patients with HBV-related liver cirrhosis (LC) and 266 patients with HBV-related chronic hepatitis (CH)] were enrolled to explore genetic polymorphisms of both SNPs using the allelic discrimination method based on MGB probe TaqMan real time PCR. We demonstrated that all genotypes of both genes were in Hardy-Wienberg equilibrium (P>0.05). Moreover, there was no significant association between rs1713449 genotypes and HCC risk, HCC progression and overall survival (P>0.05). Interestingly, we observed positive association of rs1469557 with risk of HCC when compared with the LC group under dominant (CC versus CT+TT, OR=1.89, 95% CI= 1.06-3.40, P=0.031) and allelic (C versus T alleles, OR=1.75, 95% CI=1.04-2.94, P=0.033) models, respectively. Moreover, overall survival of HCC patients with CC genotype of rs1469557 was significantly higher than non-CC genotype (Log-rank P=0.015). These findings suggest that PINX1 rs1469557 but not TEP1 rs1469557 might play a role in HCC progression in Thai patients with LC and be used as the prognosis marker to predict overall survival in HCC patients.

Study on Adsorption Kinetic Characteristics of Propineb Pesticide on Activated Carbon (활성탄에 대한 프로피네브 농약의 흡착동력학적 특성 연구)

  • Lee, Jong-Jib;Cho, Jung-Ho;Kim, Heung-Tae
    • Clean Technology
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    • v.17 no.4
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    • pp.346-352
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    • 2011
  • The adsorption characteristics of propineb pesticide onto activated carbon has been investigated for the adsorption in aqueous solution with respect to initial concentration, contact time and temperature in batch experiment. The Langmuir and Freundlich adsorption models were applied to described the equilibrium isotherms and isotherm constants were also determined. The Freundlich model agrees with experimental data well. slope of isotherm line indicate that activated carbon could be employed as effective treatment for removal of propineb. The pseudo first order, pseudo second order kinetic models were use to describe the kinetic data and rate constants were evaluated. The adsorption process followed a pseudo second order model, and the adsorption rate constant($k_2$) decreased with increasing initial concentration of propineb. The activation energy, change of free energy, enthalpy, and entropy were also calculated to predict the nature adsorption. The estimated values for change of free energy were -7.28, -8.27 and -11.66 kJ/mol over activated carbon at 298, 308 and 318 K, respectively. The results indicated toward a spontaneous process. The positive value for change of enthalpy, 54.46 kJ/mol, found that the adsorption of propineb on activated carbon is an endothermic process.

A Study on the Trade Effects of FTAs in Busan's Manufacturing Industry (FTA가 부산지역 제조업의 무역에 미치는 영향)

  • Hwang, Young-Soon;Kim, Hong-Youl
    • International Commerce and Information Review
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    • v.14 no.4
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    • pp.517-541
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    • 2012
  • Since the Korea-Chile FTA in 2003, eight FTAs are now in force including Korea-EU and Korea-US FTA. The government anticipate that FTAs increase the GDP of Korea. Government-related research institutes officially reports the positive economic impact in Korea. However, the report does not show that how much Busan economy is affected by the FTAs. For this reason, we study the economic effects of FTAs in Busan. We compare the trade statistics before and after the time each FTA is in force. The resulting figures show that the exports and trades of Busan with the FTA nations increased significantly after the enforcement. For example, the exports to Chile increased by 273% when we compare the three-year average trade. We also construct an econometrics model to estimate the price elasticity. The estimated elasticity of exports for manufactured goods is 1.38 while that of imports is 0.83. Among the manufacturing industry, machinery has the highest price elasticity, 1.8. The average tariff for manufactured goods is 3.9% for FTA nations, while that is 5.8% for Busan. This higher price fall in Busan is offset by the lower price elasticity to make Busan's export increase be greater than Busan's import increase. Busan's export increases by 4.8% while import increases by 3.7%. So, it is expected to be added to the annual trade surplus of approximately $107million.

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Economic Valuation of Green Open Spaces: The Effects of Homeownership and Residential Types (도시녹지의 경제가치 평가: 소유 여부와 주택유형의 영향)

  • Choi, Andy Sungnok;Cho, Seong-Hoon
    • Environmental and Resource Economics Review
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    • v.30 no.3
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    • pp.395-433
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    • 2021
  • This paper aims to examine the effects of homeownership and residential types on the economic values of urban green spaces. Green open spaces as public goods provide positive externalities that are comprised of pecuniary and technological externalities. Seoul, South Korea, is used as a case study using choice experiments, with split-sample online respondents of 1,000. The study results evidenced that the differentiation between the two types of externalities is imperative for equitable provisions and efficient management of various urban open spaces. There is a positively significant and substantial impact of homeownership for apartment dwellers, ceteris paribus, but not for house dwellers. For apartments, the efficiency loss can be reduced by increasing green spaces up to the critical point where the marginal cost is at equilibrium with tenants' marginal values. For non-apartment houses, it is not homeownership but the monthly household income that has a significant impact on the amenity value. In general, public benefits from green spaces are equivalent to 16% to 33% of the current residential prices on average for a view or access. Different residential types do not cause a significant impact on the access values. Residential profiles for green spaces were developed, together with tailor-made policy suggestions.

Pyrolysis Effect of Nitrous Oxide Depending on Reaction Temperature and Residence Time (반응온도 및 체류시간에 따른 아산화질소 열분해 효과)

  • Park, Juwon;Lee, Taehwa;Park, Dae Geun;Kim, Seung Gon;Yoon, Sung Hwan
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.27 no.7
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    • pp.1074-1081
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    • 2021
  • Nitrous oxide (N2O) is one of the six major greenhouse gases and is known to produce a greenhouse ef ect by absorbing infrared radiation in the atmosphere. In particular, its global warming potential (GWP) is 310 times higher than that of CO2, making N2O a global concern. Accordingly, strong environmental regulations are being proposed. N2O reduction technology can be classified into concentration recovery, catalytic decomposition, and pyrolysis according to physical methods. This study intends to provide information on temperature conditions and reaction time required to reduce nitrogen oxides with cost. The high-temperature ranges selected for pyrolysis conditions were calculated at intervals of 100 K from 1073 K to 1373 K. Under temperatures of 1073 K and 1173 K, the N2O reduction rate and nitrogen monoxide concentration were observed to be proportional to the residence time, and for 1273 K, the N2O reduction rate decreased due to generation of the reverse reaction as the residence time increased. Particularly for 1373 K, the positive and reverse reactions for all residence times reached chemical equilibrium, resulting in a rather reduced reaction progression to N2O reduction.

The Effects of Resistance Exercise on Body Composition Physical Strength, Blood Lipids and Insulin in Elderly Women (저항성 운동이 여성 노인의 신체조성, 체력, 혈중지질 및 인슐린에 미치는 영향)

  • Kim, Won-Gyeong;Kim, Hyun-Jun
    • Journal of The Korean Society of Integrative Medicine
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    • v.10 no.3
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    • pp.85-94
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    • 2022
  • Purpose : This study aimed to investigate the effects of 12 weeks of resistance exercise on body composition, physical strength, blood lipids, and insulin. Methods : The study was conducted on 24 elderly women divided into two groups: 12 subjects in an exercise group and 12 subjects in a control group. Resistance exercise was performed for 50 minutes a day, three times a week, for the duration of 12 weeks, and body composition, physical strength, blood lipids, and insulin were measured before and after the subjects completed the program. For the statistical analysis, the mean and standard deviation (M±SD) of each variable were calculated using SPSS version 20, and a paired t-test and two-way repeated ANOVA were conducted to test for the differences before and after the resistance exercise. All significant levels were set to α=.05 as a result of the experiment. Results : Changes in body composition after the 12-week resistance exercise program did not show any significant difference based on the comparison between the groups, but when noting the values for body fat percentage and body in the control group before and after, a significant difference was shown in fat mass (p<.05). As for changes in physical fitness, significant differences appeared in flexibility, muscle strength, and stenotic force (p<.01) when the groups were compared. Regarding pre- and post-values within each group concerning flexibility within the exercise group, significant differences were shown in gender (p<.001), muscle strength (p<.05), (p<.01), muscle earth strength, equilibrium (p<.01), stenosis force, and cardiopulmonary earth force (p<.001). Also, comparisons between populations in changes in blood lipids the values before and after in each group, significant differences in glucose (p<.05) and insulin (p<.05) were shown in the exercise group. When comparing the values before and after in each population, a significant difference was shown in the control group (p<.05). Conclusion : When all the results were integrated, the 12-week resistance exercise program was found to enhance physical strength (flexibility, muscle strength, and coordination) and improve the blood sugar levels of elderly women. In particular, resistance exercise is believed to lower the prevalence of obesity, type 2 diabetes mellitus, and metabolic diseases by having a positive effect on insulin. Further studies are suggested to verify the effect on body composition and blood lipids by setting up a variety of exercise treatment methods (including subjects, exercise periods, exercise plans, and exercise intensity focuses).

Investing the relationship between R&D expenditure and economic growth (연구개발투자와 경제성장의 상호관계 실증분석)

  • hyunyi Choi;Cho Keun Tae
    • Journal of Technology Innovation
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    • v.31 no.2
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    • pp.59-82
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    • 2023
  • The purpose of this research is to conduct the empirical analysis of the short- and long-term causal relationship between public R&D investment, corporate R&D investment, and university R&D investment on economic growth in Korea. To this end, based on the time series data from 1976 to 2020, a causality test was conducted through the unit root test, cointegration test, and vector error correction model (VECM). As a result, it was found that there is a long-run equilibrium relationship between economic growth in Korea, public R&D investment, corporate R&D investment, and university R&D investment, in which a causal relationship exists in the long run. Also, while public R&D investment has a short-term effect on economic growth, corporate and university R&D investment does not have a short-term effect on economic growth. In addition, the results shows that there is a bidirectional causal relationship between economic growth and public R&D investment, corporate R&D investment and public R&D investment, and university R&D investment and public R&D investment in the short term. Through this research, it was empirically found that a highly mutual relationship exists between public R&D investment, corporate R&D investment, university R&D investment and economic growth. In order to increase the ripple effect of R&D investment on economic growth in the future, R&D investment between universities and corporations should be mutually promoted, and R&D investment by corporations should have a positive effect on public R&D investment so that public R&D investment can contribute to future economic growth.

The Effects of North Korea's Mineral Export on Various Imports (북한의 광물 수출과 품목별 수입: 대중무역을 중심으로)

  • Kim, Dawool;Kim, Minjung;Kim, Byung-Yeon
    • Economic Analysis
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    • v.26 no.2
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    • pp.72-113
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    • 2020
  • This study investigates the relationship between mineral exports to China, North Korea's most important source of foreign currency acquisition, and its imports of various items from China from the first quarter of 1995 through to the third quarter of 2019. The results from a cointegration analysis suggest that there exists a long-run equilibrium relationship between mineral exports and imports of food, fuel, and some intermediate goods, such as industrial supplies, parts, and accessories. The results from a vector autoregression using first-differenced variables indicate that the short-run relationship between mineral exports and imports is different between the period before and after the third quarter of 2010. Prior to structural changes, i.e., before the third quarter of 2010, import shocks affected mineral exports. However, after the third quarter of 2010, an increase in mineral exports led to an increase in the import of vehicles, intermediate goods, and luxury goods. This paper shows both the possibilities and the limits that mineral exports can contribute to North Korea's economic growth. The results, which show that mineral exports have a long-run relationship with intermediate goods, such as industrial supplies, parts and accessories, imply that mineral exports to China could have a positive effect on the North Korean economy. However, the fact that mineral exports do not have any significant effect on the import of machinery and equipment, which helps the accumulation of capital formation, shows that mineral exports have a limited effect on inducing long-term growth in the North Korean economy.

Analysis of Shipping Markets Using VAR and VECM Models (VAR과 VECM 모형을 이용한 해운시장 분석)

  • Byoung-Wook Ko
    • Korea Trade Review
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    • v.48 no.3
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    • pp.69-88
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    • 2023
  • This study analyzes the dynamic characteristics of cargo volume (demand), ship fleet (supply), and freight rate (price) of container, dry bulk, and tanker shipping markets by using the VAR and VECM models. This analysis is expected to enhance the statistical understanding of market dynamics, which is perceived by the actual experiences of market participants. The common statistical patterns, which are all shown in the three shipping markets, are as follows: 1) The Granger-causality test reveals that the past increase of fleet variable induces the present decrease of freight rate variable. 2) The impulse-response analysis shows that cargo shock increases the freight rate but fleet shock decreases the freight rate. 3) Among the three cargo, fleet, and freight rate shocks, the freight rate shock is overwhelmingly largest. 4) The comparison of adjR2 reveals that the fleet variable is most explained by the endogenous variables, i.e., cargo, fleet, and freight rate in each of shipping markets. 5) The estimation of co-integrating vectors shows that the increase of cargo increases the freight rate but the increase of fleet decreases the freight rate. 6) The estimation of adjustment speed demonstrates that the past-period positive deviation from the long-run equilibrium freight rate induces the decrease of present freight rate.

Dynamic Limit and Predatory Pricing Under Uncertainty (불확실성하(不確實性下)의 동태적(動態的) 진입제한(進入制限) 및 약탈가격(掠奪價格) 책정(策定))

  • Yoo, Yoon-ha
    • KDI Journal of Economic Policy
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    • v.13 no.1
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    • pp.151-166
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    • 1991
  • In this paper, a simple game-theoretic entry deterrence model is developed that integrates both limit pricing and predatory pricing. While there have been extensive studies which have dealt with predation and limit pricing separately, no study so far has analyzed these closely related practices in a unified framework. Treating each practice as if it were an independent phenomenon is, of course, an analytical necessity to abstract from complex realities. However, welfare analysis based on such a model may give misleading policy implications. By analyzing limit and predatory pricing within a single framework, this paper attempts to shed some light on the effects of interactions between these two frequently cited tactics of entry deterrence. Another distinctive feature of the paper is that limit and predatory pricing emerge, in equilibrium, as rational, profit maximizing strategies in the model. Until recently, the only conclusion from formal analyses of predatory pricing was that predation is unlikely to take place if every economic agent is assumed to be rational. This conclusion rests upon the argument that predation is costly; that is, it inflicts more losses upon the predator than upon the rival producer, and, therefore, is unlikely to succeed in driving out the rival, who understands that the price cutting, if it ever takes place, must be temporary. Recently several attempts have been made to overcome this modelling difficulty by Kreps and Wilson, Milgram and Roberts, Benoit, Fudenberg and Tirole, and Roberts. With the exception of Roberts, however, these studies, though successful in preserving the rationality of players, still share one serious weakness in that they resort to ad hoc, external constraints in order to generate profit maximizing predation. The present paper uses a highly stylized model of Cournot duopoly and derives the equilibrium predatory strategy without invoking external constraints except the assumption of asymmetrically distributed information. The underlying intuition behind the model can be summarized as follows. Imagine a firm that is considering entry into a monopolist's market but is uncertain about the incumbent firm's cost structure. If the monopolist has low cost, the rival would rather not enter because it would be difficult to compete with an efficient, low-cost firm. If the monopolist has high costs, however, the rival will definitely enter the market because it can make positive profits. In this situation, if the incumbent firm unwittingly produces its monopoly output, the entrant can infer the nature of the monopolist's cost by observing the monopolist's price. Knowing this, the high cost monopolist increases its output level up to what would have been produced by a low cost firm in an effort to conceal its cost condition. This constitutes limit pricing. The same logic applies when there is a rival competitor in the market. Producing a high cost duopoly output is self-revealing and thus to be avoided. Therefore, the firm chooses to produce the low cost duopoly output, consequently inflicting losses to the entrant or rival producer, thus acting in a predatory manner. The policy implications of the analysis are rather mixed. Contrary to the widely accepted hypothesis that predation is, at best, a negative sum game, and thus, a strategy that is unlikely to be played from the outset, this paper concludes that predation can be real occurence by showing that it can arise as an effective profit maximizing strategy. This conclusion alone may imply that the government can play a role in increasing the consumer welfare, say, by banning predation or limit pricing. However, the problem is that it is rather difficult to ascribe any welfare losses to these kinds of entry deterring practices. This difficulty arises from the fact that if the same practices have been adopted by a low cost firm, they could not be called entry-deterring. Moreover, the high cost incumbent in the model is doing exactly what the low cost firm would have done to keep the market to itself. All in all, this paper suggests that a government injunction of limit and predatory pricing should be applied with great care, evaluating each case on its own basis. Hasty generalization may work to the detriment, rather than the enhancement of consumer welfare.

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