• Biodesign
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• 제5권3호
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• pp.122-125
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• 2017

Receptor for advanced glycation end products (RAGE) is one of the single transmembrane domain containing receptors and causes various inflammatory diseases including diabetes and atherosclerosis. RAGE extracellular domain has three consecutive IgG-like domains (V-C₁-C₂ domain) which interact with various soluble ligands including heparan sulfate or HMGB1. Studies have shown that each ligand induces different oligomeric forms of RAGE which results in a ligand-specific signal transduction. The structure of mouse RAGE bound to heparan sulfate has been previously determined but the electron density map of heparan sulfate was too ambiguous that the exact position of heparin sulfate could not be defined. Furthermore, the complex structure of human RAGE and heparin sulfate still remains elusive. Therefore, to determine the structure, human RAGE was overexpressed using bacterial expression system and crystallized using the sitting drop method in the condition of 0.1 M sodium acetate trihydrate pH 4.6, 8 % (w/v) polyethylene glycol 4,000 at 290 K. The crystal diffracted to 3.6 Å resolution and the space group is C121 with unit cell parameters a= 206.04 Å, b= 68.64 Å, c= 98.73 Å, α= 90.00°, β= 90.62°, γ= 90.00°.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2003년도 봄 학술발표논문집 Vol.30 No.1 (B)
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• pp.136-138
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• 2003

UML cannot meet all the requirements offered in different software system for diverse application domain. GNSS (Global Navigation Satellite System) application domain is an especial environment that requires precise measurement and precision calculation of real-world geographical entities with the help of GPS (Global Position System) in both temporal and spatial factor. Therefore in the paper new extended iconic stereotypes for better modeling GNSS application in the UML Diagram are proposed, and the implementation of a program called StereotypeCreator, which is able to create iconic stereotypes used in one of the most popular visual modeling tools for software development, Rational Rose, will be also proposed.

• Journal of Mechanical Science and Technology
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• 제16권10호
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• pp.1320-1326
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• 2002

In a one-dimensional heat conduction domain with heated and insulated walls, an integral approach is proposed to estimate time-dependent boundary heat flux without internal measurements. It is assumed that the expression of the heat flux is not known a priori. Hence, the present inverse heat conduction problem is classified as a function estimation problem. The spatial temperature distribution is approximated as a third-order polynomial of position, whose four coefficients are determined from the heat fluxes and the temperatures at both ends at each measurement. After integrating the heat conduction equation over spatial and time domain, respectively, a simple and non-iterative recursive equation to estimate the time-dependent boundary heat flux is derived. Several examples are introduced to show the effectiveness of the present approach.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 D
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• pp.2101-2102
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• 2006

In this paper, a new digital audio watermarking algorithm is presented. The proposed algorithm embeds watermark into audio signal based on human auditory system (HAS). This algorithm is a blind audio watermarking method, which does not require any prior information during watermark extraction process. This algorithm finds watermarking position using time-domain masking effect. First we insert the watermark into wavelet domain, and then we use a back-propagation neural network (BPN) to learn the characteristics of relationship between the watermark and the watermarked audio. Due to the teaming and adaptive capabilities of the BPN, the false recovery of the watermark can be greatly reduced by the trained BPN. Experimental results show that the proposed method has good inaudibility and high robustness to common audio processing attacks.

• 제어로봇시스템학회논문지
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• 제8권5호
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• pp.373-384
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• 2002

This paper presents a robust PID controller design technique using the concept of model matching method in the frequency domain. To design the robust PID controller satisfying disturbance attenuation and robust tracking property for a reference input, first an H$\infty$ controller satisfying given performance is designed using the H$\infty$ control method. And then, the parameters(proportional, integral, and derivative gains) of the robust PID controller are determined using the model matching at frequency domain. The proposed technique is applied to a position controller design of the web. The simulation results show that the proposed robust PID controller satisfies disturbance attenuation and tracking property.

• Molecules and Cells
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• 제40권12호
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• pp.889-896
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• 2017

Nuclear bodies are subnuclear, spheroidal, and membraneless compartments that concentrate specific proteins and/or RNAs. They serve as sites of biogenesis, storage, and sequestration of specific RNAs, proteins, or ribonucleoprotein complexes. Recent studies reveal that a subset of nuclear bodies in various eukaryotic organisms is constructed using architectural long noncoding RNAs (arcRNAs). Here, we describe the unifying mechanistic principles of the construction and function of these bodies, especially focusing on liquid-liquid phase separation induced by architectural molecules that form multiple weakly adhesive interactions. We also discuss three possible advantages of using arcRNAs rather than architectural proteins to build the bodies: position-specificity, rapidity, and economy in sequestering nucleic acid-binding proteins. Moreover, we introduce two recently devised methods to discover novel arcRNA-constructed bodies; one that focuses on the RNase-sensitivity of these bodies, and another that focuses on "semi-extractability" of arcRNAs.

• 한국생산제조학회지
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• 제23권2호
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• pp.157-163
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• 2014

In this paper, a robust MRAC (model reference adaptive control) scheme is applied to control an electrohydraulic positioning system under various loads. The inverse dead-zone compensator in the control system cancels out the dead-zone response, and an integrator added to the controller provides good position-tracking ability. LQG/LTR (linear quadratic Gaussian control with loop transfer recovery) closed-loop model is used as the reference model for learning the MRAC system. LQG/LTR provides a systematic technique to design the linear controller that optimizes the objective function using some compromise between the control effort and the system performance in the frequency domain. Different external load tests are performed to investigate the effectiveness of the designed MRAC system in real time. The experimental results show that the tracking performance of the proposed system is highly accurate, which offers considerable robustness even with a large change in the load.

• 대한음성학회지:말소리
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• 제45호
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• pp.63-77
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• 2003

The purpose of voice color conversion is to change the speaker identity perceived from the speech signal. In this paper, we propose a new voice color conversion algorithm through the formant shifting and the spectrum-tilt modification in the frequency domain. The basic idea of this technique is to convert the positions of source formants into those of target speaker's formants through interpolation and decimation and to modify the spectrum-tilt by utilizing the information of both speakers' spectrum envelops. The LPC spectrum is adopted to evaluate the position of formant and the information of spectrum-tilt. Our algorithm enables us to convert the speaker identity rather successfully while maintaining good speech quality, since it modifies speech waveforms directly in the frequency domain.

• 전자공학회논문지A
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• 제31A권2호
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• pp.60-66
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• 1994

The scattering problem by E-polarized plane wave with oblique incidence on a tapered resistive strip grating with infinite resistivity at strip-edges is analyzed by the method of moments in the spectral domain. Then the induced surface current density is expanded in a series of Ultraspherical polynomials of the zeroth order. The expansion coefficients are calculated numerically in the spectral domain, the numerical results of the geometricoptical reflection coefficient for the tapered resistivity in this paper are compared with those for the existing uniform resistivity. And the position of sharp variation points in the magnitude of the geometric-optical reflection coefficient can be moved by varying the incident angle and the strip spacing. It is found out that these sharp variation points are due to the transition of higher modes between the propagation mode and the evanescent mode.

• 한국전산유체공학회지
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• 제3권2호
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• pp.1-8
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• 1998

We make use of cubic B-spline interpolation function in two cases: heat conduction and fluid flow problems. Cubic B-spline test function is employed because it is superior to approximation of linear and non-linear problems. We investigated the accuracy of the numerical formulation and focused on the position of the breakpoints within the computational domain. When the domain is divided by partitions of equal space, the results show poor accuracy. For the case of a heat conduction problem this partition can not reflect the temperature gradient which is rapidly changed near the wall. To correct the problem, we have more grid points near the wall or the region which has a rapid change of variables. When we applied the unequally spaced breakpoints, the results show high accuracy. Based on the comparison of the linear problem, we extended to the highly non-linear fluid flow problems.