• 약학회지
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• 제46권1호
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• pp.63-68
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• 2002

The purpose of this study was to estimate the population pharmacokinetics of clarithromycin in healthy adult Korean and to investigate the factors influencing the pharmacokinetics of clarithromycin. The population pharmacokinetic parameters of clarithromycin were calculated with the data from healthy adult Koreans. A total of 798 plasma concentrations obtained from 78 subjects after administration of a single oral dose of 250 mg or 500 mg were used for the modeling. The concentration-time data were fitted to a one-compartment open model assuming a first-order absorption and elimination with no lag time. The correlations between various factors [such as sex, age, height, weight, sect creatinine (Scr) and dose and pharmacokinetic parameters were estimated with stepwise linear recession analyses. The selected covariates were incorporated in the population model of NONMEM, and the importance of each covariate was investigated by means of backwards elimination. The apparent clearance (CL/F) was significantly correlated to Scr and sex, and the apparent volume of distribution (Vd/F) was significantly correlated to Scr and height in a nonlinear relationship. The population values of Ka was 1.8 h $r_{-1}$, CL/F was 37.71 L/hr, Vd/F was 200 L and t/ sub 1/2 / was 3.68 hrs for a male Korean with 170 m height and 1.0 mg/dL Scr.

• 농촌계획
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• 제19권4호
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• pp.203-212
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• 2013

The aging of farm households has caused serious problems such as productivity slowdown and aggravated income polarization in South Korea. Urban-to-rural migration has been recently suggested as a measure to attenuate the aging of rural population and other related problems. The inflow of migrants for farming can have a substantial effect on agriculture and rural communities while the natural adjustment of rural population caused by birth and death is slow. This paper forecasts population distribution of different provinces using the Origin-Destination (OD) analysis, taking into account both the size and directions of migration. In the analysis, nodes where the migration takes place are divided by the industrial sectors (agriculture and non-agriculture), regions, and ages. The results of a ten-year forecast shows that the aging of total population in most provinces will be intensified, but the portion of people over sixty will decrease in the agricultural sector. This finding implies that migration into rural areas, when occurring by a large extent, can mitigate the aging process and attendant problems.

• 한국환경복원기술학회지
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• 제16권5호
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• pp.27-38
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• 2013

This study was conducted to analyze the correlation between vegetation, environmental factors, and soil characteristic of an endangered species, Eleutherococcus senticosus. Eighteen quadrats in population zones of Seoraksan, Odaesan, Chiaksna, Duckhangsan, Sobaeksan, Juwangsan, and, Jirisan were set up and ordination was analyzed. In the study sites, soil pH, available phosphorous, organic matter and nitrogen were ranged from 5.06~5.43, 24.63~57.77mg/kg, 14.01~18.37%, and 0.63~0.75%, respectively. Eleutherococcus senticosus is classified into Morus bombycis dominant population, Cornus controversa dominant population, and Eleutherococcus senticosus typical population. The importance value of Acer pictum subsp. mono, Morus bombycis, Magnolia sieboldii, Cornus controversa, Tilia taquetii, and Ulmus laciniata in Eleutherococcus senticosus population were 23.76%, 23.61%, 18.06%, 17.82, 15.31%, and 13.57%, respectively. The correlation between vegetation and environmental factors of Eleutherococcus senticosus vegetation distribution were shown to be affected by altitude, slope, and direction.

• The Plant Pathology Journal
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• 제37권3호
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• pp.280-290
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• 2021

Population genetic studies of Hemileia vastatrix have been conducted in order to describe the evolutionary dynamics of the pathogen and the disease epidemiology as consequence of changes in disease management and host distribution occurred in Peru after the 2013 epidemic. These analyses were performed by sequencing the internal transcribed spacers of the nuclear ribosomal DNA (rDNA-ITS) of H. vastatrix collected from two coffee growing areas in 2014 and 2018. H. vastatrix population showed high haplotype diversity (Hd = 0.9373 ± 0.0115) with a low nucleotide diversity (π = 0.00322 ± 0.00018). Likewise, AMOVA indicated that fungus population has behaved as a large population without structuring by geographical origin and sampling years (F_ST = 0.00180, P = 0.20053 and F_ST = 0.00241, P = 0.19693, respectively). Additionally, the haplotype network based on intraspecific phylogenetic analysis of H. vastatrix using Peruvian and NCBI sequences revealed that Peruvian ancestral haplotypes, which were maintained in time and space, would correspond to the reported sequences of the races II and XXII. This result suggests that no substantial changes have occurred through time in Peruvian Hemileia vastatrix population.

• Animal Systematics, Evolution and Diversity
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• 제39권4호
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• pp.264-271
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• 2023

The edible jellyfish Rhopilema esculentum occurs in waters throughout northeastern Asia, including in Korea, China, and Japan. In Korean waters, R. esculentum has appeared in two regions (Gangwha and Muan). Based on the appearance of young medusae and coastal distribution records, these two regions may be key R. esculentum breeding sites. In the present study, we investigate and compare the genetic structure of R. esculentum in the two regions using mitochondrial sequences (16S ribosomal RNA and cytochrome c oxidase subunit I). The genetic diversity of the R. esculentum population at Ganghwa exceeded that of the population at Muan. Despite considerable geographic separation (400 km) between the two regions(Gangwha and Muan), our haplotype network suggests that the Gangwha and Muan populations of R. esculentum are related. The simple and monotonous genetic structure of the Muan population shows that R. esculentum emergence is relatively recent. In contrast, the Gangwha population shows evolution. Moreover, jellyfish of the Gangwha population are genetically diverse and remain constant despite environmental fluctuations in the Han River. The Gangwha area is considered to be the old origin of R. esculentum in Korea.

• 한국패류학회지
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• 제24권1호
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• pp.11-24
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• 2008

GDNA was isolated from the jedo venus clam (Protothaca jedoensis, Lischke) from Boryeong (jedo venus clam from Boryeong JVCB) and Wonsan (jedo venus clam from Wonsan; JVCW) located in the West Sea and the East Sea of Korean Peninsula, respectively and we performed clustering analyses, DNA polymorphisms and the populations genetic variations. In the present study, the seven decamer primer generated the one hundred and eleven major/minor specific bands in JVCB population and ninety four-specific bands in JVCW population. Seven primers generated the unique shared bands to each population of one hundred and seventy-six, on average of 25,1, in JVCB population from Boryeong and three hundred thirty, on average of 47,1, in JVCW population from Wonsan, respectively. The dendrogram obtained by the seven oligonucleotides primers, indicates two genetic clusters. Especially, two Protothaca between the individual WONSAN no. 12 and BORYEONG no. 10 showed the longest genetic distance (0.537) in comparison with other individuals used. Accordingly, RAPD analysis showed that the JVCB was a little more genetically diverse than the JVCW population. This result implies the genetic similarity owing to rearing in the same and/or similar circumstances or inbreeding within the JVCW population. So to speak, JVCB population may have high levels of genomic DNA variability owing to the introduction of the wild individuals from the other sites to sampling sites although it may be the geographically diverse distribution of this species. However, it was confirmed that it did not appear like that really in this study. We feel convinced that RAPD analysis discovered a significant genetic distance between two Protothaca population pairs (P<0.001). The existence of population discrimination and genetic diversity between two Protothaca populations was identified by RAPD analysis.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7267-7270
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• 2014

Background: The incidence of upper aero-digestive tract (UADT) cancers, including C00-C14, C30-C32, C15 and C16, is increasing rapidly in Kamrup Urban District (KUD) of Assam, North East (NE) India. According to the NCRP (2013) report 37.6% of all cancers in both sexes are UADT cancers in the NE region, accounting for 53.3% in males and about 27.5% in females of the total cases. Materials and Methods: A retrospective study was conducted for patient information from the period of 2008-2011. Age-standardized or age-adjusted rates (ASR or AAR) (per 100,000 person-years) were calculated using the World Standard Population as proposed by Segi and modified by Doll et al. The registry population area at risk was estimated using the 1991 and 2001 census population by sex, as well as the growth rate during that interval using the difference distribution method. Results: There were 5,638 cases registered during the last four years of the study (2008-2011) accounting for 56.7% (3,198/5,638) of the total in males and 43.3% (2,440/5,638) in females. The male: female ratio was 1.31:1.00. The overall age adjusted rates (AAR) were 179.4 and 153.8 per 100 000 males and females respectively. Cancer of the oesophagus was most common in both sexes, with most appreciable gender variation for tongue and hypopharynx, presumably reflecting differential expsoure to risk factors.

• Asian Journal of Innovation and Policy
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• 제9권2호
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• pp.223-239
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• 2020

It is important for urban planners and policy makers to understand complex, diverse urban demands and social structure, but this is not easy due to lack of data that represents the dynamics of residents at micro-geographical level. This paper explores how to create population data at at a micro-level by allocating population data to building. It attempted to allocate population data stored in a grid layer (100 meters by 100 meters) into a building footprint layer that represents the appearance of physical buildings. For the allocation, this paper describes a systemic approach that classifies grid cells into five prototypical patterns based on the composition of residential building types in a grid cell. This approach enhances allocation accuracy by accommodating heterogeneity of urban space rather than relying on the assumption of uniform spatial homogeneity of populations within an aerial unit. Unlike the methods that disaggregate population data to the parcel, this approach is more applicable to Asian cities where large multifamily residential parcels are common. However, it should be noted that this paper does not demonstrate the validity of the allocated population since there is a lack of the actual data available to be compared with the current estimated population. In the case of water and electricity, the data is already attached to an individual address, and hence, it can be considered to the purpose of the validation for the allocation. By doing so, it will be possible to identify innovative methods that create a population distribution dataset representing the comprehensive and dynamic nature of the population at the micro geographical level.

• 식물분류학회지
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• 제50권2호
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• pp.239-246
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• 2020

Carex nakasimae Ohwi (Cyperaceae) is an endemic species on the Korean peninsula. This study reports a new locality of the species, updating the distribution map. A new population of the species was found during field surveys in 2014 in a small swamp in Haman-gun, Gyeongsangnam-do province, located in the southeastern part of the Korean peninsula. In the flowering and fruiting periods of the species, the population is associated with ca. 91 vascular plant taxa from 40 families. To conserve the endemic species, maintaining the habitat is critical. Furthermore, taxonomic and phylogenetic positions of the species should be clarified to establish biological conservation strategies for the rare, endemic C. nakasimae.

• The Korean Journal of Ecology
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• 제13권1호
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• pp.25-32
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• 1990

The vertical distribution and seasonal fluctuation of soil microarthropods in the forests with different flora were investigated in this study. soil micrarthropods were concentrated as much as 71.8% in the first layer subsoil (0-5cm), 22.3% in the second layer subsoil (5-10cm), and 5.9% in the third layer subsoil (10-15cm) in the decreasing order. The population density in the first layer decreased slightly in winter while that of the second layer increased. However, the density in the first layer bounced back in the following spring. Seasonal fluctuations of population density were revealed "Two peak-Two valley type", that is, the densities were high in fall and spring, and low in winter and summer.nd summer.