• Clinical and Experimental Reproductive Medicine
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• v.44 no.3
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• pp.146-151
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• 2017

Objective: To identify differences in the expression of the genes for peroxisome proliferator-activated receptor $(PPAR)-{\gamma}$, cyclooxygenase (COX)-2, and the proinflammatory cytokines interleukin (IL)-6 and tumor necrosis factor $(TNF)-{\alpha}$ in granulosa cells (GCs) from polycystic ovary syndrome (PCOS) patients and controls undergoing controlled ovarian stimulation. Methods: Nine patients with PCOS and six controls were enrolled in this study. On the day of oocyte retrieval, GCs were collected from pooled follicular fluid. Total mRNA was extracted from GCs. Reverse transcription was performed and gene expression levels were quantified by realtime quantitative polymerase chain reaction. Results: There were no significant differences in age, body mass index, and total gonadotropin dose, except for the ratio of luteinizing hormone to follicle-stimulating hormone between the PCOS and control groups. $PPAR-{\gamma}$ and COX-2 mRNA was significantly downregulated in the GCs of PCOS women compared with controls (p= 0.034 and p= 0.018, respectively), but the expression of IL-6 and $TNF-{\alpha}$ mRNA did not show significant differences. No significant correlation was detected between the expression of these mRNA sequences and clinical characteristics, including the number of retrieved oocytes, oocyte maturity, cleavage, or the good embryo rate. Positive correlations were found among the $PPAR-{\gamma}$, COX-2, IL-6, and $TNF-{\alpha}$ mRNA levels. Conclusion: Our data may provide novel clues regarding ovarian GC dysfunction in PCOS, and indirectly provide evidence that the effect of $PPAR-{\gamma}$ agonists in PCOS might result from alterations in the ovarian follicular environment. Further studies with a larger sample size are required to confirm these proposals.

• International Area Studies Review
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• v.16 no.1
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• pp.243-274
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• 2012

This research analyzes the determinants of Korea's trade using the Gravity model, Chow test and panel data anaysis. According to the pooled panel OLS analysis using the gravity model and Chow-test, Korea's trade patterns before and after the 2008 financial crisis are heterogeneous. Variables of basic gravity model, GDP per capita, distance, and population, identically showed positive and significant correlation with trade volume before and after financial crisis, but also equally showed the decrease in absolute value of coefficient. On the other hands, Overseas Direct Investments(ODI) variable showed the increase in absolute value of coefficient. But TCI was no longer significant. This research is significant in that it is able to show the strategy for the long term growth in Korea's volume of international trade through econometric analysis based on data of 55 trading partner of Korea.

• International Area Studies Review
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• v.14 no.1
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• pp.203-219
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• 2010

Nowadays an instability of the exchange rate on accounts of global finance crisis brings on a lot of an economic damage such as recession, decreasing of total trade and so on. However some countries which belong to be membership of the eurozone could escape economic slump shortly and easier than others. The reason for this is that they share with the Euro as a their own currency which is the second vehicle currency all of the world. This paper analyzes the correlation of joining the Euro zone and trade with pooled OLS, random effect estimation, and fixed effect estimation. A membership of the Euro zone are able to increase trade 11.3% ~ 25.3% one another on average since some country belongs to the Euro zone. It is very important for some countries which have a plan to affiliate the Euro zone sooner or later to realize economic effect because of a protection of the Euro zone as well as political power.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.50 no.6
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• pp.369-377
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• 2005

Precise application of topdressing nitrogen (N) fertilizer is indispensible for securing high yield and good quality of rice and minimizing N losses to the environment as well. For precise N management, growth and nitrogen nutrition status (NNS) should be diagnosed rapidly and accurately. The objective of the study was to evaluate the applicability of vegetation index (VI) calculated from hyperspectral canopy reflectance measurement and SPAD reading to nondestructive in situ diagnosis of growth and NNS of rice. Canopy reflectance, SPAD read­ing, growth parameters, and NNS characteristics were measured from various N treatments to evaluate the relationships among them for two cropping seasons from 2001 to 2002. The correlation coefficient of VIs with variables of growth and NNS increased positively as rice canopy became more closed. Regardless of growth stages, VIs had significantly high correlations with LAI, shoot dry weight (DW), shoot N content and nitrogen nutrition index (NNI). Those correlation coefficients increased steadily before heading stage as rice grew up. However, tiller number and leaf N concentration showed significantly high correlations with VIs only at and after panicle initiation stage (PIS). Among the VIs, RVIgreen had significantly higher correlation with the measured parameters than the other VIs: it showed correlation coefficients greater than 0.8 with leaf and shoot N concentration and DW, and much higher coefficients greater than 0.9 with LAI, shoot N content, and NNI. At LAI of below 2.5, VIs had non-significant or low correlations with the growth and NNS indicators due to the background effects. SPAD reading had significantly high correlation with leaf N concentration and NNI at each growth stage. In addition, it had significant correlations with variables of growth and NNS at PIS and booting stage, particularly, at booting stage. Though SPAD reading had a significantly high correlation value at a given growth stage in each year, it showed very weak relationship with variables of growth and NNS when pooled across growth stages and years. In conclusion, RVIgreen was found to be the most reliable VI to estimate the growth and NNS of rice around at PIS, but SPAD reading had much limitations.

• Journal of Environmental Health Sciences
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• v.27 no.3
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• pp.71-80
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• 2001

Blood and urine mercury level of three workers were monitored during 60~80 days after high exposure to mercury at the silver refining plant. Mercury was used to form silver-mercury amalgam from plating sludge. Workers were exposed to mercury about 70 days at the several processes, such as hand held weaving, vibration table, and heating from the furnace. mercury was analysed by atomic absorption spectroscopy-vapor generation technique. Recovery from the biological sample was 95.51% and pooled standard deviation was 0.033. At the time of study, there was no work at the workplace. So, airborne mercury concentration was measured with area sampling 5 days after the work, ranged from 0.1459 to 1.2351 mg/㎥(Arithmatic mean 0.4711 mg/㎥, Geometric mean 0.3566 mg/㎥) at the inside of the plant, that is far above the ACGIH's TLV(0.025 mg/㎥) and ranged from 0.0073 to 0.0330 mg/㎥ at the outdoor. Blood mercury levels at the beginning of the monitoring were 4~14 times greater than the American Conference of Governmental Industrial Hygienists Biological Exposure Index(ACGIH BEI, 15 ug/L). Blood mercury levels were decreased logarithmically, that is, rapidly at the high level and slowly at the low level but sustained above the level of the ACGIH BEI 60~80 days after the work. Urine mercury levels at the beginning of the monitoring were 8~16 times greater than the ACGIH BEI(35 ug/g creatinine). Urine mercury levels were decreased logarithmically, but correlation between urine level and off-days were lower than those of blood. Decreasing pattern of blood mercury levels were little affected than that of urine levels when the chelating agent, D-penicillamine, was administered. There was correlation between blood mercury level and urine mercury level(0.81~0.83) but it didn\`t mean that the highest blood mercury level corresponded the highest urine mercury level. In our study, Case 1 always shows the highest level in urine but case 3 always shows the highest level in blood. Creatinine correction represented better correlations between urine mercury levels and blood levels, and between urine levels and off-days rather than by urine volume. Spot urine sampling had a wide variation than that of whole day urine sampling. So, We recommend spot urine sampling for screening and whole day urine sampling for exact diagnosis.

• Proceedings of the Technology Innovation Conference
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• 1996.12a
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• pp.265-295
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• 1996

This paper investigates empirically the relationship between various business portfolio properties (particularly technological properties) and chaebol′s performance using data on the 50 largest chaebols in Korea. In addition to the traditional indexes to measure diversification such as entropy index we calculated inter-industry technological similarity using R&D expenditure data by industry and 1990 Input-output Table in Korea, and obtained chaebol-level technological relatedness and internal transaction proportion from chaebols′business profile, inter-industry technological similarity and 1990 input-output table. We applied factor analysis on 13 business portfolio property indexes and showed that they could be grouped into 3 dimensions, diversification scope, inter-business relatedness and degree of vertical integration. In this paper, using 50 largest chaebols′financial data (1989-1994), we analyzed empirically the effect of business portfolio properties on ROS (Return On Sales) which is conventional index for firm performance and on TFP(Total Factor Productivity) growth which is a pure measure of firm performance. To utilize the advantage of panel data, FEM(Fixed Effect Model) and REM(Random Effect Model) were used. The empirical result shows that the entropy index as a measurement of inter-business relatedness is not significant but technological relatedness index is significant. OLS estimates on pooled data were considerably different from FEM or REM estimates on panel data. By introducing interaction effect among the three variables for business portfolio properties, we obtained three findings. First, only VI (Vertical integration) has a significant positive correlation with ROS. Second, when using TFP growth as an dependent variable, both TR(Technological Relatedness) and f[ are significant and positively related to the deepened variable. Third, the interaction term between TR and VI is significant and negatively affects TFP growth, meaning that TR and VI are substitutes. These results suggest strategic directions on restructuring business portfolio. As VI is increased, chaebols will get more profit. A higher level of either TR or W will increase TFP growth rate. but increase in both TR and VI will have a negative effect on TFP growth. To summarize, certain business portfolio properties such as VI and TR can be considered "resources" themselves since they can affect profit rate and productivity growth. VI and TR have a synergy effect of change in profit rate and productivity growth. VI increases ROS and productivity growth, while TR increases productivity growth representing a technological synergy effect.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.30 no.4
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• pp.442-448
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• 1985

The objective of this study was to compare year variations of heritability, phenotypic, genotypic and environmental correlations as well as pathway coefficients for main characters of tea tree to provide useful selection information for improving tea tree. The data collected from the performance yield trials from 1979 to 1981 were used in this study. 1. The genetic variance of height of stem and length of first branch was not only greatly varied with year. but also the largest among all characteristics studied. Other characteristics showed higher genetic variance than environmental variances, and year variances were very small. 2. Both year and variety x year interaction were highly significant sources of variation for height of stem, length of first branch and number of fruits in main stem pooled from three year data. 3. All characteristics showed high broad sense heritabilities, and the broad sense heritability was not varied with year. 4. The genetic correlation coefficients between Gigolpi and height of stem, length of first branch and number of fruits in main stem were positive, and the year variation was not large. 5. The pathway coefficients of the character was not only greatly varied with year and the height of stem, length of first branch and weight of dryed root affected directly on the Giglopi.

• Proceedings of the ESK Conference
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• 1997.04a
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• pp.203-211
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• 1997

본 연구는 기온$15^{\circ}C{\pm}1^{\circ}C$ $26^{\circ}C{\pm}1^{\circ}C$,습도$55%{\pm}5%$ 환경조건에서 손가락 끝마디 부분을 얼음물에 침지시킨후 구강온과 4부위 피부온, 손가락끝 피부온, 전신온냉감, 전신쾌적감, 손가락 끝 동통감의 변화를 젊은 남자 피험자와 노인남자 피험자를 대상으로 비교측정하고자 하였다. 본 학회에서는 젊은 남자피험자 그룹에 대하여 보고하고자 한다. 결과는 다 음과 같다. $15^{\circ}C{\pm}1^{\circ}C$에서 4부위 피부온을 보면 가슴과 상완은 손가락끝 침지시 약간 하강하고 다시 상승하지만 대퇴와 하퇴에서는 하강하고 그 상태가 유지된다. 특히 하퇴의 경우는 급격히 하강하는 경향을 보이고 있다. 손가락끝 피부온은 손가락 침지와 동시에 급격한 하강을 나타내나 손가락을 꺼낸후에 손가락 침지전의 온도로 회복되지는 않았다. 평균피부온을 보면 손가락 침지시 하강하는 경향을 보이고 있다. 전신 쾌적감은 약간 불쾌하게 나타났고, 전신온냉감은 서늘하다고나타났고 손가락끝의 동통 감은 매우 아프다고 나타났다. $26^{\circ}C{\pm}1^{\circ}C$에서 4부위 피부온을 보면 가슴 상완대퇴 하퇴 모두 손가락끝 침지시 약간 하강하고 낮은 상태로 유지되는 경향을 보이고 있다. 손가락끝 피부온은 손가락 침지시 급격한 하강을 나타내었고 손가락을 꺼낸후에도 침지의 온도로 회복이 되었다. 평균피부온은 손가락 침지후에 약간 하강하였지만 큰 차이는 없었다. 전신쾌적감은 약간 쾌적하게 나타났고 전신온냉감은 약간 따뜻하다라고 나타났으며 손가락끝의 동통감은 약간 아프다고쪽으로 나타났다.때문에 이를 디자인에 곧바로 적용시키기 어려운 점이 있다. 이에 본 연구는 기존의 바용성 평가를 위한 분석도구들이 갖는 문제 점들 해결하여 제품의 사용자 인터페이스 디자인 개발과정에서 활용할 수 있는 평가 분석도구를 개발하는 것을 목표로 한다. 이를 위해 첫째, 다양한 유형의 정보를 포함하는 비디오 정보를 선정하였따. 둘째, 데이터를 다양한 측면에서 추출할 수 있는 Data logger를 개발하였다. 셋째, 데이터를 시각적으로 정리하고 분석할 수 있는 도구를 제안한다. 마지막으로 인터페이스 디자인에서 여러 가지 디자인안을 도출해 내는 작업에 이용할 수 있는 종합화과정을 개발한다. 이러한 일련의 과정이 통합된 컴퓨터 시스템 안에서 이루어지도록 프로그램을 개발하여 정보의 유용성을 높일 수 있도록 한다.at the entropy index as a measurement of inter-business relatedness is not significant but technological relatedness index is significant. OLS estimates on pooled data were considerably different from FEM or REM estimates on panel data. By introducing interaction effect among the three variables for business portfolio properties, we obtained three findings. First, only VI (Vertical integration) has a significant positive correlation with ROS. Second, when using TFP growth as an depende

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.2
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• pp.237-242
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• 2001

Colostrum deprived, newborn pigs (N=12, $1.64{\pm}0.05kg$) were used to study the renal threshold of carnitine, and effects of emulsified medium-chain triglyceride (MCT, tri-8:0) feeding on kinetics of plasma carnitine and urinary carnitine excretion. An arterial catheter was inserted through an umbilical artery, and a bladder catheter was inserted via the urachus. Piglets were oro-gastrically gavaged with one of six carnitine levels (0, 60, 120, 180, 240, $480{\mu}mol/kg\;W^{0.75}$) with (+MCT) or without medium-chain triglycerides (-MCT) in 0.9% NaCl solution. Blood was sampled into heparinized tubes at 0, 1, 2, 4, 6, 8, 14, and 20 h after gavage, and urine was collected and pooled into 1 h or 2 h composite samples to determine free- and short-chain carnitine concentrations. Plasma from the 12 newborn piglets before gavage contained $10.6{\pm}1.2{\mu}mol/L$ free carnitine and $7.2{\pm}0.6{\mu}mol/L$ acid-soluble acyl carnitine. The renal threshold for carnitine was similar between the MCT and the +MCT group (42.6 13.1 and $46.4{\pm}2.0{\mu}mol/L$, respectively), but the correlation between plasma free carnitine and urinary excretion was altered. Plasma free carnitine linearly increased with increasing carnitine dosage (-MCT group, $R^2=0.95$, p<0.001; +MCT group, $R^2=0.91$, p<0.001), but was decreased by 50% when medium-chain triglycerides were fed. The peak in plasma free carnitine concentration was depressed by medium-chain triglycerides feeding also. Therefore, the plasma and urinary short-chain/free carnitine ratio of the +MCT group was increased by 100% and 40%, respectively (p<0.01). Feeding of medium-chain triglycerides may delay plasma carnitine elevation via altering the kinetics of absorption. Similarly, the plasma and urinary short-chain/free carnitine ratio were affected by interaction between medium-chain triglycerides and time (p<0.01). The present study suggests that an oral carnitine dose over $480{\mu}mol/kg\;W^{0.75}$ may be needed to reach the free carnitine renal threshold within a short period, especially when provided together with medium-chain triglyceride.

• The Korean Journal of Applied Statistics
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• v.22 no.3
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• pp.617-626
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• 2009

A series of recent papers reported that the inter-gene correlations in Affymetrix microarray data sets were strong and long-ranged, and the assumption of independence or weak dependence among gene expression signals which was often employed without justification was in conflict with actual data. Qui et al. (2005) indicated that applying the nonparametric empirical Bayes method in which test statistics were pooled across genes for performing the statistical inference resulted in the large variance of the number of differentially expressed genes. Qui et al. (2005) attributed this effect to strong and long-ranged inter-gene correlations. Klebanov and Yakovlev (2007) demonstrated that the inter-gene correlations provided a rich source of information rather than being a nuisance in the statistical analysis and they developed, by transforming the original gene expression sequence, a sequence of independent random variables which they referred to as a ${\delta}$-sequence. We note in this report using two cDNA microarray data sets experimented in this country that the strong and long-ranged inter-gene correlations were still valid in cDNA microarray data and also the ${\delta}$-sequence of independence could be derived from the cDNA microarray data. This note suggests that the inter-gene correlations be considered in the future analysis of the cDNA microarray data sets.