• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2002년도 춘계학술대회 논문집
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• pp.132-135
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• 2002

In the present study, an electro-mechanical KAFO (knee-ankle-foot orthosis) which satisfies both the stability in stance and the knee flexion in swing was developed and evacuated in eight polio patients. A knee joint control algorithm suitable for polio patients who are lack of the stability in pre-swing was also developed and various control systems and circuits were also designed. In addition, knee flexion angles and knee moments were measured and analyzed for polio patients who used the developed KAFO with the three-dimensional motion analysis system. Energy consumption was also evaluated for the developed KAFO by measuring the movement of the COG (center of gravity) during gait. From the present study, the designed foot switch system successfully determined the gait cycle of polio patients and controlled knee joint of the KAFO, resulting in the passive knee flexion or foot clearance during swing phase. From the three-dimensional gait analysis for polio patients, it was found that the controlled-knee gait with the developed electro-mechanical KAFO showed the knee flexion of 40$^{\circ}$∼45$^{\circ}$ at an appropriate time during swing. Vertical movements of COG in controlled-knee gait (gait with the developed electro-mechanical KAFO) were significantly smaller than those in looked knee gait(gait with the locked knee Joint). and correspondingly controlled-knee gait reduced approximately 40% less energy consumption during horizontal walking gait. More efficient gait patterns could be obtained when various rehabilitation training and therapeutic programs as well as the developed electro-mechanical KAFO were applied for polio patients.

• Journal of Preventive Medicine and Public Health
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• 제16권1호
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• pp.89-97
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• 1983

From January to March in 1979 and 1982, the vaccination rate of B.C.G., D.P.T and Sabin with 392 infants who were registered at M.C.H. room in a Health Center in Seoul were as follows: 1 There were no specific relations between the sex and the vaccination for B.C.G., D.P.T. and Polio. 2. In 1982, the younger the mother's age was, the higher the vaccination rate for B.C.G. was. For the D.P.T. and Polio the rate of above 35 year group was the highest but the completion rate of the vaccination and the regular vaccination rate were the highest in the age of 30-34 year group. 3. In 1982. the higher the educational levels of tile mother were, the higher the vaccination rates for B.C.G., D.P.T. and Polio were. 4. The vaccination rate for B.C.G. within a month after birth was the highest in Salaried laborer group. The completion rate of the vaccination and regular vaccination rate for D.P.T. add Polio were also the highest in salaried laborer group. 5. In 1982, the rates of all vaccination for B.C.G. were tile highest in the first child. The completion rate of the vaccination and regular vaccination rate for D.P.T and Polio were also the highest in the first child in 1982.

• Journal of the Korean Data and Information Science Society
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• 제26권6호
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• pp.1565-1572
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• 2015

In this paper, we analyze the polio incidence data based on the Poisson autoregressive models, focusing particularly on change-point detection. Since the data include some strongly deviating observations, we employ the robust cumulative sum (CUSUM) test proposed by Kang and Song (2015) to perform the test for parameter change. Contrary to the result of Kang and Lee (2014), our data analysis indicates that there is no significant change in the case of the CUSUM test with strong robustness and the same result is obtained after ridding the polio data of outliers. We additionally consider the comparison of the forecasting performance. All the results demonstrate that the robust CUSUM test performs adequately in the presence of seemingly outliers.

• 한국정밀공학회지
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• 제20권1호
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• pp.36-42
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• 2003

• Pediatric Infection and Vaccine
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• 제7권1호
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• pp.82-82
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• 2000

• 응용통계연구
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• 제16권2호
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• pp.365-376
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• 2003

본 연구에서는 비정규 시계열 자료에 관한 다양한 회귀모형을 고찰하고, 이들 모형의 선택 기준에 관하여 연구해 보았다. 모형 선택의 기준으로는 AIC (Akaike information criterion), BIC (Baysian information criterion) 그리고 우도비 검정을 확장 적용하였다. 또한, 실제의 Polio 자료분석을 통해 이를 적용해보았다.

• Annals of Clinical Neurophysiology
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• 제5권2호
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• pp.202-209
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• 2003

Postpolio syndrome (PPS) refers to a constellation of neuromuscular and orthopedic symptoms and signs that have been noted to occur in patients with remote antecedent poliomyelitis. It has been increasingly recognized that individuals recovering from acute poliomyelitis develop new symptoms, most commonly weakness, fatigue, and pain that develops decades after initial disease in the region previously affected. Associated symptoms may include dysphagia, respiratory insufficiency, new muscular atrophy, dysarthria, muscle cramps, fasciculations, sleep abnormalities, and cold intolerance. Although the concepts of PPS was first described in the late 1800s, it was not until nearly 100 years later that the concept of PPS was more widely recognized and defined. This was due largely to the polio epidemic of the 1940s and 1950s that left many survivors in the world. The virtual epidemic of PPS that occurred among these polio survivors in the 1980s and 1990s has served as a catalyst to attract medical attention to this syndrome.

• Archives of Pharmacal Research
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• 제26권12호
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• pp.990-996
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• 2003

A novel carboacyclic nucleoside analogue, 9-[2-bromo-4-hydroxy-3-hydroxymethyl-2-butenyl] adenine, and its derivatives were designed and synthesized as open-chain analogues of neplanocin A. The syntheses were accomplished via the coupling of adenine or pyrimidine bases to the key intermediate allylic bromide 7. The bromide 7 was prepared from epichlorohydrin in a seven step process in a 54% overall yield. The synthesized compounds were evaluated for their antiviral activity against the polio virus, HSV and HIV.

• Clinical and Experimental Pediatrics
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• 제49권8호
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• pp.864-869
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• 2006

목 적 : 폴리오 백신은 OPV와 IPV가 있으며 모두 탁월한 예방효과를 보여 이제는 지구상에서의 폴리오 근절을 기대하게 되었다. 그러나 OPV 백신바이러스의 유전자 변형과 이로 인한 마비환자 발생이 알려지면서 폴리오 근절을 위해서는 반드시 OPV를 중단하고 IPV를 사용하게 되었다. 우리나라에서도 2002년 이후 새로운 eIPV 사용이 추천되었으며 2005년말 부터는 eIPV만을 사용하고 있다. 본 연구는 최근 국내에 도입된 eIPV의 면역원성과 안정성을 확인 하고자 하였다. 방 법 : 생후 2개월 된 건강한 영아 81명을 대상으로 폴리오백신을 2개월 간격으로 3회 접종한 후 혈청 내 중화항체가를 측정하였다. 폴리오 백신은 Imvax $Polio^{(R)}$(Aventis Pasteur, Lyon, France)로 단독 또는 DTaP와 B형 간염 또는 Hib 백신을 동시에 접종하였다. 면역원성은 접종 전 및 3회 접종 1개월 후에 혈청 내 중화항체가를 측정하였다. eIPV의 안전성은 접종 후 30분 동안 병원에서 조기 이상반응을 관찰하였으며 접종 후 3일간은 보호자에 의해 국소 및 전신 반응을 관찰하였다. 결 과 : 81명 중 79명이 성공적으로 연구를 마쳤다. eIPV 접종 전 및 3회 접종 후 혈청 내 중화 항체가(GMT)는 폴리오바이러스 1형은 접종 전 4.1에서 접종 후 1,531로 증가하였으며, 2형은 접종 전 7.7에서 접종 후 834로 증가하였고, 3형은 접종 전 3.3 에서 접종 후 846으로 증가하였다. 3회 접종 후 중화 항체가의 양전율은 1, 2, 3형 모두 100%를 보였다. 이상 반응으로는 발적(3.4%) 동통(2.5%) 등의 국소반응과 보챔(9.7%), 기면(5.5%), 식욕부진(4.6%), 발열(4.2%) 등의 전신반응이 있었으며 모두 해열제 사용 등 간단한 처치로 회복되었다. 결 론 : 최근 국내에 도입된 eIPV(Imovax $Polio^{(R)}$)는 면역원성이 높고 안전성이 확인되어 안심하고 사용할 수 있을 것이다.

• Archives of Pharmacal Research
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• 제20권5호
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• pp.501-506
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• 1997

Novel 9-[2-fluoro-4-hydroxy-3-hydroxymethyl-2-butenyl]adenine and its related compounds were designed and synthesized as open-chain analogues of neplanocin A. Alkylation of adenine or pyrimidine bases with the mesylate 4 was chosen as a simple approach to the synthesis of 2-fluoro-2-butenylated nucleosides. Mesylate 4 was prepared from dihydroxyacetone dimer via four steps in 58% overall yield. The synthesized compounds were evaluated their antiviral activity against HSV, HIV and Polio viruses.