• Clinical and Experimental Pediatrics
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• 제46권8호
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• pp.758-762
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• 2003

목 적 : 저자들은 발열을 주소로 입원한 3세 이하의 소아에서 초기 총 백혈구 수, 적혈구 침강 속도, C-반응성 단백질 정량적 검사를 통해 민감도와 특이도가 최대치에 이르는 수치를 차단점으로 선택하여 세균성 감염의 고위험군을 예측하고 항생제 치료의 지표로 삼고자 연구를 하였다. 방 법 : 2001년 6월부터 2002년 6월까지 조선대학교병원 소아과에 발열을 주소로 입원치료 하였던 환아 중 진찰 소견에서 발열에 대한 원인을 발견할 수 없었던 1개월에서 36개월 사이의 71명을 대상으로 하여 후향적으로 조사하였다. 대상 환아들을 세균성 감염과 비세균성 감염으로 분류한 후 각각의 진단 기준의 양성 예측치와 우도비를 계산하고 민감도와 특이도가 최대치에 이르는 수치를 차단점(cut-off point)으로 선택하여 그 수치에서의 민감도와 특이도를 조사하였다. 결 과 : 대상 환아 총 71명(남아 44명, 여아 27명)이고, 평균 연령은 12.7개월이었다. 세균성 감염인 경우는 20례(28%)이었으며, 요로 감염 12례, 세균혈증 5례, 뇌막염 3례 순이었다. 감염균은 E.coli 6례, K.pneumoniae 3례, E. faecalis 3례, Streptococcus ganguinis 3례, Salmonella 2례, S.aureus 1례, Stenotrophomonas maltophilia 1례, Streptococcus constellatus 1례였다. 총 백혈구 수, 적혈구 침강 속도, C-반응성 단백질은 세균성 감염군과 비세균성 감염군간의 유의한 차이를 보였다(P=0.038, 0.009, 0.002). 양성예측치와 우도비는 총 백혈구 수는 20,000/mm^3$ 이상에서 75%, 7.65이었으며, 적혈구 침강 속도는 30-50 mm/hr에서 60%, 3.83이었다. C-반응성 단백질의 양성 예측치와 우도비는 3-6 mg/dL에서 63%, 4.25이었다. 민감도와 특이도가 최대치에 이르는 수치는 총 백혈구 수 $20,000/mm^3$, 적혈구 침강 속도 30 mm/hr, C-반응성 단백질 3.0 mg/dL이었으며, 이 값에서의 민감도는 각각 75%, 79%, 83%, 특이도는 75%, 68%, 77%이었다. 결 론 : 비특이적 소견을 보이는 3세 이하 발열 환아에서 차단점을 총 백혈구 수 20,000/mm^3$, 적혈구 침강 속도 30 mm/hr, C-반응성 단백질 3.0 mg/dL으로 적용할 때 세균성 감염에서 선택적 치료 방침을 세울 수 있게 되리라 생각된다.

• 대한임상독성학회지
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• 제6권1호
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• pp.32-36
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• 2008

Purpose: The major complication of acute organophosphate (OP) poisoning is respiratory failure as a result of cholinergic toxicity. Many clinicians find it difficult to predict the optimal time to initiate mechanical ventilation (MV) weaning, and as a result have tended to provide a prolonged ventilator support period. The purpose of this study is to determine any clinical predictors based on patients characteristics and laboratory findings to assist in the optimal timing of mechanical ventilator weaning. Methods: We reviewed medical and intensive care records of 44 patients with acute OP poisoning who required mechanical ventilation admitted to medical intensive care unit between July 1998 and June 2007. Patient information regarding the poisoning, clinical data and demographic features, APACHE II score, laboratory data, and serial cholinesterase (chE) levels were collected. Base on the time period of MV, the patients were divided into two groups: early group (wean time < 7 days, n = 28) and delayed group (${\geq}$ 7 days, n = 16). Patients were assessed for any clinical characteristics and predictors associated with the MV weaning period. Results: During the study period, 44 patients were enrolled in this study. We obtained the sensitivity and specificity values of predictors in the late weaning group. APACHE II score and a reciprocal convert of hypoxic index but specificity (83.8%) is only APACHE II score. Also, the chE concentration (rho = -0.517, p = 0.026) and APACHE II score (rho = 0.827, p < 0.001) correlated with a longer mechanical ventilation duration. Conclusion: In patients with acute OP poisoning who required mechanical ventilation, the APACHE II scoring system on a point scale of less than 17 and decrements in cholinesterase levels on 1-3 days were good predictors of delayed MV weaning.

• Parasites, Hosts and Diseases
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• 제56권1호
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• pp.61-70
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• 2018

We developed a Rapid Diagnostic Test (RDT) kit for detecting IgG/IgM antibodies against Zika virus (ZIKV) using monoclonal antibodies to the envelope (E) and non-structural protein 1 (NS1) of ZIKV. These proteins were produced using baculovirus expression vector with Sf9 cells. Monoclonal antibodies J2G7 to NS1 and J5E1 to E protein were selected and conjugated with colloidal gold to produce the Zika IgG/IgM RDT kit (Zika RDT). Comparisons with ELISA, plaque reduction neutralization test (PRNT), and PCR were done to investigate the analytical sensitivity of Zika RDT, which resulted in 100% identical results. Sensitivity and specificity of Zika RDT in a field test was determined using positive and negative samples from Brazil and Korea. The diagnostic accuracy of Zika RDT was fairly high; sensitivity and specificity for IgG was 99.0 and 99.3%, respectively, while for IgM it was 96.7 and 98.7%, respectively. Cross reaction with dengue virus was evaluated using anti-Dengue Mixed Titer Performance Panel (PVD201), in which the Zika RDT showed cross-reactions with DENV in 16.7% and 5.6% in IgG and IgM, respectively. Cross reactions were not observed with West Nile, yellow fever, and hepatitis C virus infected sera. Zika RDT kit is very simple to use, rapid to assay, and very sensitive, and highly specific. Therefore, it would serve as a choice of method for point-of-care diagnosis and large scale surveys of ZIKV infection under clinical or field conditions worldwide in endemic areas.

• 한국정보통신학회논문지
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• 제15권12호
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• pp.2655-2663
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• 2011

지금까지 심방세동을 검출하는 방법은 P파의 형태, 시간 주파수 영역 분석법이 주를 이루었다. 하지만 P파는 잡음의 영향을 많이 받는 환경에서는 검출의 정확도가 떨어지며, 시간 주파수 영역 분석법은 RR 간격에 따라 변화하는 불규칙적 리듬에 관한 정보를 정확하게 얻지 못하는 단점이 있다. 본 연구에서는, P파의 형태는 고려하지 않고, 불규칙 RR 간격 리듬의 비선형적 특성 분석을 통한 심방세동 검출 알고리즘을 제안한다. 이를 위해 불규칙 RR 간격 리듬을 다양성, 무작위성, 복잡성으로 각각 정의하고 제곱평균제곱근(RMSSD), 전환점비(TPR), 표본 엔트로비(SpEn)의 3가지 비선형적 특성 분석을 통하여 심방세동을 분류하였다. 제안된 알고리즘의 검출 성능을 평가하기 위해 3가지 통계치의 최적값을 설정하고 MIT-BIH 심방세동 데이터베이스와 부정맥 데이터베이스를 이용하여 실험하였다. 성능 평가 결과, MIT-BIH 심방세동 데이터베이스에 대해서는 민감도(sensitivity:94.5%), 특이도(specificity:96.2%)를 각각 나타내었으며, 부정맥 데이터베이스에 대해서는 민감도(89.8%), 특이도(89.62%)를 각각 나타내었다.

• 대한물리의학회지
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• 제14권4호
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• pp.29-35
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• 2019

PURPOSE: The aim of this study was to provide the standard value of the Five Times Sit to Stand Test (FTSST) measurement on the daily life independence of the elderly in Korea and examine the effects of this test on their daily lives. METHODS: This study was conducted on elderly people over 65 years of age living in Gyeongsangbuk-do, Korea. FTSST was performed while sitting position on a chair. The subjects were classified into independent and dependent living groups according to their lifestyle, and their influence was then examined through logistic regression analysis. To determine the usefulness and cut-off value of the FTSST, the analysis was performed using the ROC curve. RESULTS: The elderly were more likely to live in a group rather than independently as the FTSST time increased (p<.05) (OR=1.098). The area of the lower part of the ROC curve was .707, and as the FTSST increased, a subject was more likely to live in a group rather than independently (p<.05). The cut-off value was assigned to the point where both the specificity and sensitivity were at the coordinates. The sensitivity and specificity were .626 and .753, respectively at 15.62 seconds. CONCLUSION: The elderly in Korea are more likely to live a group-dependent lifestyle than live independently; the likelihood of this outcome is increased further for every additional second beyond 15.62 seconds. The loss of independence of daily life could be predicted based on the status of a subject's lower leg strength using the FTSST.

• 한국콘텐츠학회논문지
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• 제12권3호
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• pp.34-43
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• 2012

두 문자열 간의 유사도를 계산하는 문제는 정보 검색, 오타 교정, 스팸 필터링 등 다양한 분야에 응용될 수 있다. 동적 계획법 기반의 유사도 계산 방법을 통하여 한글 문자열의 유사도 계산을 위해서는 우선 음소간의 유사도에 대한 정의가 필요하다. 그러나 기존의 방법들은 수동적 설정에 의한 유사도 점수를 사용하고 있다는 한계점이 있다. 본 논문에서는 PAM(Point Accepted Mutation) 행렬과 유사한 확률 모델을 이용하여 변형 단어 집합으로부터 음소 간의 유사도를 자동적으로 계산하는 기법을 제안한다. 제안 기법은 주어진 변형 단어의 집합 내 유사한 단어 쌍을 찾아 문자열 정렬(Text Alignment)을 수행함으로써 음소 변형 규칙을 도출하고, 이로부터 각 음소 쌍의 상호 변형 빈도에 따른 유사도 점수를 계산한다. 실험 결과 특이도(Specificity) 77.2~80.4% 수준에서 불일치 여부에 따른 단순 점수 부여 방식에 비해서는 10.4~14.1%, 수동으로 음소 간 유사도를 직접 설정하는 방식에 비해서는 8.1~11.8%의 민감도(Sensitivity) 향상이 있음을 확인하였다.

• 컴퓨터교육학회논문지
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• 제14권1호
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• pp.45-54
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• 2011

5차 교육과정에서 2009 개정 교육과정에 이르기까지 교육의 주요 목표로 강조되고 있는 창의성 계발을 위한 교육과정과 내용, 교재, 교수 학습 방법 등을 개발하는 데에는 창의성의 개념과 구성 요인, 교육 방향에 대한 학문적 합의가 선행되어야 한다. 이에 본 연구에서는 학문 영역마다 고유의 창의성이 존재하며 다른 영역으로 전이되지 않는다는 영역특수성과 일반적인 창의적 사고 기술에 더불어 영역 특수적 기술, 환경의 촉진이나 방해 등이 창의성 발현에 모두 요구된다는 합류 이론에 기반하여 정보과학 교과에 적합한 창의성의 구성 요소를 델파이 방법으로 탐색해 보았다. 개방형 문항으로 구성된 1차 델파이 조사 결과를 내용 분석하여 항목화한 2차 델파이 조사에서는 항목의 중요도를 리커트 5점 척도로 표시하도록 하였다. 3차 델파이 조사 결과 정보과학 창의성의 인지적, 정의적, 환경적 영역에서 전체 32개의 중요 항목들이 선정되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권24호
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• pp.10739-10743
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• 2015

The present study aimed at evaluating and comparing the diagnostic performance of B-mode ultrasound (US), elastography score (ES), and strain ratio (SR) for the differentiation of breast lesions. This retrospective study enrolled 431 lesions from 417 in-hospital patients. All patients were examined with both conventional ultrasound and elastography. Two experienced radiologists reviewed ultrasound and elasticity images. The histopathologic result obtained from ultrasound-guided core biopsy or operation excisions were used as the reference standard. Pathologic examination revealed 276 malignant lesions (64%) and 155 benign lesions (36%). A cut-off point of 4.15 (area under the curve, 0.891) allowed significant differentiation of malignant and benign lesions. ROC (receiver-operating characteristic) curves showed a higher value for combination of B-mode ultrasound and elastography for the diagnosis of breast lesions. Conventional ultrasound combined elastography showed high sensitivity, specificity, and accuracy for group II lesions (10mm${\leq}20mm$). Elastography combined with conventional ultrasound show high specificity and accuracy for differentiation of benign and malignant breast lesions. Elastography is particularly important for the diagnosis of BI-RADS 4 and small breast lesions.

• Parasites, Hosts and Diseases
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• 제52권3호
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• pp.263-271
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• 2014

PCR detection of intestinal protozoa is often restrained by a poor DNA recovery or by inhibitors present in feces. The need for an extraction protocol that can overcome these obstacles is therefore clear. $QIAamp^{(R)}$ DNA Stool Mini Kit (Qiagen) was evaluated for its ability to recover DNA from oocysts/cysts directly from feces. Twenty-five Giardia-positive, 15 Cryptosporidium-positive, 15 Entamoeba histolytica-positive, and 45 protozoa-free samples were processed as control by microscopy and immunoassay tests. DNA extracts were amplified using 3 sets of published primers. Following the manufacturer's protocol, the kit showed sensitivity and specificity of 100% towards Giardia and Entamoeba. However, for Cryptosporidium, the sensitivity and specificity were 60% (9/15) and 100%, respectively. A series of optimization experiments involving various steps of the kit's protocol were conducted using Cryptosporidium-positive samples. The best DNA recoveries were gained by raising the lysis temperature to the boiling point for 10 min and the incubation time of the InhibitEX tablet to 5 min. Also, using a pre-cooled ethanol for nucleic acid precipitation and small elution volume ($50-100{\mu}l$) were valuable. The sensitivity of the amended protocol to Cryptosporidium was raised to 100%. Cryptosporidium DNA was successfully amplified by either the first or the second primer set. When applied on parasite-free feces spiked with variable oocysts/cysts counts, ${\approx}2$ oocysts/cysts were theoretically enough for detection by PCR. To conclude, the Qiagen kit with the amended protocol was proved to be suitable for protozoan DNA extraction directly from feces and support PCR diagnosis.

• 대한의용생체공학회:의공학회지
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• 제30권3호
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• pp.213-220
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• 2009

In this study, we have developed a novel step detection algorithm for gait evaluation of patients with hemiplegia based on trunk accelerometry device. For this, we have used a bandpass filter and a least square acceleration (LSA) filter which is characterized by emphasizing the peak or valley point of the acceleration signals for each 3-axis accelerometer signals. To evaluate the algorithm, the detected steps by developed algorithm and real steps by the motion analysis system were compared. As a result, we could obtain the sensitivity of 96.44%, the specificity of 99.94% and the accuracy of 99.90% for the patients' data sets and the sensitivity of 100%, the specificity of 99.93% and the accuracy of 99.93% for the normal data sets. In conclusion, the developed algorithm is useful for the step detection for patients with hemiplegia as well as normal subjects.