• 약학회지
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• 제41권6호
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• pp.737-748
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• 1997

Distribution of rhEGF in the skin, plasma and several organ tissues following topical application of $^{125}I-rhEGF$ (0.4${\mu}$Ci) solution in 25% Pluronic F-127 on 154$mm^2$ normal and damaged (burned and stripped) skins of hairless mice was examined. The radioactivity in the stripped skin tissues increased as a function of time, and was 10-20 times higher than that in the normal and burned skins. The fractions of intact drug in the skin tissues were 40-60% for the normal and burned skins, and 60-80% for the stripped skin. It indicates that the stratum corneum layer behaves as a barrier for the dermal penetration of the drug. The radioactivity in the plasma was much higher for the stripped skin than for the normal and burned skins. However, the concentration of intact drug in the stripped skin was comparable to those in the normal and burned skins indicating most severe degradation (or metabolism) of the drug in the stripped skin. As a result, the fraction of intact drug in the plasma was lowest for the stripped skin (<10%). Body organ distribution of the drug was much higher for the stripped skin. The concentration in the stomach. Both in total radioactivity and intact drug, showed more than 10-times higher value than in the other organs (liver, kidney and spleen). The fraction of intact drug in each organ tissue was below 10-20%. And generally lowest for the stripped skin. The lowest fraction of the drug for the stripped skin could not be explained by the activity of the aminopeptidases in the skin since it was lower for the stripped skin than for the normal skin. Thereover, the fraction of intact drug appears to be determined by the balance between dermal uptake and systemic elimination of the drug, for example. The mechanism of dermal uptake of rhEGF was examined by topical applying 200${\mu}$l of 25% Pluronic F-127 solution containing 0.4 ${\mu}$Ci of $^{125}I-rhEGF$ and 0.14${\mu}$Ci of $^{14}C$-inulin (a marker of passive diffusion). The radioactivity of $^{125}I-rhEGF$ at each sampling time point (0.5, 1, 2, 4 and 8hr) was correlated (p<0.05) with the corresponding radioactivity of $^{14}C$-inulin. It appears to indicate the rhEGF may be uptaken into the skins mainly by the passive diffusion. This hypothesis was supported by the constant specific binding of EGF to the skin homogenates regardless of the skin models. Receptor mediated endocytosis (RME) appears to contribute negligibly, if any, to the overall uptake process.

• 한국응용곤충학회지
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• 제51권4호
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• pp.305-312
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• 2012

본 연구는 김포시에서 모기성충의 계절적 발생소장과 얼룩날개모기류 유충의 발생을 파악하기 위해서 실시되었다. 성충모기는 6지점에서 유문등을 이용하여, 2008년 5월부터 9월까지 조사되었다. 조사결과 8속 16종 48,919마리가 채집되었다. 금빛숲모기(Aedes vexans nipponii)가 43%로 가장 많았고, 중국얼룩날개모기(Anophels sinensis)가 34%, 작은빨간집모기(Culex tritaeniorhynchus)가 14%로 이 3 우점종이 전체의 91%를 차지했다. 얼룩날개모기류의 계절적 발생소장은 작은빨간집모기와 비교하여 다른 피크를 보였다. 얼룩날개모기류 유충은 203지점 중 138지점(63%)에서 확인되었다. 지점당 정량조사 결과에서 평균유충밀도는 연꽃 재배지가 6.9개체로 가장 높았으며, 다음으로 수로가 4.5개체, 미나리꽝이 3.4개체, 유수지가 3.2개체, 휴경논이 3.1개체, 논이 1.8개체, 습지가 1.4개체, 하천이 0.2개체 순이었다. 유충밀도와 용존산소량, 산도, 염분도, 흡밀원(축사, 돈사, 계사) 사이에 유의한 관계성은 없었다. 최근린평균거리분석(ANNA)의 결과에서, 유충 조사지점간 분포패턴은 전체 조사지점간과 4.0개체 이상 확인된 지점간에서 각각 밀집분포와 불규칙분포였다. 하성면에서는 유충이 3.0 개체 이상 확인된 지점간 분산분포를 나타냈다.

• 통상정보연구
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• 제4권1호
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• pp.107-128
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• 2002

한국 중소수출기업의 인터넷을 이용한 수출마케팅 전략과 성과와의 관계를 밝히기 위하여 본고에서는 우선 이론적 배경을 바탕으로 한 연구모형의 개발 및 연구가설이 설정되었다. 이렇게 설정된 연구가설은 설문조사를 통한 자료수집과 MANOVA에 의한 통계분석을 통하여 검정되었다. 그 결과, 주로 세일즈와 광고에 적용되는 커뮤니케이션 효과계층의 고전적인 AIDA 모델을 준용한 수출성과와 인터넷 수출마케팅전략 변수간에는 거의 대부분의 경우 통계적으로 유의미한 관계가 있음을 발견하였다. 특히 AIDA의 효과계층 중 최종 수출계약성과에 비하여 그 이전 단계인 커뮤니케이션 효과가 더 크다는 사실을 확인한 것이 이 논문의 주요한 의의라고 여겨진다. 이라한 결과는 한국의 중소수출기업이 인터넷을 이용한 마케팅 전략을 짜는데 있어서 의미있는 시사점과 유의사항을 제공하고 있으며, 차후 연구자를 위한 하나의 준거가 될 수 있을 것으로 기대된다.

• 대한간호학회지
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• 제28권1호
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• pp.81-92
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• 1998

This study is to define the caring experience of mothers with insulin-dependent diabetes mellitus children, by finding core category, contextual factors, ntervening factors, and the patterns of caring, and to velop a practice theory on it. Research method followed grounded theory methodology by Strauss & Corbin. Subjects were six mothers. whose children have had insulin-dependent diabetes mellitus for 4 months to 14 years by the interview time. They were selected by theoretical sampling. Data were collected from September, 1995 to January, 1996. Interview were done by long interview technique and observation. Each interview took 50 minutes to 2 hours. Content of interview was recorded and transcribed later. Based on the results of previous interview, content of next interview was planned until data reached to the saturation point. Results were as follows : One hundred and forty concepts were found. These concepts were grouped into thirty-three categories, and then to ten categories. Mothers with diabetic child were revealed to face “being overwhelmed by burden”. Overwhelming by burden is found to be progressed through the cycle production-coping-decrease or in crease process. Mothers showed four patterns of adaptation in caring the diabetic children. 1) If mothers felt large amount of overwhelming by burden because of difficulty of caring and unsympathizing but they had sufficient support, no condition of the child, and their coping mechanism was positive, most of them overcome with strong will, but some fell into burnout. 2) If mothers felt large amount of overwhelming by burden because of difficulty of caring, unsympathizing, insufficient support. serious condition of the child, and their coping mechanism was negative, they fell into burnout by coping with feeling. 3) If mothers felt small amount of overwhelming by burden because of little difficulty of caring and sympathizing, sufficient support. no serious condition of the child, but their coping was negative, most of them fell into burnout by coping with feeling, but some overcome. 4) If mothers felt small amount of overwhelming by burden because of little difficulty of caring and unsympathizing, sufficient support, no serious condition of the child, and their coping was positive, they overcome with strong will. On the basis of the above result, in order to help mothers take good care of their children, nursing assesment and intervention on life readjustment, and getting support should be required. Especially, through understanding mothers' personalities, individual support consistent with each of them should be required. Therefore education. counseling, mutual support and exchange of information will have to be accomplished.

• 한국수자원학회논문집
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• 제36권4호
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• pp.691-703
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• 2003

본 논문에서는 유역과 강우특성을 통합하여 오염물질 부하량을 계산할 수 있는 접근방법을 제시하였다. 이 기법의 기본적인 개념은 특정유역에서 강우시 발생하는 오염물질의 유량 가중평균 농도, 즉 EMC 변화는 오로지 강우패턴에 의해 결정된다는 가정에 기초하고 있다. 이러한 가정은 적어도 유역의 토지이용에 급격한 변화가 없고(적어도 강우가 집중되는 경작기간동안) 점 오염원이 적은 농촌유역에서는 타당하다. 따라서, 다양한 농촌유역과 강우 패턴 조건에서 조사된 많은 EMC 자료가 있다면 EMC와 토지이용, 그리고 강우특성 사이의 유용한 경험적인 관계식을 도출할 수 있을 것이다. 이러한 목적을 달성하기 위하여 9개의 서로 다른 유역에서 51개의 독립적인 강우사상에서 조사된 EMC 자료를 이용하여 강우시 발생하는 EMC 값을 예측할 수 있는 도구를 개발하였다. 통계학적인 검토결과 개발된 경험식은 실제 측정한 EMC 값을 양호한 수준에서 예측할 수 있는 것으로 판명되었을 뿐만 아니라 EMC 자료와 유효 강우량에 기초하여 강우일, 주, 월, 년 단위의 부하량을 산출이 가능하였다. 또한, EMC 값과 유효 강우량에 의해 계산된 부하량으로부터 산출한 원 단위를 기존의 잘 알려진 경험적 원 단위와 비교 평가하였다.

• 지역사회간호학회지
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• 제12권3호
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• pp.732-745
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• 2001

This study attempted to identify obese students' stress and coping method in middle and high schools. The data were collected from the total of 600 obese students from middle and high schools in Pusan. The author used a convenience sampling method. The data collection was done from March 2 to April 30. 2001. The analysis of the data was done with SPSS Win(10.0) for descriptive statistics. t-test. and ANOVA. The instrument used for the obese students' stress and coping method was a questionnaire developed by Kim. Yi-Soon and Kim. Young-Hae(200l). The tool was composed of 65 items (33stress items: 32coping method items) with the five-point Likert scale. The results were as follow: 1. The average score of stress was 2.49 (SD = .86) points in the male students. and 2.83(SD= .86) points in the female students. The subcategories were: (outward appearance), (boyfriend/girlfriend), (occurrence of an outbreak of a disease), (relationship within the family), (an obese appearance), (difficulty in exercise). The highest degree of stress came from 'an obese appearance' for the male students (mean=2.64. SD=0.87) and (mean=2.64. SD=0.87) for the female students. 2. The subcategories of the coping method were: (be concerned about other matters), (recreation activities), (self-violence), (relaxation), (hobby activities), (avoid a situation), (communication), (music), (negative behavior), (positive thinking). The highest degree of coping method were (recreation activities) in the male students (mean=3.07. SD=0.86) and (music) in the female students (mean=3.47. SD=1.01). 3. The results comparing stress with demographic variables were significant for gender (t=7.010. p=0.000). grades at school (F=2.918. p=0.02l), degree of obesity (F=5.205. p=0.006). grades (F=2.550. p=0.027). standard of living(F=8.277. p=0.000). the state of health (F=2.882, p=0.022), relationship with the father (F=4.790, p=0.001), relationship with the mother (F=6.080, p=0.000), and the educational level of the father (F=3.192, p=0.013). 4. The results comparing the coping method with demographic variables were significant for gender (t=4.597. p=0.000). These findings contribute to the understanding of the degree of stress and the type of coping methods of obese students in middle and high schools. Therefore, the result of this study aids in an effective nursing intervention to improve the mental health program for the obese.

• 한국지구과학회지
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• 제35권2호
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• pp.97-103
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• 2014

물안정동위원소를 이용하여 지하수와 강우 또는 융설이 하천에 미치는 영향을 정량적으로 분리하는 방법을 동위원소 수문분리법이라고 하며 지난 30년 동안 사용되어 왔다. 오래된 물(지하수)과 새로운 물(강우 및 융설)의 두 성분이 하천에 영향을 미치는 것으로 가정하고 새로운 물과 오래된 물의 주어진 시간동안의 동위원소를 측정하여 각각의 성분에 대한 비율을 결정할 수 있다. 본 연구에서는 동위원소 수문분리법을 수계에 적용할 때 새로운 물의 시간적인 안정동위원소분화를 고려하지 않고 새로운 물의 평균값을 이용하였을 때 계통오차가 발생함을 보였다. 이러한 표준오차의 크기는 (1) 새로운 물이 하천에 많이 기여할수록, (2) 사용된 평균값과 분화된 새로운 물의 안정동위원소 값과 차이가 클수록, 마지막으로 (3) 오래된 물과 새로운 물의 안정동위원소 값의 차이가 작을수록 커진다. 집중 호우로 유출이 증가하거나 봄철에 지면이 아직 녹지 않아 융설이 유출이 되는 경우 새로운 물이 하천에 미치는 영향이 커지게 되어 상대오차 역시 증가한다. 이러한 오차를 줄이기 위해서 각각의 새로운 물, 오래된 물, 하천의 안정동위원소를 같은 시간 간격으로 측정하여 새로운 물이 분화되는 것을 고려한 수문분리법을 수행하는 것을 고려하여야 한다.

• 센서학회지
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• 제14권2호
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• pp.69-77
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• 2005

The electronic nose (e-nose) has been used in food industry and quality controls in plastic packaging. Recently it finds its applications in medical diagnosis, specifically on detection of diabetes, pulmonary or gastrointestinal problem, or infections by examining odors in the breath or tissues with its odor characterizing ability. Moreover, the use of portable e-nose enables the on-site measurements and analysis of vapors without extra gas-sampling units. This is expected to widen the application of the e-nose in various fields including point-of-care-test or e-health. In this study, a PDA-based portable e-nose was developed using micro-machined gas sensor array and miniaturized electronic interfaces. The rich capacities of the PDA in its computing power and various interfaces are expected to provide the rapid and application specific development of the diagnostic devices, and easy connection to other facilities through information technology (IT) infra. For performance verification of the developed portable e-nose system, Six different vapors were measured using the system. Seven different carbon-black polymer composites were used for the sensor array. The results showed the reproducibility of the measured data and the distinguishable patterns between the vapor species. Additionally, the application of two typical pattern recognition algorithms verified the possibility of the automatic vapor recognition from the portable measurements. These validated the portable e-nose based on PDA developed in this study.

• 한국해양학회지
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• 제7권1호
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• pp.24-45
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• 1972

The Han River is an important water source in Seoul and neighbouring districts, for public and industrial supply, and for agriculture and fishery. Nowadays, more than six million inhabitants are supplied withe water from this river. The total length of the river is 470km, and has 17 10$\^$9/㎥ an average annual flow. The hydrographic characteristics at Seoul are 653㎥/sec in an average flow, 4,608㎥/sec in the maximum average flow, and 201㎥/sec in the minimum average flow. These are influenced in some degree by snowmelt in early spring, and greatly by the flood during summer. For the pollution problems, the periods of low flow are critical ones. As a rule they occur around the months November through June. Nowadays, most of the sewage from towns and industries is discharged untreated. Apart from domestic and industrial sewages, there are some discharges of mineral matter by mines in the upriver region. In general, water quality of the Han River is kept very clean and healthy until Kwangnaru of the upper region of Seoul. A large pollution, however, is received in the downstream by the domestic and industrial sewages of Seoul. It can be seen that dissolved oxygen, COD and BOD$\sub$5/ diminish markedly, and the intensity of almost every water parameter of the river continues to increase. Comparison of the figures for 1971 derived from a sampling point 40km downstream of Kwangnaru leads to the conclusion that hardness, Ca and Mg were no changed; alkalinity, Si and soluble- Fe were slightly increased; CO$\sub$2/, acidity, Cl, NO$\sub$2/-N, Cu, Zn and Al were increased in 2 and 3 times; total residue, total ignitious residue, COD, BOD$\sub$5/, NH$\sub$4/-N, PO$\sub$4/-P, Mn, Pb and total-Fe were increased in 4 to 7 times; and SO$\sub$4/, particulate-Fe and Cd were increased in 10 to 11 times. On the other hand, coliforms were increased in 650 times; fecal coliforms in 365 times; enterococci and total plate counts in 30 times, respectively. In view points of water quality standards, the down Han River water is now leveling out in Cd, coliforms and fecal coliforms for the agricultural use; in dissolved oxygen and some trace elements (Cu, Zn, Pb and Cd) for the fishery use; in ammonia, COD, BOD$\sub$5/, and Cd for the drinking use.

• 영재교육연구
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• 제14권3호
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• pp.41-52
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• 2004

No educational provision for the gifted and talented works in a cultural vacuum, and this is as true for out-of-school activities as for what happens in school itself. There is evidence that excellence in children's achievements can come from widely differing special provision or from no special provision at all. Cultural influences affect attitudes as to who might be gifted and talented and what might be done for them. Whatever the size and influence of special centres anywhere, there is always overlap between in-school and out-of-school activities. For all styles of provision, cooperation between the two is a vital aspect of success. The major cultural dichotomy in this field is between the perception, usually found in the Far East that 'most children have gifted potential' and the largely Western view that 'few children have gifted potential'. It is safe to say that children who are selected for aptitude and ability, and who are keen to learn, will get more from special enrichment than those who of equal potential who have not had that experience. But this does not necessarily show the provision as the best possible method for enhancing gifts and talents. In fact, I do not know of a single scientific investigation, either cross-culturally or within one country, which compares any aspect of an out-of-school programme with another. As a result it is hard to say what type of provision would be most appropriate and effective in any given situation. Outcomes are also dependent on the enthusiasm, organisation and money put into any scheme - as well as the way youngsters are chosen for it. Some of the largest and most influential out-of-school American institutions were founded on the psychological understanding of human abilities that was current in the 1920s. These early influences of seeking an IQ cut-off point (or equivalent) to identify the gifted still affect their practice. in addition, the big American Talent Searches so often select youngsters for summer-schools not only by their high-level achievements, but also by their parent's ability to pay the sometimes high fees. Opinions about the identification of the brightest children and consequential educational practice underlie all provision for their education, whether in or outside school hours. Because of cross-cultural differences, it would not seem wise to copy any action directly from one culture to another without recognising these influences and possibly modifying the model. The growing trend around the world is to offer high-level opportunities to as many youngsters as possible, so that no keen learner is turned away without even a change of sampling them.