• 대한수의학회지
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• 제38권4호
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• pp.843-852
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• 1998

From Jan. 1996 to Oct. 1997, 29 pigs with 40-70 days old showing dyspnea inappetite and polyserositis were collected and carried out necropsy, bacterial culture, histopathology, avidin biotin complex(ABC) stain, fluorescent antibody(FA) test, and electron microscopy. In the study, 4 strains from 3 pigs were isolated from meninges, pleura and synovial fluid and also were identified as Haemophilus parasuis serovar 5. Main histopathological lesions of 29 pigs with polyserositis were frequently composed of fibrinous peritonitis(27), pleurisy(22), interstitial pneumonia(21), fibrinous epicarditis(20), fibrinopurulent meningitis(8) and synovitis(4). By ABC stain, 11/29(37.9%) pigs with polyserositis were confirmed to have H parasuis serovar 5 in the cytoplasm of macrophages and neutrophils in cerebral meninges, epicardium, pleura surface of lung or serosa of spleen. ABC stain(20.8~40.0%) to detect H parasuis serovar 5 in tissues was more sensitive than bacterial culture(10.3%), but less sensitive than FA test(62.5%) using frozen tissues even though the result of 8 cases. By electron microscopy, a bacterium was also detected in the cytoplasm of macrophages in purulent exudate of cerebral meninges. Consequently, we confirmed that H parasuis serovar 5 has been involving to cause pigs with polyserositis and can be detected by FA and ABC stain as reliable diagnostic tools.

• Journal of Chest Surgery
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• 제8권2호
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• pp.159-168
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• 1975

We have experienced 61 cases of Clinically diagnosed tuberculous peripleural abscess which was surgically treated at St. Mary's Hospital of Catholic Medical College from Mar. 1963 to Feb. 1974. Out of them, 52 cases of pathologically confirmed tuberculous peripleural abscess were reviewed and its pathogenesis, treatment and so called "rib caries" were discussed. In the past, they have been described as a variety of the names, such as rib caries, cold abscess of the chest wall, pericostal abscess, lymphadenitis tuberculosa of the chest wall, chronic draining sinuses of the chest wall and other descriptive terms. Although it has been said that the tuberculous abscess on the chest wall developed as a secondary disease from so called "rib caries" but now it has been clear that this abscess occurred not from tuberculosis of the rib but from tuberculous lesion developed between end-othoracic fascia and parietal pleura usually following pulmonary tuberculosis and/or tuberculous pleurisy and the involvement of rib or ribs are secondary one from peripleural abscess, as we confirmed. Therefore we advocate that the nomination, rib caries, should not be used unless there is a primary tuberculous lesion on ribs. The results were as follows: 1. The highest age group of tuberculous peripleural abscess was ranged from the first to third decade (78%) 2. The location of tuberculous peripleural abscess on the chest wall were as follows, 31 cases on the anterior, 19 cases on lateral and 2 cases on the posterior. 3. On x-ray examination, abnormal findings including parenchymal tuberculous lesion and pleural changes were seen is 38 cases. 4. There was no destructive change of periosteum and rib in 23 cases of tuberculous peripleural abseess during operation. However the periosteal denudation and/or rib destruction were found in 29 cases. 5. The all cases of tuberculous peri pleural abscess developed from between endothoraclc fascia and parietal pleura, as we confirmed. With antituberculous therapy, operation should be radical by wide incision on the lesion including thorough curettage with proper drainage of Iiquified caseating materials and appropriate rib resection, if necessary.tion, if necessary.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제36권4호
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• pp.314-319
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• 2010

Odontogenic infections are a normally locally confined, self-limiting process that is easily treated by antibiotic therapy and local surgical treatment. However, it may spread into the surrounding tissues through a perforation of the bone, and into contiguous fascial spaces or planes like the primary or secondary fascial spaces. If the infection extends widely, it may spread into the lateral pharyngeal and retropharyngeal space. The retropharyngeal space is located posterior to the pharynx. If an odontogenic infection spreads into this space, severe life-threatening complications will occur, such as airway obstruction, mediastinitis, pericarditis, pleurisy, pulmonary abscess, aspiration pneumonia and hematogenous dissemination to the distant organs. The mortality rate of mediastinitis ranges from 35% to 50%. Therefore, a rapid evaluation and treatment are essential for treating retropharyngeal space abscesses and preventing severe complications. Recently, we encountered two cases of a retropharyngeal space abscess due to the spread of an odontogenic infection. In all patients, early diagnosis was performed by computed tomography scanning and a physical examination. All patients were treated successfully by extensive surgical and antibiotic therapy.

• 대한한방내과학회지
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• 제21권4호
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• pp.671-676
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• 2000

Pleural effusion is a state, retention of a mount of liquid in pleural cavity. Main causes of pleural effusion is Congestive Heart Failure that is caused by left ventricular heart failure. And that of Congestive heart failure is caused by increase of pleural capillary pressure or remain of effusion in pleural cavity. Bilateral venous pressure of pleura make worse pleural effusion and one way of venous pressure of that bring out pleural effusion. The purpose of this study is to examine the efficacy of oriental treatment for pleural effusion is caused by heart failure. One woman of 86 years old complained the symptom of general weakness, dyspnea, flank pain, anorexia, insomnia, coughing, secretion mixed blood. The symptom is caused by effusion that is brought out acute pneumonia, heart failure. At the time of Admission, in the diagnosis of Admission, in the diagnosis of Hyuneum(懸飮) she had taken Kungha-tang hap pleurisy-bang,(芎夏湯合助膜炎方), so improved dyspnea, flank pain, insomnia, coughing. In views of examination, decrease of heart failure' s symptom and pleural effusion. After 13days of admission, she had taken palmul-tang.(八物湯). As a conseguence of that, the symptom of general weakness. anorexia is improved and she was discharged.

• Tuberculosis and Respiratory Diseases
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• 제41권1호
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• pp.36-41
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• 1994

저자들은 호흡곤란을 주소로 내원한 44세 남자에서 기관지 내시경검사, 흉막생검, 복부초음파검사, 흉부단층촬영을 시행한 결과 흉막삼출을 동반하는 폐의 전이성 맥관육종을 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Yeungnam Medical Science
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• 제27권1호
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• pp.42-46
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• 2010

Eosinophilic myositis is a rare idiopathic inflammatory muscle disease, and the patients with this malady present with diverse signs and symptoms such as muscle swelling, tenderness, pain, weakness, cutaneous lesions and eosinophilia. The etiology and pathogenesis of eosinophilic myositis remain elusive. Several drugs may occasionally initiate an immune mediated inflammatory myopathy, including eosinophilic myositis. We report here on a case a 17-year-old female patient who had taken anti-tuberculosis medicine for tuberculosis pleurisy. She presented with many clinical manifestations, including fever, skin rash, proximal muscle weakness, dyspnea, dysphagia and hypereosinophilia. She was diagnosed with eosinophilic myositis by the pathologic study. The muscle weakness progressed despite of stopping the anti-tuberculosis medicine, but the myositis promptly improved following the administration of glucocorticoid. Although drug induced myopathies may be uncommon, if a patient presents with muscular symptoms, then physicians have to consider the possibility of drug induced myopathies.

• Pediatric Infection and Vaccine
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• 제3권2호
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• pp.128-132
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• 1996

Tuberculosis in children is an important disease because of higher incidence and mortality, especially in developing and underdeveloped countries. The objectives of this study were to evaluate the cause of antituberculosis medication in children and to find out the basic data for proper drug regimen. We reviewed the medical records of 198 patients who had been treated with antituberculosis drugs from Jan. 1991 to Dec. 1993 in Anam Hospital of Korea University Medical Center. The results are as following; 1) Of 198 patients, 69 cases(34.8%) had treated due to BCG complications. They were all medicated with INH. The durations of medication were 3 months in 46 patients(66.7%), 4~6 months in 17 patients(5.8%), 7~9 months in 4 patients(5.8%), 10-12 months in 2 patients(2.9%). 2) Of 198 patients, 68 cases(34.3%) had treated due to chemoprophylaxis, 59 patients (29.8% of all cases) had histories of house hold contact. Of 68 cases, 51 patients (86.4%) were medicated with INH only, 8 patients (13.6%) were medicated with INH and RFP. 3) Other causes of antituberculosis medication were tuberculous lymphadenitis(14.1%), pulmonary tuberculosis(10.6%), meningitis, miliary tuberculosis(2.0%), and pleurisy(2.0%). Most common causes of antituberculosis medications in children were complication of BCG vaccination and chemoprophylaxis after household contact. So early detection of adult tuberculosis and development of convenient diagnostic methods and safe vaccine for childhood tuberculosis is necessary.

• 대한한의학방제학회지
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• 제31권2호
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• pp.99-109
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• 2023

Objectives : Sihosogan-tang (SST) is one of the traditional herbal formula and also one of the Korean medical insurance medicines. It commonly used in the treatment of hepatitis, chronic gastritis, intercostal neuralgia, pleurisy, and depression in East Asia. In the present study, we have demonstrated the anti-inflammatory effects of SST in macrophage cell line. Methods : To investigate mechanism of the anti-inflammatory effect of SST, we examined the productions of nitric oxide (NO) and pro-inflammatory cytokines, and the expressions of inducible NO synthase (iNOS), nuclear factor-κ B (NF-κB) and mitogen-activated protein kinase (MAPK) on RAW 264.7 cells activated by LPS. Results : SST significantly inhibited the expression of iNOS increased by LPS, and also significantly inhibited the production of NO. In addition, SST significantly inhibited pro-inflammatory cytokines such as TNF- α and interleukines. SST inhibited the expression of NF-κB and MAPK activation. Conclusions : These results suggest that SST ameliorates inflammatory response in LPS-activated RAW 264.7 cells through the inhibition of the NF-κB and MAPK pathway. Therefore, this study supplies objective evidence for the anti-inflammatory effect of SST.

• Tuberculosis and Respiratory Diseases
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• 제48권5호
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• pp.773-780
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• 2000

연구배경 : 흉수의 pH 측정은 흉막천자시 흉수의 원인 진단을 위해 시행되는 중요한 검사항목이며, 특히 부폐렴흉막염이 농흉화되는지를 확인할 수 있는 지표중 하나이다. 흉수의 pH 측정은 혈액가스분석기계를 이용하는 것이 표준이나, 상황에 따라서는 pH meter나 pH strip을 이용하기도 한다. 본 연구에서는 흉수중 삼출액을 대상으로 위의 세가지 방법으로 pH를 측정하고 측정치들을 비교하여 보았다. 방법 : 1999년 8월부터 2000년 3월까지 중앙대학교 부속 용산의료원에 입원하여 삼출성 흉수로 의심되어 흉막 천자를 시행한 34례 (결핵성 흉막염 16명, 부폐렴성 흉수 9명, 폐암 5명, 농흉 3명, 심부전 1명)의 흉수에서 혈액가스분석기계, pH meter, pH strip의 세 가지 방법으로 pH를 측정하였다. 혈액가스분석기계와 pH meter에 의한 측정은 천자후 $0^{circ}C$로 유지하면서 30분 내에 시행하였으며, pH strip 측정은 흉막천자 직후에 pH strip으로 pH를 측정하고, 상온 상태로 검사실에 내려서 보고되는 결과를 이용하였다. 결과 : 34례 흉수의 pH 값 (평균값$\pm$표준편차)은 혈액가스 분석법 7.34$\pm$0.12, pH meter 법 7.52$\pm$0.25, pH strip 법 중, 흉막천자후 즉시검사의 경우에는 7.37$\pm$0.16 였으며, 검사실에서 측정한 pH strip법은 6.93$\pm$0.20으로, 혈액가스분석법을 기준으로 한 평균치 분석에서 검사실에서 측정한 pH strip 법은 의미있는 차이를 보였다(p<0.05). 혈액가스분석법과 pH meter 방법, 그리고 혈액가스 분석법과 천자직후 pH strip법의 사이에는 의미있는 상관관계가 있었고, 혈액가스분석법과 pH strip 법 사이에는 의미있는 상관관계가 없었다. 결론 : 흉수천자 직후에 측정한 pH strip 법은 비교적 간단하고 정확하게 흉수의 pH를 측정할 수 있을 것으로 판단된다.

• Tuberculosis and Respiratory Diseases
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• 제40권5호
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• pp.584-594
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• 1993

연구배경 : 늑막염 환자는 흔히 보는 호흡기질환으로 결핵성에 의한 늑막염이 제일 많은 것으로 보고되고 있으나 근래에 와서 진단방법의 발전, 결핵이환율의 감소, 인간수명의 연장등으로 다른 원인 질환이 증가하고 있으며 특히 폐암 및 악성종양이 증가하여 이에 따른 암성과 다른 늑막염과의 빠르고 정확한 구별을 하여 신속한 치료를 요하기 위해 늑막염 환자의 제반검사와 임상양상에 대하여 알아보았다. 방법 : 1989년 1월부터 1992년 12월까지 4년간 315명을 대상으로 임상증세와 나이, 성별을 관찰하였고 흉부 X-선 촬영 및 늑막천자, Cope침을 사용한 늑막침생검, 임파선 조직검사, 기관지경검사 그리고 동반된 폐질환 등을 이용하여 원인규명 및 진단을 내렸고 늑막천자후 단백질양, LDH 양, Cholesterol 농도와 이들의 혈청에 대한 늑막액의 비를 측정하여 여출액과 삼출액을 비교하고 그 오류빈도를 비교하였다. 결과 : 315예중 삼출액이 288예(91.4%), 여출액이 27예(8.6%)였으며 삼출액중에서 결핵성이 82.3%, 암성이 12.2%, 감염성이 5.5%였다. 주소는 호흡곤란(58.7%), 흉통(54.9%), 기침 (50.2%) 순이었고 늑막액의 위치는 우측(51.4%), 좌측(41.3%), 양측(7.3%) 순이며 늑막액의 양은 소량(42.9%), 중등량(39.4%), 다량(17.7%) 순이었다. 비중은 1.030~1.039 범위가 51.4%, 1.020~1.029 범위가 23.5%순이었고 백혈구 수는 삼출액에서 $1000{\sim}5000/mm^3$ 범위가 51.4%, $250{\sim}1000/mm3^$ 범위가 23.3%순이며 백혈구 구분은 70% 이상이 결핵은 89.5%, 암성은 82.9% 였다. 삼출액과 여출액의 구별은 단백질양은 3.0g%, LDH 양은 200단위, Cholesterol 농도는 60mg/dl과 이들의 혈청에 대한 늑막액의 비를 0.5, 0.6 그리고 0.3을 기준으로 하였을때 삼출액의 오류빈도를 비교하면 5.2%, 13.9%, 8.0%와 7.6%, 9.7%, 5.6%를 나타내었다. 늑막침생검상 결핵성이 60.8%, 암성이 13.6%, 감염성이 2.3% 그리고 비특이성 염증이 23.3% 였다. 결론 : 이상의 결과에서 우리나라에서는 결핵성 늑막염이 제일 많으며 여출액 및 삼출액의 감별에 단백질양과 LDH양 및 이들의 혈청에 대한 늑막액의 비와 더불어 Cholesterol 농도와 혈청 Cholesterol에 대한 늑막액의 Cholesterol의 비도 유용한 지표가 될 수 있으며, 늑막침생검을 다른 검사에 우선하여 시행하여야 하며 비특이성 염증시 반복생검은 진단율을 높일 수 있어 정확한 진단 및 신속한 치료에 도움이 될 것으로 생각된다.