• Parasites, Hosts and Diseases
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• v.48 no.4
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• pp.281-284
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• 2010

Due to the possible emergence of resistance and safety concerns on certain treatments, development of new drugs against parasites is essential for the effective control and subsequent eradication of parasitic infections. Several drug targets have been identified which are either genes or proteins essential for the parasite survival and distinct from the hosts. These include the phosphagen kinases (PKs) which are enzymes that playa key role in maintenance of homeostasis in cells exhibiting high or variable rates of energy turnover by catalizing the reversible transfer of a phosphate between ATP and naturally occurring guanidine compounds. PKs have been identified in a number of important human and animal parasites and were also shown to be significant in survival and adaptation to stress conditions. The potential of parasite PKs as novel chemotherapeutic targets remains to be explored.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2003.10a
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• pp.42-42
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• 2003

The contamination of the environment with pollutants is one of the main problems of modern life, and the levels pollution in industrialized regions are giving raise to increased public concern. The mitogen-activated protein kinase (MAP kinase) are playa pivotal role in the regulation of important cellular functions by activation of specific signal transduction pathways from cell the surface to the nuclei. Three major subgroups of MAP kinases have been identified, and these comprise the extracellular signal-regulated kinase (ERK), the c-Jun amino-terminal kinase (JNK), and the p38 MAP kinases [1-3]. Herein, we investigated the effect of regulation of phospho-JNK (p-JNK), phospho-p38 (p-p38) and phospho-ERK (p-ERK) by TCDD. (omitted)

• Journal of Arbitration Studies
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• v.16 no.2
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• pp.151-182
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• 2006

The International Institute for the Unification of Private Law (UNIDROIT) established UNIDROIT principles, which could be applicable as international unified rules. The UNIDROIT Principles plays the role of interpreting and complementing CISG and functions as a law applicable to international commercial disputes. As shown by cases of practical application so far, the principles are expected to be applied frequently to international commercial arbitration in the future. In the situation that there is no internationally unified judicature, it is necessary to promote rational dispute resolution and legal stability through arbitration by adopting the UNIDROIT Principles of Lex Mercatoria as a governing law of international commercial contracts. In conclusion, UNIDROIT principles, along with CISG, are expected to playa great role as the applicable law of international commercial contracts and as standards for resolving international commercial disputes.

• Journal of Mechanical Science and Technology
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• v.18 no.10
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• pp.1819-1828
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• 2004

The purpose of this paper is to investigate the effects of slits and swirl vanes on the turbulence augmentation in the flow fields of a gun-type gas burner using an X-type hot-wire probe. The gun-type gas burner adopted in this study is composed of eight slits and swirl vanes located on the surface of an inclined baffle plate. Experiment was carried out at a flow rate of 450 ι/min in burner model installed in the test section of subsonic wind tunnel. Swirl vanes playa role diffusing main flow more remarkably toward the radial direction than axial one, but slits show a reverse feature. Consequently, both slits and swirl vanes remarkably increase turbulence intensity in the whole range of a gun-type gas burner with a cone-type baffle plate.

• Journal of the Korean Mathematical Society
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• v.44 no.3
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• pp.615-626
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• 2007

A pair of pants $\sum(0,\;3)$ is a building block of oriented surfaces. The purpose of this paper is to determine the discrete conditions for the holonomy group $\pi$ of hyperbolic structure of a pair of pants. For this goal, we classify the relations between the locations of principal lines and entries of hyperbolic matrices in $\mathbf{PSL}(2,\;\mathbb{R})$. In the level of the matrix group $\mathbf{SL}(2,\;\mathbb{R})$, we will show that the signs of traces of hyperbolic elements playa very important role to determine the discreteness of holonomy group of a pair of pants.

• The Korea Journal of Herbology
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• v.20 no.2
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• pp.55-60
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• 2005

Objectives : This study was conducted to investigate the effects Innotus obliquus on the cytokine expression in Raw 264.7 cells. Methods : In Raw 264.7 cells stimulated with lipopolysaccaride(LPS) to Mimic inflammation, Innotus obliquus ethanol extract inhibited nitric oxide production in a dose-dependent manner and abrogated inducible nitric oxide sythase(iNOS) and cyclooxigenase (COX-2). The levels of cytokines were analyzed by sandwich immuno assays. Results and Conclusions : Results provided evidence that Innotus obliquus inhibited the production of IL-b, and IL-6 in Raw 264.7 cells activated with lipopolysaccharide (LPS). These finding suggested that Innotus obliquus can produce anti-inflammatory effect, which may playa role in adjunctive therapy in Gram-negative bacterial infections.

• ALGAE
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• v.23 no.3
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• pp.201-207
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• 2008

Based on samplings during 2006-2007 on the intertidal zone of Playa Tampico, Eréndira and Punta Baja, Baja California, Ulva pertusa Kjellman (Ulvales, Chlorophyta) was recorded for the first time for the Pacific coast of Mexico. An alga native to Asia, U. pertusa has just recently been recorded in the southern coast of California (USA). The identification of U. pertusa was based on the observation of the morphology and reproductive characters of the collected specimens. Furthermore, the species identity was confirmed by molecular comparison between nuclearencoded ITS2 sequences of the Mexican samples and those of other Ulva species in GenBnak data. Habitat and distribution of U. pertusa along the Pacific coast of North America are also described. Considering our new report of its occurrence in Mexico, we conclude that U. pertusa is expanding its geographical distribution by trans-ocean introductions.

• 한국생물공학회:학술대회논문집
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• 2002.04a
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• pp.30-33
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• 2002

We have shown that it is possible to form a fibrilar network of fibronectin on a polyelectrolyte polymer film whose dimensions are similar to those reported on the extra cellular matrix. The fibronectin network was observed to form only when the charge density of the polymer was in excess of the natural charge density of the cell wall. Furthermore, the self-organized fibronectin layer was much thicker than the polymer film, indicating that long ranged interaction may playa key role in the assembly process. It is therefore important to understand the structure of the polymer layer/protein interface. Here we report on a neutron reflectivity study where we explore the structure of the polyelectrolyte layer, in this case sulfonated polystyrene (PSSx,), with varying degree of sulfonation (x<30%), as a function of sulfur content and counter ion concentration. These results are then correlated with systemic study of the adsorption and the multilayer formation of fibronectin as a function of incubation time for various sulfonation levels of $PSSx.^1$

• Journal of Communications and Networks
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• v.10 no.1
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• pp.89-97
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• 2008

Anomaly detection systems playa significant role in protection mechanism against attacks launched on a network. The greatest challenge in designing systems detecting anomalous exploits is defining what to measure. Effective yet simple, Shannon entropy metrics have been successfully used to detect specific types of malicious traffic in a number of commercially available IDS's. We believe that Renyi entropy measures can also adequately describe the characteristics of a network as a whole as well as detect abnormal traces in the observed traffic. In addition, Renyi entropy metrics might boost sensitivity of the methods when disambiguating certain anomalous patterns. In this paper we describe our efforts to understand how Renyi mutual information can be applied to anomaly detection as an offline computation. An initial analysis has been performed to determine how well fast spreading worms (Slammer, Code Red, and Welchia) can be detected using our technique. We use both synthetic and real data audits to illustrate the potentials of our method and provide a tentative explanation of the results.

• Proceedings of the KACD Conference
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• 2001.11a
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• pp.581.1-581
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• 2001

Trigeminal nerve functions movement and sensation on orofacial region. Therefore, it is very important in dental clinic. Neurons with their cell bodies in trigeminal ganglion of trigeminal nerve root are primary sensory neurons and playa role of tactile sense, pressure, vibration and pain of orofacial area. Transmission of these senses depends on ion channels, we know that trigeminal ganglion neuron exists many kind of ion channels. Methods of definition on ion channel are several, but in this study we use immunostaining for detection of ion channels.(omitted)