• Toxicological Research
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• v.30 no.1
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• pp.1-5
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• 2014

Xenograft models of human cancer play an important role in the screening and evaluation of candidates for new anticancer agents. The models, which are derived from human tumor cell lines and are classified according to the transplant site, such as ectopic xenograft and orthotopic xenograft, are still utilized to evaluate therapeutic efficacy and toxicity. The metastasis model is modified for the evaluation and prediction of cancer progression. Recently, animal models are made from patient-derived tumor tissue. The patient-derived tumor xenograft models with physiological characters similar to those of patients have been established for personalized medicine. In the discovery of anticancer drugs, standard animal models save time and money and provide evidence to support clinical trials. The current strategy for using xenograft models as an informative tool is introduced.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2012.10a
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• pp.251-255
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• 2012

Structural intensity has been mainly utilized to identify vibration energy flow in a vessel. In this paper, the structural intensity of a shuttle tanker subjected to H-moment of the main engine was calculated using a finite element model. From the analysis, it was found that the top-bracing elements, which support the main engine onto the hull structure to prevent the excessive transverse vibration of the main engine, play the role of the dominant path and sink for vibration energy flow from the main engine. Therefore, the structural intensity was controlled by the modification of stiffness and damping characteristics of the top-bracing elements. As a result, it is observed that the transverse vibration level at the center of navigation bridge deck decreased after the control of structural intensity.

• Proceedings of the Korean Information Science Society Conference
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• 2005.11b
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• pp.580-582
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• 2005

본 논문에서는 홈 환경에서 정보가전 장치와 각 장치가 제공하는 서비스를 발견하고 일괄적으로 제어할 수 있는 시스템 (HSC: Home Service Controller)을 제안한다. 기존 연구에서는 서비스마다 각기 다른 인터페이스가 요구되었고, 한 번에 하나의 서비스만 수행해야 하는 제한이 있었다. 제안된 HSC에서는 UPnP (Universal Plug and Play)구조에 기반 하여 자동으로 발견된 서비스를 사용자에게 알리고, 제안된 통합 인터페이스로 다수의 서비스를 제어한다. 또한 PDA를 통해 제공되는 입체적인 3D GUI화면과, 여러 서비스를 일괄적으로 수행할 수 있는 서비스 일괄 수행을 지원함으로써, 사용자에게 보다 넓은 행동 범위와 편리를 제공한다. 이러한 시스템은 다수의 장치와 서비스가 네트워크로 연동되는 유비쿼터스 컴퓨팅 환경에서 사용자가 장소와 시간에 구애받지 않고 다양한 서비스를 일괄적으로 제공받는데 활용될 수 있다.

• International Journal of Human Ecology
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• v.5 no.1
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• pp.9-21
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• 2004

This study attempted to identify the factors related to life insurance focusing on two different types of life insurance： term life insurance and cash-value life insurance. Based on the human capital, bequest motives theories, and decision under risk, a conceptual framework was developed. The results showed a support for the conceptual framework indicating that human capital, bequest motives as well as attitude toward risk were important factors in predicting each of life insurance ownership. In addition, the factors related to each type of life insurance were different. For term life insurance, the variables representing households' bequest motives were found to play an important role while the variables reflecting human capital theory had significant impact on cash-value life insurance holding.

• Journal of Korean Association for Spatial Structures
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• v.3 no.3 s.9
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• pp.95-103
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• 2003

Frame is one of the most commonly used structural systems for the resistance of applied loads. Many researchers have recently conducted their studies to investigate the effect of several parameters such as the connection flexibility, boundary condition of each support, beam-to-column stiffness ratio. These parameters play important roles on the characteristic behavior of frames. A simplified spring model is proposed to obtain the story drifts of frames with various beam-to-column connection stiffnesses in this research. A point bracing system with adequate spring stiffness is also suggested to establish the relationship between the applied load and the resisting translational spring stiffness within the limit state of story drift.

• Journal of Life Science
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• v.18 no.3
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• pp.422-425
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• 2008

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a membrane-associated zinc-dependent endoproteinase involved in extracellular matrix remodeling. MT1-MMP hydrolyzes ECM proteins like collagen and is involved in cancer cell migration and metastasis. Caveolins are integral membrane proteins and play a role in formation of caveolae, specialized membrane microdomains involved in clathrin-independent endocytosis. Recombinant MT1-MMP was transiently expressed in PANC-1 cells. Cells expressing recombinant MT1-MMP were able to hydrolyze collagen and migrate on collagen coated trans-well. Both subjacent collagen degradation and the cell migration conferred by recombinant MT1-MMP were inhibited by co-transfection of plasmids containing caveolin-1 cDNA. The results support that MT1-MMP is localized in lipid raft of the membrane and MT1-MMP activities in invasive cells could be inhibited by caveolin.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.05a
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• pp.1091-1098
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• 2003

Flexure bearings have been used in linear-resonant compressors to maintain a non-contacting clearance seal between the piston and cylinder. There are two types of tangential cantilever bearing and spiral arm bearing with flexure bearings. A newly devised linear flexure bearing (KIMM-Ml) for compression refrigeration machines is disclosed having improved tight gas clearance maintaining capability for better system performance. KIMM-Ml is an integrated device comprising an axially moving diaphragm with circumferentially arranged arc-shaped flexure blades secured between rim and hub spacers, which turn out to have higher radial stiffness than the one with circumferential tangential cantilever flexure blades. It is expected for KIMM-Ml to play a key role in designing long life, special purpose compression refrigeration machines by providing frictionless, non-wearing, linear movement and radial support for the machines as well as a gas clearance seal by maintaining extremely tight clearances between piston and cylinder.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.32 no.2
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• pp.171-178
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• 2009

Logistic support activities for weapon systems play an important role at maintenance activities in modern warfares. These activities are essential for keeping weapon systems ready at all time. However, maintenance supplies can be delayed without a proper information system. Further, increases of mean time to repair (MTTR) and unavailability of weapon systems can be occurred. In this study, a web based information system is developed for logistic chains of class 9 supplies. Utilizing web database technologies, the developed system can provide an environment for data exchange and sharing among various participants in the supply chain.

• Journal of Digital Convergence
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• v.7 no.1
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• pp.81-98
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• 2009

Understanding what lies beneath the relationship between ISP and its implementation is an significant area of inquiry in the ISP research. Through an empirical analysis and complementary case examples the current study examines this relationship at six different university sites which undergone both of these processes years from 1995 to 2001. The face-to-face, in-depth interviews were conducted to those participated in both of these processes. A questionnaire survey was also conducted to same participants to elevate the quality of the validity and reliability of the measures. Due to the limitation of the access to the data, it was not possible to compare how similar the final implementation outcomes are from what was originally planned in ISP to some sites. However the study finds that such organizational factors as management support, communication, and organizational culture at the ISP play an important role in the implementation process. This paper proposes that these organizational factors although little they seem to directly affect each individual elements in the implementation process, its latent impact is critical as a whole.

• The Journal of Korean Academic Society of Nursing Education
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• v.17 no.2
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• pp.178-189
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• 2011

Purpose: The purpose of this study was to analyze types of undergraduate nursing student's perception toward happiness. Method: The Q-methodology, which provides a method of analyzing the subjectivity of each item, was used. The 34 selected Q-statements from each of 41 subjects were classified into a shape of normal distribution using a 9 point scale. The collected data was analyzed using a QUANL PC program. Result: Four types of perception of happiness in Korean undergraduate nursing students were identified. Type I is a family support vs. emotion type, Type II is a self satisfaction vs. perception type, Type III is a relation oriented vs. action type, and Type IV is a self regulation vs. belief type. Conclusion: It can be concluded that obtaining happiness by pursuing a satisfactory life through creation of values can play an important role in happiness. Therefore, the results of this study suggest that the concept of happiness might be included in nursing curriculum.