• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.917-923
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• 2014

Chondrosarcomas are malignant cartilage-forming tumors of bone which exhibit resistance to both chemotherapy and radiation treatment. miRNAs have been well demonstrated to regulate gene expression and play essential roles in a variety of biological processes, including proliferation, differentiation, migration, cell cycling and apoptosis. In this study, we obtained evidence that miR-100 acts as a tumor suppressor in human chondrosarcomas. Interestingly, cisplatin resistant chondrosarcoma cells exhibit decreased expression of miR-100 compared with parental cells. In addition, we identified mTOR as a direct target of miR-100. Overexpression of miR-100 complementary pairs to the 3' untranslated region (UTR) of mTOR, resulted in sensitization of cisplatin resistant cells to cisplatin. Moreover, recovery of the mTOR pathway by overexpression of S6K desensitized the chondrosarcoma cells to cisplatin, suggesting the miR-100-mediated sensitization to cisplatin dependent on inhibition of mTOR. In summary, the present studies highlight miR-100 as a tumor suppressor in chondrosarcoma contributing to anti-chemoresistance. Overexpression of miR-100 might be exploited as a therapeutic strategy along with cisplatin-based combined chemotherapy for the treatment of clinical chondrosarcoma patients.

• The Journal of the Korea Contents Association
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• v.7 no.12
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• pp.41-54
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• 2007

The recent UCC video sector possesses an explosive potential for growth as it will act as a critical factor in determining the popularity of portal sites. We identified and compared the strengths and weaknesses in the UCC sector of "Naver" and "Daum", which are currently in the development phase, and we investigated alternatives as well as proposing an outlook for both portal companies. We believe a better UCC video service will be the deciding factor in a portal's popularity and therefore researches in the UCC video sector must continue.

• Korean Institute of Interior Design Journal
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• v.22 no.1
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• pp.283-290
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• 2013

The change of shopping environment created new emerging type of shopping center after 1990's, Urban Entertainment Center(UEC) in northen America. One hand traditional shopping center was retail-centered, the other hand UEC is entertainment-centered and offers the trinity of synergy. Each components, that are retail, dining and entertainment, play a role of drawing people, extending duration of visiting and making people revisit then the synergy makes commercial profit in shopping center. As northen America many of shopping centers with complex have been built in Korea since 2000 and some projects is planning by the change of shopping environment and regenerating urban. Although the term of "UEC" is used in Korea, it seems to be added entertainment facilities to shopping center without considering on commercial strategy. This study will take a look at mix and duration of visit which ULI stresses in UEC development and comparing with those of Yongsan Station and Chyeongrangri Station which are built recently in seoul, it will get characters and situation of these UECs. Finally, the analysis is to be used as a planning data in UEC development.

• Korean Institute of Interior Design Journal
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• v.22 no.5
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• pp.68-77
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• 2013

'The Third space,' which is the concept that embraces sociological, spatial, and marketing concepts, refers to the place which is other than the home and the workplace and which is a comfortable frequented place where meditation, psychological relaxation, and social needs can be satisfied. 'The Third space' has the characteristics of comfort, openness, interactivity, playfulness, and diversity. In modern times, most of consumption spaces play the role of 'the Third space,' and the typical example is $Caf{\acute{e}}$. $Caf{\acute{e}}$ began from its origin with the characteristics of 'the Third space,' and recently it has become the complex cultural space of urban dwellers. $Caf{\acute{e}}$ as 'the Third space' has the characteristics of a healing space, communication space, personalized space, value-expressive space, culture and consumption space, nomad space. Such characteristics of $Caf{\acute{e}}$ are well represented in the cafes around the regions where 'street culture' has recently been formed. As examined through the examples, $Caf{\acute{e}}$ as 'the Third space' can be more strategically produced by establishing themes through storytelling, giving spatial identity through style creation, diversifying the sequence through complex space organization, and establishing interaction devices through experience elements.

• Journal of Technology Innovation
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• v.16 no.2
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• pp.17-40
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• 2008

The collaboration among academia, industry, and public research sector gains importance in these days. This is essential for implement competent regional and national innovation systems. There have been many governmental programs for activating collaboration among innovation actors. Most policy programs for collaboration have aimed at increasing S&T and innovation potential and constructing S&T infrastructure. However, Korea has not produced a sufficient level of collaboration, especially on regional level. Most policy programs could not reach regions and many regions have no enough innovation actors. In order to activate R&D collaboration, therefore, we suggest that Korean S&T community should build and implement "collaborative research centers" all over the regions. This concept is very new approach, especially because it focuses on collaboration among regional innovation actors. In this paper, we discuss a concept, type, and execution strategy of collaboration research centers. We expect that these centers will play an important role in implementing successful regional innovation systems, as they will link regional innovation actors very closely.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.16 no.4 s.109
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• pp.420-427
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• 2006

In this study, wind loads transmitted to a transmission tower from transmission lines are mitigated using rotational viscoelastic dampers. First, the wind load characteristics in a transmission tower is investigated considering the effect of the transmission lines through stochastic analysis. The assemblage of the transmission line and insulator are modeled as a double pendulum system connected to the SDOF model of the tower. From the result of the stochastic analysis, the background component of the overturing moment caused by the wind loads acting on the transmission lines are found to have considerable portion in the total overturning moment. Based on this observation result, a strategy Installing rotational viscoelastic damper (VED) between tower arm and transmission line is proposed for the mitigation of the transmission line reactions, which play a role as dynamic loads on a transmission tower. For the purpose of verification, time history analysis is conducted for different wind velocities and VED parameters. The analysis result shows that the rotational VED is effective for the mitigation of the background component rather than the resonance component of the transmission line reactions and achieves the reduction ratio of 50% even for higher wind speed.

• Korean Journal of Organic Agriculture
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• v.9 no.2
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• pp.39-54
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• 2001

For the development of Eco-village in Korean rural area, it was focussed to introduce the rural style which has been developed intensively in European countries such as Denmark, England and Germany. As the main concept for Eco-village it was explained briefly in the paper on the renewable energy(wind power park, bio-mass and solar energy collector and heating system), eco-architecture, methane gas device, living machine(wastewater treatment facility) and organic farming. It was also discussed how important the basic standard and guidelines for organic agriculture to run Eco-village environmentally soundly as a whole system and why it is so much essential for the system. For this reason major principles of international applicable standard for organically grown foods by FAO/WHO Codex alimentarius was also shortly described. In the paper the Eco-village concept was considered as a suitable model for Environmental Agriculture Districts Project which Korean government is going to establish at rural area in the near future. In conclusion it was suggested that the positive participation of organic farmers, enthusiastic engagement of inhabitants and support strategy of government/NGO groups might play very important role for successful management of Eco-village ecologically benign and economically sustainable after establishment.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.4
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• pp.1424-1441
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• 2014

Two-tier femtocell networks, consisting of a conventional cellular network underlaid with femtocell hotspots, play an important role in the indoor coverage and capacity of cellular networks. However, the cross- and co-tier interference will cause an unacceptable quality of service (QoS) for users with universal frequency reuse. In this paper, we propose a novel downlink interference mitigation strategy for spectrum-shared two-tier femtocell networks. The proposed solution is composed of three parts. The first is femtocells clustering, which maximizes the distance between femtocells using the same slot resource to mitigate co-tier interference. The second is to assign macrocell users (MUEs) to clusters by max-min criterion, by which each MUE can avoid using the same resource as the nearest femtocell. The third is a novel adaptive power control scheme with femtocells downlink transmit power adjusted adaptively based on the signal to interference plus noise ratio (SINR) level of neighboring users. Simulation results show that the proposed scheme can effectively increase the successful transmission ratio and ergodic capacity of femtocells, while guaranteeing QoS of the macrocell.

• Journal of the Korean Society of Clothing and Textiles
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• v.28 no.1
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• pp.100-111
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• 2004

The purpose of this study is to investigate fashion advertisements portraying ambiguous sex phenomena, including homosexuality codes and to analyze the meaning of these advertisements in order to develop effective fashion advertisements strategies. The method of this study was to observe the readings about ambiguous sex theory, including homosexuality, and analyze fashion advertisements that express this through the Internet and fashion journals. The ambiguous sex expression seen in fashion advertisements meet various consumers' needs which is what the latest advertisement market requires, and offer competitive brand image by fresh appeal. In the background, there are various complex factors like the change of contemporary spirit, and designers' tastes and values about homosexuality. The kinds of ambiguous sex expression techniques portrayed in fashion advertisements can be divided as the ambiguity of physical codes and the ambiguity of sex role identity. These advertisements do play a role as a public campaign for a change in society from the sociocultural point of view. And, from the economical viewpoint, they approach the consumer as a fresh marketing strategy. From the esthetic viewpoint, they express new esthetic sense named “edge” And seen from the designers' viewpoints, they express designers' private sexual identities.

• Health Policy and Management
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• v.23 no.3
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• pp.210-223
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• 2013

Backgrounds: Escalating pharmaceutical expenditure has threatened the sustainability of National Health Insurance system in Korea. Generic medicines allow patients to access safe, effective, high-quality medicines at low cost, thus insurers could achieve significant financial savings by promotion of generics, if they are priced much lower than the originator. The purpose of this study was to review generic pricing as well as promotion policies in other countries and assess the implication of those policies. Methods: We reviewed the main measures adopted by the developed countries such as Austria, Belgium, Denmark, Finland, France, Germany, Italy, Japan, Netherlands, Norway, Sweden, United Kingdom, especially in countries where governments are the largest third-party payers or insurance finance resource is the national health insurance. Results: The foreign countries's experience with generic medicine policy shows that demand-side policies such as physician budgets, international nonproprietary name prescribing, generics substitution, patients co-payment as well as supply-side policies relating to pricing and reimbursement seems to play a critical role in developing the generic medicines market. Conclusion: Various strategy should be implemented to promote generic drug use.