• BMB Reports
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• 제49권3호
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• pp.135-136
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• 2016

Small interfering RNAs (siRNAs) have been developed to intentionally repress a specific gene expression by directing RNA-induced silencing complex (RISC), mimicking the endogenous gene silencer, microRNAs (miRNAs). Although siRNA is designed to be perfectly complementary to an intended target mRNA, it also suppresses hundreds of off-targets by the way that miRNAs recognize targets. Until now, there is no efficient way to avoid such off-target repression, although the mode of miRNA-like interaction has been proposed. Rationally based on the model called "transitional nucleation" which pre-requires base-pairs from position 2 to the pivot (position 6) with targets, we developed a simple chemical modification which completely eliminates miRNA-like off-target repression (0%), achieved by substituting a nucleotide in pivot with abasic spacers (dSpacer or C3 spacer), which potentially destabilize the transitional nucleation. Furthermore, by alleviating steric hindrance in the complex with Argonaute (Ago), abasic pivot substitution also preserves near-perfect on-target activity (∼80-100%). Abasic pivot substitution offers a general means of harnessing target specificity of siRNAs to experimental and clinical applications where misleading and deleterious phenotypes from off-target repression must be considered.

• Tribology and Lubricants
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• 제31권6호
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• pp.294-301
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• 2015

In this paper, we predict the rotordynamic force coefficients of tilting pad journal bearings (TPJBs) with rocker-back pivots, and we compare the predictions to recently published predictions and test data. The present TPJB model considers the rocker-back pivot stiffness calculated based on the Hertzian contact-stress theory, which is nonlinear with the application of a force . For the five-pad TPJB in load-between-pad and load-on-pad configurations, the predictions show the pressure- and film-thickness distributions, the deflection and stiffness of the individual pivots, and bearing stiffness and damping coefficients. The minimum film thickness and peak pressure occur at the bottom pad on which the applied load is directed. Because of the preload, the pres- sure is positive even at the upper pad in the opposite direction to the applied load. The pivot deflection and stiff- ness are maximum at the bottom pad that receives the heaviest pressure load. The predicted stiffness coefficients increase as the static load and rotor speed increase, while the damping coefficients decrease as the rotor speed increases, but increase as the static load increases. In general, the predicted stiffness coefficients agree well with the test data. The predicted damping coefficients overestimate the test data, particularly for large static loads. In general, the current predictive model considering the pivot stiffness improves the accuracy of the rotordynamic performance compared to previously reported models.

• Korean Journal of Acupuncture
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• 제39권2호
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• pp.23-33
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• 2022

Objectives : The purpose of this study is to establish a Korean medical perspective on the human body through understanding of the meridians according to the distribution of the three yin and three yang (삼음삼양) and the opening, closing and pivot (관합추) as defined in ≪Huangdi's Internal Classic≫. Methods : A total of 8 medical databases including KISS, Earticle, DBpia, RISS, OASIS, KMbase, and ScienceON were used to search studies published through July 2021, and literature was included without limitations on the publication period. The search terms were "(meridian OR acupoint OR meridian sinew) AND position" OR "Gwan-Hap-Chu" OR "Gae-Hap-Chu" OR "three yin and three yang". Two researchers independently made choices among the searched literature based on the preplanned selection/exclusion criteria. The search terms were"(meridian OR acupoint OR meridian sinew) AND position" OR "Gwan-Hap-Chu" OR "Gae-Hap-Chu" OR "three yin and three yang". Results : Of the 36 obtained from the survey, 19 (53%) followed the definitions of "internal diameter" for "three yin and three yang" and "the opening, closing and pivot," but 6 (about 16%) took a neutral position and 10 (22%) avoided mentioning. Therefore, it was judged that research was needed to end the debate on the distribution of 'three yin and three yang' and 'the opening, closing and pivot'. In order to apply the definition of ≪Huangdi's Internal Classic≫ on 'distribution of the three-yin and three-yang' and 'the opening, closing and pivot' to the upper limb and lower limb as well as the torso of the human body, this author proposed a human body model with both upper limb and lower limb attached, inspired by the posture of the fetus in the developmental stage. Conclusions : In this study, using a new human body model, it was revealed that the distribution of the three yin and three yang and the opening, closing and pivot' as defined in the ≪Huangdi's Internal Classic≫ can be applied not only to the torso of the human body, but also to the upper limb and lower limb. Based on the understanding of meridians, the selection of meridians in the clinical acupuncture should be made accurately, and continuous interest and research on this are expected.

• Earthquakes and Structures
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• 제12권4호
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• pp.425-436
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• 2017

Vibration control using a tuned mass damper (TMD) is an effective technique that has been verified using analytical methods and experiments. It has been applied in mechanical, automotive, and structural applications. However, the damping of a TMD cannot be adjusted in real time. An excessive mass damper stroke may be introduced when the mass damper is subjected to a seismic excitation whose frequency content is within its operation range. The semi-active tuned mass damper (SATMD) has been proposed to solve this problem. The parameters of an SATMD can be adjusted in real time based on the measured structural responses and an appropriate control law. In this study, a stiffness-controllable TMD, called a leverage-type stiffness-controllable mass damper (LSCMD), is proposed and fabricated to verify its feasibility. The LSCMD contains a simple leverage mechanism and its stiffness can be altered by adjusting the pivot position. To determine the pivot position of the LSCMD in real time, a discrete-time direct output-feedback active control law that considers delay time is implemented. Moreover, an identification test for the transfer function of the pivot driving and control systems is proposed. The identification results demonstrate the target displacement can be achieved by the pivot displacement in 0-2 Hz range and the control delay time is about 0.1 s. A shaking-table test has been conducted to verify the theory and feasibility of the LSCMD. The comparisons of experimental and theoretical results of the LSCMD system show good consistency. It is shown that dynamic behavior of the LSCMD can be simulated correctly by the theoretical model and that the stiffness can be properly adjusted by the pivot position. Comparisons of experimental results of the LSCMD and passive TMD show the LSCMD with less demand on the mass damper stroke than that for the passive TMD.

• Structural Engineering and Mechanics
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• 제89권1호
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• pp.77-91
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• 2024

During strong seismic events, inelastic shear deformation occurs in beam-column joints. To capture inelastic shear deformation, an analytical model for beam-column joint in reinforced concrete (RC) frame structures has been proposed in this study. The proposed model has been developed using a rotational spring and rigid links. The stiffness properties of the rotational spring element have been assigned in terms of a moment rotation curve developed from the shear stress-strain backbone curve. The inelastic rotation behavior of joint has been categorized in three stages viz. cracking, yielding and ultimate. The joint shear stress and strain values at these stages have been estimated using analytical models and experimental database respectively. The stiffness properties of joint rotational spring have been modified by incorporating a geometry factor based on dimensions of adjoining beam and column members. The hysteretic response of the joint rotational spring has been defined by a pivot hysteresis model. The response of the proposed analytical model has been verified initially at the component level and later at the structural level with the two actually tested RC frame structures. The proposed joint model effectively emulates the inelastic behavior precisely with the experimental results at component as well as at structural levels.

• 한국공간구조학회논문집
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• 제20권3호
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• pp.81-89
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• 2020

As the damage caused by earthquakes gradually increases, seismic retrofitting for existing public facilities has been implemented in Korea. Several types of structural analysis methods can be used to evaluate the seismic performance of structures. Among them, for nonlinear dynamic analysis, the hysteresis model must be carefully applied because it can significantly affect the behavior. In order to find a hysteresis model that predicts rational behavior, this study compared the experimental results and analysis results of the existing non-seismic reinforced concrete frames. For energy dissipation, the results were close to the experimental values in the order of Pivot, Concrete, Degrading, and Takeda models. The Concrete model underestimated the energy dissipation due to excessive pinching. In contrast, the other ones except the Pivot model showed the opposite results with relatively little pinching. In the load-displacement curves, the experimental and analysis results tended to be more similar when the column axial force was applied to columns.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 1999년도 제30회 추계학술대회
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• pp.318-322
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• 1999

An analytical study about dynamic behavior of center pivot rocker arm type valve train system equipped with roller of diesel engine is developed. At first, a mathematical model for the dynamic analysis has been set up using the lumped parameter method. In that model, valve spring is divided as some mass elemehts so as to simulate spring surging, Then, how the design parameters, such as valve mass, rocker arm inertia, valve spring stiffness, and initial load on valve spring, affect valve dynamic behavior especially in the valve close area is scrutinized.

• EDISON SW 활용 경진대회 논문집
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• 제6회(2017년)
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• pp.194-203
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• 2017

The center of percussion(COP) is the point of an extended massive object attached to a pivot where a perpendicular impact will produce no reactive shock at the pivot. COP is an important concept in the field of vibration and dynamics. In vibration, COP causes reduction of vibration and in dynamics, it brings about maximum speed of an object. Many studies about COP are still in progress. However most of the researches have typically focused on the method of mathematical and numerical anlalysis. In this paper, impact analysis was proved by the mechanical energy method using EDISON co-rotational plane beam transient analysis program. The result expressed in acceleration was the relative magnitude of the impulse, which was the indicator of COP. Then, these results were compared with the reference thesis results for exact consequences. Additionally, parametric study of COP was conducted.

• 한국소음진동공학회논문집
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• 제18권10호
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• pp.1014-1023
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• 2008

Subway electric trains need to be faster for accommodation of long distance passengers. The faster run of the existing trains results in deterioration of ride quality due to noise and vibration. To reduce the noise and vibration of the electric train, a running test of the electric train was performed and an ADAMS/Rail model was set up to verify the running test results. The experimental results show that the sources of the cabin noise and vibration basically comes from the irregularity of the railroad track and the deterioration of the connection part between cabin and bogie. Consequently for mitigation of noise and vibration of the electric train, the redesign of the center pivot with softer stiffness and the minimization of rail irregularity are necessary. the frequent maintenance of the train will lead to better comport.

• 대한기계학회논문집
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• 제12권5호
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• pp.1063-1070
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• 1988

본 연구에서는 부채꼴형 유한폭 패드베어링에서의 선단압력을 구하기 위하여 3차원 유동모델을 제시하였으며, 이 유동모델을 기초로 하여 구해진 선단압력을 패드 선단에서의 압력경계조건으로 사용하여 유막내의 압력을 구하고 베어링의 하중지지능 력, 마찰토오크 및 윤활유량등을 계산함으로써 베어링의 성능을 해석하였다. 그 결 과 선단 압력이 크게 발생하는 운전조건일수록 선단압력을 무시한 종래의 베어링 성능 해석결과와는 상당한 차이가 있었으며, 특히 관성계수가 큰 운전조건에서 사용되는 피 봇식 추력베어링에서는 선단압력의 영향으로 인하여 하중지지능력을 최대로하는 피봇 점의 위치가 패드 선단부쪽으로 크게 이동되었다.