• Perspectives in Nursing Science
• /
• v.2 no.1
• /
• pp.92-104
• /
• 2005

Obesity rates are increasing worldwide, associated with excess acute and chronic disease risk. In most countries, obesity rates among women exceed rates in men, particularly during the post menopausal years. Many factors affect body weight and appetite, including age, metabolic rate, physical activity level, stress, cultural factors, socioeconomic status, health status and health literacy, diet composition, attitudes, and beliefs. Gender affects appetite and body weight indirectly by altering factors contributing to food choice. However, there is emerging evidence that gender affects appetite and body weight directly, altering the physiological control systems regulating appetite. The follicular menstrual cycle phase (estrogen-rich) is associated with relative suppression of appetite. Lower estrogen levels are associated with increased food intake, body weight gain, and altered body fat distribution in humans and animals. This paper reviews the linkages between estrogen and appetite regulation. While relationships among appetite, body weight, and gender-linked hormones are complex, research elucidating these interrelationships could lead to development of gender-specific treatment approaches for obesity and appetite dysregulation.

• Asian-Australasian Journal of Animal Sciences
• /
• v.14 no.10
• /
• pp.1497-1504
• /
• 2001

There is emerging interest in using xenotransplantation of porcine cells, tissues and organs for treatment of human illness. This article reviews the current status of xenotransplantation, with particular emphasis on the physiological and immunological barriers to xenotransplantation and genetic manipulations to overcome xenograft rejection. Preliminary success in xenotransplantation therapy for human Parkinson's disease using porcine foetal brain cells is described. Finally the zoonotic dangers of porcine xenotransplantation, most particularly porcine endogenous retroviruses (PERVs), are discussed.

• Journal of Radiopharmaceuticals and Molecular Probes
• /
• v.6 no.2
• /
• pp.116-130
• /
• 2020

The aging society is globally one of biggest issue because it is related with various degenerative brain disease such as dementia, Parkinson's disease, Alzheimer's disease, multiple sclerosis, and cerebrovascular disease. These diseases are characterized by misfolded-protein aggregation; another pathological trait is "neuroinflammation". In physiological state, the resting microglia cells are activated and it removes abnormal synapses and cell membrane debris to maintain the homeostasis. In pathological state, however, microglia undergo morphological change form 'resting' to 'activated amoeboid phenotype' and the microglia cells are accumulated by neuronal damage, the inflammatory reactions induced nerve metamorphosis with a variety of neurotoxic factors including cytokines, chemokines, and reactive oxygen species. Thus, the activated microglia cell with various receptors (TSPO, COX, CR, P2XR, etc.) was perceived as important biomarkers for imaging the inflammatory progression. In this review, we would like to introduce the current status of the development of radiotracers that can image activated microglia.

• Journal of Korean Public Health Nursing
• /
• v.15 no.1
• /
• pp.111-124
• /
• 2001

This study was conducted to identify the characteristics of pain, self-esteem, perceived health status, and self-efficacy and its influencing factors in patients with chronic arthritis. The data were obtained from 104 patients with chronic arthritis registered in one university hospital in Seoul, from May to August, 2000. For analysing the data, SAS program was used for t-test, ANOVA, Scheffe test, Pearson correlation, and stepwise multiple regression. The results were as follows: 1. The variables which showed significant difference with pain were sex, number of painful joints. 2. The variables which showed significant difference with perceived health status were age, diagnosis. number of painful joints. 3. The variables which showed significant difference with self-efficacy were duration of disease, number of painful joints. quality of sleeping. 4. Moderate negative correlation were observed between pain and perceived health status, self-efficacy, and low positive correlation was observed between self-esteem and perceived health status. Also self-esteem revealed moderate positive correlation with self-efficacy, and moderate positive correlation was observed perceived health status and self-efficacy. 5. The predictors to explain self-efficacy were number of painful joints, self-esteem, duration of disease, duration of exercise and pain. These predictors explained $36.05\%$ of variance of self-efficacy. In conclusion, the nursing intervention to improve self-efficacy for chronic arthritis patients focused not only physiological symptoms such as pain. but also psychosocial factors such as self-esteem.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.28 no.4
• /
• pp.452-459
• /
• 2014

The purpose of this study was to examine the correlation between general health condition and biopsychological traits of Sasang typology which determines the disease susceptibility and treatment responses. We had Korean Constitutional Multicenter Bank (KCMB) listed 1156 participants for measuring Sasang Personality Questionnaire (SPQ) and Body Mass Index (BMI) for biopsychological traits of each Sasang types as well as Short Form 12 (SF12) for general health status. All the analysis was performed with consideration of gender and age. We analyzed the differences in general health status between Sasang types and the correlation between general health status and biopsychological traits of Sasang typology. We also analyzed how much the selected SF12 subscales can be explained with biopsychosocial characteristics. There were no generaliszable differences among Sasang type groups in SF12, no significant correlation between biopsychological traits and SF12 Physical and Mental Component Summary. We found that there were significant correlations between SPQ-Behavior subscale and SF12 Vitality, and the regression model with SPQ-Behavior, SPQ-Emotionality, age and sex can predict 15.4% of the total variances in SF12 Vitality. We discussed the possibility that the Sasang typology is not a determinant of general health status but a moderator for the susceptibility and response. This study would contribute to the development of Sasang type-specific life nurturing program focusing on the psychological perspectives.

• Journal of Families and Better Life
• /
• v.9 no.2
• /
• pp.171-190
• /
• 1991

This study focused on time use and the influencing factors of employed wives. Its aims are specified as follows.:1) to figure out the tendency of time use spent on a holiday and weekday by employed wives ; (2) to find out factors influencing the amount of time in each domain spent on each day. The samples were composed for 396 employed wives living in Seoul and Kwangju city who had the eldest child less than 18years old. were sampled based on their work kind, work status, and residential quarter. The results are as follows; 1) Employed wives spend 423 minutes a weekday, and 513 minutes a holiday on the sleep and 522 minutes(weekday ), 618 minutes (holiday) on the total Physiological time 599 minutes (weekday), 72 minutes(holiday) were devoted to the employed time. compared to 214 minutes. 395 minutes for the housework Finally 103 minutes and 349 minutes were assigned to leisure time. Compared with the research results in Japan and the United States, this shows large difference. Korean wives; work time is excessively too long while the time for leisure and psysiological time is too short, which means the life style of Korean wives ti too simple and monotonous. 2) Social demographic variables(such as work status, education, income, wive's relative income rate, family type. family number, the younger child's age, and etc. )and variables connected with employment (such as employed work time and employment motivation) significantly differentiate the time use. A wive with higher education, employment status, and income level, spends more time for the psysiological , leisure time, and manegerial housework time, while spending less time for work and physical housework.

• Research in Community and Public Health Nursing
• /
• v.21 no.1
• /
• pp.118-127
• /
• 2010

Purpose: The purpose of this study was to evaluate the effects of a Tai-Chi exercise program on subjective health and physiological function index. Methods: This study was designed as non-equivalent control group pretestposttest research. Eighteen women in each group completed the posttest with an attendance rate of 78.3 % after 12 weeks. The Tai Chi exercise program was provided two times a week over three months for the experimental group, but no program for the control group. A questionnaire was used for subjective health index, which consisted of Korean-WOMAC Index for joint stiffness, K-HAQ for physical disability, EQ-5D for quality of life and perceived health status, and CES-D for depression. To measure the effect on the physiological function index, femoral muscle strength, shoulder joint and back flexibility were measured. Results: All variables except left anterior femoral muscle strength had significant homogeneity between the two groups. There were statistically significant differences between the experimental group and the control group in joint stiffness (t=-2.165, p=.03), physical disability (t=-2.231, p=.038), EQ-5D index (t=3.783, p=.001), perceived health status (t=-2.349, p=.025) and femoral posterior muscle strength (t=2.487, p=.038). Conclusion: The Tai-Chi exercise program was beneficial for women with arthritis in rural communities.

• The Korean Journal of Community Living Science
• /
• v.20 no.2
• /
• pp.181-191
• /
• 2009

This study was conducted to examine the distribution status, the physicochemical composition, and the physiological activity of Spergularia marina grown in the western region in Jeon-Ra-Nam-Do, looking for its potential as a local specialty goods. The amount sold of Spergularia marina to different areas from a rural market place was examined during April, 2008. The proportions of Spergularia marina are as follows; Yeongam(30.5%), Muan(24.3%), Naju(20.3%), Hampyeong(18.0%), and Haenam(7.0%), which were shown higher than those of Pimpinella brachycarpa. Total vitamin C and total chlorophyll contents in Spergularia marina were 68.61mg/100g DW and 58.11mg/g DW, respectively. Total amino acid contents were 331.94mg/100g DW and 20 kinds of amino acids were separated and classified. The contents of inorganic matters in Spergularia marina were as follows; Na(64.23mg/L), Mg(15.88mg/L) K(9.99mg/L), Ca(3.83mg/L). The total phenol and the total flavonoid contents of methanol extracts from Spergularia marina were 41.7mg/L and 18.9mg/L, respectively, with an extracting concentration of 2,000mg/L. The nitrite scavenging activity was highest (83.4%) in hot water extract. These results may be useful as basic data for using Spergularia marina as a local specialty goods.

• Korean Journal of Environmental Biology
• /
• v.35 no.4
• /
• pp.461-467
• /
• 2017

Shrimps infected with WSSV(White Spot Syndrome Virus) generally exhibit white spots in their inner space of carapaces as an acute clinical sign. In an effort to identify the correlation between this acute clinical sign and the condition, the index factors (RNA/DNA concentration and ratio, trypsin activity) were analyzed. A total 580 farmed Fenneropenaeus chinensis and 130 Lithopenaeus vannamei were collected from western and southern fifteen outdoor ponds in Korea. The status of the white spot pathology was divided into four stages (stage 0, stage I, stage II, and stage III), in accordance with the clinical signs as to the size and area of white spots. A significant decrease in RNA concentration and RNA/DNA ratio for multi-infected fleshy prawn (WSSV and vibrio sp.) occurred during the stage III (the whole carapace is covered with a white spot). In particular, RNA/DNA ratio was significantly lower as $1.47{\pm}0.04$ than other groups. A similar trend was also found in the single infection (WSSV), but the decrease was less than the multi-infection. In the species comparison, both species were vulnerable to the multi-infection, but L. vannamei was more sensitive than F. chinensis(ANOVA, p<0.05): A significant decrease in RNA concentration and RNA/DNA ratio was first found in stage II for the former species, while it was found in stage III for the latter species. Trypsin activity was also showed a similar tendency with nucleic acid variation. Multi-infected shrimp showed drastically decrease of trypsin activity. According to the results, clinical signs of the white spot under carapace have an only physiological effect on shrimp if they covered entirely with white spots.

• Journal of Korean Clinical Nursing Research
• /
• v.18 no.3
• /
• pp.368-380
• /
• 2012

Purpose: The purpose of this study was to evaluate the effects of a home-based video exercise program on cancer-related fatigue, physiological and psychological status in patients with colon and rectal cancers undergoing chemotherapy. Methods: The study design was a non-equivalent control group non-synchronized design. Data were collected from patients with colo-rectal cancers in Yonsei cancer center from July 5th to October 31st in 2011. There were 40 participants; 20 in the experimental group and 20 in the control group. The structured questionnaire was used to measure fatigue, physical function and emotional status. Data were analyzed using SPSS 18.0 and a chi-squre test, Fisher's exact test, Mann-Whitney U test and Wilcoxon signed- rank test were conducted to examine the homogeneity and the research hypotheses. Results: There was a statistically significant difference in White Blood Cell count in the experimental group compared with that of the control group. The exercise group showed a slight decrease of White Blood Cell count compared with that of the control group after 4 week program (z=-2.935, p=.003). However, there were no significant differences in fatigue, physiological and psychological status between the two groups. Conclusion: In this study, the developed video exercise program was effective in markedly slightly decreasing White Blood Cell count in patients with colo-rectal cancers undergoing chemotherapy. Therefore, utilizing the video exercise program can be an useful method to promote health among patients with cancer in clinical practice.