• 사상체질의학회지
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• 제24권3호
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• pp.50-59
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• 2012

Objectives In this research, the constitutional diagnosis based on the theory of Sasang constitutions were carried out to Japanese subjects living in Japan, and the external applicability of Sasang constitutional medicine was evaluated by analyzing the physiological symptoms and the pathological symptoms according to their constitutions. Methods Total 144 Japanese subjects who live in S city were invited from Mar. 2010 to Jul. 2011 for the research, and their constitutions were analyzed with constitution diagnosing tool that was developed by Korean institution of oriental medicine (KIOM) in 2011. The collected data was analyzed in terms of the physiological symptoms and the pathological symptoms according to the sasang constitutions with computer software of SPSS 17.0. Results In the physiological symptoms related to excrements, Soyangin more frequently did not have excrements of gold color (p=.034) and feel the tenesmus (p=.047) than the subjects of other constitutions. In the physiological symptoms related to cold & heat, Soyangin more frequently felt cold in feet and hands (p=.011), and Soeumin more frequently didn't like drinking water regardless of thirst (p=.017). In the physiological symptoms, Soyangin frequently felt dryness in eyes, and Taeumin frequently felt uncomfortable because of the phlegm. Conclusions The theory of Sasang constitution which is a Korean traditional medicine can also be applied to the health care of Japanese, and it can contribute to the health promotion of Japanese subjects.

• Korean Circulation Journal
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• 제53권9호
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• pp.581-593
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• 2023

In the catheterization laboratory, the measurement of physiological indexes can help identify functionally significant lesions and has become one of the standard methods to guide treatment decision-making. Plaque vulnerability refers to a coronary plaque susceptible to rupture, enabling risk prediction before coronary events, and it can be detected by defining a certain type of plaque morphology on coronary imaging modalities. Although coronary physiology and plaque vulnerability have been considered different attributes of coronary artery disease, the underlying pathophysiological basis and clinical data indicate a strong correlation between coronary hemodynamic properties and vulnerable plaque. In prediction of coronary events, emerging data have suggested independent and additional implications of a physiology-based approach to a plaque-based approach. This review covers the fundamental interplay between coronary physiology and plaque morphology during disease progression with clinical data supporting this relationship and examines the clinical relevance of physiological indexes in prediction of clinical outcomes and therapeutic decision-making along with plaque vulnerability.

• Archives of Pharmacal Research
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• 제13권3호
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• pp.221-226
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• 1990

A physiological pharmacokinetic hybrid model was developed in order to predict the disposition kinetics of diphenylhydantoin (DPH) in the brain from the plasma conentration data of DPH. The model was constructed under the assumptions of well-stirred, plasma flow-limited and lienar tissue diposition kinetics of DPH. DPH was administered intravenously to the rats at a dose of 10 mg/kg together with/without sodium salicylate (SA;10 mg/kg) and the DPH concentrations in the plasma and brain were determined. Plasma protein binding of DPH concentrations in the plasma and brain were determined. Plasma protein binding of DPH was also determined using equilibrium dialysis technique. Then the model was tested for its predictability of DPH concentrations in the brian from the plasma data of DPH. It was found that the predicted values of DPH concentrations in the brian were in fair agreement with the experimental values in the rats of both treatments. The 2-fold increase in the brain concentration of DPH by SA-coadinistration was predicted well from the plasma concentration and plasma free fraction ($f_p$) data of DPH using the model. Therefore, the hybrid model was concluded to be very useful for the prediction of the concentrations of DPH in the brain from the plasma concentration data. Finally, DPH concentrations in the human brian was calculated using this model from plasma DPH data in the literature, yet the scale-up of this model to the human is not convinced.

• 대한수의사회지
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• 제14권3호
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• pp.179-184
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• 1978

• 대한수의사회지
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• 제15권2호
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• pp.85-90
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• 1979

• 대한수의사회지
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• 제13권4호
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• pp.265-271
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• 1977

• 대한수의사회지
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• 제13권6호
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• pp.417-422
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• 1977

• 대한수의사회지
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• 제14권1호
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• pp.45-50
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• 1978

• Journal of Acupuncture Research
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• 제19권1호
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• pp.101-110
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• 2002

Background and Purpose : Most diagnostic method for lumbago were invasive and complex. So we need to simplify and objectify diagnostic method for lumbago. Some study with EAV which is one of Physiological Signal Measuring Instruments, report significantly result as objective diagnostic method for other clinical symptom. By using EAV, we have obtained some physiological signal data from meridian-acupoints of 31 lumbago cases. Objective and Methods : This study researched into the clinical statistics for 31 case who ware in lumbago, and they ware treated with oriental medical care at the Dong-shin university oriental hospital during 6 month from June 1 2001 to November 10 2001. The data were analyzed and interpreted to compare with traditional differentiation of symptom-complexes, then further evaluated as the Five Evolutive Phases to make them differentiated. The EAV valus of Five Evolutive Phases were identified with the sequence of wood(木), fire(火), earth(土)steel(金), water(水). Results and Conclusion : These values of physiological signal were identical with standard differentiation of symptom-complexes of lumbago which is the main cause of deficiency of Qi and blood of the kidney and bladder. Among Five Evolutive Phases, Earth and wood values were increased, steel, fire and water were decreased significantly. This data imply the possibility of somewhat generalization from measuring instruments.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2002년도 ICCAS
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• pp.89.5-89
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• 2002

The technology to predict new chemical compounds by using properties of already known compounds is a kind of data mining and an important technology in chemical industrial fields. Many knowledge have been accumulated in the fields, and especially nowadays in the field of medicine development industry, the technology is connected with the post genome technology, and generates a new conception, physiome. The word is defined as followings. It is the quantitative and integrated description of the functional behavior of the physiological state of an individual or species. The physiome describes the physiological of the normal intact organism and is built on information and structure, that is geno...