• 한국산림과학회지
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• 제103권4호
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• pp.664-669
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• 2014

본 연구는 도시림에서의 경관감상과 산책이 인체의 생리적 안정에 미치는 영향을 규명하기 위해 수행되었다. 실험은 대전광역시에 위치한 한밭수목원에서 실시하였으며, 대조실험은 대전시청 앞에서 실시하였다. 20대 남자 대학생 24명(평균나이 $21.1{\pm}2.5$세)이 피험자로 참여하였고, 피험자를 세 그룹으로 나누어 수목원 내 소나무 숲, 수목원 내 연못, 도시 세 장소에 무작위 배치하였으며, 자리에 앉아 10분간 경관을 감상한 후 15분 동안 산책을 실시하였다. 측정지표로써 HRV, 혈압, 맥박수를 이용하여 생리적 변화를 측정하였다. 그 결과 도심 수목원 내에서 경관감상과 산책을 했을 때 도심과 비교하여 통계적으로 유의한 HF 성분의 증가와 수축기 혈압의 감소를 확인할 수 있었다. 본 연구를 통해 도심 수목원에서의 경관감상 또는 산책과 같은 활동이 도시민의 생리적 안정감을 향상시키는데 효과가 있음을 알 수 있었다.

• 한국발생생물학회지:발생과생식
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• 제11권1호
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• pp.13-20
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• 2007

암컷 포유동물의 노화 과정에서 생식계는 체내 여러 시스템 가운데 가장 먼저 기능 저하가 나타난다. 생식 노화(reproductive aging) 과정 중인 암컷 포유동물은 비록 종 특이성이 있지만 주기성(cyclicity)의 소실과 같은 생식 능력의 감소와 함께 여러 기능들의 변화가 동반되면서 궁극적으로 인간의 폐경 현상과 같은 생식 능력 상실이 나타난다. 본 증설은 암컷 포유동물의 생식호르몬 축, 특히 신경내분비 회로의 노화에 대한 정보들과 노화 연구에 유용한 설치류 모델들을 소개하고자 한다. 암컷 설치류의 중년(middle age, 생후 $8{\sim}12$개월)은 인간의 폐경기 진입 직전에 해당되는 시기로, 이 시기에 시상하부 GnRH 분비의 맥동성과 급등(surge)이 현저히 지연되기 시작하고, 곧 이어 뇌하수체 LH 분비의 맥동성과 급등이 역시 약화 내지 지연된다. 노화와 관련된 GnRH-LH 신경내분비 활성의 결손은 시상하부 GnRH 뉴런의 활성을 조절하는 여러 자극(예, glutamate)들의 변화와 밀접하게 연관되어 있다. 많은 연구자들이 이러한 '시상하부 결손(hypothalamic defects)'이 생식 노화의 주된 요인임을 지지하지만, inhibin과 같은 난소 요인의 변화 역시 생식 노화의 유도와 관련된 것으로 보인다. 생식 노화를 연구함에 유용한 몇몇 설치류 모델이 있다; FSH 수용체 녹아웃(follitropin receptor knockout; FORKO) 생쥐 모델의 경우는 homozygous(null) 뿐만 아니라 heterozygous(haploinsufficient) 상태도 노화에 따른 난자/난포의 고갈을 나타낸다. Dioxin/aryl hydrocarbon 수용체 녹아웃 (AhRKO) 생쥐 모델도 유사한 상태를 유발할 수 있다. 생식 노화의 기작에 관한 연구는 삶의 질을 높이기 위한 수단들, 예를 들어 호르몬 보충요법(HRT)의 장단점을 평가하고 안전성을 제고하는데 도움이 될 것이다.

• 대한의생명과학회지
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• 제16권1호
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• pp.25-32
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• 2010

Sprague-Dawley(SD) rats were orally administered with $N^G$-nitro-L-arginine methyl ester(L-NAME) which inhibits or blocks the production of nitric oxide from L-arginine in vascular endothelial cells and vessel tissue to statistically examine the effects of nitric oxide on some physiological changes such as blood pressure and heart rate, and to confirm the apoptosis induced by the suppressed nitric oxide activity in some related organs under light microscope. Systolic blood pressure significantly increased 28.5% by the chronic treatment of L-NAME for 8 weeks (P<0.001), no significant difference, however, was observed in heart rate between the control group and the L-NAME-treated group regardless of their age. Hematoxylin-eosin staining showed some histological alterations only in kidney among the examined organs; heart, liver, pancreas, and adrenal gland from the L-NAME-treated group. TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) test showed a strong positive reaction, representing that the chronic treatment of L-NAME facilitates apoptosis, in the cortex and medulla of kidney, but not any significance detectable in the other organs. These results conclude that chronic treatment of L-NAME significantly increases blood pressure, and that the followed inhibition of nitric oxide synthesis occurs a typical inducement of apoptosis in kidney.

• Journal of Korean Neurosurgical Society
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• 제53권2호
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• pp.89-95
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• 2013

Objective : Similar to back pain, neck pain has recently shown to have increasing prevalence. Magnetic resonance imaging (MRI) is useful in identifying the causes of neck pain. However, MRI shows not only pathological lesions but also physiological changes at the same time, and there are few Korean data. The authors have attempted to analyze the prevalence of disc degeneration in highly selective asymptomatic Korean subjects using MRI. Methods : We performed 3 T MRI sagittal scans from C2 to T1 on 102 asymptomatic subjects (50 men and 52 women) who visited our hospital between the ages of 14 and 82 years (mean age 46.3 years). All images were read independently by three observers (two neurosurgeons and one neuroradiologist) who were not given any information about the subjects. We classified grading for cervical disc herniation (HN), annular fissure (AF), and nucleus degeneration (ND), using disc degeneration classification. Results : The prevalence of HN, AF, and ND were 81.0%, 85.9%, and 95.4%, respectively. High prevalence of HN, AF, and ND was shown compared to previous literature. Conclusion : In asymptomatic Korean subjects, the abnormal findings of 3 T MRI showed a high prevalence in HN, AF, and ND. Several factors might play important roles in these results, such as population-specific characters, MRI field strength, and disc degeneration grading system.

• International Journal of Industrial Entomology and Biomaterials
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• 제10권2호
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• pp.137-141
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• 2005

Though many insecticides are commercially available, development of resistance, pest resurgence and effects on non-target organisms led to the search for alternate insect pest management (IPM) strategy based on larval growth and reproductive fitness. Reproductive potential of insects depends on its acquiring of vitellogenic competence which is under hormonal control. Exogenous application of analogues of JR (JHAs) and ecdysterone could derail normal development and reproduction in insects by manipulating an array of physiological processes. In the rice pest, brown planthopper, Nilaparvata lugens, JHA, hydroprene induced metathetely from the fifth (final) instar nymphs in an age-dependent manner. Day 0 of the final instar showed highest sensitivity to induce this abnormal development. Adults emerged from treated day 3 nymphs looked normal. Both the morphotypes were reproductively incompetent and showed partial to complete sterility. Pre-adult exposure of the ovarian tissue to hydroprene suppressed mitotic division of germinal cells and induced abnormalities in the later s1ages of growth and differentiation of ovary in N. lugens. More over the nymphal exposure to hydroprene inhibited patency changes of follicular epithelium and affected competence of the follicles for yolk sequestration. In the absence of ovarian growth and oocyte differentiation, germarium found disintegrated, trophic core regressed and terminal oocytes resorbed. Hydroprene exposure to newly ecdysed brachypterous females did not affect ovarian development and egg production. Proper larval-adult transition appeared as a. prerequisite for vitellogenic competence in N. lugens for which the ovarian tissues must be exposed to ecdysterone in the internal milieu devoid of JH.

• 동의생리병리학회지
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• 제19권4호
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• pp.878-883
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• 2005

The dream is a well-known experience in the routine life. It is the image and thought being occurred during the sleep, and the complex reaction of our mental world to the event of everyday. In particular, there are so many opinions of the reason why people have a dream and this thesis is telling about the physical and pathological changes in the human as one of that various opinions. The aspects of this thesis are often founded in the diverse texts of oriental Medicine, including the Internal Classics(내경), and there were some cases that regarded the dream as diagnostic object and put to clinical uses. These attempts were not only tried out by particular orient thoght, also the ancient Greeks thought that the dream would represent important informations about the health. But, these ideas have been treated lightly by the impacts of the western medicine since the modern age. Straightforwardly, before the psycho-analytics was not development, most of the doctors and scientists regarded the dream as things like dregs of mind. The central operating bodies of the dream are the Spirit(신) and Hon and Beak(혼백), and the Spirit(신) is more essential part between the two.

• 인간행동과 음악연구
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• 제2권2호
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• pp.69-79
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• 2005

This study was purported to examine the definition of tone deafness, various factors for the cause based on literature review of research findings, and to examine therapeutic application of music for treatment of tone deafness. With research, it was found that there can be three different kinds of tone deafness; amusia, agnosia, and asonia. Literature review showed that tone deafness has been frequently dealt in many research in order to verify the causal factors, such as gender, age, and environments. With time, the research trend on tone deafness has shifted towards neurological approach closely examining brain activity, presenting the statement that the brain's capacity to perceive modest pitch changes may be congenitally impaired. Also physiological factors contribute to tone deafness called diplacusis, which is a phenomenon wherein a given tone is heard as different pitches by the two ears, resulting in conflicting bilateral perception of pitch. Music can be used for treatment of various factors causing tone deafness. The most efficient intervention was singing program. Pitch-matching training can be effective training using operant conditioning procedure. Successive approximation or reinforcement of correct response alone was more efficient procedure in helping uncertain singers to sing on pitch. Also progressive breathing exercises helped the training the pitch-matching where one had to coordinate hearing and voice.

• Journal of Preventive Medicine and Public Health
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• 제46권sup1호
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• pp.50-54
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• 2013

Out-of-home mobility is necessary for accessing commodities, making use of neighborhood facilities, and participation in meaningful social, cultural, and physical activities. Mobility also promotes healthy aging as it relates to the basic human need of physical movement. Mobility is typically assessed either with standardized performance-based tests or with self-reports of perceived difficulty in carrying out specific mobility tasks. Mobility declines with increasing age, and the most complex and demanding tasks are affected first. Sometimes people cope with declining functional capacity by making changes in their way or frequency of doing these tasks, thus avoiding facing manifest difficulties. From the physiological point of view, walking is an integrated result of the functioning of the musculoskeletal, cardio-respiratory, sensory and neural systems. Studies have shown that interventions aiming to increase muscle strength will also improve mobility. Physical activity counseling, an educational intervention aiming to increase physical activity, may also prevent mobility decline among older people. Sensory deficits, such as poor vision and hearing may increase the risk of mobility decline. Consequently, rehabilitation of sensory functions may prevent falls and decline in mobility. To promote mobility, it is not enough to target only individuals because environmental barriers to mobility may also accelerate mobility decline among older people. Communities need to promote the accessibility of physical environments while also trying to minimize negative or stereotypic attitudes toward the physical activity of older people.

• Journal of Ginseng Research
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• 제48권3호
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• pp.286-297
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• 2024

Brain plasticity refers to the brain's ability to modify its structure, accompanied by its functional changes. It is influenced by learning, experiences, and dietary factors, even in later life. Accumulated researches have indicated that ginseng may protect the brain and enhance its function in pathological conditions. There is a compelling need for a more comprehensive understanding of ginseng's role in the physiological condition because many individuals without specific diseases seek to improve their health by incorporating ginseng into their routines. This review aims to deepen our understanding of how ginseng affects brain plasticity of people undergoing normal aging process. We provided a summary of studies that reported the impact of ginseng on brain plasticity and related factors in human clinical studies. Furthermore, we explored researches focused on the molecular mechanisms underpinning the influence of ginseng on brain plasticity and factors contributing to brain plasticity. Evidences indicate that ginseng has the potential to enhance brain plasticity in the context of normal aging by mediating both central and peripheral systems, thereby expecting to improve age-related declines in brain function. Moreover, given modern western diet can damage neuroplasticity in the long term, ginseng can be a beneficial supplement for better brain health.

• 한국가금학회지
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• 제34권2호
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• pp.91-97
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• 2007

산란계에서 일령에 따른 생리적인 변화를 구명하기 위하여 혈액의 성상이 분석되었다. 13개의 산란계 농장에서 수집된 48계군에서 1, 11, 21, 50, 80, 120, 180, 240, 300, 400, 500일령에 채혈하였으며, 포도당, 지질, 단백질, 효소, 전해질 등 17종의 혈액을 구성하는 물질이 혈액 자동분석기에 의하여 분석되었다. 혈청 내 포도당의 함량은 사료 내 탄수화물의 함량이나 에너지가와 상관없이 부화시에 가장 높고 서서히 감소되는 경향을 보였지만, 총 단백질, 알부민, 그리고 글로불린의 함량은 사료 내 단백질 함량이 감소되었을지라도 일령이 경과함에 따라 증가하였다. 혈청 내 지방 함량은 사료에 포함된 지방의 함량에 관계없이 지방의 종류에 따라 변화가 상이하였다. 콜레스테롤은 부화 시 가장 높고 120일령까지는 낮은 상태를 유지하다가 180일령 이후에 증가하였으나, HDL-콜레스테롤은 부화 시 가장 높고 이후에 서서히 감소하다가 180 일령 이후에는 급격히 감소하였다. 트리글리세라이드는 부화시에 가장 낮고 120일령까지는 부화시보다 약간 높은 수준을 유지하다가 180일령 이후에 10배 이상 급격히 증가하는 경향을 보였다. 효소의 수치는 AST, ALT, 그리고 GGT는 비교적 일정하게 유지되었으나, 아밀라제는 부화 후 일령이 경과함에 따라 서서히 감소되었다. 또한 인, 나트륨, 칼륨, 그리고 염소의 함량은 대체로 일정하게 유지되었으나, 칼슘의 함량은 180일령을 전후로 2배 이상 상승하여 유지되었다. 혈청내 노폐물인 요소와 요산은 부화시 가장 높고 급격히 감소한 후에 요소는 일정하게 유지되었으나, 요산은 120일령부터 증가하여 180일령 이후에는 일정한 상태를 유지하였다. 이 실험의 결과로 혈청 내 칼슘 함량의 변화와 사료 내 칼슘 함량의 변화 간의 상관 관계에 대한 구명이 추후에 필요하지만 혈청 내 존재하는 여러 종류의 혈청 성분은 대부분이 사료의 성상과 관계없이 일령이 경과함에 따라서 대사 변화에 의해 함량이 변화되는 경향을 보였다.