• Journal of Ginseng Research
• /
• v.41 no.4
• /
• pp.548-555
• /
• 2017

Background: Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of ginseng, including its anticancer, antiaging, and anti-inflammatory activities. These activities are mediated by ginsenosides present in the ginseng plant. Ginsenoside Rg3, an effective compound from red ginseng, has been shown to have antiplatelet activity in addition to its anticancer and anti-inflammatory activities. Platelets are important for both primary hemostasis and the repair of the vessels after injury; however, they also play a crucial role in the development of acute coronary diseases. We prepared ginsenoside Rg3-enriched red ginseng extract (Rg3-RGE) to examine its role in platelet physiology. Methods: To examine the effect of Rg3-RGE on platelet activation in vitro, platelet aggregation, granule secretion, intracellular calcium ($[Ca^{2+}]_i$) mobilization, flow cytometry, and immunoblot analysis were carried out using rat platelets. To examine the effect of Rg3-RGE on platelet activation in vivo, a collagen plus epinephrine-induced acute pulmonary thromboembolism mouse model was used. Results: We found that Rg3-RGE significantly inhibited collagen-induced platelet aggregation and $[Ca^{2+}]_i$ mobilization in a dose-dependent manner in addition to reducing ATP release from collagen-stimulated platelets. Furthermore, using immunoblot analysis, we found that Rg3-RGE markedly suppressed mitogen-activated protein kinase phosphorylation (i.e., extracellular stimuli-responsive kinase, Jun N-terminal kinase, p38) as well as the PI3K (phosphatidylinositol 3 kinase)/Akt pathway. Moreover, Rg3-RGE effectively reduced collagen plus epinephrine-induced mortality in mice. Conclusion: These data suggest that ginsenoside Rg3-RGE could be potentially be used as an antiplatelet therapeutic agent against platelet-mediated cardiovascular disorders.

• The Journal of The Korea Institute of Intelligent Transport Systems
• /
• v.19 no.5
• /
• pp.70-81
• /
• 2020

Point-by-point data, which is abundantly collected by vehicles with embedded GPS (Global Positioning System), generate useful information. These data facilitate decisions by transportation jurisdictions, and private vendors can monitor and investigate micro-scale driver behavior, traffic flow, and roadway movements. The information is applied to develop app-based route guidance and business models. Of these, speed data play a vital role in developing key parameters and applying agent-based information and services. Nevertheless, link speed values require different levels of physical storage and fidelity, depending on both collecting and reporting intervals. Given these circumstances, this study aimed to establish an appropriate collection interval to efficiently utilize Space Mean Speed information by vehicles with embedded GPS. We conducted a comparison of Probe-vehicle data and Image-based vehicle data to understand PE(Percentage Error). According to the study results, the PE of the Probe-vehicle data showed a 95% confidence level within an 8-second interval, which was chosen as the appropriate collection interval for Probe-vehicle data. It is our hope that the developed guidelines facilitate C-ITS, and autonomous driving service providers will use more reliable Space Mean Speed data to develop better related C-ITS and autonomous driving services.

• The Journal of Korean Academy of Sensory Integration
• /
• v.15 no.2
• /
• pp.1-21
• /
• 2017

Objective : The aims of the this study is to identify job characteristics, to generate job description, and additionally to investigate duty task of the job for Korean pediatric occupational therapist focused on sensory integration intervention. Methods : In the first stage, job analysis of pediatric occupational therapist focused on sensory integration intervention was performed by an advisory committee consist of the DACUM panel. Through the job analysis, job description with definition was established. In the second stage, a survey was performed for 141 pediatric occupational therapist using a questionnaire based on the job description in order to investigate importance, frequency and difficulty of duty task and task elements of the job. This process was done from May to September 2017. Results : The job definition drew from this study was 'Pediatric occupational therapist provides occupational therapy services to children and adolescents to support occupational performance and social participation including daily activities and play". Through the job description established in this study, 9 duties (consulting, evaluation, intervention plan, intervention, document, education, self-development, management, and administration), 28 tasks and 169 task elements were drew. In the survey, among the duty tasks and task elements, 'ensure physical safety' and 'perform a session' were selected as the most important task, and 'ensure safety of children, sensory integrative equipment and environment' and 'prepare a safe environment' were selected as the most important element. Conclusion : This study defined job demands and characteristics of pediatric occupational therapist who performs sensory integration intervention. It is expected that this study can be used a resource to develop and/or improve educational program related.

• Korean Institute of Interior Design Journal
• /
• v.21 no.6
• /
• pp.224-232
• /
• 2012

Although evolution of construction materials brought about development of modern architecture, they caused destruction of the environment and pollution. This problem is not a new one in terms of ecological esthetics and materials of sustainable architecture in light of the Eastern view of nature and this idea became a background of this study. The basic concept is to try to find out their characteristics from a perspective of ecological esthetics in relation to traditional building materials that nature, architecture, and humans coexist and live with each other to balance. Based on ecological esthetics and precedent studies on materials of traditional architecture, we investigated connections, expressive methods and characteristics in traditional residential construction space. This attempt has meanings in that it can propose a new framework of forming various viewpoints and spatial perceptions in relation to esthetics and traditional construction materials. The current study examined the characteristics by dividing them into tangible and intangible elements based on expressive features of elements of nature. The characteristics found by this process are not simply notion of physical materials, but plays a key role aesthetically and ecologically. Nature and materials take circulation of the law of nature, regulate energy, increase efficiency and play a major role in an economic way. Nature in itself becomes natural alternative energy, and plays its role in an invisible fashion. It examined how expressive characteristics of construction materials are reflected through analyzing residential space and Korean traditional garden having relationships with Eastern viewpoint of nature in relation to Korean traditional construction materials from a perspective of ecological esthetics. Findings of the above study indicate that expressive characteristics of Korean traditional construction materials from a perspective of ecological esthetics are that nature, space, humans coexist and live together and they will provide a clue to an alternative to solve ecological and environmental problems modern society will have in the future. Through this process, it provided a possibility that traditional space and materials can be succeeded in creative and new ways, and it found out the way for nature, space, and humans to coexist and a possibility of ecological esthetics. It addition, it will provide a key base as an alternative of sustainable design of the future.

• Geophysics and Geophysical Exploration
• /
• v.11 no.2
• /
• pp.116-126
• /
• 2008

In gas hydrate survey, seismic amplitude and frequency characteristics play a very important role in determining whether gas hydrate exists. According to the variation of source frequency and scatterer size, we study seismic amplitude characteristics using elastic modeling applied at staggered grids. Generally speaking, scattering occurs in proportion to the square of source frequency and the scatterer volume, which has an effect on seismic amplitude. The higher source frequency is, the more scattering occurs in gas hydrate bearing zone. Therefore, BSR is hardly observed in high frequencies. On the other side, amplitude blanking zone and BSR is clearly observed in lower frequencies although the resolution is poor as a whole. Seismic reflections traveling through free-gas layer below gas hydrate bearing zone decay so severely a high frequency component that a low frequency term is dominant. Amplitude anomaly of BSR result from high acoustic impedance contrast due to free-gas, which is a very crucial factor to estimate gas hydrate bearing zone. Seismic frequency analysis is carried out using wavelet transform method that frequency component could be decomposed with time variation. In application of wavelet transform to the seismic physical experiments data, we can observe that reflections traveling through air layer, which corresponds to the free-gas layer, decay a high frequency component.

• Food Science and Preservation
• /
• v.19 no.3
• /
• pp.361-367
• /
• 2012

The purpose of this study was to investigate the rheological properties of pound cake cotaining ginger powder. Ginger powder was added to pound cake bases at 1, 3 and 5%. concentrations. The physical properties of the pound cake with ginger powder were tested by rapid viscoanalyzer (RVA), a farinogram, and an alveogram. The falling numbers were increased with the increment of ratio of ginger powder, but they did not show a significant difference. The higher quantity of ginger powder with cake flour made MTI value the higher and these results showed typical cake flour. The farinogram quality number did not show a significant difference between the control and the other samples. The highest initial gelatinization temperature was that of the control, and the increment of ginger powder on the cake flour made initial gelatinization temperature lower. The peak and final viscosities, however, were higher with the quantity increment of ginger powder. The holding strength did not show a significant difference. As the 5% - ginger-powder pound cake showed the highest setback, it was predicted that the addition of ginger powder to the flour would not play the role of anti-retrogradation. The Pmax and L value of the alveogram decreased with the ginger powder increments.

• Journal of Korean Academy of Nursing
• /
• v.28 no.1
• /
• pp.7-16
• /
• 1998

Various difficulties and inconveniences arise from having a mentally handicapped child in a family and these place many demands on mothers. There are few studies in Korea on these demands nor on what mothers go through with their mentally handicapped daughters' menarche and puberty. The purpose of the study was to examine the experiences of mothers of mentally handicapped daughters, as it relates to their daughters' menarche and the beginning of puberty. With indepth interviews, both in person and by telephone and participant observation the study used a qualitative research methodology to attempt to understand the experiences of these mothers. The data were gathered from October 1995 to April 1996. The subjects for the research included nine mothers of mentally handicapped daughters whose ages ranged from 12 to 18 and who attended one of three special schools located in either Inchon or Seoul. The data were recorded and analyzed : meaningful statements were grouped according to subjects raised by the mothers. Content Analysis was also applied to identify similar content and confirm common experiences. and to highlight concepts and categorized them. The results of this study are as follows. Five categories were identified : mothers' emotional responses to their mentally handicapped daughters' menarche and menstration were of severe despair accompanied by anxiety, guilt, fear, anguish, shame and pity because the mothers were afraid their daughters would not be able to use appropriate hygienic measures during menstration and the mothers felt heavily burdened in having to look them. The mothers also had negative feelings about their daughters' physical development. The experience of mothers related to their daughters' possibilities for marriage and pregnancy were of powerlessness, distress, withdrawal, fear. pity and desperation and they were afraid that their daughters might be violated sexually. The mothers rejected the possibility of marriage and pregnancy for their daughters and instead planned very restricting futures for them. The mothers used various coping methods to bring meaning to their lives. Because the negative emotional responses of the mothers. nurses need to work to empower mothers to overcome these negative responses. Sex education can also play an important role especially for the daughters especially through the use of visual aids. Further, nurses should understand the tearing difficulties of mentally handicapped daughters, what mothers need and also what they experience with their mentally handicapped daughters. In conclusion, nurses should understand the negative experiences of the mothers in relation to their mentally handicapped daughters' menarche, help the mothers cope with the negative. emotions through real life education and counselling. In addition, there is a need for nursing interventions and an administrative system which will minimize the prejudices of society towards handicapped people.

• Korean Journal of Plant Resources
• /
• v.25 no.5
• /
• pp.578-585
• /
• 2012

Cytokines released from innate immune cells play key roles in the regulation of the immune response. Red Ginseng (RG, steamed and dried root of Panax ginseng C.A. Meyer) is known to show different pharmacological effects by changed composition of saponins compared with Panax Ginseng. In this study, we examined the immunomodulatory effects of RG on the regulation of cytokine release in mice. RG was injected i.p at doses of 0.5, 5 and 50 mg/kg for 6 weeks. We assessed that the weight index of immune organs such as thymus, and spleen, and the mitogen blastogenesis of splenocytes. We also determined the levels of circulating cytokines in serum from RG-treated mice using ELISA assay. The weight index of thymus and spleen, and proliferation of mitogen response of splenocytes have increased in the RG-injected groups. In addition, the levels of IFN-${\gamma}$, TNF-${\alpha}$, IL-6, IL-12 and IL-2 concentrations have significantly increased in the serum of RG-treated mice, but that of IL-10 has not. These results suggest that RG has immune stimulating effects and could be useful as a immunoregulator of circulating cytokine release in vivo.

• Journal of the Korean GEO-environmental Society
• /
• v.11 no.6
• /
• pp.85-91
• /
• 2010

As enormous construction projects of land development are carried out around Korea, useful construction materials are needed to perform the construction projects. However, there are no more enough of fill and reclamation materials in our country. That is why the coal ash is expected to be utilized as an alternative material. Since the coal ash has the characteristics of a pozzolan and a selfhardening material, it is adjudged that coal ash has a great possibility to be used as a fill and reclamation material. In this study, grain size analysis, Atterberg limit test, and specific gravity test were performed to examine the physical characteristics of the coal ash about a self-hardening material before utilizing the coal ash in the construction. Compaction test, unconfined compression test, direct shear test, and flexible wall permeability test were conducted to investigate the engineering characteristics according to mixture ratios of fly ash and bottom ash. As a result of the tests, it was confirmed that the mixing ratio 1:1 of fly ash and bottom ash is the most effective to use as a fill and reclamation material. If the mixture of coal ash is used as a backfill material with light weight around structure, it is expected to play a significant role in reducing earth pressure on the back of the structure. As the age of the mixture of coal ash goes by, it intends to decrease the coefficient of permeability. As described above, the coal ash should be considered as an alternative material of fill and reclamation materials since the result of the tests indicates that the coal ash is suitable to a useful material on the construction design.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.16 no.9
• /
• pp.6425-6431
• /
• 2015

Invertase, that hydrolyzes sucrose into glucose and fructose, plays a great role in carbohydrate reallocation between the photosynthetic source tissue and various sink tissues. Invertase also occurs in a variety of isoforms for various functions in plants. Insoluble invertases were extracted only in buffer solutions containing high concentrations of salt. Within these classes, acid invertase has an optimum activity at acidic pH (pH 4-5). Induction of insoluble acid invertase (INAC-INV) in leaf, stem, and root tissues in response to physical wounding has been investigated. To detect the localization of INAC-INV within the plant, immunolocalization has been performed. In this study, the accumulation of INAC-INV was noticeable to reach maximum levels on 72 hr after mechanical injuries. INAC-INV was induced in wounded leaves 3 times more than control leaves. Immunolocalization results showed that INAC-INV accumulated in wall appositions and intercellular spaces. INAC-INV was also localized at sieve cell walls in phloem tissues close to the site of wounding. Taken together, this study suggested that INAC-INV induction upon wounding injuries can play a role on responses to the high energy demand for wound healing process.