• Applied Biological Chemistry
• /
• 제38권2호
• /
• pp.147-150
• /
• 1995

에탄올처리 찰가자미껍질 젤라틴의 젤라틴농도, pH, 정치온도 및 시간과 같은 겔화조건에 대한 물리적 특성 및 색조의 변화를 측정하였다. 젤라틴의 농도가 증가할수록 겔강도, 녹는점과 같은 물리적 특성은 증가하였고, 일정농도에서의 이러한 값들은 에탄올처리한 젤라틴이 무처리한 젤라틴에 비하여 컸다. 젤라틴 졸의 pH가 에탄올처리한 젤라틴의 경우 6.0일 때, 무처리한 젤라틴의 경우 5.0일 때, 겔강도, 졸화온도 및 겔화온도가 가장 높았고, 이를 벗어난 $pH\;5.0{\sim}7.0$의 범위에서는 서서히 감소하였으며, pH 5.0이하 및 pH 9.0이상에서는 급격히 감소하였다. 젤라틴 졸을 겔화시키기 위하여 정치시키는 온도의 경우 낮을수록, 정치시키는 시간의 경우 길어질수록 겔강도 및 졸화온도는 높았다. 겔화조건을 동일하게 하였을 때 에탄올처리한 젤라틴이 무처리한 젤라틴보다 물리적 특성값이 높게 나타났다.

• 대한임상전기생리학회지
• /
• 제5권1호
• /
• pp.45-58
• /
• 2007

This study aims to examine the effects on nociceptive neuron excitability by application of electroacupuncture and Meloxicam gel in rat with inflammation. It used 24 rats for experiment, divided them into control group, electroacupuncture group(EA group), Meloxicam group(ME group), combination of electroacupuncture with Meloxicam group(EA+ME group), caused hyperalgesia by injecting ${\lambda}$-carrageenan into hindpaw and conducted treatment three times for experimental period. Noxious flexion withdrawal reflex(NFR) and somatosensory evoked potential(SEP) were measured immediately after induction, at 24 hours, 48 hours and 72 hours after induction. Change of NFR(reaction time, RMS) showed no significant differences among EA group, Meloxicam group, and EA+Meloxicam group, but all treatment groups showed significant differences compared to control group from 48 hours. In NFR threshold, there were significant differences between EA+Meloxicam and other groups. In SEP amplitude, there were significant differences between EA+Meloxicam and control group from 48 hours. This study showed that EA+Meloxicam gel had an effect on nociceptive neurone excitability. Therefore, it is considered that appropriate combination of anti-inflammatory drug with electroacupuncture for pain control will be very desirable.

• 한국식품과학회지
• /
• 제27권4호
• /
• pp.483-486
• /
• 1995

가공적성이 우수한 알코올처리 각시가자미껍질 젤라틴을 식품산업소재로 이용하기 위한 기초자료를 얻을 목적으로 젤라틴농도, pH, 정치온도 및 시간과 같은 겔화조건에 대한 알코올처리 젤라틴의 물리적 특성 및 색조의 변화를 알코올 무처리 젤라틴과 비교하여 검토하였다. 알코올처리 및 무처리 젤라틴이 모두 농도가 증가할수록 겔강도, 졸화온도 및 겔화온도 및 점도 등과 같은 물리적 특성은 증가하였다. 젤라틴 졸의 pH가 에탄올처리한 젤라틴의 경우 6.0일 때, 무처리한 젤라틴의 경우 5.0일 때 겔강도, 졸화온도 및 겔화온도가 가장 높았으나, $pH\;5.0{\sim}8.0$의 범위에서는 거의 차이가 없었고, pH 5.0 이하 및 pH 9.0 이상에서는 급격히 감소하였다. 젤라틴 졸을 겔화시키기 위하여 정치시키는 경우 온도는 낮을수록, 시간은 길수록 겔강도 및 졸화온도는 높았다. 겔화조건을 동일하게 하였을 때 에탄올처리한 젤라틴이 무처리한 젤라틴보다 물리적 특성이 우수하였다.

• 약학회지
• /
• 제18권1호
• /
• pp.20-28
• /
• 1974

Physical studies of ageing inhibition of aluminum hydroxide gel were carried out. Sorbitol, mannitol and fructose were found to be an ageing inhibitor of the aluminum hydroxide gel. IR spectra and DTA curves showed that the ageing products of the gel by sorbitol orl mannitol were monohydrous alumina. This differs from hydrated hydrous alumina of other ageing products. This evidence indicates that sorbitol and mannitol prevent the hydrous alumina from its hydration.

• 대한임상전기생리학회지
• /
• 제4권1호
• /
• pp.49-61
• /
• 2006

This study conducted the following experiment to examine and compare transdermal permeation effects according to parameters of ultrasound and physiochemical characteristics of meloxicam. Permeation by ultrasound among these experimental drugs was relatively higher and it was involved in COX-2 inhibition unlike other drugs. Recently use of oral agents has been rapidly increased, but it was not generalized to transdermal agent and this study selected meloxicam that transdermal permeation research using ultrasound was not performed and conducted transdermal permeation experiment with skin of hairless mouse and analyzed permeation with HPLC. It made gel first and analyzed permeation depending on frequency and intensity of ultrasound of meloxicam with the same experimental procedures as the above experiment. The results of this study can be summarized as follows. Transdermal permeation by ultrasound frequency was higher in 1.0 MHz and it was higher as intensity increased. In comparison by parameters of ultrasound, there was similar permeation in $1.0\;W/cm^2$ of continuous mode and $3.0\;W/cm^2$ of pulsed mode and it was effective to high intensity for using pulsed mode. It was found that duty cycle of ultrasound affected transdermal permeation in meloxicam gel used in this experiment and transdermal permeation was higher in used ultrasound as phonophoresis than non-ultrasound for anti-inflammatory effects.

• The Journal of Korean Physical Therapy
• /
• 제14권4호
• /
• pp.147-162
• /
• 2002

Transdermal permeation enhancer has been used to increased skin absorption. External control of drug release and skin absorption can also be achieved by iontophoresis or phonophoresis. However, because several problems with iontophoresis are that it has a risk to skin damage because of the change of pH and the increase of current density in applying it and that it can be applied only in the form of water solution, This study is to enhance drug permeation via skin following application of ultrasound. For this goal, in gel containing piroxicam, the degree of skin permeation in vitro and anti-inflammatory effect in in vivo were investigated. Permeation study using hairless mouse skin was performed at 37 $^{\circ}C$ using buffer saline as the receptor solution. The amount of piroxicam were quantified using a HPLC system consisting of solvent delivery system. Following adoption of ultrasound 1 MHZ, it showed relatively high permeation rate where it was compared with non treated by ultrasound. The influence of duty cycle having an effect on skin permeation rate was slight higher in the case of using pulsed mode. Skin permeation increase attended by intensity of ultrasound, the permeation of trice was accelerated at 2.0 W/$cm^{2}$ than 1.0 W/$cm^{2}$. The skin permeation of piroxicam was substantially influenced by ultrasound. Anti-inflammatory effects were determined using carrageenan-induced paw swelling method in SD rat. Paw swelling tests showed that pulsed phonophoresis group was more effective than control group and only gel application group. The conclusion of phonophoresis was found to improve significantly the skin permeation in vitro and the anti-inflammatory effect in vivo.

• 대한정형도수물리치료학회지
• /
• 제1권1호
• /
• pp.99-104
• /
• 1995

Markolf and Morris suggests that the deranged disk and torn annulus have an exellent recovery ability from the position of spine extension, where the posterior annulus is not under stress and the gel can move anterioly. McKenzie explains side gliding as a combination of rotation and side bending, his clinical studies indicate that side-gliding can gel laterally. In conclusion, the prone unilateral traction on the opposite side from the patient's pain along with the other treatment appered to have helped reduce those patient's pain. The method of treatment described in this report is suggested for Korean physical therapists who treat patients suspected of posterolateral herniated nucleus pulposus.

• 대한물리치료과학회지
• /
• 제2권2호
• /
• pp.481-486
• /
• 1995

Markolf and Morris suggests that the deranged disk and torn annulus have an exellent recovery ability from the position of spine extension, where the posterior annulus is not under stress and the gel can move anterioly. McKenzie explains side gliding as a combination of rotation and side bending, his clinical studies indicate that side-gliding can gel laterally. In conclusion, the prone unilateral traction on the opposite side from the patient's pain along with the other treatment appered to have helped reduce those patient's pain. The method of treatment described in this report is suggested for Korean physical therapists who treat patients suspected of posterolateral herniated nucleus pulposus.

• 대한안전경영과학회:학술대회논문집
• /
• 대한안전경영과학회 2003년도 추계학술대회
• /
• pp.351-357
• /
• 2003

The optimum polymer gel electrolyte composition ratio was 23 : 66 : 11 wt% of P(VdF-co-HFP) : PVP =20 : 3), (PC: EC =44 : 22) and TEABF$_4$. And the optimal thickness of polymer gel electrolyte was 50 ${\mu}{\textrm}{m}$. The electrochemical characteristics result of unit cell were 31.41 Fig of specific capacitance, and 3.21$\times$10$^{-3}$ S/cm of ion conductivity. Ion conductivity of polymer gel electrolytes decreased according to added PVP through impedance analysis, and it was higher in 7 wt%, but electrochemical characteristics of unit cell were better in 3 wt% PVP. And for excellent ion conductivity of polymer gel electrolytes, the use of a thin layer electrolyte(20 $\mu\textrm{m}$) was an effective method, but with unit cell application, the best thickness was 50 $\mu\textrm{m}$. Unit cell showed higher capacitance and more stable electrochemical performance when hot pressed between polymer gel electrolyte and electrode. This results from enhancement of the physical contact between the electrode and the polymer gel electrolyte and good accessibility of the liquid electrolyte to the electrode surface.

• Food Science and Biotechnology
• /
• 제16권5호
• /
• pp.715-721
• /
• 2007

In this study, the sphericity of calcium alginate gel beads was optimized using response surface methodology. The optimum conditions for bead sphericity were a concentration of 2.24% sodium alginate, a flow rate of 0.059 mL/sec for the sodium alginate solution, and a 459 rpm rotation for the calcium chloride solution. The predicted and experimental bead sphericities under the optimum conditions were 94.5 and 96.7%, respectively, showing close agreement. We also investigated the processing condition effects for the physical properties of the optimized calcium alginate gel beads. Immersion in hot water slightly decreased bead size and rupture strength. NaCl treatment increased bead size and decreased rupture strength. While the pH of the calcium chloride solution had little effect on bead sphericity, the bead sizes and gel strengths decreased with longer times in each pH solution. The beads coated with pectin and glucomannan showed no significant changes in sphericity, but their sizes decreased with time. The coated beads showed higher rupture strengths than the uncoated beads.