Journal of the Korean Academy of Clinical Electrophysiology (대한임상전기생리학회지)

The Korean Academy of Clinical Electrophysiology (대한임상전기생리학회)
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Effects on Nociceptive Neuron Excitability by application of Electroacupuncture and Meloxicam gel in Rat with Inflammation

염증유발 백서에서 전침자극과 Meloxicam gel 적용이 유해성굴곡반사 및 체성감각유발전위에 미치는 효과

  • Kim, Young-Pil (Dept. of Physical Therapy, Graduate School, Dongshin University) ;
  • Lee, Jeong-Woo (Dept. of Physical Therapy, Hyoin Hospital) ;
  • Seo, Sam-Ki (Dept. of Physical Therapy, Graduate School of Seonam University) ;
  • Yoon, Se-Won (Dept. of Physical Therapy, Jinju International University) ;
  • Yoon, Hee-Jong (Dept. of Physical Therapy, Mokpo science college) ;
  • Kim, Tae-You (Dept. of Physical Therapy, Dongshin University)
  • 김영필 (동신대학교 대학원 물리치료학과) ;
  • 이정우 (효인병원 물리치료실) ;
  • 서삼기 (서남대학교 대학원 물리치료학과) ;
  • 윤세원 (진주국제대학교 물리치료학과) ;
  • 윤희종 (목포과학대학 물리치료과) ;
  • 김태열 (동신대학교 물리치료학과)
  • Published : 2007.03.31
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Abstract

This study aims to examine the effects on nociceptive neuron excitability by application of electroacupuncture and Meloxicam gel in rat with inflammation. It used 24 rats for experiment, divided them into control group, electroacupuncture group(EA group), Meloxicam group(ME group), combination of electroacupuncture with Meloxicam group(EA+ME group), caused hyperalgesia by injecting ${\lambda}$-carrageenan into hindpaw and conducted treatment three times for experimental period. Noxious flexion withdrawal reflex(NFR) and somatosensory evoked potential(SEP) were measured immediately after induction, at 24 hours, 48 hours and 72 hours after induction. Change of NFR(reaction time, RMS) showed no significant differences among EA group, Meloxicam group, and EA+Meloxicam group, but all treatment groups showed significant differences compared to control group from 48 hours. In NFR threshold, there were significant differences between EA+Meloxicam and other groups. In SEP amplitude, there were significant differences between EA+Meloxicam and control group from 48 hours. This study showed that EA+Meloxicam gel had an effect on nociceptive neurone excitability. Therefore, it is considered that appropriate combination of anti-inflammatory drug with electroacupuncture for pain control will be very desirable.

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