• The Journal of Korean Physical Therapy
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• 제19권3호
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• pp.1-9
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• 2007

Purpose: Previous studies have suggested that BDNF has a role in plasticity and survival following spinal cord injury and treadmill exercise increases BDNF levels in the normal brain and spinal cord. We attempted to determine whether swimming exercise improve motor function following experimental contusive spinal cord injury and whether motor outcome is associated with BDNF expression. Methods: Thirty six Sprague-Dawley rats (weight, 250 to 300 g) were divided into control (n=18) and experimental swimming group (n=18). Spinal cord injury was produced using NYU-spinal impactor at the eleven thoracic levels in both groups. Swimming exercise started $7^{th}$ day from SCI operation, lasted 5 min per day, 5 days a week for 4 weeks and then exercise times a day were increased in one number to each week. Motor functional recovery was determined by the Basso-Beattie-Bresnahan (BBB) locomotor rating scale, modified inclined board plane test, histological findings, H&E and BDNF expression observed at $1^{th}$, $3^{rd}$, $7^{th}$, $14^{th}$, $21^{st}$ and $28^{th}$day after injury. Results: 1. The BBB scores were higher in experimental group than control group at $14^{th}$, $21^{st}$ day (left hind limb) and at $21^{th}$ day (right hind limb) (p<0.05) after injury. 2. The inclined board plane test were significantly greater in experimental group than control group at $7^{th}$ day (p<0.05), $14^{th}$ and $28^{th}$ day (p<0.01) after injury. 3. The BDNF expression was severe revealed in experimental group than control group at $7^{th}$, $14^{th}$ and $28^{th}$ day after injury. Conclusion: This study suggests that swimming applied from the early phase after spinal cord injury be beneficial effects in motor functional recovery.

• 대한물리치료과학회지
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• 제10권1호
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• pp.180-189
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• 2003

The experiments were designated to evaluate the anti-nociceptive effect of low power laser stimulation on acupoint or non-acupoint using arthrogenic solution induced poly arthritis animal model. Evaluation of potential antinociceptive effect of low power laser on arthritis has employed measurements of the foot bending test, the development of either thermal or mechanical hyperalgesia following the arthritis induction. The analysis of thermal hyperalgesia includes Hargreaves's method. Randall-Sellitto test was utilized for evaluating mechanical hyperalgesia. In addition, the antinociceptive effect of low power laser stimulation on arthritis induced spinal Fos expression was analyzed using a computerized image analysis system. The results were summerized as follows: 1. In laser stimulation on acupoint treated animal, laser stimulation dramatically inhibited the development of pain in foot bending test as compared to those of non acupoint treated animal group and non treated animal group. 2. The threshold of thermal stimulation was significantly increased by low power laser stimulation on acupoint as compared to that of non treated control group. 3. Laser stimulation on acupoint dramatically attenuated the development of mechanical hyperalgesia as compared to that of non treated group. 4. Low power laser stimulation on acupoint significantly suppressed arthritis induced Fos expression in the lumbar spinal cord at 3 week post arthritis induction. In conclusion, the results of the present study demonstrated that low power laser stimulation on acupoint has potent anti-nociceptive effect on arthritis. Additional supporting data for an antinociceptive effect of laser stimulation was obtained using Fos immunohistochemical analysis on spinal cord section. Those data indicated that laser stimulation induced antinociception was mediated by suppression of spinal neuron activity in pain sensation.

• BMB Reports
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• 제55권10호
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• pp.512-517
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• 2022

Traumatic brain injury (TBI) is brain damage which is caused by the impact of external mechanical forces. TBI can lead to the temporary or permanent impairment of physical and cognitive abilities, resulting in abnormal behavior. We recently observed that a single session of early exercise in animals with TBI improved their behavioral performance in the absence of other cognitive abnormalities. In the present study, we investigated the therapeutic effects of continuous exercise during the early stages of TBI in rats. We found that continuous low-intensity exercise in early-stage improves the locomotion recovery in the TBI of animal models; however, it does not significantly enhance short-term memory capabilities. Moreover, continuous early exercise not only reduces the protein expression of cerebral damage-related markers, such as Glial Fibrillary Acid Protein (GFAP), Neuron-Specific Enolase (NSE), S100β, Protein Gene Products 9.5 (PGP9.5), and Heat Shock Protein 70 (HSP70), but it also decreases the expression of apoptosis-related protein BAX and cleaved caspase 3. Furthermore, exercise training in animals with TBI decreases the microglia activation and the expression of inflammatory cytokines in the serum, such as CCL20, IL-13, IL-1α, and IL-1β. These findings thus demonstrate that early exercise therapy for TBI may be an effective strategy in improving physiological function, and that serum protein levels are useful biomarkers for the predicition of the effectiveness of early exercise therapy.

• 교육시설 논문지
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• 제28권4호
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• pp.11-17
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• 2021

This study is aimed at presenting an efficient management plan of user participatory design in a situation where the School Space Innovation Project is in progress. 2 schools that were the targets of the Incheon School Space Innovation Project in 2019 were selected for this, and features such as the physical environment of that classroom, classroom usage plan, and the stepwise outcome of the user participatory design workshop were contemplated. Especially the workshop outcome was compared and analyzed quantitatively, focusing on the actual master plan and zoning plan, in order to identify the feature that opinions of various users are reflected on the actual plan. As a result, the following conclusion could be reached. Firstly, it was confirmed that the expression about the user preferential space influences the classroom usage plan of that classroom. Vague expressions about the whole space held a large majority of the objects for the linguistic expression of the preferential space. The expression mode as limited as the expression of the actions that users want to carry out in the space. On the other hand, when the usage purpose of the classroom was definite, it was confirmed that the demand for furniture·facility is relatively high. Secondly, according to the analysis of zoning for each function, it seems that the stereotype, which is arranged on the basis of the chalkboard at the front of existing classrooms, was applied in the case of the learning zone. However, in cases of other functions, a tendency was identified that the user carries out an image description that reflects the physical features of the space. Sufficient preparation will need to precede for the efficient management of the user participatory design workshop and the acceptance of various opinions. It seems that especially the classroom usage plan, number of workshops, consultation of each step, and the education about the space expression mode affect the master plan.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2009년도 학술대회
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• pp.449-454
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• 2009

일반적인 물체와 달리 사람의 얼굴은 표정이라는 중요한 시각적 요소를 포함하고 있다. 이러한 이유로 만화가들은 빛에 의한 음영 이외에도, 장면의 분위기와 캐릭터의 특징을 효과적으로 전달하기 위해 특별한 음영을 얼굴에 그려 넣는다. 이러한 음영은 물리적으로 타당하지는 않지만 얼굴의 형태와 표정을 강조하기 때문에 얼굴 표정의 카툰 렌더링에서 반드시 고려해야 할 사항이다. 이 논문에서는 실제 만화가의 음영 표현방식에 착안하여 캐릭터 얼굴을 위한 새로운 카툰 렌더링 방법을 제안한다. 이를 위해 먼저 다양한 만화 이미지를 수집하여 얼굴의 음영표현을 분석하고, 캐릭터의 표정에 따라 카툰 렌더링을 달리 하기 위해서 음영표현 템플릿을 정의하였다. 그리고 이러한 만화가들의 음영표현방식을 바탕으로 기존의 카툰 렌더링 방법을 발전시켜 효과적으로 캐릭터의 표정을 강조하는 캐릭터 얼굴 카툰 렌더링 시스템을 구현하였다. 마지막으로 사용자평가를 통해 논문에서 제안한 방법의 유용성을 증명한다.

• 한국디지털건축인테리어학회논문집
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• 제9권3호
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• pp.85-93
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• 2009

In this study, the ex-formal expressions observed in space form of Korean modern architecture are distributed for characteristic analysis based on the period and type. The result of the study is certified by the work analysis and the result is as follows. Initially, due to the limited materials and influence of western brutalism, the works developed during 1960~70 tend to be plastic and contain expressionism. Around 1980's, the works tend to show forms of amusement and popularity. In 1990's the works show significance in deconstructive expression. From after 2000, ecological concept of architecture was introduced and organic expression started increasing Secondly, the ex-formal expressions are found to be in four different types. The organic expression is shown regardless of the period. In modern days, not only the physical properties of materials, but also the ecological concept is combined with the organic expression and is in increase. The plural expression started appearing after the 1980's and the sculptural diversity is enhancing with the addition of decorative factors or modification of geometrical form. The ex-construction and deconstructive expression show significance in some characteristics such as folding, inclination, and geometrical explosion. The free form and nonlinear expression tend to increase dramatically based on the development of structure technology as well as execution and introduce of the digital design technique.

• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2006년도 The 6th Intermational Symposium on Developmental Biotechnology
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• pp.60-61
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• 2006

• The Journal of Korean Physical Therapy
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• 제14권2호
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• pp.16-25
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• 2002

Low energy laser irradiation(LELI) therapy in physical therapy is widespread but the mechanisms are not fully understood. The purpose of the present study was to examine the epidermal growth factor(EGF)'s expression within lumbar spinal cord which corresponding with crushed extensor digitorum longus(EDL) of rats after low-power laser irradiation applied. After a crushed injury on the right EDL, low-power laser irradiation was applied by using 2000mW, 2000Hz, 830nm GaAlAs(Gallium-aluminum-arsenide) semiconductor diode laser. The laser treatment was performed with 10 minutes daily for 3days. After EDL crush injury, EGF immunoreactive positive neurons in experimental group were progressively decreased from the first to third days. Especially 1 day subgroup is highly expressed in dorsal horn(Lamina I, II, III) and around of central cannal of spinal cord(Lamina VII). Control group was only expressed slightly at 3 days. This study suggests that LELI stimulate that release and migration of EGF in spinal cord, which distict to wound site, therfore promote wound healing of EDL crush injury.

• 한국실내디자인학회논문집
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• 제14권6호
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• pp.228-235
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• 2005

This study analyzes the new possibility of design through the research for the expression of cladding design architectural materials, and applies to connection with creative design concept. In these modern days, architectural materials became the subject of expression as itself thanks to the development of new technology and materials. The physical properties of materials and their beauty value made possible the variety and possibility of expression in space design. The expressional properties of materials can lead mutual communication between commodity and brand by association, presenting brand image and the distinction of its value. Therefore, the trends of designed material expression in space design according to modern aspect can offer the possibility of material space design for ahead. This study suggest an alternative idea for revitalizing design by materials.

• International Journal of Internet, Broadcasting and Communication
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• 제10권4호
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• pp.43-49
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• 2018

Modern people communicate in a digital space without being limited by physical space and time. On the internet, people's desire for self-expression is getting bigger, and the most common self-expression tool is characters. Characters are visual materials to express human thoughts and desires. This study is a method to positively express the viewer's self in an interactive Hangeul system. The proposed system produces new formative shapes and meanings of Hangeul through the process of deconstructing and reconstructing the characters. Immediate character transformations that are synchronized with the motion of the viewer act as a tool of self-expression by inducing the viewer's active interaction repeatedly. Therefore, the proposed interactive Hangeul is more than enough to be used as a new graphic tool beyond the text to be read, and it is highly likely to develop into cultural contents using it.