• Korean Journal of Veterinary Pathology
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• v.1 no.1
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• pp.40-45
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• 1997

The phototoxic potentials of LB20304a a new quinolone compound being developed by LG Chemical Ltd, and reference compounds (Ciprofloxacin; CPFX, Enoxacin; ENX and Lomefloxacin; LFLX) were compared in a murine model. in addition photostability of these compunds was studied after irradiation with long-wave UV light(UVA, 0, 0.3 1 or 3 Joule/$Cm^2$) When hairless mice(9 to 11 weeks old 19-26g) were orally administered with different dose levels of test compunds and exposed to UVA(40J/$cm^2$) inflammatory reactions were observed in a dose dependent manner. Among the compounds tested, LB20304a demonstrated the least phototoxic effects and showed no inflammatroy lesions at a dose level of 100mg.kg (Low dose). ENX and LFLX demonstrated much greater phototoxic reactions while CPFX showed similar or slightly greater phototoxic reactions compared to LB20304a. Similar to the in-vivo results the solutions of LB20304a and CPFX irradiated with UVA demonstrated reduced spectral changes compared to those of ENX and LFLX. In conclusion these data suggest that phototoxic potencies of the quinolones tested were; LFLX > ENX > CPFX $\geq$ LB20304a. No phototoxic dose of LB20304a in mice was 100 mg/kg.

• Natural Product Sciences
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• v.27 no.4
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• pp.300-306
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• 2021

Chronic ultraviolet (UV) radiation causes photoaging, which represents skin damage, disrupts skin barrier function, and promotes wrinkle formation. We investigated that the polysaccharide extract of an edible basidiomycetous white jelly mushroom, Tremella fuciformis, (TF-Glucan^®) exhibited statistically photoprotective activity by inhibiting matrix metalloproteases (MMPs) and increasing collagen synthesis, and an anti-inflammatory activity by inhibiting nitric oxide and pro-inflammatory cytokines at the concentrations of less than 1000 ㎍/ml, which is not cytotoxic (p < 0.05). Additionally, TF-Glucan^® increased the expression of involucrin and filaggrin to prevent the disruption of UVB-induced barrier function (p < 0.05). TF-Glucan^® was assessed as a safe material by the human primary skin irritation (1, 3, 5%), human repeated insult patch test (no sensitization at 5%), 3T3 NRU phototoxicity assay (no phototoxicity, PIF < 2, MPE < 0.1), eye irritation test test by BCOP (no category, IVIS ≤ 3) and local lymph node assay (negative at 10, 25, 50%) for identifying potential skin sensitizing. These results suggest that TF-Glucan^® may be useful as an anti-photoaging ingredient for developing cosmeceuticals.

• Journal of Photoscience
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• v.9 no.2
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• pp.174-177
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• 2002

Sugar-linked porphyrin and chlorin compounds have been synthesized. Phototoxicity of these compounds against the HeLa cell line was also examined. For the porphyrin derivatives, the higher activity was observed for a derivative having four OH-protected sugar moieties. For the chlorin derivatives, OH-unprotected free-base derivatives were generally effective. Singlet oxygen producing ability were examined to evaluate the activity on photodynamic therapy of the compounds.

• Environmental Analysis Health and Toxicology
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• v.5 no.1_2
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• pp.45-50
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• 1990

In order to investigate the phototoxicity of five phenothiazine derivatives and one thioxanthen derivative were examined by using in vitro method based on growth inhibition of Candida albicans and red blood cell hemolysis. Effects of the test compounds on RBCs were monitored with a spectrophotometer and a drug PI in the Candida albicans was calculated on the basis of the lowest concentration giving a yeast-free zone. All phenothiazines phototoxic in the red blood cell hemolysis method were positive in the yeast test except promethazine. It was also observed that toxic photo-products were formed by perphenazine and chlorpromazine in the red blood cell hemolysis.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2001.05a
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• pp.117-117
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• 2001

We investigated Free radical generation of endocrine disrupter, bisphenol A and alkyl esters of phthalic acid (DEP, DBP) using lipid peroxidation, enzyme assay (SOD, Catalase, Gpx-px), Cell viability and phototoxicity. Bisphenol A are monomers of various plastics including polycarbonates and epoxy resins which are used in numerous consumer products. The release of BPA from some of these materials has recently been reported. (omitted)

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2004.11a
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• pp.102-102
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• 2004

• Archives of Pharmacal Research
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• v.3 no.2
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• pp.87-88
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• 1980

The goal of this research is to provide information that will lead to the development of new non-phototoxic antimalarial compounds. The goal was approached by first learning the chemical mechanism of phototoxicity of six representative compounds 1a-f: a[(diethyl-, -dihexyl-, and -dioctyl- aminomethyl)]-2-(3', 4' -dichlorophenyl)-6-methoxy-4-quinolinemethanol (1a, 1b, and 1c) and .alpha. [(diethyl-, -dibutyl-, and -dihexyl-aminomethyl)]-2-(-4'-methoxyphenyl-6-methoxy-7-chloro-4-quinolinemethan ol (1d, 1e, and 1f). The photochemical reaction of these compounds was investigated in 2-propanol. Similar photochemical fragmentation reactions accurred in all compounds.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2003.05a
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• pp.158-159
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• 2003

Fluoranthene, a common polycyclicaromatic hydrocarbon (PAH), exhibits phototoxicity which may affect aquatic organisms. The eventual goal of this study is to develop a biomarker used in monitoring abnormal behaviors of Japanese medaka (Oryzias latipes) as a model organism caused by hazardous chemicals that are toxic and persistent in the ecosystem. In this study, we investigated neural toxicity of fluoranthene in Japanese medaka (Oryzias latipes) which was correlated with its behaviors.

• Toxicological Research
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• v.18 no.3
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• pp.267-273
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• 2002

Fructose 1,6-diphosphate(FDP), a glycolytic metabolite, is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FDP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart, and may play a protective role in ultraviolet B (UVB, 280~320 nm)-injured keratinocyte by attenuating prostaglandin (PG)-E$_2$production and cyclooxygenase (COX)-2 expression, which are possibly through blocking the intracellular reactive oxygen species (ROS) accumulation. Therefore FDP is considered to act as a potent antioxidant especially in the skin. We conducted the several safety tests (single-dose toxicity, primary skin irritation test, eye irritation test, skin sensitization test, phototoxicity test, photosenitization test and human patch test) to see if FDP is safe in case used for the skin application. Our data obtained hitherto suggest that FDP is very safe if applied to the skin.

• Journal of Environmental Health Sciences
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• v.27 no.2
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• pp.43-50
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• 2001

This paper reviews the results of a series of efforts to develop structure-activity models for slow-reacting chemicals and olefins whose toxicity may be enhanced by the ultraviolet radiation. Photoinduced toxicity of 14 compounds was found to be a different result of competing factors of structure, having carbon-carbon double bonds. To mimic the biological consequences of photooxidative damage in mammalian cells, the photochemical mutagenicith of 14 chemicals was tested in the CAS. Simple olefins were photochemically mutagenic or carcinogenic with irradiation, increasing the alkylating activity from zero level to 0.87(abs/gram) for styrene, 0.25 for 1-butene, 0.11 for 1-hexene, respectively, whereas no photochemical mutagenicity was observed with 1-octene in the absence of the CAS. Oxide compounds, however, showed a decreasing trend of photoalkylating activities in the presence or absence of the CAS. We found that the structure-activity relationship was not applicable to our data.