• 공업화학
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• 제3권4호
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• pp.670-677
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• 1992

2, 3-Dibromopropyl alcohol과 chlorophenyl phosphate로 부터 (2, 3-dibromopropyl)phenyl phosphate[DPP]를 합성하고, 또한 DPP에 n-octadecyl chloride를 가하여 (2,3-dibromopropyl)phenyl octadecyl phosphate[DPOP]를 합성하였다. DPP와 DPOP에 각각 유화제를 블렌딩시켜 난연제 DPPF와 DPOPF를 제조하였는데, 모두 o/w(oil in water)유화형 난연제였다. 이 2종류의 난연제를 각종 합성직물에 처리하여 난연성과 인열강도를 측정한 결과 DPPF는 난연성만이, 그리고 DPOPF는 난연성과 유연성 모두 양호하였다.

• Applied Biological Chemistry
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• 제37권3호
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• pp.210-215
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• 1994

${\underline{O}},{\underline{O}}-Diethyl-{\underline{S}}-phenyl\;phosphorothiolate-^{18}O$와 관련화합물들을 합성하고 MCPBA로 산화시켰다. 각 반응을 $^{31}P$ NMR로 추적하였고 반응산물을 GC-MS로 분석하였다. ${\underline{O}},{\underline{O}}-Diethyl-{\underline{S}}-phenyl\;phosphorothiolate-^{18}O$은 메탄올에서 MCPBA에 의해 diethyl methyl phosphate로 전환되며 $^{18}O$를 포함하고 있어 이 산화반응은 Segall과 Casida가 제안하였던 반응기작을 따르고 있음이 증명되었다.

• 대한화학회지
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• 제11권4호
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• pp.170-172
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• 1967

2-Phenyl-5-substituted phenyltetrazole and 2-substituted phenyl-5-phenyltetrazole were prepared from the corresponding hydrazone and phenyl azide with 2-methoxyethanol and metallic sodium as reaction medium at 110~115 $^{\circ}C$. At this reaction condition, however, the preparation of 2-substituted phenyl-5-phenyltetrazoles with substituents of relatively high Hammett substituent constant was unsuccessful. Surprisingly it was found that the solvent molecule was exchanged with substituent during the reaction when tried to obtain 2-m-fluorophenyl-5-phenyltetrazole using benzaldehyde m-fluorophenylhydrazone as starting material. Also disscussed the effect of electronic nature of substituents on the formation of 2,5-diphenyltetrazole derivatives.

• Korean Chemical Engineering Research
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• 제56권5호
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• pp.732-737
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• 2018

Experimental data of phase equilibria are reported for the binary mixture of 1-phenyl-2-pyrrolidone in supercritical carbon dioxide. Phase behavior data was measured in a synthetic method at a temperature ranging from 333.2 to 393.2 K and at pressures up to 97.14 MPa. The solubility of 1-phenyl-2-pyrrolidone in the carbon dioxide + 1-phenyl-2-pyrrolidone system increased as temperature increased at a constant pressure and it exhibited the type-I phase behavior. The experimental data for the binary mixture were correlated with the Peng-Robinson equation of state using mixing rule and the critical properties of 1-phenyl-2-pyrrolidone were predicted with the Joback and Lyderson method.

• Bulletin of the Korean Chemical Society
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• 제24권7호
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• pp.981-985
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• 2003

Fluorine-19 NMR solution measurements have been made for various phenyl-fluorinated iron porphyrin complexes. Large chemical shifts for phenyl fluorine signals of iron(III) and iron(II) are observed, and these signals are sensitive to electronic structure. The chemical shift differences in ortho-phenyl fluorine signals between high-spin ferric and low-spin ferric tetrakis(pentafluorophenyl)porphyrins are approximately 40 ppm, whereas the differences are approximately 7 ppm between high- and low-spin states of ferrous tetrakis(pentafluorophenyl)porphyrin complexes. Analysis of fluorine-19 isotropic shifts for the iron(III) tetrakis(pentafluorophenyl) porphyrin using fluorine-19 NMR indicates there is a sizable contact contribution at the ortho-phenyl fluorine ring position. Large phenyl fluorine-19 NMR chemical shift values, which are sensitive to the oxidation and spin states, can be utilized for identification of the solution electronic structures of iron(III) and iron(II) porphyrin complexes.

• 약학회지
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• 제52권6호
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• pp.514-519
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• 2008

We developed a convenient synthetic route to 3-alkylated 2-phenyl-4-quinolone derivatives (4a-h and 5a-c), which were expected to retain antitumor activity. A series of 2,3-dihydro-2-hydroxy-2-phenyl-4-quinolones (3a-h) was synthesized through dehydration, dealcoholation and hydration using acid-catalyzed one-pot reaction from anilines and ethyl benzoylacetates. 3-Methyl (or 3,3-dimethyl)-2-phenyl-4-quinolone derivatives 4 and 5 were synthesized from 3a-h through the methylation using methyl iodide. Formation of quinolone nucleus was undertaken with p-toluenesulfonic acid (p-TSA) at $90{\sim}110^{\circ}C$ in toluene for 3${\sim}$7.5 hr over the Dean-Stark apparatus. The key intermediates in these preparations are ${\beta}$-ketoesters 2a-h, which can be readily obtained from the corresponding anilines 1a-e by reaction with ethyl bezoylacetates.

• Archives of Pharmacal Research
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• 제24권6호
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• pp.499-502
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• 2001

To evaluate the role of imidazolidinone moiety of potential anticancer 4-phenyl-1-arylsulfonylimidazolidinones 1 for their cytotoxicity conformationally similar 4-phenyl-2-arylsulfonylaminooxazolines 2 were synthesized and compared their cytotoxicities with those of the corresponding 1. Compounds 2 showed much reduced activity compared to N-arylsulfonylimidazolidinones 1. This result might indicate that the imidazolidinone ring of 1 have the other roles for the activity as an essential structural motif in addition to conformational contribution .

• Applied Biological Chemistry
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• 제37권4호
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• pp.287-294
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• 1994

새로운 3-(4-치환-phenyl)-1-(2-furyl)propenone, 1과 3-(4-치환-phenyl)-1-(2-furyl)-3-thiophenylpropanones, 2 유도체를 합성하여 in vitro에서 잿빛 곰팡이균(Botrytis cineria, BC), 사과 부란병균(Valsa ceratosperma, VC), 마늘 균핵병균(Sclerotium cepivorum, SC) 및 고추 역병균(Phytophthora capsici, PC) 등의 곰팡이 균류에 대한 구조-항균활성 관계(SAR)를 알아보았다. 그 결과, 2보다 1이 비교적 큰 항균활성을 나타내었으며 특히, E(Syn)형의 4-chloro group 치환체, 1d나 비 치환체, 1a가 4가지 균중의 BC균에 대하여 가장 강력한 항균활성$(EC_{50}=10{\sim}11\;ppm)$을 보였다. 1의 가수분해 반응속도상수(logk)와 ${\sigma}$상수사이에 좋은 상관성 $(r^2=0.90)$으로부터 치환기 (X)의 음하전과 ${\beta}$탄소원자의 양하전에 의존적인 항균활성을 나타낼 것으로 예상되었다.

• Archives of Pharmacal Research
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• 제23권6호
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• pp.579-584
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• 2000

To explore the effect of substituents' on phenyl motif on sulfonyl function of novel anticancer 4-phenyl-1-benzenesulfonylimidazolidinones (1), electron donating or withdrawing sub-stituents were introduced at 3 or 4-position and the analogs were tested against human lung (A549) and colon (HCT-15) cancer cell lines. Quantitative structure activity relation-ship of the 4-substituted series shows that only STERIMOL L values are well correlated. The increment of substituent's volume enhances the activity against both cell lines. The small substituent at 3-position additionally increases the activity. However naphthyl group in place of phenyl reduces the activity, Therefore the phenyl motif with sterically large substituent at 4-position and small substituent at 3-position may be important for their activity. Integration of these substituents' effects into the structural design led to discover the more potent analog, 4-phenyl-1-(N-acetylindoline-5-sulfonyl) imidazolidinone (1n).

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 추계학술대회 논문집 전기물성,응용부문
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• pp.182-185
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• 2001

A photoalignment material based N-(phenyl)maileimide were synthesized and the liquid crystal (LC) aligning capabilities on the photopolymer layer were studied. A goof LC alignment with UV exposure on the PM15CA(N-(phenyl)maileimide with 5-carbon chain cinnamoyl group) can be obtained However, the LC alignment defects were observed on the PM13CA (N-(phenyl)maileimide with 3-carbon cam cinnamoyl group) and PMIF (N-(Phenyl)maileimide including fluoro cinnamoyl group). Also, the good LC alignment with UV exposure on the PM15CA surface was observed at until $150^{\circ}C$ of annealing temperature. The LC aliging ability on the photopolymer layer based N-(phenyl)maleimide depends on the side chin length of photopolymer.