• Title/Summary/Keyword: phase-contrast

Search Result 833, Processing Time 0.027 seconds

Membrane interaction of the coiled-coil motif of HIV gp41 and its implication in the membrane fusion process

  • Jin, Bong-Suk;Yu, Yeon-Gyu
    • Proceedings of the Korean Biophysical Society Conference
    • /
    • 2003.06a
    • /
    • pp.58-58
    • /
    • 2003
  • The envelope glycoprotein of HIV, gp41, mediates the membrane fusion with human cells. The extracellular domain of gp41 has two helical regions. The N-terminus helical region (N-helix) forms trimeric coiled coil, interacts with the C-terminus helical region (C-helix) of gp41 to form a stable helical bundle structure. In this study, we have shown that the N-helix of gp41 has membrane interacting and disrupting abilities. It was localized into the interface of the lipidic phase and head group of the membrane. In contrast, the N-helix region with membrane fusion defective mutations could not bind to membrane. In addition, the N-helix bound on the membrane was released from the membrane by the C-helix, and the complex of the N- and C-helix did not interact with membrane. These results suggested that the membrane binding ability of the N-helix is necessary for the fusion activity of gp41, and such property is possibly controlled by the C-helm.

  • PDF

In Vivo Visualization of Flow in Xylem Vessels of a Bamboo Using X-ray Micro-imaging Technique (X-ray 미세영상기법을 이용한 식물 목질부 내부 수액 유동의 계측)

  • Kim, Yang-Min;Lee, Sang-Joon
    • Proceedings of the KSME Conference
    • /
    • 2004.04a
    • /
    • pp.1693-1696
    • /
    • 2004
  • Synchrotron X-ray micro-imaging technique was employed to monitor non-invasively the refilling process of water inside the xylem vessels in bamboo leaves. The consecutive phase-contrast X-ray images clearly show both plant anatomy and the transport of water inside the xylem vessels. Traces of water-rise, vapor bubbles and variations of contact angle between the water front and the xylem wall were measured in real time. During the refilling process, air bubbles are removed when the rising water front halts at a vessel end for a while. Subsequently, it starts rising again at a higher velocity than the normal refilling speed. Repeated cavitation seems to deteriorate the refilling ability in xylem vessels. In dark environment, the water refilling process in xylem vessels is facilitated more effectively than in bright illuminated conditions. Finally, X-ray micro-imaging was famed to be a powerful, high resolution, real time imaging tool to investigate the water refilling process in xylem vessels.

  • PDF

Comparison between BSCCO Thin Films Fabricated by Co-Deposition and Layer-by-Layer Deposition

  • Lee, Hee-Kab;Park, Yong-Pil;Lee, Joon-Ung
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
    • /
    • 2000.07a
    • /
    • pp.230-234
    • /
    • 2000
  • Bi$_2$Sr$_2$Ca$_{n}$Cu$_{n+1}$ O$_{y}$(n$\geq$0; BSCCO)thin film is fabricated via two different processes using an ion beam sputtering method i.e. co-deposition and layer-by-layer deposition. A single phase of Bi2212 can be fabricated via the co-deposition process. While it cannot be obtained by the layer-by-layer process. Ultra-law growth rate in our ion beam sputtering system brings out the difference in Bi element adsorption between the two processes and results in only 30% adsorption against total incident Bi amount by layer-by-layer deposition, in contrast to enough Bi adsorption by co-deposition.on.n.

  • PDF

Development and Applications of New Thermochromism Inks used Chiral Nematic Liquid Crystal-UV Curing Resin (키랄네마틱 液晶-UV경화형 수지를 이용한 새로운 온도변색성 잉크의 개발 및 응용)

  • 김준곤;남수용;구철회;윤종태;심성보
    • Journal of the Korean Graphic Arts Communication Society
    • /
    • v.18 no.2
    • /
    • pp.113-124
    • /
    • 2000
  • It is well known that the characteristics of liquid crystal polymer composite(LCPC) films are possessed of large-area and flexible display, polarizer free, high contrast, wide angle of visual filed and high responsiveness. In this study, we have investigated to the best optimal mixing rates chiral nematic liquid crystals and UV-curable resins having different properties acrylate moleculars. The purpose of this study has been the development of new functional application with liquid crystal polymer composite films. For example the films were applied a new thermal sensor. In results, best phase separation behaviors turned out liquid crystal/monomer/oilgomer mixture system.

  • PDF

Synthesis, Molecular Structure and Mesomorphic Phase Behavior of${\eta}^1$-Benzylideneaniline Palladium(II) Complexes

  • Yu, Yong Sik;Im, Jun Hwan;Han, Bong Hwan;Lee, Myeong Su;Choe, Mun Geun
    • Bulletin of the Korean Chemical Society
    • /
    • v.22 no.12
    • /
    • pp.1350-1360
    • /
    • 2001
  • The synthesis and characterization of very stable Pd(Ⅱ) η1-imine complexes of bis(3,4-dialkyloxybenzylidene-3', 4'-dialkyloxyaniline)dichloropalladium(Ⅱ) with alkyl chain of hexyl (8), octyl (9), decyl (10) and dodecyl (11) groups, a nd of bis(4-ethyloxybenzylidene-4'-ethyloxyaniline)dichloropalladium(Ⅱ) as a model complex are described. The molecular structure with twisted board-like geometry of the complex resulting from the coordination of Pd(Ⅱ) with η1-imine bonding was confirmed by X-ray crystallographic analysis of the model complex. In contrast to the imine ligands, all the complexes with an exception of 11 display a thermally stable monotropic smectic A mesophase without any decomposition of the complex. These results, characterized by a combination of differential scanning calorimetry, optical polarized microscopy, and powder X-ray scattering experiments, are discussed.

Theoretical Studies on Phenyl Group Rearrangement of Protonated Ketones

  • 김창곤;이진각;박형연;이익춘
    • Bulletin of the Korean Chemical Society
    • /
    • v.18 no.6
    • /
    • pp.657-662
    • /
    • 1997
  • Gas-phase phenyl group migration within the protonated ketones has been studied MO theoretically using the AM1 method. The initial state structure shows relatively strong resonance delocalization of positive charge into the nonmigrating (Y) ring, while the ring migration (Z-ring) is nearly complete in the transition state. These results are reflected in the large $p^+_Z$ (<0) and $p^+_$Y (>0) values and in the predominant contribution of resonance (r) over inductive (field, f) effect, r/f ranging from 1.3 ($p^+_r$) to 1.5 ($p^+_z$). The cross-interaction constant $p_{YZ}$ is vanishingly small ($p_{YZ}$=0.03) which is in contrast to the larger magnitudes for benzilic ($p_{YZ}$=-0.48) and azibenzil ($p_{YZ}$=-0.53) rearrangement processes. The relationship found between the extent of resonance contribution in the initial state and the magnitude of $p_{YZ}$ provides strong support for the proportionality between the magnitude of $p_{YZ}$ and the change in the intensity of interaction, ${\Delta}I^{\cdot}_{YZ}$, in the activation process.

Research Trends on Inverse Reinforcement Learning (역강화학습 기술 동향)

  • Lee, S.K.;Kim, D.W.;Jang, S.H.;Yang, S.I.
    • Electronics and Telecommunications Trends
    • /
    • v.34 no.6
    • /
    • pp.100-107
    • /
    • 2019
  • Recently, reinforcement learning (RL) has expanded from the research phase of the virtual simulation environment to a wide range of applications, such as autonomous driving, natural language processing, recommendation systems, and disease diagnosis. However, RL is less likely to be used in these complex real-world environments. In contrast, inverse reinforcement learning (IRL) can obtain optimal policies in various situations; furthermore, it can use expert demonstration data to achieve its target task. In particular, IRL is expected to be a key technology for artificial general intelligence research that can successfully perform human intellectual tasks. In this report, we briefly summarize various IRL techniques and research directions.

Basic Physical Principles and Clinical Applications of Computed Tomography

  • Jung, Haijo
    • Progress in Medical Physics
    • /
    • v.32 no.1
    • /
    • pp.1-17
    • /
    • 2021
  • The evolution of X-ray computed tomography (CT) has been based on the discovery of X-rays, the inception of the Radon transform, and the development of X-ray digital data acquisition systems and computer technology. Unlike conventional X-ray imaging (general radiography), CT reconstructs cross-sectional anatomical images of the internal structures according to X-ray attenuation coefficients (approximate tissue density) for almost every region in the body. This article reviews the essential physical principles and technical aspects of the CT scanner, including several notable evolutions in CT technology that resulted in the emergence of helical, multidetector, cone beam, portable, dual-energy, and phase-contrast CT, in integrated imaging modalities, such as positron-emission-tomography-CT and single-photon-emission-computed-tomography-CT, and in clinical applications, including image acquisition parameters, CT angiography, image adjustment, versatile image visualizations, volumetric/surface rendering on a computer workstation, radiation treatment planning, and target localization in radiotherapy. The understanding of CT characteristics will provide more effective and accurate patient care in the fields of diagnostics and radiotherapy, and can lead to the improvement of image quality and the optimization of exposure doses.

MNDO Studies on the Gas-Phase S$_N$2 Reaction$^*$

  • Lee Ikchoon;Lee Bon-Su;Song Chang Hyun
    • Bulletin of the Korean Chemical Society
    • /
    • v.6 no.4
    • /
    • pp.191-196
    • /
    • 1985
  • The MNDO was found to be the most reliable semi-empirical SCF-MO method for the studies of $S_N2$ reactions involving anion and neutral molecule. The results of our MNDO calculations on the $S_N2$ reactions of $CH_3X$ + $Y^-$$CH_3Y$ + X- where X = H, F, Cl, CN, $CH_3$, and Y = F, $CH_3$ showed that the order of the leaving group ability is the reverse of the order of proton affinities. It was also found that there is no symbiosis involved in the SN2 transition state and the departure of the leaving group is relatively late in contrast to the early bond formation of the nucleophile. The Marcus equation was found to apply to the MNDO barriers and energy changes.

Rise of Geopolitics and Changing Korea and Japan Trade Politics

  • Choi, Byung-il;Oh, Jennifer S.
    • East Asian Economic Review
    • /
    • v.26 no.1
    • /
    • pp.27-48
    • /
    • 2022
  • In the past decade, Korea and Japan have increasingly exhibited different strategic priorities in trade in face of China's rising global economic prowess and worsening US-China trade conflict. Japan's trade policy decisions have worked to reinforce its economic and security ties with the US as a means to counter China. Japan has used both bilateral and multilateral means to secure its ties with the US against China. In contrast, Korea's trade policy positions have been one of 'strategic ambiguity'. Korea has been more conciliatory towards China, reluctant to take actions that would counter China's interest. Korea has mainly resorted to bilateral channels to maintain favorable relations with both China and the US. Korea's reluctance to clearly ally with the US against China has been observed across different administrations with opposing political orientations. This paper examines Korea and Japan's diverging strategic priorities in trade through the 2017 World Trade Organization Ministerial Conference; the 2017 US imposition of Section 232 on steel; the Comprehensive and Progressive Agreement for Trans-Pacific Partnership, the Korea-US FTA renegotiation and the Korea-China FTA Phase Two Negotiation; and the 2019 Japan-US Trade Agreement.