• Progress in Medical Physics
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• v.33 no.4
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• pp.114-120
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• 2022

Purpose: Particle beam therapy is advantageous over photon therapy. However, adequately delivering therapeutic doses to tumors near critical organs is difficult. Nanoparticle-aided radiation therapy can be used to alleviate this problem, wherein nanoparticles can passively accumulate at higher concentrations in the tumor tissue compared to the surrounding normal tissue. In this study, we investigate the dose enhancement effect due to gold nanoparticle (GNP) when Carbon-12, He-4, and proton beams are irradiated on GNP. Methods: First, monoenergetic Carbon-12 and He-4 ion beams of energy of 283.33 MeV/u and 150 MeV/u, respectively, and a proton beam of energy of 150 MeV were irradiated on a water phantom of dimensions 30 cm×30 cm×30 cm. Subsequently, the secondary-particle information generated near the Bragg peak was recorded in a phase-space (phsp) file. Second, the obtained phsp file was scaled down to a nanometer scale to irradiate GNP of diameter 50 nm located at the center of a 4 ㎛×4 ㎛×4 ㎛ water phantom. The dose enhancement ratio (DER) was calculated in intervals of 1 nm from the GNP surface. Results: The DER of GNP computed at 1 nm from the GNP surface was 4.70, 4.86, and 4.89 for Carbon-12, He-4, and proton beams, respectively; the DER decreased rapidly with increasing distance from the GNP surface. Conclusions: The results indicated that GNP can be used as radiosensitizers in particle beam therapy. Furthermore, the dose enhancement effect of the GNP absorbed by tumor cells can aid in delivering higher therapeutic doses.

• Journal of the Korean Institute of Rural Architecture
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• v.25 no.4
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• pp.25-35
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• 2023

According to this study, it is estimated that the ILDU historic house was constructed around the late Goryeo period, approximately in the year 1360, and the founder moved to Hamyang no earlier than 1350. The main house, the inner store-house, the inner gatehouse, and the ancestral shrine, which are situated on elevated ground, were initially constructed around 1360, and substantial expansions and renovations occurred around 1620. The shrine was relocated and reconstructed in its present location and form around 1843. Subsequent to that period, it underwent various architectural changes, including repairs and reconstructions. The sub-main house was originally constructed around 1620 and underwent a reconstruction in 1843. The main storehouse was built in 1930. Also, the man's part of house, located on lower ground, was erected in 1843, while the other sub-main house seems to constructed around 1860. The auxiliary buildings, the main gatehouse and the outer storehouse, were initially constructed around 1360. It is estimated that they were similarly relocated and reconstructed in their current form, along with the construction of the man's part of house in 1843. It has undergone a four-stage transformation process, influenced by various internal and external factors, including the local indigenization of the ILDU families of the same clan, as well as the popularization of Confucian ideology. These four stages include its formative period, growth phase, developmental stage, and maturity. It actively incorporated the contemporary factors of change into its residential architecture. This continuous adaptation is evident in its the space and floor plan, ultimately leading to its present-day architectural legacy.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.18 no.1
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• pp.192-210
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• 2024

Most frequency-domain remote sensing image watermarking algorithms embed watermarks at random locations, which have negative impact on the watermark invisibility. In this study, we propose an adaptive watermarking scheme for remote sensing images that considers the information complexity to select where to embed watermarks to improve watermark invisibility without affecting algorithm robustness. The scheme converts remote sensing images from RGB to YCbCr color space, performs two-level DWT on luminance Y, and selects the high frequency coefficient of the low frequency component (HH^Y₂) as the watermark embedding domain. To achieve adaptive embedding, HH^Y₂ is divided into several 8*8 blocks, the entropy of each sub-block is calculated, and the block with the maximum entropy is chosen as the watermark embedding location. During embedding phase, the watermark image is also decomposed by two-level DWT, and the resulting high frequency coefficient (HH^W₂) is then embedded into the block with maximum entropy using α- blending. The experimental results show that the watermarked remote sensing images have high fidelity, indicating good invisibility. Under varying degrees of geometric, cropping, filtering, and noise attacks, the proposed watermarking can always extract high identifiable watermark images. Moreover, it is extremely stable and impervious to attack intensity interference.

• Korean Journal of Radiology
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• v.24 no.6
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• pp.564-573
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• 2023

Objective: To investigate the feasibility of assessing the viscoelastic properties of the brain using magnetic resonance elastography (MRE) and a novel MRE transducer to determine the relationship between the viscoelastic properties and glymphatic function in neurologically normal individuals. Materials and Methods: This prospective study included 47 neurologically normal individuals aged 23-74 years (male-to-female ratio, 21:26). The MRE was acquired using a gravitational transducer based on a rotational eccentric mass as the driving system. The magnitude of the complex shear modulus |G^*| and the phase angle 𝛗 were measured in the centrum semiovale area. To evaluate glymphatic function, the Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS) method was utilized and the ALPS index was calculated. Univariable and multivariable (variables with P < 0.2 from the univariable analysis) linear regression analyses were performed for |G^*| and 𝛗 and included sex, age, normalized white matter hyperintensity (WMH) volume, brain parenchymal volume, and ALPS index as covariates. Results: In the univariable analysis for |G^*|, age (P = 0.005), brain parenchymal volume (P = 0.152), normalized WMH volume (P = 0.011), and ALPS index (P = 0.005) were identified as candidates with P < 0.2. In the multivariable analysis, only the ALPS index was independently associated with |G^*|, showing a positive relationship (β = 0.300, P = 0.029). For 𝛗, normalized WMH volume (P = 0.128) and ALPS index (P = 0.015) were identified as candidates for multivariable analysis, and only the ALPS index was independently associated with 𝛗 (β = 0.057, P = 0.039). Conclusion: Brain MRE using a gravitational transducer is feasible in neurologically normal individuals over a wide age range. The significant correlation between the viscoelastic properties of the brain and glymphatic function suggests that a more organized or preserved microenvironment of the brain parenchyma is associated with a more unimpeded glymphatic fluid flow.

• Tunnel and Underground Space
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• v.34 no.2
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• pp.127-142
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• 2024

The robustness of a numerical method means that its computational performance is maintained under various modeling conditions. New numerical methods or codes need to be assessed for robustness through benchmark testing. The TOUGH-FLAC modeling approach has been applied to various fields such as subsurface carbon dioxide storage, geological disposal of spent nuclear fuel, and geothermal development both domestically and internationally, and the modeling validity has been examined by comparing the results with experimental measurements and other numerical codes. In the present study, a benchmark test of the TOUGH-FLAC approach was performed based on a coupled thermal-hydro-mechanical behavior problem with an analytical solution. The analytical solution is related to the temperature, pore water pressure, and mechanical behavior of a fully saturated porous medium that is subjected to a point heat source. The robustness of the TOUGH-FLAC approach was evaluated by comparing the analytical solution with the results of numerical simulation. Additionally, the effects of thermal-hydro-mechanical coupling terms, fluid phase change, and timestep on the computation of coupled behavior were investigated.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.44 no.2
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• pp.223-229
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• 2024

The Ministry of Land, Infrastructure and Transport presented the "Construction Industry BIM Enforcement Guidelines Constructors Edition" to reflect the design BIM data in the construction stage. The enforcement guidelines were prepared with the aim of providing guidelines for detailed common implementation plans such as minimum BIM business methods and procedures necessary for ordering, designing, and construction stages for the full-scale BIM application in all fields of the construction industry. In this study, interference and design errors were examined based on the enforcement guidelines, and the application effects were grasped for various sites where equipment placement and operation plans were established. As a result, intuitive examination was possible by comparing the digital field 3D model and the planned model in one space, and the optimum equipment arrangement and operation plan were derived through simulation examination according to the execution stage.

• Nuclear Engineering and Technology
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• v.56 no.6
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• pp.2011-2018
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• 2024

Since RF breakdown is one of the primary limitations to improving the performances of RF accelerators, extensive efforts have been dedicated to locating the breakdowns. However, most existing methods rely on specialized techniques, resulting in high financial burdens. Although the method based on transient response of transmission line (TL) is suitable for facilities with sporadic recoverable breakdowns, practical operations are susceptible to notable errors. This study revisits the fundamental theories of lossless TL and investigates the wave process to understand the characteristics of the reversed pulse induced by the breakdowns. By utilizing steadystate response of the TL and employing phasor method, we derive analytical formulas to determine the exact location of breakdowns within the faulty cell for constant-gradient TW accelerator. Furthermore, the derived formulas demonstrate their independence from RF phase, thereby distinguishing them from traditional phasebased methods. Additionally, experimental validations are conducted at the HUST injector, and the results confirm the consistency of the analysis. Thus, the proposed method represents a promising improvement over the TL-based approaches and serves as a valuable complement to current techniques. Importantly, this method demonstrates particular advantages for constructed TW accelerators seeking to achieve a balance among high performance, low costs, and compact layouts.

• Tunnel and Underground Space
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• v.34 no.4
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• pp.413-420
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• 2024

When planning gripper TBM, which is highly applicable to urban areas, the excavation characteristics are not considered. In addition the excavation stability and constructability are degraded by installing reinforcements in the adjacent construction site considering the relaxation load theory of the pre-existing NATM. In this study, a rationalization plan for the support was proposed considering the excavation characteristics of gripper TBM when planning reinforcements for adjacent pre-existing construction. The effect of excavation on the surrounding ground was analyzed by conducting three-dimensional stability analyses considering the construction stage for each excavation phase. In NATM, relaxation phenomenon is concentrated in tunnel face due to non-supporting time occurring simultaneously with excavation, but gripper TBM supports the ground around the tunnel face through the cutter head and skin plate, simultaneously causing ground relaxation behind the skin plate. Considering these excavation characteristics, problems in reinforcement planning for adjacent construction at the study site were pointed out. A performance improvement plan for a reasonable supporting system was proposed.

• Journal of Chest Surgery
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• v.40 no.7 s.276
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• pp.485-491
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• 2007

Background: Thoracoplasty has become a rarity in current clinical practice, although it has been widely employed for well over a century as a procedure for reducing the capacity of the thoracic cavity. Yet we have perform tailoring thoracoplasty following or concomitant with pulmonary resection in 20 patients. The aim of this study is to evaluate the early and late clinical results and also the significance of tailoring thoracoplasty. Material and Method: From March 1995 to June 2005, modified thoracoplasty following or concomitant with pulmonary resection was performed in 20 patients out of a total of 298 pulmonary resections for closing air leaks and for treating persistent pleural space following pulmonary resections, and to tailor the thoracic cavity to accept a diminished lung volume. Of the 20 patients, 14 patients had tailoring thoracoplasty performed concomitant with pulmonary resection, and the remaining 6 patients also had tailoring thoracoplasty performed following pulmonary resection. The subjects ages ranged from 24 to 77 (mean $59.1{\pm}6.4$) and a male preponderance was noted (17 : 3); the number of left and right surgeries was equal. The preoperative primary underlying diseases were lung cancer in 7 patients, pneumothorax with giant bullous change in 6 patients, bronchiectasis in 2 patients, previous pulmonary tuberculosis associated with aspergilloma in 2 patients, empyema with fibrothorax in 2 patients and multiple lung abscesses & destruction due to previous trauma in 1 patient. The operative methods were apicolysis and subperiosteal removal of the 2nd, 3rd and 4th ribs (the costochondral junction to the posterior portions of the ribs) with preservation of the first rib and compression of the anterior chest via cotton bags and elastic bandages. Result: The mean duration of the air leaks after thoracoplasty was $1.6{\pm}0.2$ days (range: $0{\sim}7$ days) and the mean duration of an indwelling chest tube was 7 days (range: $5{\sim}11$ days); the mean duration of hospitalization was $19.2{\pm}2.8$ days (range: $8{\sim}47$ days). The postoperative complications were wound infection (2) and pneumonia (2); reoperation was done due to bleeding (1) in one patient who underwent concomitant thoracoplasty and there was 1 case of wound infection (1) after postresection thoracoplasty. The mortality was 1 patient in the early phase and 4 patients in the late phase. Conclusion: We conclude that tailoring thoracoplasty may be performed to close anticipated persistent pleural spaces and to accommodate the diminished lung volume with acceptable cosmetic results when this procedure is combined with pulmonary resection in selected patients.

• Korean Chemical Engineering Research
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• v.44 no.5
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• pp.505-512
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• 2006

Characteristics of particle holdup and heat transfer were investigated in a liquid-particle swirling fluidized bed whose diameter was 0.102 m and 2.5 m in height. Effects of liquid velocity, particle size and swirling liquid ratio($R_s$) on the particle holdup and immersed heater-to-bed overall heat transfer coefficient were examined. The particle holdup increased with increasing particle size and swirling liquid ratio but decreased with increasing liquid velocity.The local particle holdup was relatively high in the region near the heater when the $R_s$ value was 0.1~0.3, but the radial particle holdup was almost uniform when the $R_s$ value was 0.5, whereas, when the $R_s$ value was 0.7, the local particle holdup was relatively low in the region near the heater. The heat transfer characteristics between the immersed heater and the bed was well analyzed by means of phase space portraits and Kolmogorov entropy(K) of the time series of temperature difference fluctuations. The phase space portraits of temperature difference fluctuations became stable and periodic and the value of Kolmogorov entropy tended to decrease with increasing the value of $R_s$ from 0.1 to 0.5. The Kolmogorov entropy exhibited its maximum value with increasing liquid velocity. The value of overall heat transfer coefficient(h) showed its maximum value with the variation of liquid velocity, bed porosity or swirling liquid ratio, but it increased with increasing particle size. The value of K exhibited its maximum at the liquid velocity at which the h value attained its maximum. The particle holdup and overall heat transfer coefficient were well correlated in terms of dimensionless groups of operating variables.