• BMB Reports
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• v.46 no.8
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• pp.416-421
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• 2013

Genome-wide association studies (GWAS) have become popular as an approach for the identification of large numbers of phenotype-associated variants. However, differences in genetic architecture and environmental factors mean that the effect of variants can vary across populations. Understanding population genetic diversity is valuable for the investigation of possible population specific and independent effects of variants. EvoSNP-DB aims to provide information regarding genetic diversity among East Asian populations, including Chinese, Japanese, and Korean. Non-redundant SNPs (1.6 million) were genotyped in 54 Korean trios (162 samples) and were compared with 4 million SNPs from HapMap phase II populations. EvoSNP-DB provides two user interfaces for data query and visualization, and integrates scores of genetic diversity (Fst and VarLD) at the level of SNPs, genes, and chromosome regions. EvoSNP-DB is a web-based application that allows users to navigate and visualize measurements of population genetic differences in an interactive manner, and is available online at [http://biomi.cdc.go.kr/EvoSNP/].

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.34 no.2
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• pp.161-169
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• 2016

This paper is intended to propose a novel approach to select an optimal site for a small-scaled artificial recharge system installation using TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) with geospatial data. TOPSIS is a MCDM (Multi-Criteria Decision Making) method to choose the preferred one of derived alternatives by calculating the relative closeness to an ideal solution. For applying TOPSIS, in the first, the topographic shape representing optimal recovery efficiency is defined based on a hydraulic model experiment, and then an appropriate surface slope is determined for the security of a self-purification capability with DEM (Digital Elevation Model). In the second phase, the candidate areas are extracted from an alluvial map through a morphology operation, because local alluvium with a lengthy and narrow shape could be satisfied with a primary condition for the optimal site. Thirdly, a shape file over all candidate areas was generated and criteria and their values were assigned according to hydrogeologic attributes. Finally, TOPSIS algorithm was applied to a shape file to place the order preference of candidate sites.

• Proceedings of the KSEEG Conference
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• 1999.04a
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• pp.90-93
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• 1999

We present a high frequency electromagnetic (EM) inversion scheme for detecting and characterizing a fracture using single-hole data. At high frequencies, say above tens of mega-hertz, since displacement currents cannot be ignored, electrical permittivity as well as electrical conductivity is to be considered together for analyzing the EM scattering data. In this paper, we have developed a three-step inversion scheme to map the fracture and to evaluate its electrical conductivity and permittivity. We performed EM profiling along the z-axis using three-component receivers for each source. The model was excited by a vertical magnetic dipole and the resistant magnetic fields were inverted using the non-linear least-squares method. Background resistivity and permittivity were easily obtained using vertical magnetic fields below 1 MHz and above 10 MHz, respectively. Both the vertical and dipping sheets were successfully mapped using the phase difference between 40 and 41 MHz. The electrical property of the sheet was well resolved using the information obtained in the previous two steps and secondary magnetic fields. Our study shows the potential of imaging the fracture in single-hole survey environment using the high frequency EM method.

• Transactions of the Korean Society of Mechanical Engineers
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• v.14 no.3
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• pp.656-663
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• 1990

To investigate the optimum design conditions of Stirling Engines at the preliminary design stage, comparative study between adoabatoc analysis based on an approximate analytical solution to the Ideal Adiabatic Model and the existing isothermal analysis has been carried out. The optimum phase angle obtained from adiabatic analysis to achieve the maximum work with given combination of design parameters is greater than that from isothermal analysis, while the optimum swept volume ratio is smaller. Effect of variation in the temperature ratio on the work parameter is proved to be stronger in adiabatic analysis. On the contrary, the work parameter by adiabatic analysis is less sensitive to a change in the dead volume ratio. Especially in adiabatic analysis there exists the optimum dead volume ratio maximizing the work parameter, which may provide a lower limit of it. Considering that the adiabatic model is more reasonable, signifiant differences between two methods lead to the conclusion that adiabatic analysis is preferable to isothermal one for the preliminary design of Stirling Engines.

• KIEE International Transactions on Electrophysics and Applications
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• v.11C no.2
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• pp.6-11
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• 2001

Abstract- In this paper, a new Partial Discharge (PD) detection using Pockels cell was proposed and considerable apparent chaotic characteristics were discussed. For this purpose, PD was generated from needle-plane electrode in air and detecte by optical measuring system using Pockels cell, based on Mach-Zehner interferometer, consisting of He-Ne laser, single mode optical fiber, 50/50 beam splitter and photo detector. In addition, the presence of chaos of the PD signals has been investigated by examining their means of qualitative and quantitative information. For the former, return map and 3-dimensional strange attractor have been drawn in order to investigate the presence of chaotic characteristics relevant to PD signals, detected through CT and Peckels sensor respectively, in the normalized time series. The presence of strange attractor indicates the existence of fractal structures in it's phase space. For the latter, several dimension values of strange attractor were verified sequentially. Throughout this paper, it is likely that the chaotic characteristics regarding the PD signals under air are verified.

• Journal of Communications and Networks
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• v.15 no.3
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• pp.283-291
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• 2013

In this paper, we propose new multiuser detectors (MUDs) based on compressed sensing approaches for the large-scale multiple antenna systems equipped with dozens of low-power antennas. We consider the scenarios where the number of receiver antennas is smaller than the total number of users, but the number of active users is relatively small. This prior information motivates sparsity-embracing MUDs such as sparsity-embracing linear/nonlinear MUDs where the detection of active users and their symbol detection are employed. In addition, sparsity-embracing MUDs with maximum a posteriori probability criterion (MAP-MUDs) are presented. They jointly detect active users and their symbols by exploiting the probability of user activity, and it can be solved efficiently by introducing convex relaxing senses. Furthermore, it is shown that sparsity-embracing MUDs exploiting common users' activity across multiple symbols, i.e., frame-by-frame, can be considered to improve performance. Also, in multiple multiple-input and multiple-output networks with aggressive frequency reuse, we propose the interference cancellation strategy for the proposed sparsity-embracing MUDs. That first cancels out the interference induced by adjacent networks and then recovers the desired users' information by exploiting the low user activity. In simulation studies for binary phase shift keying modulation, numerical evidences establish the effectiveness of our proposed MUDs exploiting low user activity, as compared with the conventional MUD.

• The Journal of the Korea institute of electronic communication sciences
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• v.6 no.5
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• pp.709-716
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• 2011

Recently, there are many difficult for maintenance in the power in established sensor networks. In order to solve this problems, the power development has been interested using vibration in MEMS that insert the MEMS oscillator. In this paper, we propose the MEMS system with Duffing equation to generate vibration signal that can be use power signal in MEMS and confirm and verify the chaotic behaviors in vibration signal of MEMS by computer simulation. As a verification methods, we confirm the existence of period motion and chaotic motion by parameter variation through the time series, phase portrait, power spectrum and poincare map.

• Advances in Energy Research
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• v.5 no.3
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• pp.255-275
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• 2017

The advantages of using natural circulation (NC) as a cooling system, has prompted the worldwide development to investigate this phenomenon more than before. The interesting application of the NC in low power experimental facilities and research reactors, highlights the obligation of study in these laminar flows. The inherent oscillations of NC between hot source and cold sink in low Grashof numbers necessitates stability analysis of cooling flow with experimental or numerical schemes. For this type of analysis, numerical methods could be implemented to desired mass, momentum and energy equations as an efficient instrument for predicting the behavior of the flow field. In this work, using the explicit, implicit and Crank-Nicolson methods, the fluid flow parameters in a natural circulation experimental test loop are obtained and the sensitivity of solving approaches are discussed. In this way, at first, the steady state and transient results from explicit are obtained and compared with experimental data. The implicit and crank-Nicolson scheme is investigated in next steps and in subsequent this research is focused on the numerical aspects of instability prediction for these schemes. In the following, the assessment of the flow behavior with coarse and fine mesh sizes and time-steps has been reported and the numerical schemes convergence are compared. For more detail research, the natural circulation of fluid was modeled by ANSYS-CFX software and results for the experimental loop are shown. Finally, the stability map for rectangular closed loop was obtained with employing the Nyquist criterion.

• Journal of the Korea Society for Simulation
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• v.14 no.3
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• pp.21-31
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• 2005

In state-of-the-art games, characters can move in a goal-directed manner so that they can move to the goal position without colliding obstacles. Many path-finding methods have been proposed and implemented for these characters and most of them use the A* search algorithm. When .the map is represented with a regular grid of squares or a navigation mesh, it often takes a long time for the A* to search the state space because the number of cells used In the grid or the mesh increases for higher resolution. Moreover the A* search on the grid often causes a zigzag effect, which is not optimal and realistic. In this paper we propose to use visibility graphs to improve the search time by reducing the search space and to find the optimal path. We also propose a method of taking into account the size of moving characters in the phase of planning to prevent them from colliding with obstacles as they move. Simulation results show that the proposed method performs better than the grid-based A* algorithm in terms of the search time and space and that the resulting paths are more realistic.

• YAKHAK HOEJI
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• v.56 no.1
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• pp.26-34
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• 2012

Mast cells play an important role in early and late phase allergic reactions through allergen and IgE-dependent release of histamine, proteases, prostaglandins, and several multifunctional cytokines. In this study, we investigated whether Cudrania tricuspidata extract (CTE) suppresses IgE-mediated allergic responses in mast cells, an allergic animal model, and its mechanism of action in mast cells. We found that CTE inhibited IgE-mediated degranulation and cytokine production in rat basophilic leukemia (RBL)-2H3 mast cells and bone marrow-derived mast cells (BMMC), as well as passive cutaneous anaphylaxis (PCA) in mice. With regard to its mechanism of action, CTE suppressed the activating phosphorylation of spleen tyrosine kinase (Syk), a key enzyme in mast cell signaling processes and that of LAT, a downstream adaptor molecule of Syk in $Fc{\varepsilon}RI$-mediated signal pathways. CTE also suppressed the activating phosphorylation of mitogen-activated protein (MAP) kinases and Akt. The present results strongly suggest that the anti-allergic activity of CTE is mediated through inhibiting degranulation and allergic cytokine secretion by inhibition of Syk kinase in mast cells. Therefore, CTE may be useful for the treatment of allergic diseases.