• Natural Product Sciences
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• v.25 no.4
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• pp.285-292
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• 2019

A crude drug "Dang-Gui", belonging to the genus Angelica, has been used as a traditional herbal medicine in Asia. Various studies have investigated the chemical components and pharmacological activities of Dang-Gui worldwide. However, domestic research results published in Korean are undervalued in international academia due to language barriers. Therefore, it is necessary to summarize the domestic research findings systematically for greater accessibility. This review focuses on the results published in four Korean pharmaceutical journals between 1970 and 2018, which detail the botanical, phytochemical, and pharmacological properties of three Angelica species (A. gigas, A. sinensis, and A. acutiloba) used as "Dang-Gui" in Korea, China, and Japan.

• Natural Product Sciences
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• v.13 no.1
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• pp.46-53
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• 2007

The effects of the alcoholic extract of Bacopa monniera (BMA) on morphine-induced pharmacological activities were studied in mice. Oral administration of the extract (40 mg/kg) significantly inhibited morphine-induced analgesic tolerance, withdrawal symptoms, hyperactivity, reverse tolerance, Dopamine receptor supersensitivity and apo-morphine-induced climbing behaviour in mice. The results of this study showed that, alcoholic extract of Bacopa monniera (BMA) exerted inhibitory effect against morphine-induced pharmacological effects, suggesting that the extract could be useful in the treatment of morphine toxicity.

• Biomolecules & Therapeutics
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• v.20 no.5
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• pp.446-456
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• 2012

Actoprotectors are preparations that enhance body stability against physical loads without increasing oxygen consumption or heat production. Or, in short, actoprotectors are synthetic adaptogens with a significant capacity to improve physical performance. This paper explores the history of actoprotectors' development, their pharmacological properties, mechanism of action, and practical application to the improvement of mental and physical performance. A brief summary of the clinico-pharmacological characteristics of the main representatives of this class (bemitil and bromantane) is provided. Some other synthesized compounds, and even natural ones such as ginseng, also are regarded as potential actoprotectors, and these are treated herein as well. Actoprotectors, owing to their wide-ranging pharmacological activities, high efficiency and safety, can be applied under either normal or extreme conditions.

• Journal of Ginseng Research
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• v.35 no.3
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• pp.301-307
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• 2011

To evaluate the difference in expressing pharmacological effects of ginseng by intestinal microflora between Koreans, metabolic activities of ginseng, ginsenoside $Rb_1$ and $Rg_1$ by 100 fecal specimens were measured. The ${\beta}$-glucosidase activity for p-nitrophenyl-${\beta}$-D-glucopyranoside was 0 to 0.42 mmol/min/mg and its average activity (mean${\pm}$SD) was $0.10{\pm}0.07$ mmol/min/mg. The metabolic activities of ginsenosides Rb1 and Rg1 were 0.01 to 0.42 and 0.01 to 0.38 pmol/min/mg, respectively. Their average activities were $0.25{\pm}0.08$ and $0.15{\pm}0.09$ pmol/min/mg, respectively. The compound K-forming activities from ginsenoside Rb1 and ginseng extract were 0 to 0.11 and 0 to 0.02 pmol/min/mg, respectively. Their average compound K-forming activities were $0.24{\pm}0.09$ pmol/min/ mg and $2.14{\pm}3.66$ fmol/min/mg, respectively. These activities all were not different between males and females, or between ages. Although compound K-forming activity from the aqueous extract of ginseng was low compared to that from ginenoside $Rb_1$, their profiles were similar to those of isolated compounds. Based on these findings, we believe that the intestinal bacterial metabolic activities of ginseng components are variable in individuals and may be used as selection markers for responders to ginseng.

• Korean Journal of Pharmacognosy
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• v.10 no.1
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• pp.1-8
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• 1979

The naturally occurring coumarins are likely to be a large and important group of plant products which are not only metabolic products of the living cells but possess varied physiological and pharmacological actions. Investigations concerning various biological activities of natural coumarins have been undertaken by many investigators in continuing effort. The authors describe on experimental results of biological activities of coumarin derivatives with particular emphasis on 10 different activities that are considered to be of importance in view of the development of new drugs from natural resources.

• Biomolecules & Therapeutics
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• v.8 no.1
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• pp.1-12
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• 2000

Although the first pyridazine was obtained in 1886, this heterocycle was not thoroughly investigated such isomers as pyrimidine and pyrazine especially in the field of drug development because pyridazine derivatives do not occur as natural products. Recently medicinal chemists have an growing interest in the pyridazine derivatives, since many Pyridazine derivatives were found to possess various potential therapeutic activities. In this paper sixty-eight pyridazine derivatives, which are already introduced as medicines or are being developed as drugs were classified according to their pharmacological activities, reviewed since 1955 and the relationship of structure-activities was discussed.

• Archives of Pharmacal Research
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• v.12 no.3
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• pp.231-232
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• 1989

Although it has been known that organometallic $\beta$-lactam compounds improve the resistance to $\beta$-lactamases as well as their pharmacological activities, only a few results on organometallic $\beta$-lactam antibiotics were reported. In the course of our extensive study on the development of new cephalosporins, we were interested in organotin compounds since they show some biological activities.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.118-118
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• 2002

It has been reported that vitamin K analogues have various pharmacological effects such as antiviral, antifungal, anticancer, and antiplatelet activities. It has also been reported that some synthetic naphthoquinone compounds showed antiplatelet activities.(omitted)

• Journal of Marine Bioscience and Biotechnology
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• v.1 no.3
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• pp.144-155
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• 2006

This report reviews the literatures on chemical constituents of marine sponges of the genus Spongosorites and also highlights our own research. Specific biological activities of the metabolites from these sponges include: cytotoxic, antitumor, antibacterial, antifungal, antiviral, anti-inflammatory, and other pharmacological activities.

• Korean Journal of Pharmacognosy
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• v.40 no.4
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• pp.257-279
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• 2009

Plants of genus Dioscorea have long been served as important carbohydrate-stuffed foods in the tropical and subtropical regions, and utilized as traditional herb medicines to enhance digestive function, improve anorexia, and treat diarrhea in oriental countries. It is known that around 600 species of Dioscorea are distributed in the world including 107 species in Asia, but actually utilized Dioscorea species are restricted to small numbers. Phytochemical investigations for Dioscorea species have revealed a number of chemical components such as sapogenins, saponins, phenanthrenes, stilbenes, diterpenes and purine derivatives. According to recent pharmacological studies, Dioscorea species possess significant antioxidant, antibacterial and anti-inflammatory activities as well as anticancer, antidiabetic, cholesterol-lowering and hypolipidemic effects. Here, seven Dioscorea species (D. batatas, D. japonica, D. bulbifera, D. opposita, D. tokoro, D. nipponica and D. alata), mainly distributed and used in Korea, China, and Japan, are reviewed to provide their botanical, phytochemical and pharmacological properties were described.