• Title/Summary/Keyword: pharmaceutical research

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Highly Enantioselective Synthesis of a-Alkyl-alanines via the Catalytic Phase-Transfer Alkylation of 2-Naphthyl aldimine tert-butyl ester by using O(9)-Allyl-N(1)-2'3'4'-trifluorobenzylhydrocinchoni

  • Jew, Sang-Sup;Lee, Jeong-Hee;Yoo, Mi-Sook;Lee, Yeon-Ju;Jeong, Byeong-Seon;Park, Boon-Saeng;Kim, Myoung-Goo;Park, Hyeung-Geun
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.252.1-252.1
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    • 2003

  • Systematic investigations to develop an efficient enantioselective synthetic method for a-alkyl-alanine by the catalytic phase-transfer alkylation were performed. The alkylation of 2-naphthyl aldimine tert-butyl ester, 1 E with RbOH and O(9)-allyl-N-2'3'4'-trifluorobenzylhydrocinchonidinium bromide, 6, at \ulcorner5 \ulcorner\ulcorner showed the highest enantioselectivities, up to 96％ ee.

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Attenuation of monocrotaline-induced pulmonary hypertension with DA-8159, a potent PDE 5 inhibitor

  • Ahn, Gook-Jun;Kang, Kyung-Koo;Sohn, Yong-Sung;Choi, Seu-Min;Kim, Ju-Mi;Kim, Dong-Hwan;Ahn, Byoung-Ok;Kim, Won-Bae
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.249.1-249.1
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    • 2002

  • This study was carried out to demonstrate the effects of oral administration of DA-8159. a selective phosphodiesterase 5 inhibitor. on development of pulmonary hypertension induced by monocrotaline (MCT). MCT-treated rats(60mg/kg) were divided into three groups and orally administered vehicle, 1 mg/kg or 5 mg/kgg of DA-8159 twice a day for 3 weeks. Increased right ventricular weights, medial wall thickening in pulmonary arteries. myocardial fibrosis, decrease of plasma cyclic guanosine monophosphate (cGMP) level and body weight gains were shown in MCT group. (omitted)

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