• 기술혁신연구
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• 제9권1호
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• pp.167-187
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• 2001

Bioindustry is rapidly changing. Many biologists redefine biotechnlolgy as 'reprogramming the genetic codes of living things to suit cultural and economic needs and desires.'We regarded this change as the 'paradigm shift'in bioindustry. The genome research is reorganizing agricultural and environmental industries as well as a pharmaceutical industry. By analysing patent data granted in the United States from 1997 to 1999, we tried to explore the international patterns and trends of technological innovation in bioindustry, especially in the genome research. As the result, we could find that the United States'monopolistic position in the bioindustry was consolidated by the genome research. Competitive positions in the countries such as Japan and Germany, however, have been aggravated continuously. Korean inventors weren't also active in many biotechnological areas as comparing to developed countries such as US and UK. Especially, the gaps between Korea and developed countries in genome research were greater than any other areas.

• 한국독성학회:학술대회논문집
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• 한국독성학회 1997년도 국제 심포지움 및 춘계 학술대회
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• pp.20-27
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• 1997

Chinin is the second most plentiful natural polymer. Currently, chitin and chitosan are manufactured commercially in large scale from crab and shrimp shell as fish processing waste. They is being used in many commercial application because of their various functional properties. Chitosan, in particular, is being evaluated as biomedical materials in a number of food and pharmaceutical industries. Despite their potential abilities, the perfect safety had been demonstrated until now. However, the long-term feeding with chitin was not any negative effect the body weights and serum enzymatic activities in mice. And, in rats supplied with $5\%$ of chitosan diet for 450 days, there was no changes of Ca concentration in blood, bone and other organs except for in muscle. Consequently, there was no direct toxicity of chitin and chitosan against some animals such as rat and mouse by recently reports.

• KSBB Journal
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• 제23권5호
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• pp.449-451
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• 2008

Saccharomyces cerevisiae를 배양하여 ceramide를 생산하였다. 각기 다른 growth phase에서의 ceramide 생산량을 비교 실험하였다. Ceramide는 ELSD가 장착된 HPLC를 통하여 분석하였으며 stationary phase에 접어든 후 12시간 후에 회수, 추출된 양(2.01 mg ceramide/g cell)이 최대인 것으로 나타났다.

• Journal of Advanced Marine Engineering and Technology
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• 제28권6호
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• pp.938-945
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• 2004

Intrinsic safety is generally considered the safest method of operating electrical instrumention in potentially explosive atmospheres. The method of intrinsic safety limits the energy passing into the hazardus area. The energy limitation is provided by the use of safety barriers which are mounted in the safe area. Because of the energy limitation, regardless of the fault in the hazardous area, sufficient energy cannot be released to ignite the explosive atmosphere. The following industries are known to have hazardous locations: chemical. munitions, petrochemical, auto(paint spray booths), grain, waste water, printing, distillers, pharmaceutical. breweries, cosmetics, and utilities. In this paper, a isolator type barrier for ship(LNG, LPG, etc,) and test equipment confidence are proposed. The test equipments are designed for mechanical electrical life time test and vibration. All of test results satisfy the goal and the studied barrier shows the improved confidence.

• Food Science and Biotechnology
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• 제16권3호
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• pp.329-336
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• 2007

Caking has been a serious problem in food, feed, pharmaceutical, and related industries, where dry powdered materials are produced and/or utilized. Caking of dry food powders occurs when water is redistributed or absorbed by the powders during processing and storage. The powders become sticky when their surfaces are mobilized by water, resulting in inter-particle binding, formation of clusters, and inter-particle fusion, which lead to caking. As a result of caking, the solubility of the powdered materials may decrease, lipid oxidation and enzymatic activity may increase, and sensory qualities such as flavor and crispness may deteriorate. Caking may also lead to microbial growth. For consumers, caking of powder products is a sign of poor quality and possible food safety problems. This paper provides a review of factors affecting caking, caking mechanisms, and analysis of caking based on previous studies.

• 한국미생물·생명공학회지
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• 제27권1호
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• pp.35-40
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• 1999

Alternan known as a kind of dextran is a linear and cyclic polysaccharide which is synthesized with sucrose by alternaansucrase (EC2.4.1.140) of Leuconostoc mesenteroides. But this polysaccharide is different from dextran in its structure and other properties. For the purpose of applying alternan for the food, cosmetic, and pharmaceutical industries, we isolated an excellent alternan-porducing strain, Leu. mesenteroides CBI-110. The optimum culture conditions were studied to improve the yield, and the activity of alternansucrase was increased up to 33U/ml in the optimum culture media. The concentrations of $Mn^{2+}$ and $Cu^{2+}$ ions were 0.01% and 0.03%, respectively, for the effective production of alternan. Finally, we obtained 25.6g/L of alternan.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2003년도 춘계학술발표강연 및 논문개요집
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• pp.220-220
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• 2003

The microencapsulation of droplets or particles within a solid shell leads to the formation of core-shell particles. Microencapsulation provides protection and controlled release of core materials such as drugs, vitamins, enzymes, perfumes, and the like. Such particles have, therefore, found a diverse range of applications in the pharmaceutical, agricultural, cosmetic, and food industries. UV absorbers are widely used for cosmetics to screen out ultra violet (UV) rays which have side effects on human skin. The absorbers are made generally from synthetic organic compounds, which can stimulate the human skins to develop allergic phenomena.

• 한국안전학회지
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• 제33권2호
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• pp.39-44
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• 2018

Dust explosions are occurring in a variety of industries. A dust explosion caused by a specific energy generates huge amount of energy in the ignition and releases decomposition gas. Damages can be increased since this released decomposition gas can cause second and subsequent explosions. In this study, the goal was to obtain practical information on what could affect the explosion by comparing the characteristics of two kinds of dusts with completely different chemical properties. Three kinds of dusts were measured and evaluated for explosion pressure, dust explosion index, explosion limit and minimum ignition energy. It is possible to grasp the characteristics of each dust and use it as useful accident prevention data in the production of raw material powder.

• 한국유가공학회:학술대회논문집
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• 한국유가공기술과학회 2002년도 제54회 춘계심포지움 - 우유와 국민건강
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• pp.45-55
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• 2002

Recent developments in the application of molecular biology to food grade lactic acid bacteria (LAB) have shown that it could be feasible to engineer metabolic pathways to either enhance specific metabolic fluxes or to divert metabolites for the production of different or new end products. This engineering requires detailed knowledge of enzymes involved in metabolism and regulation within the targeted organism but little works have been done in this area. During biochemical and molecular characterisation of lactic bacterial enzymes, some of probiotic Lactobacillus and Bifidobacterium species were found to be very useful for food, nutraceutical and pharmaceutical industries. The enzymes are usually intracellular and the yields are very low to be useful for industrial applications. Among many enzymes and proteins of lactic bacteria studied, some of our gene cloning achievements have contributed to overproduction of lactic bacterial enzymes such as peptidases, esterases, lactases, bile salt hydrolases and linoleate isomerases for foods and nutraceuticals.

• Journal of Nutrition and Health
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• 제30권6호
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• pp.727-732
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• 1997

Dietary supplements are generally defined as concentrated sources of nutrients prescribed in addition to the daily diet to increase nutrient intake. These supplements are usually in the form of tablets, capsules, pills, powders, or liquids. Sales of dietary supplements are roughly $4 billion per year in the United States. Nearly 4 out of every 10 adults use dietary supplements regularly. This article is to report the pros and cons in the use of dietary supplements and a brief overview of current law, proposed regulations, and related activities in the United States. It provides what information should be known to the public before federal regulations governing health claims are made . These regulations may decide whether health food industries or pharmaceutical companies can make claims about the function of nutrients.