• Journal of the Korean Mathematical Society
• /
• v.44 no.2
• /
• pp.327-342
• /
• 2007

In this paper, a kind of pest-predator model with impulsive effect and infinite delay is considered by the method of chain transform. By using Floquet's theorem, it is shown that there exists a globally asymptotically stable periodic pest eradication solution when the impulsive period is less than or equal to some critical value which is a directly proportional function with respect to the population of release. Furthermore, it is proved that the system is permanent if the impulsive period is larger than some critical value. Finally, the results of the corresponding systems are compared, those results obtained in this paper are confirmed by numerical simulation.

• 한국디지털정책학회:학술대회논문집
• /
• 2004.11a
• /
• pp.39-53
• /
• 2004

Data production systems are generally very large, distributed and complex systems used for creating advanced (mainly statistical) reports. Typically, data is gathered periodically and then subsequently aggregated and separated during numerous production steps. These production steps are arranged in a specific sequence (workflow or production chain), and can be located worldwide. Today, a need for improving and automating methods of supervision for data production systems has been recognized. Supervision in this context entails planning, monitoring and controlling data production. Two significant approaches are introduced here for improving this supervision. The first is a 'closely-coupledd' approach (meaning direct communication between production jobs and supervisory tool, informing the supervisory tod immediately about delays in production) - based upon traditional production planning methods typically used for manufacturing (goods) and adopted for working with data production. The second is a 'loosely-coupled' approach (meaning no direct communication between supervisory tool and production jobs is used) - having its origins in proven traditional project management. The supervisory tool just enquires continuously the progress of production. In both cases, dates, costs, resources, and system health information is made available to management. production operators and administrators to support a timely and smooth production of periodic data. Both approaches are theoretically described and compared. The main finding is that, both are useful, but in different cases. The main advantages of the closely coupled approach are the large production optimisation potential and a production overview in form of a job execution plan, whereas the loosely coupled method mainly supports unhindered job execution and offers a sophisticated production overview in form of a milestone schedule. Ideas for further research include investigation of other potential approaches and theoretical and practical comparison.

• Korean Journal of Ecology and Environment
• /
• v.37 no.3 s.108
• /
• pp.304-312
• /
• 2004

The transient dynamics of three-trophic populations (prey, predator, and super predator) using ratio-dependent models responding to environmental impacts is analyzed. Environmental factors were divided into two parts: periodic factor (e.g., temperature) and general noise. Periodic factor was addressed as a frequency and bias, while general noise was expressed as a Gaussian distribution. Temperature bias ${\varepsilon}$, temperature frequency ${\Omega}$, and Gaussian noise amplitude ${\`{O}}$ accordingly revealed diverse status of population dynamics in three-trophic food chain, including extinction of species. The model showed stable limit cycles and strange attractors in the long-time behavior depending upon various values of the parameters. The dynamic behavior of the system appeared to be sensitive to changes in environmental input. The parameters of environmental input play an important role in determining extinction time of super predator and predator populations.

• 제어로봇시스템학회:학술대회논문집
• /
• 2004.08a
• /
• pp.1859-1864
• /
• 2004

An effective methodology is reported for the optimal design of multisite batch production/transportation and storage networks under uncertain demand forecasting. We assume that any given storage unit can store one material type which can be purchased from suppliers, internally produced, internally consumed, transported to or from other plant sites and/or sold to customers. We further assume that a storage unit is connected to all processing and transportation stages that consume/produce or move the material to which that storage unit is dedicated. Each processing stage transforms a set of feedstock materials or intermediates into a set of products with constant conversion factors. A batch transportation process can transfer one material or multiple materials at once between plant sites. The objective for optimization is to minimize the probability averaged total cost composed of raw material procurement, processing setup, transportation setup and inventory holding costs as well as the capital costs of processing stages and storage units. A novel production and inventory analysis formulation, the PSW(Periodic Square Wave) model, provides useful expressions for the upper/lower bounds and average level of the storage inventory. The expressions for the Kuhn-Tucker conditions of the optimization problem can be reduced to two sub-problems. The first yields analytical solutions for determining lot sizes while the second is a separable concave minimization network flow subproblem whose solution yields the average material flow rates through the networks for the given demand forecast scenario. The result of this study will contribute to the optimal design and operation of large-scale supply chain system.

• Nutrition Research and Practice
• /
• v.9 no.4
• /
• pp.343-349
• /
• 2015

BACKGROUND/OBJECTIVES: Fermentation of dietary fiber results in production of various short chain fatty acids in the colon. In particular, butyrate is reported to regulate the physical and functional integrity of the normal colonic mucosa by altering mucin gene expression or the number of goblet cells. The objective of this study was to investigate whether butyrate modulates mucin secretion in LS174T human colorectal cells, thereby influencing the adhesion of probiotics such as Lactobacillus and Bifidobacterium strains and subsequently inhibiting pathogenic bacteria such as E. coli. In addition, possible signaling pathways involved in mucin gene regulation induced by butyrate treatment were also investigated. MATERIALS/METHODS: Mucin protein content assay and periodic acid-Schiff (PAS) staining were performed in LS174T cells treated with butyrate at various concentrations. Effects of butyrate on the ability of probiotics to adhere to LS174T cells and their competition with E. coli strains were examined. Real time polymerase chain reaction for mucin gene expression and Taqman array 96-well fast plate-based pathway analysis were performed on butyrate-treated LS174T cells. RESULTS: Treatment with butyrate resulted in a dose-dependent increase in mucin protein contents in LS174T cells with peak effects at 6 or 9 mM, which was further confirmed by PAS staining. Increase in mucin protein contents resulted in elevated adherence of probiotics, which subsequently reduced the adherent ability of E. coli. Treatment with butyrate also increased transcriptional levels of MUC3, MUC4, and MUC12, which was accompanied by higher gene expressions of signaling kinases and transcription factors involved in mitogen-activated protein kinase (MAPK) signaling pathways. CONCLUSIONS: Based on our results, butyrate is an effective regulator of modulation of mucin protein production at the transcriptional and translational levels, resulting in changes in the adherence of gut microflora. Butyrate potentially stimulates the MAPK signaling pathway in intestinal cells, which is positively correlated with gut defense.

• Journal of Institute of Control, Robotics and Systems
• /
• v.10 no.6
• /
• pp.537-544
• /
• 2004

An effective methodology is reported for determining the optimal lot size of batch processing and storage networks which include uncertain demand forecasting. We assume that any given storage unit can store one material type which can be purchased from suppliers, internally produced, infernally consumed, transported to or from other sites and/or sold to customers. We further assume that a storage unit is connected to all processing and transportation stages that consume/produce or move the material to which that storage unit is dedicated. Each processing stage transforms a set of feedstock materials or intermediates into a set of products with constant conversion factors. A batch transportation process can transfer one material or multiple materials at once between sites. The objective for optimization is to minimize the probability averaged total cost composed of raw material procurement, processing setup, transportation setup and inventory holding costs as well as the capital costs of processing stages and storage units. A novel production and inventory analysis formulation, the PSW(Periodic Square Wave) model, provides useful expressions for the upper/lower bounds and average level of the storage inventory. The expressions for the Kuhn-Tucker conditions of the optimization problem can be reduced to two sub-problems. The first yields analytical solutions for determining lot sires while the second is a separable concave minimization network flow subproblem whose solution yields the average material flow rates through the networks for the given demand forecast scenario. The result of this study will contribute to the optimal design and operation of the global supply chain.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.20 no.4
• /
• pp.1-13
• /
• 2017

The purpose of this study is to analyze a term of decade of water quality data of the Mulgum intake station on the Nakdong river(dam) to find the cause of algal blooms and to set an alternative to prevent artificial lake water pollution. Our study shows that water quality changes have regular periodic regularity and there was a certain correlation between specific analytical items. According to the analysis results of each factor, the decline in precipitation was not the main reason for algal blooms. TP concentration had a slight effect on Chl-a concentration but was not a limiting nutrient of a bloom. TN concentration had a strong correlation with Chl-a and strongly negative correlation with temperature, but was not a bloom's limiting nutrient, and was only a dependent variable. As the temperature was negatively correlated with the Chl-a concentration, it is found that the aspect of the ecological influence of the temperature was the most important factor of the phytoplankton concentration change. The N/P ratio lies under a power function with a high degree of reliability by the TP concentration, and the phenomenon appeared to be the same as the results of two other comparative areas. This result confirms that TN is dependent on TP and the biota in the lake that TN is a dependent variable whose concentration is determined by TP it. In conclusion, the increase in lake bloom is the result of a food chain change, and it is necessary to control the ecosystem by the food chain in the lake in order to reduce the lake's bloom. In particular, it is important to keep the benthic ecosystem as wide as possible in the aerobic state.

• Journal of the Society of Naval Architects of Korea
• /
• v.53 no.3
• /
• pp.237-248
• /
• 2016

As OPB and IPB moment-induced fatigue damage on mooring chain links were reported for a offloading buoy, verification of OPB and IPB fatigue has been a key engineering item in offshore structure mooring design. Mathematical and physical features of the conventional approach which was mainly explained in BV guideline are reviewed and disadvantages of the conventional approach are addressed in terms of stress proportionality and nonlinearity of OPB and IPB moments. In order to eradicate these disadvantages, a novel approach is newly proposed which is able to dispel apprehension on stress proportionality and is not dependent of nonlinearities of OPB and IPB moments. Significant differences between two approaches are suggested by comparing relations of OPB moment versus OPB interlink angle and IPB moment versus IPB interlink angle. For periodic OPB tension angle processes having three different OPB angle ranges with a simple irregular tension process, fatigue damage calculation reveals that OPB moment-induced fatigue damage has dominant portion to total fatigue damage. Comparative studies between two approaches also show that the conventional approach based on BV guideline predicts fatigue damage far conservatively since it assume unrealistic high stress concentration factor for tension load. Meanwhile IPB moment-induced fatigue damage is negligible compared to tension-induced fatigue damage.

• Journal of the Korean Operations Research and Management Science Society
• /
• v.31 no.1
• /
• pp.91-103
• /
• 2006

Given a bill of materials (BOM) tree T labeled by the breadth first search (BFS) order from node 0 to node n and a general network ${\Im}=(V,A)$, where V={1,2,...,m} is the set of production facilities and A is the set of arcs representing transportation links between any of two facilities, we assume that each node of T stands for not only a component. but also a production stage which is a possible stocking point and operates under a periodic review base-stock policy, We also assume that the random demand which can be achieved by a suitable service level only occurs at the root node 0 of T and has a normal distribution $N({\mu},{\sigma}^2)$. Then our integrated model of facility location problems and safety stock optimization problem (FLP&SSOP) is to identify both the facility locations at which partitioned subtrees of T are produced and the optimal assignment of safety stocks so that the sum of production cost, inventory holding cost, and transportation cost is minimized while meeting the pre-specified service level for the final product. In this paper, we first formulate (FLP&SSOP) as a nonlinear integer programming model and show that it can be reformulated as a 0-1 linear integer programming model with an exponential number of decision variables. We then show that the linear programming relaxation of the reformulated model has an integrality property which guarantees that it can be optimally solved by a column generation method.

• Archives of Plastic Surgery
• /
• v.37 no.4
• /
• pp.477-480
• /
• 2010

Purpose: Ganglioneuromas are well-differentiated tumors derived from neuroectodermal neural crest cells. Although these tumors can occur anywhere along the sympathetic chain from the base of the skull to the pelvic cavity, they usually develop in the posterior mediastinum and retroperitoneum these tumors are rarely found in the cervical region. Method: We report the case of a 16-year-old male patient with neurofibromatosis type 1 who was admitted because of a palpable mass centrally located on the left side of the neck. A preoperative contrast-enhanced neck computed tomography image showed a low-density homogeneous mass on the parapharyngeal space along with marked displacement of the trachea and carotid vessels. Round and soft masses were also detected on both axillae. Results: The patient subsequently underwent complete excision of the neck mass via the transcervical approach. The mass was smooth and well encapsulated between the sternocleidomastoid muscle and the trachea. Further, the mass appeared to arise from the cervical sympathetic chain, which was preserved during surgery. Both the axillary masses were also excised. The histopathological findings were ganglioneuroma for the neck mass and neurofibroma for both the axillary masses. Conclusion: Cervical ganglioneuromas are rare tumors that present as enlarging parapharyngeal cervical masses in the oropharynx or neck. To our knowledge, a case of cervical ganglioneuroma associated with neurofibromatosis type 1 has never been reported. In patients with neurofibromatosis, multiple tumors may develop, and therefore periodic clinical and radiological follow-up is recommended. Further, repeated imaging analysis should be performed if the presence of another tumor is suspected.