• The Journal of Korean Society for Radiation Therapy
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• v.7 no.1
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• pp.15-31
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• 1995

The radiosurgery treatment is one time, non surgical approach to the treatment of patients with intracranial disorders whose conditions would be difficult or dangerous to treat with conventional sugical procedures. The LINAC based radiosurgery is based on the combination of multiple isocentric arc irradiation with small fields centered in the stereotactic target. The absorption of the beam in a tissue equivalent medium, such as water, as well as the uniformity, or profile, of the beam must be precisely documented. The beam characteristics and dosimetric measurememts of the 6MV X-ray beam from a ML-6M linear accelerator are examined. The percent depth dose (PDD) and beam profile (including flatness, symmetry and penumbra) is calibrated with the radiosurgery cone in water phantom. The cone is made of lead which size is from $10{\times}10mm{\phi}$ to $30{\times}30mm{\phi}$ All of these dosimetric measurements sufficiently characterized the beam to permit safe clinical use.

• The KIPS Transactions:PartB
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• v.15B no.6
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• pp.527-532
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• 2008

This paper proposes a novel approach to shadow detection from a single natural image regardless of orientation and type of light sources. This approach is based on the assumption that shadow brightness changes linearly, and the axiom that a region cast shadow on is darker than that not having shadow under the same environment. Firstly, candidates for shadow are extracted by preprocessing. Then, they are quantized to replace the similar values with a representative value because of the more quantization steps of a pixel brightness, the higher linear independency among the neighboring pixels. Finally, shadows are detected according to linear independency of shadow brightness based on the assumption. The experimental results showed the proposed approach can robustly detect umbra as well as self-shadow and penumbra cast on a single-colored background.

• Journal of The Korean Astronomical Society
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• v.32 no.1
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• pp.65-73
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• 1999

In this study we present a new improved nonlinear calibration method for vector magnetograms made by the Solar Flare Telescope of BOAO. To identify Fe I 6302.5 line, we have scanned monochromatic images of the line integrated over filter passband, changing the location of the central transmission wavelength of a Lyot filter. Then we obtained a filter-convolved line profile, which is in good agreement with spectral atlas data provided by the Sacramento Peak Solar Observatory. The line profile has been used to derive calibration coefficients of longitudinal and transverse fields, employing the conventional line slope method under the weak field approximation. Our improved nonlinear calibration method has also been used to calculate theoretical Stokes polarization signals with various angles of inclination of magnetic fields. For its numerical test, we have compared input magnetic fields with the calibrated ones, which have been derived from the new improved non-linear method and the conventional method respectively. The numerical test shows that the calibrated fields obtained from the improved method are consistent with the input fields, but not with those from the conventional method. Finally, we applied our new improved method to a dipole model which characterizes a typical field configuration of a single, round sunspot. It is noted that the conventional method remarkably underestimates the transverse field component near the inner penumbra.

• Journal of Korean Neurosurgical Society
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• v.55 no.3
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• pp.125-130
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• 2014

Objective : This study was conducted to elucidate neuroprotective effect of carnosine in early stage of stroke. Methods : Early stage of rodent stroke model and neuroblastoma chemical hypoxia model was established by middle cerebral artery occlusion and antimycin A. Neuroprotective effect of carnosine was investigated with 100, 250, and 500 mg of carnosine treatment. And antioxidant expression was analyzed by enzyme linked immunosorbent assay (ELISA) and western blot in brain and blood. Results : Intraperitoneal injection of 500 mg carnosine induced significant decrease of infarct volume and expansion of penumbra (p<0.05). The expression of superoxide dismutase (SOD) showed significant increase than in saline group in blood and brain (p<0.05). In the analysis of chemical hypoxia, carnosine induced increase of neuronal cell viability and decrease of reactive oxygen species (ROS) production. Conclusion : Carnosine has neuroprotective property which was related to antioxidant capacity in early stage of stroke. And, the oxidative stress should be considered one of major factor in early ischemic stroke.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.2
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• pp.46.2-46.2
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• 2018

The active region NOAA AR 12673 is the most flare productive active region in the solar cycle 24. On 2017 September 07, it produced an X1.3 flare, three M-class, and several C-class flares. We successfully observed several C-class flares from 16:50 UT to 22:00 UT using the 1.6m Goode Solar Telescope (GST; formerly NST) at Big Bear Solar Observatory (BBSO). The GST provides us with unprecedented high-resolution data of the Sun since 2009. Interestingly, we observed the active region in He I D3 and 10830 lines simultaneously. The data shows several interesting features: (1) D3 emission seems to be much weaker than 10830 emission around 21:29 UT; (2) a small loop seen in 10830 is moving upward and is brightened around 21:16 UT, but it is not clear in D3; (3) there are waves in the penumbra seen in 10830 line center; (4) there is a jet with twisting motion. In this presentation, we will give the results of our analysis and interpretations.

• Progress in Medical Physics
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• v.31 no.3
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• pp.63-70
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• 2020

Stereotactic radiosurgery is one of the most sophisticated forms of modern advanced radiation therapy. Unlike conventional fractionated radiotherapy, stereotactic radiosurgery uses a high dose of radiation with steep gradient precisely delivered to target lesions. Lars Leksell presented the principle of radiosurgery in 1951. Gamma Knife^® (GK) is the first radiosurgery device used in clinics, and the first patient was treated in the winter of 1967. The first GK unit had 179 cobalt 60 sources distributed on a hemispherical surface. A patient could move only in a single direction. Treatment planning was performed manually and took more than a day. The latest model, Gamma Knife^® Icon^TM, shares the same principle but has many new dazzling characteristics. In this article, first, a brief history of radiosurgery was described. Then, the physical properties of modern radiosurgery machines and physicists' endeavors to assure the quality of radiosurgery were described. Intrinsic characteristics of modern radiosurgery devices such as small fields, steep dose distribution producing sharp penumbra, and multi-directionality of the beam were reviewed together with the techniques to assess the accuracy of these devices. The reference conditions and principles of GK dosimetry given in the most recent international standard protocol, International Atomic Energy Agency TRS 483, were shortly reviewed, and several points needing careful revisions were highlighted. Understanding the principles and physics of radiosurgery will be helpful for modern medical physicists.

• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.1016-1023
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• 2022

In proton therapy, a highly conformal proton dose can be delivered to the tumor by means of the steep distal dose penumbra at the end of the beam range. The proton beam range, however, is highly sensitive to range uncertainty, which makes accurately locating the proton range in the patient difficult. In-vivo range verification is a method to manage range uncertainty, one of the promising techniques being prompt gamma imaging (PGI). In earlier studies, we proposed gamma electron vertex imaging (GEVI), and constructed a proof-of-principle system. The system successfully demonstrated the GEVI imaging principle for therapeutic proton pencil beams without scanning, but showed some limitations under clinical conditions, particularly for pencil beam scanning proton therapy. In the present study, we upgraded the GEVI system in several aspects and tested the performance improvements such as for range-shift verification in the context of line scanning proton treatment. Specifically, the system showed better performance in obtaining accurate prompt gamma (PG) distributions in the clinical environment. Furthermore, high shift-detection sensitivity and accuracy were shown under various range-shift conditions using line scanning proton beams.

• Proceedings of the Korean Society of Medical Physics Conference
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• 2003.09a
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• pp.64-64
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• 2003

Objectives: Patient dose verification is clinically the most important parts in the treatment delivery of radiation therapy. The three dimensional(3D) reconstruction of dose distribution delivered to target volume helps to verify patient dose and determine the physical characteristics of beams used in intensity modulated radiation therapy(IMRT). We present Beam Intensity Scanner(BInS) system for the pre treatment dosimetric verification of two dimensional photon intensity. The BInS is a radiation detector with a custom made software for relative dose conversion of fluorescence signals from scintillator. Methods: This scintillator is fabricated by phosphor Gadolinium Oxysulphide and is used to produce fluorescence from the irradiation of 6MV photons on a Varian Clinac 21EX. The digitized fluoroscopic signals obtained by digital video camera will be processed by our custom made software to reproduce 3D relative dose distribution. For the intensity modulated beam(IMB), the BInS calculates absorbed dose in absolute beam fluence, which are used for the patient dose distribution. Results: Using BInS, we performed various measurements related to IMRT and found the followings: (1) The 3D dose profiles of the IMBs measured by the BInS demonstrate good agreement with radiographic film, pin type ionization chamber and Monte Carlo simulation. (2) The delivered beam intensity is altered by the mechanical and dosimetric properties of the collimating of dynamic and/or static MLC system. This is mostly due to leaf transmission, leaf penumbra, scattered photons from the round edges of leaves, and geometry of leaf. (3) The delivered dose depends on the operational detail of how to make multileaf opening. Conclusions: These phenomena result in a fluence distribution that can be substantially different from the initial and calculative intensity modulation and therefore, should be taken into account by the treatment planing for accurate dose calculations delivered to the target volume in IMRT.

• Progress in Medical Physics
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• v.14 no.1
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• pp.1-7
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• 2003

In this work we developed a EGS4 control code to calculate the dose distributions for high energy electron beams in water phantom applied longitudinal magnetic field. We reviewed the electron's motion in magnetic field and delivered equations for direction changs of the electron by the external magnetic field. The mathematical results are inserted into the EGS4 code system to account for the presence of external magnetic fields in phantom. The electron pencil beam paths of 6 MeV in water phantom are calculated for magnetic fields of 1-3 T and the dose distributions for a field of 1.0 cm in diameter are calculated for magnetic fields of 0.6-1 T using the code. From the results of path calculations we found that the lateral ranges of the electrons are reduced in the magnetic field of 3 T. For a field of 1 cm diameter and a magnetic field of 1 T, the small dose enhancement near the range of the electrons on the depth dose and the penumbra reduction of 0.15 cm on the beam profile are observed. We discussed and evaluated the results from the theoretical concepts.

• The Journal of Korean Society for Radiation Therapy
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• v.8 no.1
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• pp.29-35
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• 1996

We are often faced with the clinical situations that is inevitably extended SSD for electron beam therapy due to anatomical restriction or applicator structure. But there are some difficulties in accurately predicting output and properties. In electron beam treatment , unlike photon beam the decrease in output for extended SSD does not follow inverse-square law accurately because of a loss of side scatter equilibrium, which is particularly significant for small cone size and low energies. The purpose of our study is to analyze the output in changing with the energy, cone size, air gap beyond the standard SSD and to compare inverse-square law factor derived from calculated effective SSD, mominal SSD with measured output factor. In addition, we have analyzed the change of PDD for several cones with different SSDs which range from 100cm to 120cm with 5cm step and with different energies(6MeV, 9MeV, 12MeV, 16MeV, 20MeV). In accordance with our study, an extended SSD produces a significant change in beam output, negligible change in depth dose which range from 100cm to 120cm SSDs. In order to deliver the more accurate dose to the neoplastic tissue, first of all we recommend inverse-square law using the table of effective SSDs with cone sizes and energies respectively or simply to create a table of extended SSD air gap correction factor. The second we need to have an insight into some change of dose distribution including PPD, penumbra caused by extended SSD for electron beam therapy.