• Proceedings of the Korean Society of Life Science Conference
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• 2008.10a
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• pp.93.2-93.2
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• 2008

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2002.11a
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• pp.139-140
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• 2002

반 휘발성 유기화합물(Semivolatile organic compounds; 이하 SOCs)은 높은 중기압과 낮은 반응성 때문에 지구 전역에 폭넓게 존재하고 있다. SOCs중 Polychlorinatd Biphenyls(이하 PCBs)는 난분해성 및 친지질성에 특성으로 환경중에서 순환하기 때문에 최근 들어 맡은 관심의 대상이 되고 있다. 이들 대부분은 태초의 환경과 모든 matrix(예, 토양, 식물, 대기, 수계 등)에서 발견되어 지고 있다 이처럼 PCBs는 독성 유발물질로 관리되고 있으며 먹이연쇄를 통해 생농축성(bioaccumulation)을 야기 시킬 수 있다. (중략)

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2001.05a
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• pp.107-108
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• 2001

본 연구에서는 부산, 경남 주민의 중요한 식수원인 낙동강에 큰 영향을 미치고 있는 금호강을 대상으로 하여 난분해성 물질이며 내분비계 장애물질인 PCBs의 분포 상태를 조사하였다. 금호강 저니토에서의 PCBs 분석은 용매 추출법을 사용하였고 실리카 겔과 플로리실 칼럼을 통과시켜 정제한 다음 GC-ECD로 분석하였다. 모든 조사 지점에서 26개 congener가 고루 검출되어 있는 것으로 보아 금호강으로 유입되었던 PCBs의 종류는 다양했던 것으로 추정되고 금호강 유역의 저니토에 축적되어 있는 PCBs가 낙동강 하류로 유입될 수 있을 것으로 판단된다.

• JOURNAL OF ELECTRICAL WORLD
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• s.365
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• pp.42-45
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• 2007

• JOURNAL OF ELECTRICAL WORLD
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• s.355
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• pp.29-30
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• 2006

• Journal of Environmental Health Sciences
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• v.36 no.2
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• pp.118-127
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• 2010

Bivalve samples from 30 locations Korean coastal waters were analyzed to characterize the contamination with and distribution of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs). The congeners of PBDE in 30 bivalve samples were analyzed by high resolution gas chromatography with a high resolution mass detector. The levels of PBDEs in bivalve samples ranged from 0.092 to 13.5 ng/g wet weight. These values for PBDEs concentrations in bivalves from Korea were higher than or comparable to available values for bivalves from other countries. In the congener profiles, BDE-47 (mean contribution=42.2%) was predominant, followed by BDE-99 (23.1%), BDE-100 (11.9%) and BDE-154 (3.5%). Among the OCs analyzed, $\Sigma$PCBs and $\Sigma$DDTs levels were highest, followed by $\Sigma$HCHs, $\Sigma$CHLs and HCB. The wet weight based $\Sigma$PCBs and $\Sigma$DDTs ranged from 0.28 ng/g to 19.4 ng/g, and from 0.19 ng/g to 4.86 ng/g, respectively. The $\Sigma$PCBs and $\Sigma$DDT slevels in bivalves along the entire Korean coast were lower than those of the USA, and below the Food and Drug Administration (USA. FDA) limits for fish and shell fish. However, the human health criteria and wild life criteria of the USA. Environmental Protection Agency (USA. EPA) were exceeded for DDE and $\Sigma$HCHs at most of the sampling points.

• Toxicological Research
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• v.28 no.2
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• pp.107-112
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• 2012

Polychlorinated biphenyls (PCBs) are persistent and bioaccumulative environmental pollutants. Recently, it is suggested that neurotoxic effects such as motor dysfunction and impairment in memory and learning have been associated with PCB exposure. However, structure relationship of PCB congeners with neurotoxic effects remains unknown. Since PKC signaling pathway is implicated in the modulation of motor behavior as well as learning and memory and the role of PKC are subspecies-specific, we attempted to study the effects of structurally distinct PCBs on the total PKC activity as well as subspecies of PKC in cerebellar granule cell culture model. Cells were exposed to 0, 25 and 50 ${\mu}M$ of PCB-126, PCB-169, PCB-114, PCB-157, PCB-52 and PCB-4 for 15 min. Cells were subsequently analyzed by [$^3H$] phorbol ester binding assay or immunoblotted against PKC-${\alpha}$ and -${\varepsilon}$ monoclonal antibodies. While non-dioxin-like-PCB (PCB-52 and PCB-4) induced a translocation of PKC-${\alpha}$ and -${\varepsilon}$ from cytosol to membrane fraction, dioxin-like PCBs (PCB-126, -169, -114, -157) had no effects. [$^3H$] Phorbol ester binding assay also revealed structure-dependent increase similar to translocation of PKC isozymes. While PCB-4 induced translocation of PKC-${\alpha}$ and -${\varepsilon}$ was inhibited by ROS inhibitor, the pattern of translocation was not affected in presence of AhR inhibitor. It is suggested that PCB-4-induced PKC activity may not be mediated via AhR-dependent pathway. Taken together, our findings suggest that chlorination of ortho-position in PCB may be a critical structural moiety associated with neurotoxic effects, which may be preferentially mediated via non-AhR-dependent pathway. Therefore, the present study may contribute to understanding the neurotoxic mechanism of PCBs as well as providing a basis for establishing a better neurotoxic assessment.

• Journal of Preventive Medicine and Public Health
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• v.45 no.2
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• pp.62-69
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• 2012

Objectives: Chronic inflammation is now thought to play a key pathogenetic role in the associations of obesity with insulin resistance and diabetes. Based on our recent findings on persistent organic pollutants (POPs) including the lack of an association between obesity and either insulin resistance or diabetes prevalence among subjects with very low concentrations of POPs, we hypothesized that POP concentrations may be associated with inflammation and modify the associations between inflammation and insulin resistance in non-diabetic subjects. Methods: Cross-sectional associations among serum POPs, C-reactive protein (CRP), and homeostasis model assessment of insulin resistance (HOMA-IR) were investigated in 748 non-diabetic participants aged ${\geq}20$ years. Nineteen types of POPs in 5 subclasses were selected because the POPs were detectable in ${\geq}60%$ of the participants. Results: Among the five subclasses of POPs, only organochlorine (OC) pesticides showed positive associations with CRP concentrations, while polychlorinated biphenyls (PCBs) showed inverse associations with CRP concentrations. There were statistically significant interactions between CRP and OC pesticides and between CRP and PCBs, in estimating HOMA-IR (P for interaction <0.01 and <0.01, respectively). CRP was not associated with HOMA-IR among subjects with low concentrations of OC pesticides or PCBs, while CRP was strongly associated with HOMA-IR among subjects with high concentrations of these POPs. Conclusions: In the current study, OC pesticides were associated with increased levels of CRP, a marker of inflammation, and both OC pesticides and PCBs may also modify the associations between CRP and insulin resistance.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.11
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• pp.1228-1237
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• 2005

In order to predict the long-term effects of pollutants in sediment on the water quality and the improvement of water quality according to dredging operation, models applied to decide the location and the propriety of dredging were developed. At first, the area was divided into several segments and the developed model was applied to simulate the behaviors of contaminants in an aquatic environment by using estimated parameters. And then through the sensitivity analysis between parameters, the optimum values were determined. The long-term modelling in the area A forecasted that PCBs concentration in the hot spot was decreased from $3.1\;{\mu}g/L$ to $2.4\;{\mu}g/L$ in 30 years. Contaminants in sediment as a source of water pollution did not reduce remarkably in the long run. Therefore it is difficult to expect the improvement of water qualities without the fundamental isolation of contaminants from sediment. It is considered that the selective dredging in the spot improves the water quality consequently.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.36 no.3
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• pp.283-289
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• 2003

The effect on kidney, gill, and hepatopancreas of juvenile olive flounder, Paralichthys olivaceus were investigated by histological method under limit concentration of effulent of PCBs for 60 days. The free surface of epithelial cell layer in the renal tubules of kidney showed a strong positive reaction in alcian blue during all exposure period. There were also observed swelling of hemocyte in glomerulus and macrophage. At 60 days after exposure, epithelium of the renal tubules was fused and some of organism $(20\%)$ showed damage of glomerulus and eosinophlic cell in epithelium of the renal tubules. The phenomena such as the activation and increase of the chloride cell, and swelling of hemocyte in the capillary of gill were observed during all exposure period. At 60 days after exposure, swelling of the gill filament and mucous cell appeared in gill and some of organism $(30\%)$ showed swelling of the gill lamellar. Swelling of hemocyte in the capillary of hepatopancreas was observed and the free surface of epithelial layer of the bile duct showed positive reaction in alcian blue during all exposure period. Degenerated zymogen in the pancreas and swelling of the hepatocyte were occurred at 60 days after exposure.