• 대한화장품학회지
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• 제30권4호
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• pp.533-541
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• 2004

아토피 피부염은 다른 말로 태열이라고도 하며, 유아 시기에서부터 성인까지 광범위한 연령층에 병변의 특징적인 분포 그리고 개인적 혹은 가족적인 병력을 가진 특히 유전적 소인을 보이는 질환으로 심한 가려움증과 건조증 등을 동반하는 일종의 재발성, 만성의 알레르기성 습진을 말한다. 그 유병율은 매우 흔하여 어린이의 약 $9~12\%$ 에서발생한다. 그러나 최근에는 사회 자연환경의 변화와 음식문화의 변화, 삶의 방식의 변화에 의해서 계속 증가하는 추세를 보이고 있다. 인간의 피부는 외부 환경으로부터의 물리적, 화학적 자극에 대한 장벽기능의 역할을 하는데 아토피 피부염 환자의 피부는 각질층에서의 피부 장벽기능 및 수분유지 기능이 감소되어 있고 이러한 기능 장애의 원인으로 최근 연구에 의하면 세라마이드의 감소에 따른 것으로 밝혀지고 있다. 세라마이드는 스핑고신에 지방산이 연결되어 있는 구조를 가지고 있는 스핑고 지질의 일종이다. 세라마이드는 피부 각질층을 구성하는 각질세포간 지질 중 약 $40\%$를 차지하며, 수분 증발을 억제하는 지질 방어벽 역할과 각질층의 정연한 구조를 유지하게 하는 기능을 가지고 있다. 피부 각질층은 각화된 세포가 벽돌모양의 다층 구조로 구성되어 있으며 이러한 각화세포는 세라마이드, 콜레스테롤, 유리 지방산에 의해 견고히 결합되어 있다 따라서 이 세라마이드가 함유된 크림이나 연고를 아토피 피부염 환자에 도포함으로써 환자의 피부 장벽기능의 복구에 도움을 주어 아토피 피부염을 치료할 수 있다는 보고가 있다. 본 연구는 아토피 피부염 전용화장품으로서 아토피 피부에서 피부장벽을 복구하는데 기여한다고 증명된 각질 세포간 지질 성분들(세라마이드, 콜레스테롤, 유리지방산)을 포함하는 유액제품과 피부 면역조절과 항 염증 효과가 있다고 보고된 베타글루칸, 신이화 추출물 감초 추출물 등을 포함하는 세럼형태의 액상제품으로 구성된 두 가지 제품을 아토피 피부염 환자에게 도포하게 하여 그 제품의 안전성과 유효성을 확인하여 보았다. 그리고 그 제품이 새로운 시장인 아토피 피부염 전용 보습화장품으로서의 시장진입 가능성을 확인하여 보았다.

• Journal of Gastric Cancer
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• 제9권4호
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• pp.215-222
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• 2009

목적: 원위부 위절제술 후 재건술의 하나인 Billroth II 위공장문합술은 오랫동안 사용되어온 방법이나 역류성 위염의 빈도가 높다는 것이 문제점 중의 하나이다. 이를 보완하기 위한 여러 시도가 있었으나 그 중 잔위의 크기에 따라 Roux-en-Y 위공장문합술, Braun 공장문합술 및 Billroth II 위공장문합술을 달리 시행한 후 그 적용의 적합성을 알아보고자 하였다. 대상 및 방법: 2003년 9월부터 2007년 4월까지 하부 및 중위 위선암으로 단일 술자에 의해 원위부 위절제를 받은 후 잔위의 크기가 10% 이하일 때 Roux-en-Y 위공장문합술 (14명)을, 잔위가 10~20%일 때 Braun 공장문합술(17명)을, 잔위가 20~40%일 때 Billroth I이 부적합하다고 판단된 경우 - Billroth II 위공장문합술(14명)을 시행 후, 각각의 치료성적을 분석하였다. 분석 방법은 전화 설문과 의무기록을 조사하여 환자의 증상 및 내시경 소견을 평가하였고 술 후 영양 상태를 평가하기 위하여 혈중알부민, 혈색소농도 및 체중의 변화를 측정하였다. 결과: 수술 사망률 0%, 수술 합병률 8.9% (4/45)로 모든 수술은 안전하게 시행되었다. 내시경 소견에서 역류성 위염은 Roux-en-Y군, Braun군 및 Billroth II군에서 각각 7.63%, 18.65%, 40.0%에서 보였다(P=0.13). 가벼운 역류성 식도염이 Roux-Y군과 Braun군에서 각각 1명씩 있었다. 내시경적 위저류는 Roux-en-Y군에서 2예가 보였으며 이 중 1예는 역류성식도염의 원인이 되었다. Roux-en-Y군과 Braun군이 Billroth II 군보다 식사량의 감소가 적었으며(각각 7.1%, 0.0%, 28.7%, P=0.036), 식후 불편감(각각 14.3%, 23.5%, 57.1%, P=0.035)과 역류 증상(각각 0.0%, 11.8%, 42.9%, P=0.009)을 적게 호소하였다. 결론: 작은 잔위를 가지는 환자에서 시행된 Roux-en-Y 위공장문합술과 Braun 공장문합술은 역류증상의 방지와 위절제 후 불편감을 줄이는데 효과적이라고 생각하며, 10% 미만의 잔위에서는 Roux-en-Y를, 그 외의 경우에는 Braun 문합을 확대적용을 고려하는 것이 좋겠다.

• 동의생리병리학회지
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• 제23권1호
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• pp.1-6
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• 2009

Many of our contemporaries suffer from the symptoms of phlegm-fire, which is caused by stress, processed food, heavy diet, and unseasonal fruits and vegetables. With consultations from 'Euihaklpmoon', 'DongeuiBogham', and 'Ji-San's clinical lectures' this research, which is mainly focused on phlegm-fire, concluded as following. Phlegm-fire is caused by congestion of seven emotions, congestion of qi, complication of phlegm on fire, depletion of body fluids after long periods of disease, heavy diet, or congenital unbalance of yin-yang and qi-hyul. Concentration of phlegm-fire on the head causes headache, dizziness, frontal headache, tinnitus, and auditory dysfunction. The patient usually complains breaking pain. Dhamhwabang of Yijin-tang, Chunghoonhwadham-tang, and Yijin-tang variation for right headache can be used. Concentration of phlegm-fire on the thorax causes insomnia, palpitation, and insanity. Samhoohndham-tang variation, Chungsimgondhanhwan can be used. Concentration of phlegm-fire on the gastric region causes reflux of gastric acid, eructation, vomiting, abdominal discomfort, dysmenorrhea, and fluor gentalis. Yijin-tang variation for abdominal discomfort, Yanghyulsamul-tang, Hwadhamchunghwa-tang can be used. Shin type or Gi type, female with prevalence of qi and tendency of fire, female with dark facial color, female with raised eye tails and large noses, female with pointed noses, and male or female with large noses and mouths are likely to possess phlegm-fire. Abdominal discomfort of male with thick eyebrow and headache of Gi type female is usually caused by phlegm-fire.

• Journal of Pharmaceutical Investigation
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• 제39권3호
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• pp.207-216
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• 2009

Fluconazole is used as an orally administrated antifungal drug for the treatment of tinea corporis, candidiasis including skin mycotic pneumonia infections. The dosage of fluconazole varies with indication ranging from 50 mg/day to 400 mg/day. The fluconazole capsule 50 mg (3 capsules daily) is already available in Korean market. To improve the patient compliance, a fluconazole tablet 150 mg (once a day administration) was developed recently. The purpose of this study was to evaluate the bioequivalence of three doses of fluconazole capsule 50 mg (Diflucan 50 mg, Pfizer Korea Inc., as a reference drug) and a single dose of fluconazole tablet 150 mg (Plunazol 150 mg, Daewoong Pharm. Co., Korea) according to the guidelines of the Korea Food and Drug Administration (KFDA). The bioequivalence for three capsules of Diflucan 50 mg and a single tablet of Plunazol 150 mg was investigated in twenty-four healthy male volunteers under a randomized 2${\times}$2 crossover trial design. The average age of twenty-four volunteers was 24.78${\pm}$3.27 year-old, average height was 175.56${\pm}$5.45 cm and average weight was 67.24${\pm}$6.86 kg. After three capsules of Diflucan 50 mg or a single tablet of Plunazol 150 mg were orally administered, blood was taken at predetermined time intervals and the plasma concentrations of fluconazole in plasma were determined using LC-MS-MS. The 90% confidence intervals for the main parameters of statistical results after logarithmic transformation were AUCt 0.9272-1.0084 and Cmax 0.8423-0.9544 respectively, which are in the range of log 0.8 to log 1.25 and the statistical results of additional parameters (AUClast, t1/2 and MRT) were also in the 90% confidence interval that is in the range of log 0.8 to log 1.25. Therefore, the results of this study confirm the bioequivalence of three capsules of Diflucan 50 mg to one tablet of Plunazol 150 mg.

• 한국환경보건학회지
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• 제46권4호
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• pp.433-443
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• 2020

Objective: This study aimed to introduce the use of humidifier disinfectant (HD) in hospitals based on an on-site investigation. Methods: A preliminary survey and on-site investigation of HD use were conducted in 23 hospitals. Among them, one hospital without previous information on HD use was selected for a pilot investigation; 22 hospitals were selected based on previous documents and exposure statements from parliamentary investigation and exposure assessment regarding HD. Descriptive statistics were used to present distribution and characteristics of HD purchase and HD use in hospitals. Also, details on interviews from the on-site investigation were described. Results: Among the 23 hospitals, a total of ten were confirmed to have purchased and used an HD (nine hospitals) or HD-like product (one hospital). For the purchased HD products, four hospitals reported 'Aekyung Gaseupgi Mate', two hospitals reported 'Oxy Ssakssak New Gaseupgi Dangbun', and one hospital reported 'Homeplus Gaseupgi Chungjungje' (one hospital used three kinds of HD products). One hospital reported an HD-like product and four hospitals were 'Unknown'. For the number of HD products purchased, five hospitals reported '100 or less', two hospitals reported 'More than 100', and three hospitals were 'Unknown'. For each of the ten hospitals, we described detailed characteristics of HD purchase and its exposure status obtained through on-site investigation, including the purchase volume (i.e., number of products), exposure space (i.e., patient's room, staff space), and exposure period. Additionally, a comparison of on-site investigation and parliamentary investigation or exposure assessment regarding HD was reported. Conclusion: This study introduced detailed cases of HD purchase and HD use in hospitals based on an on-site investigation, and our findings revealed a possibility of a considerable volume of HD exposure in various multiuse facilities, including hospitals.

• Journal of Preventive Medicine and Public Health
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• 제2권1호
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• pp.77-80
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• 1969

In the cities nowadays, the dwelling conditions of Cackroach are provided by use of various kinds of construction material, installation of heating and cooling facilities that maintain moderate temperature, filthy sanitation, and lack of knowledge about insect as mechanical Vector. Cakroach is infectious disease Vector, and it proves to be of much importance in the public health. Considering such importance, the author has surveyed the distribution of Cackroach in the housing areas of Seoul City from May 1969 to the end of August 1969, and has come to the following conclusion: 1. House dwelling Cackroach collected in the City of Seoul are of two species, i. e. Blatella Germanica Linneaus and Periplaneta Japonica Karny. 2. Most of cackroach collected in Seoul are Blatella Germanica Linneaus and they are distributed in whole area of Seoul while that of Periplaneta Japonica Karny is distributed only in the limited area. 3. Dwelling places of Blatella Germanica Lineaus are in grog shop, Korean food restaurants, bakery shops, and patient rooms in hospitals. Many of them are found in tile kitchens and dining rooms of restaurants, and tearooms. They live in groups at older houses with much crack, warm and humid places. 4. For method of collection, the hand collection was the most effective. In trap collection during the day time, when the trap is placed at the narrow corners off the ground after confirming the dwelling places of cackroach, the match trap was more effective than the flask trap in collecting. In case of collecting during the night time, the flask trap was much more effective method than the match trap.

• 구강회복응용과학지
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• 제36권1호
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• pp.12-20
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• 2020

목적: 본 연구는 일반 인구의 대표 표본에서 우울증의 발현과 심각도, 씹기 불편감 사이의 관계를 분석하였다. 연구 재료 및 방법: 전국 대표 표본(n = 8150)을 대상으로 하였으며, 씹기 불편감은 해당 문제에 관한 설문 조사에 응답한 사람들로 정의하였다. 우울증은 PHQ-9 설문 조사에서 총 점수가 10점 이상인 대상자로 정의하였다. 인구 통계, 사회적 경제적 특성 및 동반 질환에 관한 데이터를 포함하여 다중 로지스틱 회귀 분석을 수행하고 분석하였다. 결과: 한국인의 경우 씹기 불편감이 없는 사람(10.2%)보다 씹기 불편감이 있는 사람(17.2%)에서 우울증의 유병률이 유의하게 더 높았다. 다변량 로지스틱 회귀 분석에서 우울증의 존재는 CP와 유의하게 관련 있었다(adjusted odd ratio [aOR]: 1.90, P < 0.001). 씹기 불편감의 위험은 우울증의 심각도가 증가함에 따라 증가하였다: 중증 우울증(OR: 2.62, P < 0.001), 중등도 우울증(OR: 2.19, P < 0.001). 결론: 중증 우울증을 보이는 개인에서 우울증의 공존여부가 씹기 불편감과 상당히 연관되었다. 씹기 불편감 환자 치료에 있어 우울증의 선별검사가 고려되어야 한다.

• 한국환경보건학회지
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• 제39권3호
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• pp.239-246
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• 2013

Objectives: Antimicrobial resistance and multidrug resistance patterns have been studied with a total of 189 samples of Salmonella Enteritidis and Salmonella Typhimurium isolated from diarrhea patients in Incheon from 2008 to 2012. Methods: Antimicrobial resistance tests were determined by Disc Diffusion method. Results: The serological distribution of Salmonella spp. showed 108 strains (30.1%) of S. Enteritidis, 81 strains (22.6%) of S. Typhimirium, eight strains (8.0%) of S. Typhi, 11 strains ( 3.1% ) of S. Paratyphi, and the 151 other strains (42.1%). The separation rate of Salmonella spp. by year showed 14.5% (52 strains) in 2008, 13.6% (49 strains) in 2009, 22.8% (82 strains) in 2010, 25.3% (91 strains) in 2011, and 23.7% (85 strains) in 2012. Additionally, the separation rate of S. Enteritidis and S. Typhimirium in 2010 was the highest. The Salmonella spp. isolated from diarrhea patients showed significant differences according to age (p<0.05), gender (p<0.01) and medical institution (p<0.05). The highest resistance was found to the following antimicrobial agents: imipenem 77 strains, ampicillin 47 strains, ciprofloxacin 34 strains, nalidixic acid 29 strains for S. Enteritidis, and ampicillin 45 strains, nalidixic acid 45 strains for S. Typhimurium. Separated S. Enteritidis and S. Typhimurium resistance to the antibiotics by the year showed significant differences (p<0.05). The patterns of multidrug resistance rates were 43.1% (47 strains) for one drug, 8.3% (9 strains) for two drugs, 11.0% (12 strains) for three drugs, 15.62% (17 strains) for four drugs, and 13.7% (15 strains) for five or more drugs for S. Enteritidis. For S. Tyhpimurium, the rates were 15.0% (12 strains) for one drug, 10.0% (8 strains) for two drugs, 6.3% (five strains) for three drugs, 18.7% (15 strains) for four drugs, and 23.8% (19 strains) for five or more drugs. Conclusion: The antibiotic resistance issue is directly related to people's lives. Thus, the usage of antibiotics should be reduced in order to manage antibiotic resistance.

• 대한약침학회지
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• 제18권4호
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• pp.26-31
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• 2015

Objectives: This study used semiology based on traditional Chinese medicine (TCM) to investigate vital energy (Qi) behavior in women with abdominal myofascial pain syndrome (AMPS). Methods: Fifty women diagnosed with chronic pelvic pain (CPP) secondary to AMPS were evaluated by using a questionnaire based on the theories of "yin-yang," "zang-fu", and "five elements". We assessed the following aspects of the illness: symptomatology; specific location of myofascial trigger points (MTrPs); onset, cause, duration and frequency of symptoms; and patient and family history. The patients tongues, lips, skin colors, and tones of speech were examined. Patients were questioned on various aspects related to breathing, sweating, sleep quality, emotions, and preferences related to color, food, flavors, and weather or seasons. Thirst, gastrointestinal dysfunction, excreta (feces and urine), menstrual cycle, the five senses, and characteristic pain symptoms related to headache, musculoskeletal pain, abdomen, and chest were also investigated. Results: Patients were between 22 and 56 years old, and most were married (78%), possessed a elementary school (66%), and had one or two children (76%). The mean body mass index and body fat were 26.86 kg/cm2 (range: 17.7 - 39.0) and 32.4% (range: 10.7 - 45.7), respectively. A large majority of women (96%) exhibited alterations in the kidney meridian, and 98% had an altered gallbladder meridian. We observed major changes in the kidney and the gallbladder Qi meridians in 76% and 62% of patients, respectively. Five of the twelve meridians analyzed exhibited Qi patterns similar to pelvic innervation Qi and meridians, indicating that the paths of some of these meridians were directly related to innervation of the pelvic floor and abdominal region. Conclusion: The women in this study showed changes in the behavior of the energy meridians, and the paths of some of the meridians were directly related to innervation of the pelvic floor and abdominal region.

• Journal of Nutrition and Health
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• 제39권7호
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• pp.617-623
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• 2006

The mortality and morbidity rate of hemodialysis patients (HD) remain high. Among many factors, protein and calorie malnutrition has been shown to be a major risk factor for increased mortality in the HD patients population. Malnutrition can be caused by insufficient amino acid intake, nutrient losses in dialysate, oxidant stress and muscle catabolism. In this study, we evaluated the association of markers of nutritional status and essential amino acids intake in HD patients. We investigated nutritional status of 41 HD patients (mean age: $64.2\;{\pm}\;11.5\;y$, men: 24, women: 27) by measuring anthropometric, biochemical parameters and food intakes by using 24 hr recall methods. Subject's total energy intake and total protein intake were $1,648.0\;{\pm}\;397.31\;kcal/day,\;79.2\;{\pm}\;27.2\;g/day$:, respectively. The animal protein intake was $42.7\;{\pm}\;22.1\;g/day$, essential amino acids intake was $23.4\;{\pm}\;9.92\;g/day$, and the ratio of essential amino acids to total protein intake was $29.6\;{\pm}\;5.42%$. There were significantly positive correlation between muscle mass and lean body mass with serum creatinine level (r=0.435, p<0.01; r=0.435, p<0,01). There were also significant positive correlation in muscle mass and lean body mass with pre hemodialysis blood urea nitrogen (preHD BUN) (r=0.329, p<0.05; r=0.329, p<0.05). There were no significant correlation in total energy intake and total protein intake per kg ideal body weight (IBW) to muscle mass and lean body mass. However, there were significantly positive correlation between the ratio of essential amino acids and muscle mass and lean body mass (r=0.368, p<0.05; r=0.405, p<0.01). And serum hematocrit concentration was positively correlated with the ratio of essential amino acids (r=0.032, p<0.05). The results of this study indicate that strong associations exist in essential amino acid intakes with malnutrition than total protein intakes in HD patient. In conclusion, specialized nutrition education should be necessary to efficiently improve the quality of protein intakes.