• 한국임상약학회지
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• 제29권3호
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• pp.202-208
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• 2019

Objective: Suicide has recently become an important social problem. Thus, we analyzed prescription drugs that cause suicidal ideation. Methods: Of 156 drugs on the the Minister of Food and Drug Safty (MFDS) EZ-Drug site that had "suicide" listed as a side effect, 78 had "suicide" listed as a warning or contraindication; those 78 drugs were analyzed using data from the 2016 Health Insurance and Review and Assessment Services National Patient Sample (HIRA-NPS). Results: 51 "suicide risk" drugs was identified. Of all patients, 5.2% had received such drugs. The prescription rate was 0.8% of all prescriptions, accounting for 1.6% of all prescription days. From logistic regression analysis, the prescription rate for the drugs was approximately 1.1 times higher for women than for men. With regard to age, the prescription rate for patients 66 years and older was 15.5 times higher than those for patients 25-years and lower. With regard to medical departments, the prescription rates in psychiatry and dermatology departments were 8.1 times higher and 0.6 times lower than those in internal medicine departments, respectively. With regard to region, the prescription rates in Daegu and Jeju were 1.3 times higher and 0.79 times lower than those in Seoul, respectively. Conclusion: Drug-induced suicidal behavior is possible, and therefore efforts are needed to prevent it.

• Journal of Yeungnam Medical Science
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• 제38권3호
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• pp.175-182
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• 2021

Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare T-cell non-Hodgkin lymphoma characterized as CD30 positive and anaplastic lymphoma kinase (ALK) negative. In 2016, the World Health Organization declared BIA-ALCL as a new disease entity. The first case of BIA-ALCL was reported in 1997, and as of July 2019, the United States Food and Drug Administration had cited a total of 573 United States and global medical device reports of BIA-ALCL, including 33 deaths. In all clinical case reports, except for those with unknown clinical history, the patient had received at least one textured surface breast implant. Although the etiology is not yet clear, chronic inflammation has been proposed as a potential precursor to tumorigenesis. The most common presentation of BIA-ALCL is peri-implant fluid collection following aesthetic or reconstructive implantation with textured surface breast implants. It can be accompanied by breast swelling, asymmetry, pain, skin lesions, lymphadenopathy, and B-type symptoms. Most cases are detected on average 7 to 10 years after implantation. Diagnostic specimens can be obtained with fine-needle aspiration or biopsy. BIA-ALCL is CD30 positive, epithelial membrane antigen positive, and ALK negative. It can be cured with complete surgical excision at the T1-T3 stage.

• 대한의용생체공학회:의공학회지
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• 제44권2호
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• pp.99-108
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• 2023

According to the COVID-19, development of various medical software based on IoT(Internet of Things) was accelerated. Especially, interest in a central software system that can remotely monitor and control ventilators is increasing to solve problems related to the continuous increase in severe COVID-19 patients. Since medical device software is closely related to human life, this study aims to develop central monitoring system that can remotely monitor and control multiple ventilators in compliance with medical device software development standards and to verify performance of system. In addition, to ensure the safety and reliability of this central monitoring system, this study also specifies risk management requirements that can identify hazardous situations and evaluate potential hazards and confirms the implementation of cybersecurity to protect against potential cyber threats, which can have serious consequences for patient safety. As a result, we obtained medical device software manufacturing certificates from MFDS(Ministry of Food and Drug Safety) through technical documents about performance verification, risk management and cybersecurity application.

• 대한두경부종양학회지
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• 제39권1호
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• pp.1-9
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• 2023

Technological advancement in human genome analysis and ICT (information & communication technologies) brought 'precision medicine' into our clinical practice. Precision medicine is a novel medical approach that provides personalized treatments tailored to each individual by precisely segmenting patient populations, based on robust data including a person's genetic information, disease information, lifestyle information, etc. Precision medicine has a potential to be applied to treating a range of tumors, in addition to non-small cell lung cancer, in which precision oncology has been actively practiced. In this article, we are reviewing precision medicine in head and neck cancer (HNC) with focus on tumor agnostic biomarkers and treatments such as NTRK, MSI-H/dMMR, TMB-H and BRAF V600E, all of which were recently approved by U.S. Food and Drug Administration (FDA).

• 대한심미치과학회지
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• 제32권1호
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• pp.8-15
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• 2023

심하게 위축된 하악 치조제의 경우, 총의치의 통상적인 기능인상 과정을 통해서는 의치의 적절한 유지력과 안정성을 얻기가 어려울 수 있습니다. 이러한 환자에서는 중립대 인상기법을 사용하는 방식이 효과적인 대안이 될 수 있습니다. 중립 영역은 근육 신경계의 정상적인 구강 기능 동안 입 바깥쪽으로 향하는 혀의 압력과 안쪽으로 향하는 뺨과 입술의 압력이 균형을 이루는 영역으로 정의됩니다. 중립 영역 인상을 통해 만들어진 총의치는 유지력과 안정성을 향상시킬 뿐만 아니라 구치 부위에 적절한 혀 공간을 제공합니다. 또한 인공치아 주변 부위의 음식물 찌꺼기가 줄어들고 적절한 안면 지지대를 통해 미관이 개선됩니다.

• 대한방사선기술학회지:방사선기술과학
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• 제27권4호
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• pp.55-60
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• 2004

유방 X선촬영검사에서 환자가 받는 피폭선량과 장치의 이용 현황을 조사하기 위하여, 대한병원협회에 등록된 전국의 278개 의료기관(종합병원)에 설문지를 발송하여 설문에 응답한 161개 의료기관의 자료를 분석하였다. 조사 결과, 평균유선선량은 0.5 mGy 이하 14.9%, $0.51{\sim}1.0\;mGy$ 8.6%, $1.01{\sim}1.5\;mGy$ 14.9%, $1.51{\sim}2.0\;mGy$ 11.1%, $2.01{\sim}2.5\;mGy$ 9.8%, $2.51{\sim}3.0\;mGy$ 33.3%, 3.01 mGy 이상 7.4%이었다. 92.6%가 3 mGy 이하로 조사되었으며, 식품의약품안정청이 정한 평균유선선량 한도치인 3 mGy 근사값을 응답한 곳이 많았다. 최근, ICRP 등 방사선 방어 관련 국제기구는 유방 X선 촬영에서 평균유선선량을 성인 환자(50%지방, 50%유선)에 대해서 Mo target+Mo filter, 필름/스크린 시스템, 상하방향 촬영에서 4.2 cm로 압박된 유방에 대해서 1방향 3 mGy 이하로 제시하고 있으며, 점차 2 mGy, 또는 1.5 mGy로 낮추어 엄격하게 권고하고 있다. 따라서, 우리나라에서 유방 X선 촬영검사를 시행함에 있어 환자에 대한 피폭선량을 감소하기 위한 관심과 대책이 절실하게 요구된다. 아울러, 이번 조사를 바탕으로 의료기관의 유방 X선촬영 시 피폭선량을 실측하여 우리나라의 유방 X선촬영 시 환자피폭선량의 기준을 개발하기 위한 연구를 계속할 예정이다.

• 한국식품영양과학회지
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• 제32권8호
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• pp.1357-1363
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• 2003

면역 물질인 IgY가 함유된 다기능성 계란 섭취로 인체에서 H. priori제균 치료에 어떠한 효과를 나타내는지 알아보고자 H. pylori 양성인 위염 환자 63명을 대상으로 임의로 IgY 함유 계란 투여군(17명), 항생제 투여군(17명) 및 항생제와 IgY 함유 계란 병합투여군(16명)으로 나누고 2주간 치료하였고 IgY 정제 투여군(13명)은 1개월간 치료하였다. 치료후 H. pylori 박멸률, $^{13}$$CO_2$ 변화율($\Delta$$^{13}$$CO_2$) 및 updated sydney system에 따른 H. pylori 균체 밀도, 급만성 염증 활성도, 장상피화생을 비롯한 위축도등의 조직학적 변화에 대한 시험결과는 다음과 같다. IgY 함유 계란 투여군, 항생제 투여군, 항생제와 IgY 함유 계란 병합투여군 및 IgY 정제 투여군에서 H. pylori 박멸률은 각각 0%, 88%, 94% 및 0%로 IgY 함유 계란을 항생제와 병합투여 했을 때 항생제만 투여할 때 보다 H. pylori 박멸률이 높게 나타났지만 유의성은 없었다. IgY함유 계란 투여군 17명중 1명이 $\Delta$$^{13}$$CO_2$이 감소하는 경향을 보였지만 나머지는 변함이 없었다. 항생제와 IgY 함유 계란 병합투여군 16명중 15명에서 치료 1주째 $\Delta$$^{13}$$CO_2$이 모두 4이하로 치료전보다 유의하게 감소하였으며 (p<0.05), 나머지 1명도 치료 1주와 2주째 $\Delta$$^{13}$$CO_2$이 치료 전에 비해 감소하는 경향을 보였다. IgY 함유 계란 투여군과 IgY 정제 투여군에서 위전정부의 급성 염증 활성도가 유의하게 감소하였다 (p<0.01). IgY 함유 계란 투여군과 IgY 정제 투여군에서 위전정부의 H pylori 균체 밀도가 유의하게 감소하였다 (p<0.05). IgY정제 투여군에서 위체부의 만성 염증 활성도가 감소하는 경항을 보였다. IgY 함유 계란 투여군에서 위전정부 및 위체부의 장상피화생과 위축도는 치료전후 변화가 없었다. IgY정제 투여군의 1예에서만 치료전 위전정부에 경도의 장상피화생이 관찰되었으며 치료후 정상으로 호전되었다. 위점막 위축은 대상환자 모두에서 치료전후 변화가 없었다.

• 한국임상약학회지
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• 제20권2호
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• pp.159-164
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• 2010

Radiofrequency ablation (RA) is being used to manage atrial fibrillation (AF) with patients failed at the $1^{st}$-line anti-arrhythmic medications. Patients undergoing this procedure are at increased risk of thromboembolism after ablation, and anticoagulation management surrounding the ablation remains controversial. Although no conclusive recommendations can be made, published guidelines and data support therapeutic anticoagulation with warfarin. The purpose of this study was to analyze effectiveness of current therapy and to find factors fluctuate International Normalized Ratio (INR) values in patients undergone RA followed by anticoagulation service (ACS). Retrospective review was conducted utilizing database in a hospital. Among 110 patients under warfarin around ablation between January 2006 to September 2007, 54 patients were selected and allocated into 2 groups: Group A included 47 who discontinued warfarin after ablation, while 7 in B continued the medication. Information on demographics, amount and length of warfarin dosing, INR values and measuring frequencies, and the causing factors on INR fluctuation were abstracted. Differences were analyzed using chi-squared test, Fisher's Exact test, and unpaired Student t-test. Mean amount of warfarin before and after surgery was 4.0 mg, 4.1 mg in Group A and was 5.1 mg, 4.6 mg in Group B, respectively. Average duration of warfarin doing before ablation was 73.7 days in Group A, 129.9 days in B with no significant difference (p = 0.312). The duration time of warfarin on groups after ablation lasted several months. The number of checking INRs was 4.1 and 7.6, respectively. Inter-individual variability of INR fluctuations were $2.1{\pm}0.6$ in Group A and $2.2{\pm}0.7$ in B which were not significantly different (p = 0.062). 164 cases of decreased INR were: 'omission in taking medication, stressfulness and headache, 'increased intake of high vitamin K foods', 'lifestyle change of increased physical activities', and 'increase of food-intakes'. To the contrary, 36 cases of increased INR were: 'reduce of food-intake', 'use of non-prescription drugs', 'reduction in physical activities', and 'excessive restriction on food-intake', consecutively. In conclusion, the study validated therapeutic outcomes of RA patients who we treated with standard guideline and demonstrated 9 factors of INR fluctuations in the patient. A well-trained, pharmacist-monitored anticoagulation service could reduce the risk of adverse effects and prevent complications in patients with AF around RA operation.

• 대한방사선기술학회지:방사선기술과학
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• 제36권3호
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• pp.193-200
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• 2013

2011년 3월 일본 동북해안의 지진과 해일, 그리고 연이은 후쿠시마 원전사고에 따른 국내의 방사선 피폭에 대하여 심각하게 우려되고 있다. 후쿠시마 원전에서 누출된 방사성 물질이 미량이나마 국내에도 검출되고 있어 방사성 물질에 대한 시민들의 불안감이 고조됨과 동시에, 국내 언론에서는 과학적인 접근 보다는 실시간으로 시민의 불안감에 편승하여 대중들을 방사선에 대한 공포로 몰아가는 상황이 자주 연출되고 있다. 이에 현상을 올바르게 직시하고 대안을 제시하기 위해 세계 각국의 보건, 의료기관 및 학술 단체에서는 의료방사선 안전문화 확산을 위해 다양한 정보를 제공하고, 의료방사선이 안전하다는 인식을 일반인에게 확산시키기 위한 캠페인을 실시하고 있다. 이에 국내에서도 지난 2011년 6월 초 식품의약품안전처의 제안으로 '의료용 방사선 관련 유관학회의 공동 심포지엄'의 개최를 위하여 마련된 유관학회 전문가 회의에서 공동 심포지엄의 개최 결정과 더불어, 의료용 방사선 안전을 위한 연합회 구성을 공식화하여 '의료방사선안전문화연합회(KARSM, the Korean Alliance for Radiation Safety and Culture in Medicine)'를 창립하게 되었다. 따라서 본 보고에서는 국외 의료방사선 안전문화 활동들에 대한 소개와 더불어 국내 의료방사선 안전문화 확산을 위한 의료방사선안전문화 연합회의 사업을 중점적으로 소개하고자 한다. 의료방사선 안전문화 확산과 관련한 여러 활동들을 통하여 일반 대중들에게 의료방사선의 막연한 공포감을 해소하고 바람직한 인식 형성에 기여하고자 한다.

• 대한지역사회영양학회지
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• 제14권2호
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• pp.236-244
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• 2009

Dietary therapy is a basic and emphasized treatment for diabetes. Several clinical studies have shown that diet can play a major role in preventing and managing diabetes. The purposes of this study were to evaluate the dietary behavior and to find solutions to barriers of diabetes mellitus patients. From February to July in 2007, questionnaires were distributed to one hundred and ten patients who were diagnosed DM by physicians and excluded first coming out-patients. One hundred and three data were used for statistical analysis using SPSS/Win 12.0. The main results of this study included the following: To measure dietary behaviors and barriers, a five point scale was used with the following labels: 'strongly yes', 'yes', 'fair', 'no', 'strongly no'. Thirteen dietary behaviors related to diabetes were grouped into the following 4 factors using factor analysis; 'taste control factor', 'blood glucose influence factor', 'practice volition factor', and 'exercise factor'. The mean scores of 4 factors were 3.88, 3.48, 3.55, 3.21, respectively. The 'taste control behaviors' score of subjects who had practiced diet therapy(4.00) was higher than those who had not practiced diet therapy(P<0.05). The 'blood glucose influence behaviors' score of subjects who had nutrition education(3.59) was higher than those who had no nutrition education(P<0.05) and subjects who had practiced diet therapy showed higher score(3.59) than those who had not practiced diet therapy(P<0.05). 'Exercise behaviors score' of subjects who were over 60(3.59) was the lowest(P<0.05). Subjects who had nutrition education showed higher 'exercise behaviors' scores(3.38) than those who had no nutrition education(P<0.05). Subjects who had practiced diet therapy showed higher 'practice volition behaviors' scores(3.72) than those who had not practiced diet therapy(P<0.001). Subjects who were over weight showed the highest 'practice volition behaviors' scores(3.78) concerning BMI(P<0.05). In conclusion, this study expected that Nutrition educators(Dietitian) applied to patient effective nutrition education and counseling through evaluation of Dietary behaviors and barriers considered management types and ecological factors of diabetes patients. Also diabetic patients were easy to change dietary habits because they formed behaviors through education and counsel and there were positive effects in their blood glucose control through removing barriers related to dietary therapy.