• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.172-172
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• 2000

• 대한약학회:학술대회논문집
• /
• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.173.2-174
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• 2000

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
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• pp.186.1-186.1
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• 2001

• Journal of Korean Biological Nursing Science
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• 제15권3호
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• pp.139-146
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• 2013

Purpose: The purpose of this study was to identify knowledge and the Need of pathophysiology, perceived connectivity between knowledge of pathophysiology and clinical practice, and confidence and satisfaction with clinical performance by applying the knowledge to clinical practice, and to analyze the correlation between the knowledge, perceived connectivity, and confidence and satisfaction of clinical nurses. Methods: Subjects consisted of 149 clinical nurses who work at 7 general hospitals and 6 university hospitals located in Seoul, Incheon, and Gyeonggi province in Korea. Those who learned pathophysiology during their undergraduate program were recruited by using a convenient sampling. The data were collected between April 23 and May 24 in 2012. Participants responded to self-administered questionnaires about knowledge and the need of pathophysiology, and the perceived connectivity between knowledge and clinical practice, and confidence and satisfaction with clinical performance by applying knowledge to clinical practice. Results: Mean scores of knowledge and the need of pathophysiology were $2.88{\pm}0.34$ and $2.33{\pm}0.39$ each. Scores of knowledge and the need of 3 units such as fluid and electrolyte imbalance, acid-base imbalance, and alterations in the respiratory system were high among 23 units while that of adolescent disorders was the lowest. The mean score of perceived connectivity between knowledge and clinical practice was $7.32{\pm}1.57$, and those of confidence and satisfaction with clinical performance by applying the knowledge to clinical practice were $7.66{\pm}1.66$ and $7.42{\pm}1.67$ respectively. Knowledge of pathophysiology was positively correlated with the perceived connectivity between knowledge and clinical practice, and confidence, and satisfaction with clinical performance. Conclusion: The results indicate that knowledge and the need of pathophysiology in clinical nurses is above average, and that knowledge of pathophysiology is important in promoting perceived connectivity with clinical practice and increasing confidence and satisfaction with clinical performance by applying knowledge to clinical practice.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.193.2-194
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• 2003

Effect of phenylpropanoids on Phospholipase A2 (PLA2) and phosphodiesterase (PDE) activities in the asthmatic lung tissue were studied in guinea pigs. Bronchial asthma were introduced by the challenge of aerosolized ovalbumin (OA) in the double-chambered plethysmograph at twenty one days after sensitization of OA in guinea pigs. Bronchoalveolar lavage fluids (BALF) were taken by brochalveolar lavage with HEPES buffer. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.194.2-195
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• 2003

Phenylpropanoids(PP), C6-C3 compounds, are widely distributed in many plants. In this experiments, effect of PP on sheep red bood cells (sRBC)-induced delayed type hypersensitivity (DTH) were studied in ICR male mice. SRBC were challenged by i.p. injection at two weeks after sensitization of Lp. injection of sRBC. Five days after the challenge of antigen, paw edema induced 24 hours after the last challenge by DTH, respectively. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.195.1-195.1
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• 2003

Many kinds of phenylpropanoids(PP), C6-C3 compounds, are widely distributed in many plants. In this experiments, effect of PP on sheep red bood cells (sRBC)-induced Arthus reaction (AR) were studied in ICR male mice. SRBC were challenged by i.p. injection two weeks after sensitization of Lp. injection of sRBC. Five days after the challenge of antigen, paw edema induced 3 hours after the last challenge by AR. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.196.1-196.1
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• 2003

Cinnamic acid derivatives(CAD) originating from vegetable kingdom have some biological activity. Effect of CAD on reversed cutaneous anaphylaxis (RCA) and hemolysin (HY) titer were studied in rats. Experiments were carried out to determine RCA as the skin edema induced at 2 hours after injection of 0.05 $m\ell$/site of anti-rat serum rabbit serum. Drugs were orally administered at one hour before antigen challenge. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.299.2-299.2
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• 2002

For the activity-guided separation on anti-asthmatic action from 4 fractions as n-hexane (yield. 0.09%), EtOAc (0.48%), BuOH (3.0%) and H2O (5.17%) fractions from MeOH extract (11.64%) of powdered Gastrodia elata Rhizoma (GER), some biological active agents were isolated by column chromatography (column, silica gel: elution solvent. CHCl3 : MeOH) according to the method of Junko Hayashi et. al. and Heihachiro Taguchi et. al. (omitted)

• Molecules and Cells
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• 제21권2호
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• pp.186-191
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• 2006

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV), a distant member of the Group 2 coronaviruses, has recently been identified as the etiological agent of severe acute respiratory syndrome (SARS). The genome of SARS-CoV contains four structural genes that are homologous to genes found in other coronaviruses, as well as six subgroup-specific open reading frames (ORFs). ORF3 encodes a predicted 154-amino-acid protein that lacks similarity to any known protein, and is designated 3b in this article. We reported previously that SARS-CoV 3b is predominantly localized in the nucleolus, and induces G0/G1 arrest and apoptosis in transfected cells. In this study, we show that SARS-CoV 3b fused with EGFP at its N- or C- terminus co-localized with a mitochondriaspecific marker in some transfected cells. Mutation analysis of SARS-CoV 3b revealed that the domain spanning amino acids 80 to 138 was essential for its mitochondria localization. These results provide new directions for studies of the role of SARS-CoV 3b protein in SARS pathogenesis.