• Journal of Chest Surgery
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• v.6 no.2
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• pp.151-158
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• 1973

Author studied the pathogenesis of Sino-bronchiectasis with review of clincal and pathological findings of resected lungs in 24 eases of bronchiectasis,and the results were as follows: 1. Of the 24 eases of bronchiectasis, Sino-bronchiectasis were found in 11 cases and these cases most commonly, developed in first and second decade of life. In a majority of these cases,the main symptoms were the signs of wet bronchiectasis. 2. The typical roentgenograrn changes of plain chest x rays were increase in size and loss of definition of the markings and bronchographically revealed the cylindrical or tubular form in majority of these cases. 3. Pathologically Sino-bronchiectasis involved specific segmental areas of the lungs such as left basal and S4+5 segments and revealed commonly tubular dilatation. The most common findings of bronchial wall of dilated bronchus were the inflammatory cellular infiltration and cylindrical hyperplasia of mucus epithelial layers. 4. It was suspected that there were some causal relations in pathogenesis between chronic sinusitis and bronchiectasis.

• Korean Journal of Veterinary Research
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• v.22 no.2
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• pp.233-237
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• 1982

Pathological studies on 6 milk goats administrated with urea were carried out to determine the effects of acute and chronic poisonings on the animal. Clinical signs appeared about 10 minutes after ingestion of the urea and they consisted chiefly in dullness, staggering, uncontrolled urination, dyspnea, frothy salivation, bloating, muscular tremor, humping of back and tetanic spasms. Macroscopic lesions were failure of blood clot, frothy and bloody contents in the highly congested respiratory tract, pulmonary edema, rumenitis and abomatitis accompanying with petechiation of the upper small intestine. Microscopically, the liver showed vacuolar degeneration, fatty change and areas of necrosis and partial proliferation of the interlobular connective tissues in chronic crises. The renal epithelium displaced vacuolar degeneration, necrosis and hyaline casts in their lumens. In the lungs, there were hyperemia, edema, hemorrhages, and acute catarrhal bronchitis. Neuronal degeneration and necrosis in the central nervous system, catarrhal rumenitis, abomatitis, doudenitis and myocardial hemorrhage were also demonstrated.

• Journal of the korean veterinary medical association
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• v.20 no.5
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• pp.314-317
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• 1984

Pathological findings and its possible pathogenesis in a race horse dying from enterolith were described. Clinical signs were abdominal pain, anorexia, diarrhea, recumbency, and collapse. Gross lesions consisted mainly of failure to blood clot, peritoniti

• Toxicological Research
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• v.12 no.2
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• pp.319-322
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• 1996

This study was carried out to investigate the acute toxicity of KDRD-010 in Sprague-Dawley rats. KDRD-010 was administratered orally at a dose level of 26, 78, 233, 700, and 2,100 mg/kg. In this study, we daily examined number of deaths, clinical signs, body weights, and pathological examinations for 14 days after administration of KDRD-010. The results indicate that KDRD-010 did not show any toxic effect in rats and oral $LD_50$ value was over 2,100 mg/kg in Sprague-Dawley rats.

• Korean Journal of Veterinary Service
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• v.13 no.1
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• pp.32-43
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• 1990

In order to investigate the clinico-pathological and immunohistochemical changes in the rats infected with Aujeszky’s disease virus(ADV), 100 heads of 4 weeks-old rats were inoculated intraperitoneally and intranasally, with the domestically isolated ADV, NYJ-1-87 strain, at $10^{3.0}$ or $10^{5.0}$$TCID_ {50}$/0.2ml. Results obtained through the experiments were summarized as follows : 1. Clinical signs such as dulness, anorexia, pruritus, fascial edema, dyspnea and ataxia were observed from the 2nd day and died at the 3rd to 5th day after ADV inoculation. By necropsy, congestion and hemorrhage were observed in the abdominal organs, while no specific changes were detected in the other organs. 2. In histopathological observation, degeneration and necrosis of the nervous cells, non-suppurative meningoencephalitis, microgliosis and perivascular cuffing were manifested in central nerve system but no specific changes were observed in the other organs. 3. By immunohistochemical staining using peroxidase antiperoxidase, the positive cells were detected in the tissues of kideny, spleen, urinary bladder and lung.

• Korean Journal of Veterinary Research
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• v.28 no.1
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• pp.175-177
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• 1988

Light-microscope studies of the coccidial organisms found in the bursa of Fabricius from chickens shelwng some specific signs were carried out, and the etiological agent was estimated as the parasite belonging to the Family Cryptosporiidae. The specific gross Pathological signs were intestinal hemorrhage and atrophy of the bursa of Fabricius and hyperplasia was associated with the presence of organisms attached to the epithelial cells lining the plicae of the bursa of Fabricius in the microscopical findings.

• Toxicological Research
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• v.16 no.1
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• pp.67-71
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• 2000

It has been demonstrated that the injection of naked DNA expressing vascular endothelial growth factor 165(VEGFl165) to the affected area can provide significant therapeutic effects on peripherol artery occlusive diseases. Success with this type of gene therapy highly depends on the quality of the vector delivering the therapeutic gene, especially in terms of the level and duration of gene expression in the localized area. We have recently developed a vector expressing VEGF165(pCK-VEGF) for the treatment of peripheral artery occulsive diseases and demonstrated high level expression of VEGF165 in mouse skeletal muscle. This study was designed to assess the acute toxicity of intramuscularly injected pCK-VEGF in BALB/c mice and Sprague-Dawely rats. There was no evidence of any changes in clinical signs, body weights, or gross pathological signs. We estimate LD50 values of pCK-VEGF higher than 50mg/kg in mice and 20 mg/kg in rats by intramuscular injection.

• Korean Journal of Veterinary Pathology
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• v.7 no.1
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• pp.27-41
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• 2003

The purpose of this study was to evaluate the effect of a subsequent infection of porcine reproductive and respiratory syndrome(PRRS) virus to pigs with A. pleuropneumonia in pigs. Twenty three 7-weeks-old commercial pigs were infected with PRRS virus and/or A. pleuropneumoniae serotype 5 intratracheally. Feed conversion, clincal signs, gross and histopathological lesions and immunohistochemical findings were examined. 1. Feed conversion ratio in dual-infected pigs with PRRS virus and A. pleuropneumoniae were higher than that of single- infected pigs with PRRS virus or A. pleuropneumoniae. 2. Dual-infected pigs with PRRS virus followed by A. pleuropneumoniae showed more severe clinical signs and gross, histopathological and immunohistochemical pulmonary lesions. The results indicated that dual infections with PRRS virus and A. pleuropneumoniae caused more severe respiratory lesions and growth retardation in pigs than single infection with PRRS virus or A. pleuropneumoniae.

• Biomolecules & Therapeutics
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• v.6 no.3
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• pp.328-336
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• 1998

The subacute oral toxicity study of DWP-311 was carried out in Sprague-Dawley rats of both sexes. We daily examined clinical signs, body weights, hematological and biochemical parameters, and histopathological examinations for 30 days after administration of DWP-311 with different dose levels (0, 0.04, 0.2, and 1.0 g/kg). There were no clinical signs and pathological changes compared with control group except slight decreases in spontaneous motor activities and locomotions at high dose group of DWP-311. Body weights were not significantly changed in animals treated with DWP-311, In histopathological examinations, there were 2 cases of pneumonia in control group for one male and one female, but it was not directly related to DWP-311. These results indicate that subacute oral toxicities of DWP-311 were low and the no-observed a dverse effect level (NOAEL) was considered to be 1.0 g/kg in rats.

• Korean Journal of Veterinary Research
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• v.15 no.1
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• pp.39-45
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• 1975

The authors believe that farm livestok will be greatly affected by the marked increasing use of organic phosphate. This study was carried out to observe the clinical signs and histopathological changes of mouse, guinea pig, hamster and rabbit that were orally administered with diazinon used usually as agricultural insecticide, and cholinesterase (ChE) activity was histochemically examined in the liver, heart, kidney, adrenal gland, duodenum and salivary gland of these experimental animals administered with diazinon. The results obtained were as follows: 1. Clinical signs such as dullness, severe salivation, ataxia, dyspnea, irregular slight convulsion and inappetance and as the histopathological changes cloudy swelling, congestion and hemorrhage of parenchymal organs, catarrh or local necrsois of the gastrointestinal tract, congestion or hemorrhage of the other organs were observed. Especially, hemorrhage of adrenal glands (rabbit, guinea pig) and pulmonary congestion and hemorrhage were necessarily constant. 2. In the histochemical study, ChE activity appeared intensely in the liver, heart, medulla of adrenal glands and salivary glands (submaxillary and parotid) of control animals, but ChE activity was negative or markedly decreased in experimental animals administered with diazinon. There was no marked difference between the control and experimental animals in ChE activity of the kidney. 3. Histochemical observation of ChE activity was helpful to explain the clinical signs and histopathological changes and was regarded as a diagnostic method for organic phosphate poisoning.