• Journal of Korean Neurosurgical Society
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• v.58 no.1
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• pp.30-35
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• 2015

Objective : The clinical and pathological characteristics of 10 cases of cerebral amyloid angiopathy (CAA)-related cerebral lobar hemorrhage (CLH) that was diagnosed at autopsy were investigated to facilitate the diagnosis of this condition. Methods : The clinical characteristics of 10 cases of CAA-related CLH were retrospectively reviewed, and a neuropathological examination was performed on autopsy samples. Results : The 10 cases included two with a single lobar hemorrhage and eight with multifocal lobar hemorrhages. In all of the cases, the hemorrhage bled into the subarachnoid space. Pathological examinations of the 10 cases revealed microaneurysms in two, double barrel-like changes in four, multifocal arteriolar clusters in five, obliterative onion skin-like intimal changes in four, fibrinoid necrosis of the vessels in seven, neurofibrillary tangles in eight, and senile plaques in five cases. Conclusion : CAA-related CLHs were located primarily in the parietal, temporal, and occipital lobes. These hemorrhages normally consisted of multiple repeated CLHs that frequently bled into the subarachnoid space. CAA-associated microvascular lesions may be the pathological factor underlying CLH.

• Korean Journal of Veterinary Pathology
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• v.3 no.1
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• pp.45-50
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• 1999

Canine dermatosis associated with zinc deficiency naturally occurred in three districts of Kyungpook. A diagnosis was made by clinical findings, clinico-pathological examinations, skin biopsy, and therapeutic tests. The result was diagnosed as a zinc-deficient dermatosis. The disease occurred in rapidly growing Tosa-dog hybrids 5 to 7 months old. Skin lesions included erytherma, alopecia, crusting, scaling around the mouth, eyes, legs and tail. Clinico-pathological findings were decreased serum zinc levels, slightly increased white blood cells, and secondary Staphylococcus intermedius infection of the crusts. The skin biopsies for histopathological examination revealed marked parakeratotic hyperkeratosis. The patients with skin lesions were successfully treated by zinc methonine(Zinpro) medication In conclusion, serum zinc level and skin biopsy are very helpful in diagnosis of canine zinc-deficient dermatosis.

• Childhood Kidney Diseases
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• v.11 no.1
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• pp.1-8
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• 2007

Many children with microscopic hematuria have been found on school screening examinations. There are not, however, nation-wide criteria for us(specifically, pediatric nephrologists) how to take care of them. Recently, quite a few research papers concerning microalbuminuria with microscopic hematuria, which can predict the renal pathological findings, are published. Here I have reviewed articles on microalbuminuria which gives us the information how to manage microscopic hematuria.

• YAKHAK HOEJI
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• v.43 no.3
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• pp.358-368
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• 1999

Subacute toxicity study was performed in Sprague-Dawley rats after daily dermal administration of Sangmosu (0.2, 1.0 and 5.0 g/kg) for one month. There were no clinical signs and pathological changes compared with control group. Bodyweights were not significantly changed between control and Sangmosu treatment groups. In histopathological examinations, there were some pneumonia in lung tissues at all groups of Sangmosu treatment including control, but it was not considered to be caused by Sangmosu. These results suggest that Sangmosu does not induce any significant subacute dermal toxicities in Sprague-Dawley rats.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.6
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• pp.565-571
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• 2016

Paeoniflorin (PAE) is the most abundant compound in Xuebijing injection widely used to treat sepsis. We aimed to investigate effect of PAE on expression of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in a rat model of sepsis. Wistar rats were divided into Normal, Model, and PAE groups (n=20 each). Endotoxin was administrated at 5 mg/ml/kg in Model and PAE rats to establish rat sepsis model. 1 h after endotoxin administration, PAE was administrated at 4 ml/kg in PAE group once per day for 3 days. Routine blood tests and biochemical indexes were assessed, including aspartate aminotransferase (AST) and creatine kinase-MB (CK-MB). The plasma sTREM-1 level was measured using quantitative ELISA. At the end of experiment, the small intestine, liver, kidney and lung were subjected to pathological examinations. A rat model of sepsis-induced multiple organ dysfunction syndrome (MODS) was established successfully with endotoxin administration (5 mg/ml/kg), evidenced by histo-pathological examinations, routine blood tests and biochemical indexes: platelet count decreased and white blood cell count increased (p<0.05), CK-MB and AST increased (p<0.05). PAE treatment significantly reduced the plasma levels of AST, CK-MB, and sTREM-1, compared to Model group (p<0.05). Meanwhile, sepsis-induced damages in the liver, lung, stomach and intestinal mucosa were also markedly ameliorated by PAE treatment. PAE demonstrated a significantly protective effect in a rat model of sepsis by decreasing plasma sTREM-1 level, reducing inflammation, preventing MODS and protecting organ functions.

• Parasites, Hosts and Diseases
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• v.51 no.2
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• pp.223-229
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• 2013

This study aimed to explore the clinical, radiological, and pathological characteristics of intraocular cysticercosis due to Taenia solium metacestode infection. Total 8 patients diagnosed with intraocular cysticercosis at the Red Cross Hospital of Yunnan Province, China were examined retrospectively. Patients with clear dioptic media had undergone fundus chromophotography. All patients underwent B ultrasonography of the ocular region (CT) successive scanning of the orbit and cerebral tissues. Parasites were extracted surgically and then examined pathologically. The fundus chromophotography showed a white and condensing scolex package in the vesicle. The B ultrasonic examination showed a vesicle-like echogenic mass in the vitreous chamber, in which the high-level echo spot was the cysticercus scolex. The pathological examinations showed that the vesicle wall exhibited hyaline degeneration, inflammatory cell infiltration, neuroglial fiber, and glial cell proliferation layers from the inside to the outside. The scolex is round and is composed of the outer tissue (the body wall) and the inner furrow tissue; these tissues migrated together. Primordially differentiated sucking discs were found in one case, but no hooklets were found. The inner scolex tissue was folded like a paper flower. The severity of intraocular disease is closely correlated with the pathophysiological processes of the cysticercus worm. Pathological examination of the intraocular lesions can help to evaluate the course of the disease as well as to provide a scientific basis for effective antiparasitic medication.

• Journal of Korean Neurosurgical Society
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• v.30 no.4
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• pp.463-471
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• 2001

Objective : The authors reviewed 51 patients of spinal cord tumor located at the craniovertebral junction and high cervical area to determine which factors influenced resectability, complications, and postoperative outcomes. Methods : Radiological examinations, clinical data, and operation notes were evaluated, and additional follow-up information was obtained from outpatient examinations. The mean follow-up period was 3.5 years Results : The most common neurological findings were motor deficit(72.5%) and sensory change(47.1%). There was no clinical finding that is considered as pathognomic. Meningioma(18 cases, 35.3%) was the most common tumor in this region. Total removal was achieved in 45 patients. There was no surgical mortality. Immediate postoperative motor weakness were encounted in 11 cases(21.6%) which improved in long term followup except two patients. Conclusions : The location and relationship of the tumor to surrounding struncture determine its resectability. Postoperative results were related to the preoperative neurological status and pathological findings.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.18 no.2
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• pp.351-356
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• 2014

Although the demand for histopathological examinations has been increasing, medical accidents in management of specimens also have been increasing because most of the examinations are processed manually which can cause careless handing, confusing information and mismatching during the procedure. In the future, histopatological examination will be used frequently for handing incurable diseases and verification of new drug. Thus, efficient and error-free management system for handling personalized medical history and test results is infallibly necessary. In this paper, I have proposed an integrated printing system for informatization of histopathological examination that support the u-Healthcare environment based on RFID in near future. The proposed system supports systematization of whole examination process and information of pathological samples. This system will contribute to reduction of costs, improvement of operational efficiency, and mostly fundamental prevention of medical accidents.

• Korean Journal of Pharmacognosy
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• v.45 no.2
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• pp.181-185
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• 2014

This study was carried out to investigate the acute toxicity of the bark of Diospyros kaki (Ebenaceae) in mice. The aqueous extract of the bark of Diospyros kaki (AEDK) was administered orally at a doses of 5 mg/kg, 50 mg/kg, 300 mg/kg and 2,000 mg/kg. In this study, number of deaths, clinical signs, body weights and pathological examinations were investigated after administration of AEDK. There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and AEDK treated groups in clinical signs, organ weights and gross pathological findings. AEDK did not show any toxic effect in mice.

• Journal of Korean Neurosurgical Society
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• v.52 no.5
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• pp.484-487
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• 2012

Glioblastoma multiforme (GBM) is the most common primary brain tumor and the most malignant astrocytoma in adults, with rare extra-cranial metastases, especially for subcutaneous metastases. It could be easily misdiagnosed as primary subcutaneous tumor. In this report, we describe a patient with pontine GBM who developed a subcutaneous swelling at the ipsilateral posterior cervical region 8 months after operation, and the pathological and immunocytochemical examination carry the same characteristics as the primary intracranial GBM cells, which defined it as subcutaneous metastasis. GBM with subcutaneous metastasis is extremely rare, and knowledge of a prior intracranial GBM, pathological examinations and immunocytochemical tests with markers typically expressed by GBM are of vital importance for the diagnosis of GBM metastasis. Surgical resection of subcutaneous swelling, followed by chemotherapy and radiotherapy, could be the best strategy of treatment for the patients with GBM subcutaneous metastasis.