• Speech Sciences
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• v.14 no.4
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• pp.179-200
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• 2007

In voice pathology, various measurements calculated from pitch values are proposed to show voice quality. However, those measurements frequently seem to be inaccurate and unreliable because they are based on some wrong pitch values determined from pathological voice data. In order to solve the problem, we compared several pitch estimation methods to propose a better one in pathological voices. From the database of 99 pathological voice and 30 normal voice data, errors derived from pitch estimation were analyzed and compared between pathological and normal voice data or among the vowels produced by patients with benign vocal fold lesions. Results showed that gross pitch errors were observed in the cases of pathological voice data. From the types of pathological voices classified by the degree of aperiodicity in the speech signals, we found that pitch errors were closely related to the number of aperiodic segments. Also, the autocorrelation approach was found to be the most robust pitch estimation in the pathological voice data. It is desirable to conduct further research on the more severely pathological voice data in order to reduce pitch estimation errors.

• Speech Sciences
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• v.4 no.2
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• pp.17-24
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• 1998

In this paper a method to diagnose pathological voices using wavelet transform is sug gested. Pathological voices are collected from hospital and analyzed by the suggested method. Normal voices are collected separately and analyzed. Then the results are compared to find the differences in their characteristics. Three level wavelet transform is used. Normalized energy ratios between the levels and normalized peak-to-peak values are used as parameters. As a result, it was possible to distinguish between normal and pathological voices.

• The Korean Journal of Rehabilitation Nursing
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• v.9 no.2
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• pp.109-116
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• 2006

Purpose: This study is a descriptive research in which the pathological syndromes of the schizophrenic patients in the community mental health centers, the degrees of the insights, and the correlations between them were examined. Method: The subjects included 114 SPR pt. people who were enrolled in community mental health centers located in D City. The research was conducted during the period from Aug. 1st, 2002 to Jul. 30th, 2004. The instruments were PANSS developed by Kay(1987) and SUMD developed by Amador(1993). Results: Among the pathological syndromes, positives ones were $12.64{\pm}3.80$ on the average, negative ones were $32.00{\pm}5.36$, and general pathological syndromes were $30.50{\pm}6.24$. In the evaluation of the insights, the mean score was $11.81{\pm}5.09$. There were some significant correlations between positive syndromes and general pathological ones (r=.572, p=.000), and negative syndromes and general pathological ones(r=.262, p=.029), while there was no significant correlation between the insights and the sub-measures of general pathological syndromes. Conclusion: Therefore, the schizophrenic patients taking advantage of the community mental health centers have more negative syndromes than those in hospitalized, and rehabilitation programs are needed to help them continuously. And the further study of the correlations between the pathological syndromes and the degrees of the insights are required, and still, it should be analyzed what effects the insight acquirement brings about to the improvements of the pathological syndromes after the application of the insight-oriented programs.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4187-4192
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• 2014

Matrix metalloproteinase (MMP)-2 and MMP-9 are important proteases involved in invasion and metastasis of various tumors. Extra-gastrointestinal stromal tumors (EGISTs) are rare neoplasms. This study was performed to assess MMP-2 and MMP-9 expression in EGIST tissue samples for association with clinicopathological data from the patients. Twenty-one surgical EGIST tissue specimens were collected for analysis of MMP-2 and MMP-9 expression using immunohistochemistry. MMP-2 and MMP-9 proteins were expressed in all of the epithelial cell types of EGISTs, whereas they were only expressed in 75% of the spindle cell type, although there was no statistically significant difference (p>0.05). Expression of MMP-2 and MMP-9 proteins was associated with tumor size, mitotic rate, tumor necrosis, and distant metastasis (p<0.05). MMP-2 expression was linked with MMP-9 levels (p<0.05). However, there was no correlation between MMP-9 expression and age, sex, primary site, or cell morphology in any of these 21 EGIST patients (p>0.05). Moreover, expression of MMP-2 and MMP-9 proteins increased with the degree of EGIST risk. This study provided evidence of an association of MMP-2 and MMP-9 expression with advanced EGIST behavior.

• Journal of Korean Academy of Nursing
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• v.42 no.4
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• pp.589-598
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• 2012

Purpose: The purpose of this study was to examine risk factors for pathological gambling of horse race participants. Methods: The participants, 508 horse race gamblers, completed the DSM-IV criteria of pathological gambling, Alcohol Use Disorders Identification Test (AUDIT-K) and Symptom Checklist-47-Revision (SCL-47-R). Data were analyzed using t-test, $x^2$-test, Fisher's exact test, and logistic regression analyses. Behaviors related to horse racing, alcohol abuse, and mental health were analyzed between problem or pathological gamblers compared to recreational gamblers. Results: The prevalence rates of recreational, problem, and pathological gambling were 36.6%, 39.4%, and 24.0%, respectively. Frequency of gambling (${\geq}4/day$), frequency of racetrack visiting (${\geq}3/month$), accompaniment (alone), and mental health (SCL-47-R scores) were all associated with increased risks of problem and pathological gambling. Expenditure on betting (${\geq}200,000$ won/day) and alcohol abuse (AUDIT-K 8-20 scores) group members had higher levels of gambling pathology than recreational gamblers. Conclusion: Problem and pathological gambling are highly associated with alcohol abuse and mental health disorders, suggesting that clinicians should carefully evaluate this population.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.1797-1798
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• 2007

In field of voice pathology, diverse statistics extracted form pitch estimation were commonly used to assess voice quality. In this study, we proposed robust pitch detection algorithm which can estimate pitch of pathological voices in benign vocal fold lesions. we also compared our proposed algorithm with three established pitch detection algorithms; autocorrelation, simplified inverse filtering technique, and nonlinear state-space embedding methods. In the database of total pathological voices of 99 and normal voices of 30, an analysis of errors related with pitch detection was evaluated between pathological and normal voices, or among the types of pathological voices. According to the results of pitch errors, gross pitch error showed some increases in cases of pathological voices; especially excessive increase in PDA based on nonlinear time-series. In an analysis of types of pathological voices classified by aperiodicity and the degree of chaos, the more voice has aperiodic and chaotic, the more growth of pitch errors increased. Consequently, it is required to survey the severity of tested voice in order to obtain accurate pitch estimates.

• Proceedings of the KSLP Conference
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• 1998.11a
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• pp.208-209
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• 1998

It is generally known that many cases of pathological rough voice are characterized not by simple random perturbations but by quasi-periodic perturbations in the speech wave. However, there are few studies on the characteristics of perturbations in vocal fold vibrations associated with this type of voice. We have been conducting studies of pathological vocal fold vibration using a high-speed digital image recording system developed by our institute, Compared to the ordinary high-speed-motion picture system, the present system is compact and simple to operate and thus, it suited for pathological data collection. (omitted)

• MALSORI
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• no.64
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• pp.77-88
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• 2007

Nowadays, mel-frequency cesptral coefficients (MFCCs) and Gaussian mixture models (GMMs) are used for the pathological voice detection. This paper suggests a method to improve the performance of the pathological/normal voice classification based on the MFCC-based GMM. We analyze the characteristics of the mel frequency-based filterbank energies using the fisher discriminant ratio (FDR). And the feature vectors through the linear discriminant analysis (LDA) transformation of the filterbank energies (FBE) and the MFCCs are implemented. An accuracy is measured by the GMM classifier. This paper shows that the FBE LDA-based GMM is a sufficiently distinct method for the pathological/normal voice classification, with a 96.6% classification performance rate. The proposed method shows better performance than the MFCC-based GMM with noticeable improvement of 54.05% in terms of error reduction.

• Anxiety and mood
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• v.2 no.2
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• pp.86-93
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• 2006

Depression, anxiety and stress are important components of theories of pathological gambling and are often foci of treatment with patients with gambling problems. In the present review we attempt to examine the relationship between anxiety, depression, stress and pathological gambling. Although the previous studies on this subject are limited and the relationship is unclear and complex, our review on the previous studies and clinical experiences on this subject could offer new insights for the assessment and treatment of pathological gamblers.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1783-1786
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• 2012

Objectives: To analyze esophageal cancer incidence and pathological data of Zhongshan in China in 1970-2007, and to provide scientific information for its prevention and control. Methods: From Zhongshan Cancer Registry esophageal cancer incident and pathological data were obtained. Pathological proportions and trends were calculated and analyzed. Results: Although there was a continuously and obviously increasing trend for male incidence rates in 1970-2007 in Zhongshan, squamous cell carcinoma (SCC) and adenocarcinoma (AD) incident proportions during 1990-2007 remained relatively stable. Moreover, SCC was the major pathological type, accounting for 70.6 percent of all new cases, while AD were relatively few and accounted for only 2.66 percent throughout the period. Conclusion: The male esophageal cancer incident pattern in Zhongshan in 1970-2007 was quite different from most other domestic areas. The data suggest that etiological analysis should be enhanced for improved control in Zhongshan.