• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.12 no.2
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• pp.115-120
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• 2001

In this paper, we synthesized vowel /ae/ with voice synthesis program of Dr. Speech Science, and we also synthesized pathologic vowel /ae/ by some parameters such as high frequency gain (HFG), low frequency gain(LFG), pitch flutter(PF) which represents jitter value and flutter of amplitude(FA) which represents shimmer value, and grade ranked as mild, moderate and severe respectively. And then we analysed all pathologic voice by analysis program of Dr. Speech Science. We expect that this synthesized pathologic voices are useful for understanding the parameter such as noise, jitter and shimmer and feedback effect to patient with voice disorder.

• Journal of Sasang Constitutional Medicine
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• v.10 no.1
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• pp.55-63
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• 1998

The symptoms that have same pathologic pattern written in the chapter of Soyangin's general pathology of the book 'Dongyi Soose Bowon' can give us a key to the Dr.Lee Je-Ma's point of view about the constitutional pathophysiology. As the result, Dr. Lee called the person who has yang-hyperactivity/yin-hypoactivity as So-Yang-In. And the Soyangin has two basic pathologic pathway ; excess of Yang-hyperactivity/excess of Yin-hypoactivity. Each pathologic pathway has variatons though, the pathologic pattern results in above two type. Excess Yin-hypoactivity has three variations of pathologic pattern. 1. smaller excess of Yin-hypoactivity with the normal range of Yang-hyperactivity 2. larger excess Yin-hypoactivity with the excitation of Yang-hyperactivity by the extrinsic factor 3. smaller excess Yin-hypoactivity with the loss of Yang-hyperactivity. And excess Yang-hyperactivity also has three variations. In my point of view, CVA, Hematemesis, Vommiting, Abdominal Pain, Gastric Dyscomfort has No.3 type and Asthmatic condition, Dysentery, Edema has No.1 type.

• Phonetics and Speech Sciences
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• v.2 no.3
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• pp.165-170
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• 2010

In this study, the most stable portion was identified using 5% moving window during /a/ sustained phonation in normal and pathologic voice signals and the perturbation values were compared between normal and pathologic voices at the mid-point and at the most stable portion using moving window, respectively. The results revealed that some severe pathologic voice signals can be eligible for perturbation analysis by identifying the most stable portion with Err less than 10. In addition, the perturbation acoustic parameters did not differentiate the pathologic voice signals from the normal voice signals when the mid-point was selected to measure the perturbation analysis(p>0.05). However, significantly higher %shimmer and lower SNR values were observed in pathologic voices (p<0.05) when the most stable portion was selected by moving window. In conclusion, moving window could identify the most stable portion objectively which can allow toget the minimum perturbation values (%jitter, %shimmer) and maximum SNR values. Thus, moving window technique can be applicable for more reliable and accurate perturbation acoustic analysis.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.33 no.6
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• pp.529-534
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• 2011

Pathologic fractures of the mandible can occur for many reasons including osteoradionecrosis, osteomyelitis, malignancy and cyst. Pathologic fractures are difficult to treat because management is needed not only for the fractures of the mandible but also the underlying disease the is weakening the bone. Additionally, the diseased mandible in the pathologic fracture frequently has abnormal bone healing capacity. We experienced three cases of pathologic fractures of the mandible resulting from cyst, malignancy and osteomyelitis. The treatment of these cases was complicated and time-consuming. Therefore, we present our three cases and discuss the management of pathologic fractures of the mandible.

• Journal of Sasang Constitutional Medicine
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• v.22 no.3
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• pp.18-28
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• 2010

1. Objectives: Purpose of this paper is to study the reinterpretation of Taeyang disease(太陽病) in "Shanghanlun(傷寒論)" based on the pathologic perspective of Sa-sang Constitutional Medicine by comparing factors as pathologic mechanisms, clinical symptoms, and remedies. 2. Methods: The texts referred to pathologic mechanisms, clinical symptoms, and remedies of Taeyang disease(太陽病) described in "Donguisusebowon Gabobon(東醫壽世保元 甲午本)", "Donguisusebowon Sinchookbon(東醫壽世保元 辛丑本)", and Shanghanlun(傷寒論)" in "Donguibogam(東醫寶鑑)" were analysed. 3. Results and Conclusions 1) Early phase of Ulgwang symptomatic pattern(鬱狂證 初證) and of Mangyang symptomatic pattern(亡陽證初證) of Kidney Heat-based Exterior Heat disease(腎受熱表熱病), a category of Soeumin(少陰人) diseases, were described by adopting pathologic models of Taeyang-sangpung symptomatic pattern(太陽傷風證) and Sanghan-hyeol symptomatic pattern(傷寒血證) from "Sanghanlun(傷寒論)". 2) Soyang-sangpung symptomatic pattern(少陽傷風證) of Spleen Cold-based Exterior Cold diseae (脾受寒表寒病) and Hyunggyeok-yeol symptomatic pattern(胸膈熱證) of Stomach Heat-based Interior Heat disease(胃受熱裏熱病), categories of Soyangin(少陽人) diseases, were described by adopting pathologic models of Taeyang-yangsangpunghan symptomatic pattern(太陽兩傷風寒證), Soyang-sangpung symptomatic pattern(少陽傷風證) and Tayangbyong-sahak symptomatic pattern(太陽病似瘧證) from "Sanghanlun(傷寒論)". 3) Baechu-pyo symptomatic pattern(背顀表病輕證) and Hangual symptomatic pattern(寒厥證) of Esophagus Cold-based Exterior Cold disease(胃脘受寒表寒病), a category of Taeeumin(太陰人) diseases, was described by adopting pathologic models of Taeyang-sanghan symptomatic pattern(太陽傷寒證) and Hangual symptomatic pattern(寒厥證) from "Sanghanlun(傷寒論)". 4) Je-Ma Lee reinterpreted various diseases classified as Taeyang disease(太陽病) with the pathologic perspective of Sa-sang Constitutional Medicine. Different from existing medicine, diseases were analysed and treated by the standard, constitution of the patient.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1111-1116
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• 2015

Background: To investigate the relationship between pathologic tumor response to concurrent chemoradiotherapy and variation of serum VEGF in patients with esophageal cancer. Materials and Methods: Forty six patients with esophageal cancer who were treated with concurrent chemo-radiotherapy were enrolled. Endoscopic and pathologic examination was conducted before and four weeks afterwards. Serum level of VEGF was documented before, four weeks later and after chemo-radiotherapy. The relationship between pathologic response and the variation of serum level of VEGF and its influence on the prognosis were investigated. Results: Serum level of VEGF decreased remarkably during and after chemo-radiotherapy in patients whose pathologic response was severe (F=5.393, 4.587, P(0.05). There were no statistical differences of serum VEGF level before, during and after chemo-radiotherapy for patients whose pathologic response was moderate or mild. There were 18 (85.7%), 7 (53.8%) and 6 patients (50.0%) whose serum VEGF level dropped in the severe, moderate and mild group, respectively, with significant differences among these groups (p=0.046). Two year survival rates of patients with severe, moderate and mild pathologic response were 61.9%, 53.8% and 33.3% respectively, and no statistically difference between severe and mild group regarding OS (p=0.245) was tested. Conclusions: Tumor pathologic response during chemo-radiotherapy and the changes of serum VEGF lever could predict curative effects of chemo-radiotherapy in patients with esophageal cancer.

• Korean Journal of Radiology
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• v.24 no.7
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• pp.626-639
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• 2023

Objective: To investigate the association of clinical, pathologic, and magnetic resonance imaging (MRI) variables with progressive disease (PD) during neoadjuvant chemotherapy (NAC) and distant metastasis-free survival (DMFS) in patients with triple-negative breast cancer (TNBC). Materials and Methods: This single-center retrospective study included 252 women with TNBC who underwent NAC between 2010 and 2019. Clinical, pathologic, and treatment data were collected. Two radiologists analyzed the pre-NAC MRI. After random allocation to the development and validation sets in a 2:1 ratio, we developed models to predict PD and DMFS using logistic regression and Cox proportional hazard regression, respectively, and validated them. Results: Among the 252 patients (age, 48.3 ± 10.7 years; 168 in the development set; 84 in the validation set), PD was occurred in 17 patients and 9 patients in the development and validation sets, respectively. In the clinical-pathologic-MRI model, the metaplastic histology (odds ratio [OR], 8.0; P = 0.032), Ki-67 index (OR, 1.02; P = 0.044), and subcutaneous edema (OR, 30.6; P = 0.004) were independently associated with PD in the development set. The clinical-pathologic-MRI model showed a higher area under the receiver-operating characteristic curve (AUC) than the clinical-pathologic model (AUC: 0.69 vs. 0.54; P = 0.017) for predicting PD in the validation set. Distant metastases occurred in 49 patients and 18 patients in the development and validation sets, respectively. Residual disease in both the breast and lymph nodes (hazard ratio [HR], 6.0; P = 0.005) and the presence of lymphovascular invasion (HR, 3.3; P < 0.001) were independently associated with DMFS. The model consisting of these pathologic variables showed a Harrell's C-index of 0.86 in the validation set. Conclusion: The clinical-pathologic-MRI model, which considered subcutaneous edema observed using MRI, performed better than the clinical-pathologic model for predicting PD. However, MRI did not independently contribute to the prediction of DMFS.

• Hip & pelvis
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• v.34 no.2
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• pp.122-126
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• 2022

Tumoral calcinosis is a rare disease characterized by massive subcutaneous soft tissue deposits of calcium phosphate around large joints in patients with chronic kidney disease. Invasion of bone by tumoral calcinosis is rare. We experienced a case involving a femoral neck pathologic fracture due to bony invasion of tumoral calcinosis in a 46-year-old female with chronic kidney disease who had been on dialysis for 15 years. Successful outcomes were obtained by performance of total hip arthroplasty for treatment of the pathologic fracture of the femoral neck. Careful precaution is necessary to prevent pathologic fractures in patients with tumoral calcinosis around the hip joint.

• Journal of Chest Surgery
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• v.47 no.1
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• pp.13-19
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• 2014

Background: The aim of this study is to evaluate prognostic factors for survival in pathologic stage IIIA/N2 non-small-cell lung cancer (NSCLC), to identify the prognostic significance of the metastatic patterns of mediastinal lymph nodes (MLNs) relating to survival and to recurrence and metastasis. Methods: A total of 129 patients who underwent radical resection for pathologic stage IIIA-N2 NSCLC from July 1998 to April 2011 were retrospectively reviewed. The end points of this study were rates of loco-regional recurrence and distant metastasis, and survival. Results: The overall 5-year survival rate was 47.4%. A univariate analysis showed that age, pathologic T stage, and adjuvant chemotherapy were significant prognostic factors, while in multivariate analysis, pathologic T stage and adjuvant chemotherapy were significant prognostic factors. The metastasis rate was higher in patients with multi-station N2 involvement and with more than 3 positive MLNs. Further, non-regional MLN metastasis was associated with a higher loco-regional recurrence rate. Conclusion: Pathologic T stage and adjuvant chemotherapy were independent prognostic factors for long-term survival in pathologic stage IIIA/N2 NSCLC. The recurrence and the metastasis rate were affected by the metastatic patterns of MLNs. These results may be helpful for planning postoperative therapeutic strategies and predicting outcomes.

• The Journal of Korean Medicine
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• v.38 no.3
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• pp.111-123
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• 2017

Objectives: To develop and investigate the reliability of the pathologic aging scale based on korean medical theory and korean medical pattern identification for dementia. Methods: We searched the textbook of korean neurophychiatry and Donguibogam and selected items through professional consensus. We compared between dementia(n=40) and normal elderly(n=38) and tested the reliability of two scales. Results: After professional consensus, we drafted the Korean Medical Pathologic Aging Scale(12 items, Likert 3 scale) and Korean Medical Pattern Identification for Dementia(4 patterns, 28 items, Likert 5 scale). On Korean Medical Pathologic Aging Scale, There is no significant difference between two groups. We had good internal consistency(Cronbach's alpha = 0.6) and test-retest reliability(r=0.631) but low inter-rater reliability(r=0.430). On Korean Medical Pattern Identification for Dementia, dementia patients diagnosed with Qi deficiency are significantly more than those in normal group. We had fairly good internal consistency(Cronbach's alpha = 0.574) and excellent test-retest(kappa= .800) and inter-rater reliability(kappa = .733). Conclusions: Korean Medical Pattern Identification for Dementia is appropriate for diagnosing korean medical pattern. But Korean Medical Pathologic Aging Scale isn't appropriate to discriminate dementia from normal elderly because of many subjective items. Therefore objective measurement of sensory dysfunction would be needed to measure pathologic aging based on korean medical theory.