• Korean Journal of Veterinary Research
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• v.33 no.4
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• pp.747-751
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• 1993

During the period from April 1991 to July 1992 clinical, hematological, and pathohistological findings of Holstein-friesian calves 47 with bovine leukocyte adhesion deficiency(BLAD, immunologically ascertained), which were referzed to the clinic for diseases of cattle, veterinary school, Hannover, were described. Most cases show poor body condition, rough and dry in haircoat, salivation, gingivitis, reduction of gingiva and alveolar bone, exposing the incisors' necks, loss of teeth, phlegmonous subcutaneous swellings, ulcerated tongue, recurang fever, coughing, dyspnea, pharyngeal and laryngeal stertor, periodical diarrhea, impaired swallowing, placid and less painsensitive. Relevant laboratory findings are persistent leucocytosis(with more than 30,000 up to 150,000 cells per $mm^3$ of blood), marked neutrophilia(without "shift to the left"), hyperproteinemia, and hypergammaglobulinemia. At post-mortem the carcass of BLAD-affected calves is usually emaciated. All lymphnodes of the respiratory and gastrointestinal tract appear markedly activated(swollen). Lesions in the mouth(gingivitis, defective dentition, pulpitis/alveolar paraodontitis, ulcerated tongue), throat and larynx(inflammation/ulceration), and lungs(pneumonic foci) correspond to the clinical symptoms seen on the living animal. There may be ulcers on the prestomachal mucosa, hyperemia of the intestinal mucosa with hyperplasia of Peyer's patches, ulceration and/or intramural abscesses. The spleen shows follicular hyperplasia. Microscopically, both myeloand erythropoesis are markedly activated in the bone marrow ; capillaries in many organs show leucocytostasis.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.10
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• pp.4393-4399
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• 2015

Background: To explore the independent prognostic factors for the recurrence/metastasis of patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). Materials and Methods: A total of 604 patients initially diagnosed as LANPC by pathohistology in Fujian Provincial Cancer Hospital were selected to analyze the relationship between the clinical pathological patterns, therapeutic protocols and clinical stages with the recurrence/metastasis of LANPC. Results: The 1-, 3- and 5-year locoregionally recurrent rates of LANPC patients were 2.0%, 9.5% and 12.9% respectively, with average recurrent period being 78 months. Univariate analysis results indicated that clinical stages had certain influence on the recurrent period of LANPC patients. However, COX regression models showed that ages, genders and clinical stages were not the independent prognostic factors influencing the recurrence. The 1-, 3- and 5-year metastatic rates of LANPC patients were 6.6%, 17.5% and 18.8% respectively, with average metastatic period of 73 months. Univariate analysis results demonstrated that ages, N stages, clinical stages, locations of lymph node, retropharyngeal lymph node and extracapsular invasion of lymph node had certain influence on the metastatic period of LANPC patients. Additionally, further COX regression analysis results suggested that T stages, reduction protocols and extracapsular invasion of lymph node were the independent prognostic factors influencing the metastasis of patients with LANPC, in which T stages and extracapsular invasion of lymph node were the pestilent factors while reduction protocols the protective factor. Conclusions: Induction chemotherapy is beneficial to LANPC patients with initial treatment, and the metastatic rate decreases greatly after the application of reduction chemotherapy.

• Development and Reproduction
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• v.23 no.3
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• pp.255-262
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• 2019

Previously, we reported negative effects of low-dose nonylphenol (NP) exposure on the reproductive organs of F1 male mice. In the present study was further investigated the endocrine disrupting effect of NP exposure to F2 generation male mice. Mice were divided into 2 groups; (1) CON, control animals and (2) NP-50 ($50{\mu}g/L$), animals were treated with NP via drinking water. NP exposures were continuously conducted from parental pre-mating period until the postnatal day (PND) 55 of F2 offsprings. Mice were sacrificed on PND 55 and the reproductive tissue weights were measured. The initial (at PND 21) and terminal (PND 55) body weights of the NP-50 group animals were not significantly different from those of control group animals. NP exposure fail to induce a significant weight change of the testes, seminal vesicle and prostate except absolute epididymal weight (p<0.05). However, pathohistological studies revealed that NP-treated F2 animals showed evident decrease in seminiferous tubule diameters, reduced luminal area and number of germ cells. Also, sloughing morphologies in the tubules were notable. In the caudal epididymis, fewer mature sperms and swollen epithelial cells were found in the NP-treated group. The present study demonstrated that the subchronic low-dose NP exposure induced pathohistological abnormalities in testis and epididymis of F2 mice, and we assumed that these 'qualitative' changes in reproductive tissues could be derived from the epigenetic modifications such as DNA methylation, histone modification, altered DNA accessibility and chromatin structure. Further studies are needed to achieve a better understanding on the multi- or trans-generational effects of NP on the reproductive health and a human application.