• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제20권1호
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• pp.23-28
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• 2009

Objectives : This study was conducted to investigate the association between the symptoms of boys with attention-deficit hyperactivity disorder (ADHD) and the attention-deficit hyperactivity symptoms, temperament and character patterns of their parents. Methods : Forty-five boys with ADHD and who met the DSM-IV criteria were evaluated by using the ADHD rating scale (ADHD-RS), and their parents completed the Korean Adult ADHD scale (K-AADHDS) and the Temperament and Character Inventory (TCI). Results : The parental K-AADHDS scores were not associated with the ADHD-RS total score and the subscale scores of their siblings. The most potent variable related to the ADHD-RS total score was the maternal self-directedness, and the second was the maternal persistence. The maternal self-directedness was the variable that was most correlated with the hyperactivity/impulsivity subscale scores of the ADHD-RS. Conclusion : The results suggest that the paternal ADHD symptoms may not be related to the ADHD symptoms of boys with ADHD. Higher maternal self-directedness and persistence may decrease overall the ADHD symptoms of these boys, and higher maternal self-directedness itself may predict lower hyperactivity/impulsivity symptoms of the boys with ADHD.

• 한국조사연구학회지:조사연구
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• 제13권1호
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• pp.89-112
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• 2012

본 연구는 세대간 애정적 결속의 양상과 결정요인을 부계와 모계로 구분하여 분석하고자 하였다. 세대간의 경제적, 도구적 정서적 지원을 통한 기능적 결속이나 잦은 만남 내지 연락을 통한 교류적 결속 거주지의 근접성을 바탕으로 한 구조적 결속의 양상과 변화에 대한 연구들과 달리 세대간 친밀감을 나타내는 애정적 결속에 대한 연구는 부족한 편이었다. 본 연구에서는 손자녀가 조부모에 대해 느끼는 정서적 친밀감을 종속변수로 하여 애정적 결속이 어떻게 나타나는지 살펴보고자 하였다. 또한 앞서 언급한 기능적, 교류적, 구조적 결속같은 요인들이 어떻게 애정적 결속에 영향을 미치는지를 살펴보고자 하였다. 이를 위하여 2011년 7월에 조사된 세대별 문화경험과 문화인식에 관한 설문조사에서 자녀가 있는 기혼이면서 양가 부모중 적어도 한분씩은 생존해 있는 30~59세 응답자 330명을 대상으로 분석하였다. 방법론으로는 '양가 조부모에게 느끼는 친밀감이 같다'라는 응답을 준거집단으로 삼은 다항로짓회귀분석을 사용하여 부계와 모계간에 변수별 영향력이 어떻게 다르게 나타나는지 보았다. 그 결과 부계에서는 경제적 지원 관계가 애정적 결속을 높이는 주요한 요인으로 드러난 반면, 모계에서는 경제적 지원뿐 아니라 도구적, 정서적 지원도 주요한 요인으로 작용하고 있음을 확인할 수 있었다.

• Journal of Genetic Medicine
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• 제2권1호
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• pp.41-47
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• 1998

Human uniparental gestations such as gynogenetic ovarian teratomas provide a model to evaluate the integrity of parent-specific gene expression - i.e. imprinting - in the absence of a complementary parental genetic contribution. The few imprinted genes characterized so far include the insulin-like growth factor-2 gene (IGF2) coding for a fetal growth factor and H19 gene whose normal function is unknown but it is likely to act as an mRNA. IGF2 is expressed by the paternal allele and H19 by the maternal allele. This reciprocal expression is quite interesting because both H19 and IGF2 genes are located close to each other on chromosome 11p15.5. In situ RNA hybridization analysis has shown variable expression of the H19 and IGF2 alleles according to the tissue origin in 11 teratomas. Especially, Skin, derivative of ectoderm, is expressed conspicuously. We examined imprinting of H19 and IGF2 in teratomas using PCR and RT-PCR of exonic polymorphism. H19 and IGF2 transcript could be expressed either biallelically or monoallelically in the teratomas. Biallelic expression (i.e., loss of imprinting) of IGF2 occurred in 5 out of 6 mature teratomas and 1 out of 1 immature teratoma. Biallelic expression of H19 occurred in 4 out of 10 mature teratomas and 1 out of 1 immature teratoma. Expression levels of H19 and IGF2 transcript using the semi-quantitative RT-PCR had no relation between monoallelic and biallelic expression. Moreover, IGF2 biallelic expression did not affect allele-specificity or levels of H19 expression. These results demonstrate that both genes, H19 and IGF2, can be imprinted, expressed and regulated independently and individually of each other in ovarian teratoma.

• 한국가축번식학회지
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• 제27권4호
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• pp.309-315
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• 2003

DNA methylation at CpG sites, which is a epigenetic modification, is associated with gene expression without change of DNA sequences. During early mouse embryogenesis, dynamic changes of DNA methylation occur. In this study, DNA methylation patterns of porcine embryos produced in vivo and in vitro were examined at various developmental stages by the immunocytochemical staining method. Interestingly, active demethylation was not observed on the paternal pronucleus of porcine zygotes. However, differences were detected in the passive demethylation process between in vivo and in vitro embryos. There was no change in the DNA methylation state until the blastocyst stage of in vivo embryos, whereas partial demethylation was observed in several blastomeres from a 4 cell stage to a morula stage of in vitro embryos. The whole genome of inner cell mass (ICM) and trophectoderm (TE) cells in porcine blastocysts were evenly methylated without de novo methylation. Our findings demonstrate that genome-wide demethylation does not occur in pig embryos during preimplantation development unlike murine and bovine embryos. It indicates that the machinery regulating epigenetic reprogramming may be different between species.

• Asian-Australasian Journal of Animal Sciences
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• 제28권8호
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• pp.1066-1074
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• 2015

In contrast to high genetic diversity of mitochondrial DNA (mtDNA), equine Y chromosome shows extremely low variability, implying limited patrilines in the domesticated horse. In this study, we applied direct sequencing and restriction fragment length polymorphism (RFLP) methods to investigate the polymorphisms of 33 Y chromosome specific loci in 304 Chinese indigenous horses from 13 breeds. Consequently, two Y-single nucleotide polymorphisms (SNPs) (Y-45701/997 and Y-50869) and one Y-indel (Y-45288) were identified. Of those, the Y-50869 (T>A) revealed the highest variation frequency (24.67%), whereas it was only 3.29% and 1.97% in Y-45288 (T/-) and Y-45701/997 (G>T) locus, respectively. These three mutations accounted for 27.96% of the total samples and identified five Y-SNP haplotypes, demonstrating genetic diversity of Y chromosome in Chinese horses. In addition, all the five YSNP haplotypes were shared by different breeds. Among 13 horse breeds analyzed, Balikun horse displayed the highest nucleotide diversity (${\pi}=5.6{\times}10^{-4}$) and haplotype diversity (h = 0.527), while Ningqiang horse showed the lowest nucleotide diversity (${\pi}=0.00000$) and haplotype diversity (h = 0.000). The results also revealed that Chinese horses had a different polymorphic pattern of Y chromosome from European and American horses. In conclusion, Chinese horses revealed genetic diversity of Y chromosome, however more efforts should be made to better understand the domestication and paternal origin of Chinese indigenous horses.

• Journal of Nutrition and Health
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• 제35권1호
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• pp.69-77
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• 2002

The purpose of this study was to determine the probability of overweight throughout childhood in relation to the presence of overweight at birch or in early childhood, and presence of overweight in children's parents. Weight and height measures were collected at birth and at ages of 7, 10, 12 years from 655 6th grade primary schoolchildren. Childhood overweight was defined as a body mass index at or above the 85th percentile for age and sex, and overweight in children's parents as a body mass index at or above 27. The prevalence of overweight increased with age of the children. Overweight at birth was not associated with overweight at 12 years of ages. However, overweight at 12 years old was already related to overweight at 7 years old. In comparison to non-overweight peers, overweight children at ages 7(OR = 7.64, 95% CI = 4.32-13.51) and 10 years(OR = 19.69, 95% CI = 11.42-33.94) had a higher rick of becoming overweight at 12 years of age. Among children who was overweight at age 7years, 60.7% remained overweight 5 years later, Yearly increment in BMI of overweight children was larger than that of non-obese children (1.15-1.65kg/m$^2$vs 0.50-0.71kg/m$^2$. As compared with the lower case in mealy increment of BMI, the probability of being overweight at age of 12 years was greater in higher case. BMI values at age 7years were positively correlated with BMI values at age of 10 and 127ear,i, and with annual increments in BMI. But those relationships with birth weight were not observed. Children were at greater risk for overweight if at least ogle parent was overweight. The odds ratio for child overweight associated with maternal overweight was 2.41(95% CI = 1,13-5.IS), and those associated with paternal overweight 1.70(95% CI = 0.92-3.17). And parents' BMIs were positively correlated with children's BMI values and yearly BMI increment. In conclusion, overweight at early childhood and annual inclement in BMI can be important in predicting the prevalence of overweight and the risk that overweight will remain after 7 years of age. The risk of being overweight throughout the childhood increases by the parents'overweight.

• Asian-Australasian Journal of Animal Sciences
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• 제18권10호
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• pp.1475-1478
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• 2005

Statistical analysis was conducted on sow stillbirth traits of three genotypes with 2,400 litters including the Erhualian, Large White and the $F_1$ cross of these two breeds. Number of stillborn piglets per litter in the Erhualian, Large White and the $F_1$ averaged 0.85, 0.31 and 0.70, and percentage born alive averaged 95.0%, 97.0% and 95.5%, respectively. Erhualian sows with a greater litter size also had a higher stillbirth rate. Results of analysis of variance indicated that genotype, parity, farrowing year${\times}$farrowing season interaction and total number born had highly significant effects on both number of stillborn piglets per litter and percentage born alive in sows (p<0.0001). Farrowing year had no significant effect on number of stillborn piglets per litter (p>0.05), and highly significant effect on percentage born alive (p<0.01). Farrowing season had highly significant effects on both number of stillborn piglets per litter and percentage born alive (p<0.01). From parity one to parity ten, least squares means for number of stillborn piglets per litter progressively increased with increasing parity and least squares means for percentage born alive progressively decreased with increasing parity. Sows that farrowed in winter had the highest number of stillborn piglets per litter and the lowest percentage born alive, sows that farrowed in autumn had the lowest number of stillborn piglets per litter and the highest percentage born alive. With increasing total number born, least squares means for number of stillborn piglets per litter markedly increased and least squares means for percentage born alive markedly decreased. Results from analysis of paternal half sibs indicated that the heritabilities for number of stillborn piglets per litter and percentage born alive were 0.110 and 0.124, and the genetic, phenotypic and environmental correlations between them were -0.989, -0.951 and -0.948, respectively. These results indicated that number of stillborn piglets per litter and percentage born alive were traits with the similar genetic background.

• 한국콘텐츠학회논문지
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• 제15권9호
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• pp.374-383
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• 2015

본 연구의 목적은 우리나라 다문화가족과 일반가족 청소년의 주관적 구강증상을 알아보고, 건강형평성 확보를 위한 정책결정과정에 있어서 기초자료를 제공하고자 하는 것이다. 본 연구는 제10차(2014년)청소년건강행태 온라인조사의 원시자료를 이용하였으며, 만 12-18세 청소년 총 66,857명을 연구대상자로 선정하였다. 주관적 구강증상 여부를 종속변수로 한 로지스틱 회귀분석 결과 모든 변수가 보정된 상태에서 성별, 연령, 학업성적, 아버지의 교육수준, 어머니의 교육수준, 주관적 경제 상태, 거주형태, 흡연여부, 음주여부, 하루 탄산음료 섭취빈도, 하루 과일 섭취빈도, 하루 과자 섭취빈도 및 하루 칫솔질 횟수가 주관적 구강 증상 여부와 유의한 관련성이 있는 것으로 나타났다(p<0.05). 따라서 앞으로 다문화가족 관련 복지와 보건 서비스 사업을 점층적으로 확대함과 동시에 그 수가 증가하는 다문화 청소년에 초점을 맞춰 실시되어야 한다.

• 한국학교ㆍ지역보건교육학회지
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• 제7권
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• pp.33-49
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• 2006

Background & Objectives: This study was designed to examine relationships between smoking behavior and smoking attitudes among 6th-grade students in Korea in order to provide knowledge on school-based programs for preventing adolescent smoking behaviors. Methods: Questionnaires were administered to 464 students attending three public elementary schools in O city from June 13 to June 16, 2006. The total sample size is 458 (response rate = 98.7%). Data were statistically analyzed by frequency analysis, cross tabulation, and multiple regression. Results: First, smoking behavior was significantly influenced by the factors of gender, self-concept, family structure, sibling smoking, school achievement, relationship with teachers, satisfaction with school life, and smoking friends. Theprevalence of ever-smoking was 12.7% among 6th grade students in this study. Students were most likely to initiate smoking in the 5thgrade with curiosity and smoke at their own home. Second, students showed negative attitude toward smoking overall. From the detailed section, students respondednegatively about smoking in public places while they thought that adult smoking with moderate level was okay. Student who showed positive attitudes toward smoking in the present study were significantly related to the factors of self-concept, family environment, parental and sibling smoking status, school achievement, satisfaction with school life, and smoking friends. Third, Students who had tried cigarette smoking were likely to report less negative attitudes toward tobacco than non-smoking students. Fourth, this study found that smoking friends were the most significant predictor of positives smoking attitudes. Other factors significantlyassociated with smoking attitudes were gender, relationship with friends, self-concept, relationship with teachers, paternal smoking status. Conclusions: The study results suggest that smoking prevention programs focus on resisting peer influence and need to be community-incorporated and/or comprehensive from elementary to high school.

• 아동학회지
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• 제7권1호
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• pp.1-23
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• 1986

The present study investigated the current child care practices of professional working mothers in Korea and their needs for substitute child care outside the home. Three hundred twenty-two professional working mothers who have children under 6 years of age in Seoul, Pusan, Taegu, and Taejon were surveyed with the use of a questionnaire. It was found that during their working hours, most of the professional working mothers put their children in the care of either the paternal or the maternal grandmothers. Others put the children in the care of a full-time housekeeper or a part-time housekeeper. While all the mothers had worked out a way to care for their children, almost all of them would use day care if facilities were available. Specifically, 42 per cent prefer child care at their work site, 21 per cent prefer family day care, and only 3 per cent indicated that they would not use any child care facilities. Most of the working mothers think that their employer should manage the day care program. Others prefer social agency or government management. Regarding costs, most prefer that costs should be split 50-50 between the employer and the family. In addition, professional working mothers wanted quality programs with educational components rather than mere custodial care. It was concluded that variety in types of quality child care programs should be available to provide working mothers the options of choosing what they want for their children. The main type of programs suggested by this study is work site based child care for children under 3 years of age. The existing law for the Saemaul Nursery School program should be implemented so as to include programs for children under 3.