• 제목/요약/키워드: patch test

검색결과 301건 처리시간 0.029초

봉독의 인체 피부자극성 평가 (Evaluation on Skin Irritation of Bee Venom in Human)

  • 한은혜;임미경;이상호;박근태;박지은;임영희;심인숙
    • 생약학회지
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    • 제48권3호
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    • pp.202-207
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    • 2017
  • The purpose of this study was to investigate the skin irritation of bee venom (melittin) in human. Skin irritation test was performed at 0.05% bee venom by 48 h single patch test in 30 healthy volunteers with no skin disease and skin sensitization test was performed by local lymph node assay in animal. In single patch test, 28 human subjects showed no reaction and 2 subjects showed 1+ or 3+ grade skin reaction. In a skin sensitization test of bee venom conducted using mice. no erythema was observed on the dorsal side of mice up to 8 days after application of bee venom on the skin. The results of the average stimulation index by ATP values showed that there was no irritation to the mice skin at 0.005% and 0.01% of bee venom. Therefore, bee venom is not likely to induce a significant skin irritation under 0.05% concentration.

New slave-node constraints and element for adaptive analysis of C0 plates

  • Sze, K.Y.;Wu, D.
    • Structural Engineering and Mechanics
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    • 제39권3호
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    • pp.339-360
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    • 2011
  • In the h-type adaptive analysis, when an element is refined or subdivided, new nodes are added. Among them are the transition nodes which are the corner nodes of the new elements formed by subdivision and, simultaneously, the mid-side nodes of the adjacent non-subdivided elements. To secure displacement compatibility, the slave-node approach in which the DOFs of a transition node are constrained by those of the adjacent nodes had been used. Alternatively, transition elements which possess the transition nodes as active mid-side/-face nodes can be used. For C0 plate analyses, the conventional slave-node constraints and the previously derived ANS transition elements are implemented. In both implementations, the four-node element is the ANS element. With reference to the predictions of the transition elements, the slave-node approach not only delivers erroneous results but also fails the patch test. In this paper, the patch test failure is resolved by developing a set of new constraints with which the slave-node approach surpasses the transition-element approach. The accuracy of the slave-node approach is further improved by developing a hybrid four-node element in which the assumed moment and shear force modes are in strict equilibrium.

자기변형 패치 트랜스듀서를 이용한 비자성 축의 비틀림 모달 테스팅 (Torsional modal testing of a non-ferromagnetic shaft by magnetostrictive patch transducers)

  • 조승현;한순우;박찬일;김윤영
    • 한국소음진동공학회:학술대회논문집
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    • 한국소음진동공학회 2006년도 춘계학술대회논문집
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    • pp.1159-1164
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    • 2006
  • Torsional vibration is an important vibration mode when shafts, cylinders and pipes are considered. However, the modal testing of torsional vibrations is not an easy job to carry out because of the lack of proper transducers. This work presents a new torsional vibration transducer based on the magnetostrictive principle and its application to torsional modal testing. The transducer is so designed as to generate/measure only torsional vibrations excluding other vibration modes such as longitudinal and bending vibrations. The transducer is composed of ferromagnetic patches bonded to a test structure, permanent magnets, and a solenoid. Though patches and magnets are bonded to a structure, torsional vibrations are generated and measured wirelessly by a solenoid encircling a test structure. The proposed transducer works even at considerably high frequencies, say, tens of kilohertz. Furthermore, the transducer can be manufactured at a low price. To check the performance of the proposed method, the torsional modal testing on a hollow aluminum shaft was conducted. The results, such as eigenfrequencies, obtained by the proposed transducer agreed favorably with theoretical results.

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요철 형상의 스테인레스강 Z-핀으로 보강된 복합재 접합 구조물의 피로강도 (Fatigue Strength of Composite Joint Structures Reinforced by Jagged Shaped Stainless Steel Z-pins)

  • 최익현;임철호
    • 한국항공우주학회지
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    • 제41권12호
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    • pp.967-974
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    • 2013
  • 저자는 최근 산업체 생산 현장에서 Z-피닝 복합재 구조물을 간편하게 제작할 수 있는 Z-피닝 패치 개념을 제안하였고, 이를 적용하여 복합재 단일-겹침 전단 접합시편을 제작하였으며, 정적시험을 통하여 54~68%의 접합강도의 향상을 발표하였다. 본 연구는 상기 연구의 후속으로서, 반복하중에 대한 접합강도의 향상을 측정하기 위하여 피로시험을 수행하였다. 사용된 Z-핀은 스테인레스강 핀이며, 복합재료와의 결합력을 증가시키기 위하여 표면을 요철 형상으로 가공하였으며, 화학적으로 부식시켰다. 반복하중 조건에서 접합강도는 약 98~125% 향상되었다.

자기변형 패치 트랜스듀서를 이용한 비자성 축의 비틀림 모달 테스팅 (Torsional Modal Testing of a Non-ferromagnetic Shaft by Magnetostrictive Patch Transducers)

  • 조승현;한순우;박찬일;김윤영
    • 한국소음진동공학회논문집
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    • 제16권8호
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    • pp.879-885
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    • 2006
  • Torsional vibration is an important vibration mode when shafts, cylinders and pipes are considered. However, the modal testing of torsional vibrations is not an easy task to carry out because of the lack of proper transducers. This work presents a new torsional vibration transducer based on the magnetostrictive principle and its application to torsional modal testing. The transducer is so designed as to generate/measure only torsional vibrations excluding other vibration modes such as longitudinal and bending vibrations. The transducer is composed of ferromagnetic patches bonded to a test structure, permanent magnets, and a solenoid. Though patches and magnets are bonded to a structure, torsional vibrations are generated and measured wirelessly by a solenoid encircling a test structure. The proposed transducer works even at considerably high frequencies, say, tens of kilohertz. Furthermore, the transducer can be manufactured at a low price. To check the performance of the proposed method, the torsional modal testing on a hollow aluminum shaft was conducted. The results, such as eigenfrequencies, obtained by the proposed transducer agreed favorably with theoretical results.

평면형 패치 안테나의 최적설계를 위한 PSO와 APSO 알고리즘 비교 연구 (A Comparative Study on the PSO and APSO Algorithms for the Optimal Design of Planar Patch Antennas)

  • 김군태;김형석
    • 전기학회논문지
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    • 제62권11호
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    • pp.1578-1583
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    • 2013
  • In this paper, stochastic optimization algorithms of PSO (Particle Swarm Optimization) and APSO (Adaptive Particle Swam Optimization) are studied and compared. It is revealed that the APSO provides faster convergence and better search efficiency than the conventional PSO when they are adopted to find the global minimum of a two-dimensional function. The advantages of the APSO comes from the ability to control the inertia weight, and acceleration coefficients. To verify that the APSO is working better than the standard PSO, the design of a 10GHz microstrip patch as one of the elements of a high frequency array antenna is taken as a test-case and shows the optimized result with 5 iterations in the APSO and 28 iterations in th PSO.

텍스쳐 추출시 제한된 수의 참여 영상을 이용한 multi-view 영상 개선 알고리즘 (An algorithm for the multi-view image improvement with the restricted number of images in texture extraction)

  • 김도현;양영일
    • 대한전자공학회:학술대회논문집
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    • 대한전자공학회 1998년도 하계종합학술대회논문집
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    • pp.773-776
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    • 1998
  • In this paper, we propose an efficient multi-view images coding algorithm which finds the optimal texture from the restricted number of multi-view images. The X-Y plane of the normalized object space is divided into triangular patches. The depth value of the node is determined by applying the block based disparity compensation method and then the texture of the each patch is extracted by applying the affine transformation patch is extracted by applying the affine transformation based disparity compensation method to the multi-view images. We restricted the number of images contributed to determining the texture comapred to traditional methods which use all the multi-view images in the texture extraction. Experimental results show that the SNR of images encoded by the proposed algorithm is better than that of imaes encoded by the traditional method by the amount about 0.2dB for the test sets of multi-view images called dragon, kid, city and santa. The recovered images from the encoded data by the proposed method show the better visual images than the recovered images from the encoded data by the traditional methods.

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동적 Range 검출에 의한 원료 Pile 형상 관리 시스템 (Profile Management System of Material Piles by Dynamic Range Finding)

  • 안현식
    • 융합신호처리학회 학술대회논문집
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    • 한국신호처리시스템학회 2000년도 하계종합학술대회논문집
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    • pp.333-336
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    • 2000
  • In this paper, a profile management system consisting of global and local range finders is presented for the automat ion of material pile handling. A global range finder detects range data of the front part of the piles of material and a profile map is obtained from a 3D profile detection algorithm. A local range finder attached on the side of the arm of the reclaimer detects range data with the handling function dynamically, and a local profile patch is acquired from the range data A yard profile map manager constructs a map by using the 3D profile of the global range finder and revises the map by replacing it with the local profile patch obtained Iron the local range finder. The developed vision system was applied to a simulator and the results of test show that it is appropriate to use for automating the material handling.

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몰입형 비디오 부호화를 위한 패치 패킹 정보의 효율적인 표현 (Efficient Representation of Patch Packing Information for Immersive Video Coding)

  • 임성균;윤용욱;김재곤
    • 한국방송∙미디어공학회:학술대회논문집
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    • 한국방송∙미디어공학회 2021년도 추계학술대회
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    • pp.126-128
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    • 2021
  • MPEG(Moving Picture Experts Group) 비디오 그룹은 사용자에게 움직임 시차(motion parallax)를 제공하면서 3D 공간 내에서 임의의 위치와 방향의 시점(view)을 렌더링(rendering) 가능하게 하는 6DoF(Degree of Freedom)의 몰입형 비디오 부호화 표준인 MIV(MPEG Immersive Video) 표준화를 진행하고 있다. MIV 표준화 과정에서 참조 SW 인 TMIV(Test Model for Immersive Video)도 함께 개발하고 있으며 점진적으로 부호화 성능을 개선하고 있다. TMIV 는 여러 뷰로 구성된 방대한 크기의 6DoF 비디오를 압축하기 위하여 입력되는 뷰 비디오들 간의 중복성을 제거하고 남은 영역들은 각각 개별적인 패치(patch)로 만든 후 아틀라스에 패킹(packing)하여 부호화되는 화소수를 줄인다. 이때 아틀라스 비디오에 패킹된 패치들의 위치 정보를 메타데이터로 압축 비트열과 함께 전송하게 되며, 본 논문에서는 이러한 패킹 정보를 보다 효율적으로 표현하기 위한 방법을 제안한다. 제안방법은 기존 TMIV10.0 에 비해 약 10%의 메타데이터를 감소시키고 종단간 BD-rate 성능을 0.1% 향상시킨다.

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항산화력이 우수한 Fructose 1,6-diphosphate(FDP)를 피부적용제로 응용하기 위한 안전성 평가 (The Safety Evaluation of a Potent Antioxidant, Fructose 1,6-diphosphate(FDP), for the Skin Application)

  • 김배환;이병석;정경미;안수미;안수선;심영철
    • Toxicological Research
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    • 제18권3호
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    • pp.267-273
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    • 2002
  • Fructose 1,6-diphosphate(FDP), a glycolytic metabolite, is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FDP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart, and may play a protective role in ultraviolet B (UVB, 280~320 nm)-injured keratinocyte by attenuating prostaglandin (PG)-E$_2$production and cyclooxygenase (COX)-2 expression, which are possibly through blocking the intracellular reactive oxygen species (ROS) accumulation. Therefore FDP is considered to act as a potent antioxidant especially in the skin. We conducted the several safety tests (single-dose toxicity, primary skin irritation test, eye irritation test, skin sensitization test, phototoxicity test, photosenitization test and human patch test) to see if FDP is safe in case used for the skin application. Our data obtained hitherto suggest that FDP is very safe if applied to the skin.